Probe-free biophysical force and torque measurements with optical tweezers (2018–2020)

Abstract:
This project aims to develop probe-free biophysical force and torque measurement methods based on optical tweezers to determine (a) forces on chromosomes during cell division and answer long standing questions on the character of these forces; (b) the forces exerted by cells while swimming, and map out how these forces are affected by their environment; and (c) the change in the elasticity of red blood cells over storage time. Studies of these biological systems are hampered by a lack of quantitative measurements. These accurate quantitative measurements will enable in-depth understanding of forces at work during cell division, properties of blood cells and sperm motility which could generate further research leading to health benefits.
Grant type:
ARC Discovery Projects
Researchers:
Funded by:
Australian Research Council