USP9X: a master gene for neuronal development and autism (2018–2021)
Autism spectrum disorder (ASD) is a common, yet poorly understood neurodevelopmental disorder. Defining the nodes
by which different signaling pathway intersect is the key to understand such complex, heterogeneous disorders. This
proposal will define how USP9X, a key factor controlling numerous signaling pathways, regulates cortical development,
and how mutations to this gene contribute to ASD. The work aligns with the research strengths of the Faculty of Medicine,
and will provide significant advances to our understanding of ASD. Moreover, the research environment and the teaching
component of the Fellowship will provide the ideal basis for me to further my career goals of becoming an independent
researcher in this competitive field.