The University of Queensland

Phase-variable epigenetic regulators in bacterial veterinary pathogens (ARC Discovery Project administered by Griffith University) (2018–2020)

Abstract:

This work will identify phasevarion regulated genes in the major bacterial swine pathogens Streptococcus suis and Actinobacillus pleuropneumoniae. Both species contain randomly switching epigenetic regulators that control expression of multiple genes by epigenetic mechanisms. In all examples studied to date, phasevarions control genes involved in pathobiology, and regulate vaccine candidates. Phasevarions have never been studied in veterinary pathogens. To identify stably expressed proteins with a view to develop and improve vaccines, it is important to fully understand which genes phasevarions control. By identifying phasevarion controlled genes, we will inform and direct future vaccine development for important livestock species.

Grant type:

Griffith University

Funded by:

Griffith University