Developing a drug lead to target a new and abundant immune cell (2018)

Abstract:
The project aims to develop new drug-like compounds to block MAIT cell activation, which are the only immune T cells that are activated by drug-like molecules. Like many immune cells, uncontrolled MAIT activation is linked to pathology and disease. The study aims to redevelop two already approved drugs into new blockers of MAIT activation. The study expects to shed new light on the chemical requirements for blocking MAIT activation and pathology, in order to aid in developing a new drug-lead.
Grant type:
UQ Early Career Researcher
Researchers:
Funded by:
University of Queensland