Herpesvirus entry into mammalian hosts

Abstract:: Herpesviruses infect most mammals and cause much chronic disease. Our poor understanding of their host entry pathways limits infection control. I have identified the olfactory neuroepithelium as a key entry portal for both a murid herpesvirus and a human pathogen, Herpes simplex virus, suggesting that many herpesviruses use this route. Virions cross the olfactory mucus on neuronal cilia, then either infect neurons or transfer to glial cells for local spread. I will identify key receptor interactions and map the extent of invasion. By advancing our basic understanding of these important viruses and their uptake at an abundantly exposed but little explored anatomical site, I can establish a basis for vaccinating against chronic disease.
Grant type:: ARC Future Fellowships
Funded by:: Australian Research Council

The University of Queensland