A new physical strategy for therapeutic delivery (2019)

Abstract:
The physical attributes of nanoparticles are critical parameters for designing therapeutic delivery vehicles. This project aims to investigate a new mechanical property ¿ stiffness ¿ on nanoparticle-cell interactions. This will be achieved by developing a library of core-shell nanocapsules with tunable stiffness, and systematically investigating the effect of this parameter on in vitro and in vivo behaviour including cell uptake, circulation time, and tumour targeting. This is the first study to explore the effect of nanoparticle stiffness on biological functions covering a broad range of stiffness (KPa to GPa). The fundamental understanding achieved will offer a new physical strategy for designing efficient drug delivery carriers.
Grant type:
UQ Development Fellowships
Researchers:
Funded by:
University of Queensland