Single molecule imaging laboratory (ARC LIEF project administered by UNSW) (2014–2015)
The goal of the proposal is to establish a single molecule imaging laboratory to close the century-old gap between structural imaging and cellular imaging. Utilising the expertise of the ARC Centre of Excellence in Advanced Molecular Imaging, we will design, build and apply three microscopes that go beyond the current commercial solutions for single molecule localisation microscopy (PALM, STORM) and perform single molecule imaging (i) deep inside cells and tissue, (ii) with fast acquisition rate to monitor highly dynamic molecular events, and (iii) improved precision to image molecules and complexes in intact cells with . 1nm resolution. There is no comparable imaging facility in the world.