Molybdenum enzyme electrochemical communication (2019–2022)
This project aims to apply high throughput electrochemical methods to understand the activity of three novel but related molybdenum enzymes; human mARC and its bacterial homologs YcbX and YiiM. The role of mARC in humans remains unknown 12 years after its discovery. All three enzymes catalyse the reduction of potentially harmful N-hydroxylated compounds and there is interest in this area from the perspective of drug design. Recent research has disclosed an electrochemical methodology to rapidly identify enzyme substrates and inhibitors and this will be applied in this project. Molybdenum enzymes pervade all life forms and the outcomes of this research include a unified understanding of an emerging enzyme class involved in drug metabolism.