Automated high resolution & high contrast cryoTEM for 3D structural biology (2018–2019)
- Abstract:
- The aim of this proposal is to establish a frontier facility in automated single particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable state-of-the-art atomic molecular structure research and 3D subcellular and cellular imaging for Australian scientists. It will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic resolution protein structure determination. With more than 200 new protein structures in 2016 achieved at 2-5Å resolution by the Titan Krios, cryo-single particle analysis and tomography are recognised as revolutionary technologies in molecular structural biology and powerful enablers of future ground-breaking discovery.
- Grant type:
- ARC Linkage Infrastructure, Equipment and Facilities
- Researchers:
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NHMRC Leadership Fellow
School of Chemistry and Molecular BiosciencesFaculty of Science -
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ARC Laureate Fellow - Group Leader
Institute for Molecular BioscienceAffiliate Professor
School of Biomedical SciencesFaculty of Medicine -
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Associate Professor
School of Chemistry and Molecular BiosciencesFaculty of Science
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- Funded by:
- Australian Research Council
