Investigating changes in lamellar proteins during sepsis-associated laminitis using open-flow microprefusion (2018)
Sepsis-associated laminitis is a major complication of infectious disease in horses. Despite intensive research its cause
remains unclear and treatment elusive. Recently, phosphorylation of ribosomal protein S6 (rpS6) was suggested as the
earliest event in laminitis development. Combining experimental laminitis induction, sampling using lamellar open
flow-microperfusion and western blot analysis, this study will assess phosphorylation and dephosphorylation of lamellar
proteins during laminitis.