Deciphering novel control mechanisms in the skin (2015–2017)
The overall aim of this proposal is to understand the cellular mechanisms that maintain skin integrity, and in
particular, the role of a novel population of regulatory cells in mediating this process. This is important for our
understanding of fundamental physiological interactions in the skin. The proposed research will uncover
essential new information regarding a recently discovered population of regulatory cells, with particular
respect to understanding their mechanisms of action. The outcomes of this work will therefore provide
fundamental new knowledge of skin physiology and lead to novel insights regarding how skin integrity may
be maintained following the disruption of homeostasis mechanisms.