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The functional impact of new genes acquired through retrotransposition (2015–2018)

Abstract:
Novel copies of genes often arise through retrotransposition of processed messenger RNAs. Many thousands of gene copies have arisen over evolutionary time and some of these have retained functionality while diverging from the parental gene leading to new paralogs under different regulatory regimes. Through analysis of whole-genome sequence data, we are now able to identify very recent gene copies that are not present in the reference genomes for various species, giving us the opportunity to explore the effects of new copies on the regulation of the original gene and the surrounding genomic environment into which the new copy inserted. We propose to address these important open questions through computational and biochemical approaches.
Grant type:
ARC Discovery Early Career Researcher Award
Researchers:

  • Dr Adam Ewing

    Honorary Associate Professor
    Mater Research Institute-UQ
    Faculty of Medicine
Funded by:
Australian Research Council