Identifying parent-of-origin effects and their impact on complex traits. (2018–2021)

Abstract:
This project aims to systematically identify genetic variants whose effects depend on whether they were inherited from the mother or the father, and to assess their impact on complex human traits. Most gene mapping studies to date assume that the effects of genetic variants are equal regardless of the parent of origin, thus have not explored this source of genetic variation. However, animal studies indicate that parent-of-origin specific effects (POEs) are important contributors to variability of developmental and behavioural traits. Leveraging genetic and epigenetic data from some of the world¿s largest cohorts, this project aims to improve our understanding of POEs on complex human traits related to early development, growth and behavior.
Grant type:
ARC Discovery Early Career Researcher Award
Funded by:
Australian Research Council