The link between oxidative stress, ageing and cardiovascular disease involves pathophysiological regulation of GAG hyperelongation on the lipid-binding proteoglycan Biglycan (2018)
Atherosclerosis commences by the trapping of lipoproteins to modified glycosaminoglycan (GAG) chain on proteoglycans
(PGs). Signalling pathways of growth factors present in early diseased vessel wall lead to the modification of PGs.
Vasoactive factors such as G protein coupled receptors agonists are involved in modification of PGs. Multiple but specific
signalling pathways modify PGs and this project seeks to find a common mechanism to inhibit GAG chain modification.