Genetical Genomics of Mutational Variance (2010)

Genetic variation in natural populations is epitomized by two fundamental but contradictory observations; genetic variation in individual traits is ubiquitous, and yet natural and sexual selection that should deplete genetic variation is also strong. Reconciling this conflict has been a long-standing aim of evolutionary genetics over the last 30 years. Using measurements of the mutational variance in gene expression that accumulates in the presence and absence of selection, I will test if selection preferentially depletes genetic variance generated by highly pleiotropic mutations, thus explaining why genetic variation can be high in trait combinations not under strong selection, and low in trait combinations that are.'',
Grant type:
ARC Future Fellowships
Funded by:
Australian Research Council