Centre of Research Excellence for the Study of Naevi (2015–2020)

Abstract:
Most melanomas grow adjacent to or within pre-existing benign neoplasms of the skin called naevi. Phenotypically few differences exist between benign and early stage malignant skin tumours, and also biologically they show almost all cellular features that are essential characteristics of malignancy, including increased proliferation rates, avoidance or low response to tumour suppressors, evasion of programmed apoptosis or destruction by natural killer cells. This CRE will be internationally unique through its focus on tumorigenesis by studying naevi from epidemiological, clinical, molecular, genetic, dermoscopic and personal behavioural scientific viewpoints. Across three research programs and an inbuilt CRE Core Study as a unique training resource for the CRE fellows/students, this CRE will progress five major aims: ¿ Generate new knowledge on naevus life cycle by age, sex, body site, specifically, correlate phenotypic with germline genotypic characteristics to identify genetic markers that can ultimately contribute to personalised medicine via risk stratified naevi prevention and surveillance programs; ¿ Build a reference annotated naevus database as a valuable international resource in collaboration with the International Societies for Digital Imaging of the Skin (led by AI Halpern) and Dermoscopy (led by AI Hofmann-Wellenhof); ¿ Generate new evidence for risk-adjusted early detection of melanoma. Translate research outcomes into improved professional and patient education materials, and melanoma prevention, early detection and clinical practice guidelines; ¿ Facilitate collaboration, and develop the health and medical research workforce in clinical dermatology, teledermatology, epidemiology, genetics, molecular biology, behavioural science, nanotechnology and bioinformatics; ¿ Inspire young clinicians and scientists to use the latest technological advances in skin cancer diagnostics and care with a...
Grant type:
NHMRC Centres of Research Excellence
Researchers:
  • Professor
    The University of Queensland Diamantina Institute
    Faculty of Medicine
  • Principal Research Fellow
    The University of Queensland Diamantina Institute
    Faculty of Medicine
    Affiliate Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
  • Principal Research Fellow (Stats Ge
    The University of Queensland Diamantina Institute
    Faculty of Medicine
    Honorary Associate Professor
    School of Biomedical Sciences
    Faculty of Medicine
  • Professor in Behavioural Science
    Centre for Health Services Research
    Faculty of Medicine
  • Associate Professor Dermatology
    The University of Queensland Diamantina Institute
    Faculty of Medicine
Funded by:
National Health and Medical Research Council