Early formation of the preplate establishes the cerebral cortex (2014–2016)
The cerebral cortex is arguably the most complex area of the brain due to its ability to process and integrate a wide variety of information in a seamless manner. To understand how this occurs, it is essential to understand how the cerebral cortex is built during embryonic life. Here, we focus on the formation of the very earliest neurons of the cortex, called preplate neurons. We have developed a new model for preplate development and here test this model with regards to their origin (aim 1), and their function in formation of the cerebral cortex (aim 2), as well as the molecular mechanisms underlying their development (aim 3). This work provides a developmental framework for understanding how the cerebral cortex is established.