Endogenous bone regenerative technique to repair hard tissue defects in congenital craniofacial clefts

Abstract:: Cleft lip and palate is the most common birth defect deformity of the face. Conventional interventions for the bony defect in clefts largely rely on multi-surgical procedures of bone grafts. However, systematic review has shown shortcomings with this method. Therefore, we aim to develop a novel strategy to repair the bony defect through an endogenous bone regenerative technique (EBRT). The development of EBRT involves the selection of an ideal scaffolding biomaterial, optimization of instructive niche components, and design of a controllable Nano and microparticle release system. The EBRT will stimulate patients' latent auto-repair mechanisms and revive their innate capacity for regeneration to successfully repair bony defects in clinical settings.
Grant type:: ARC Discovery Early Career Researcher Award
Funded by:: Australian Research Council

The University of Queensland