Controlling the adhesome to regulate cell fate on biomaterials (2014–2016)

Abstract:
Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. In this proposal, we will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how we may manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering.
Grant type:
ARC Discovery Projects
Researchers:
  • Head of School
    School of Chemical Engineering
    Faculty of Engineering, Architecture and Information Technology
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council