Clay nanoparticle-facilitated RNAi for non-transgenic modification of crops (2019–2022)

Abstract:
Topical application of double-stranded RNA (dsRNA) for induced RNA interference (RNAi) represents an attractive alternative to genetically engineered crops. However, naked dsRNA is unstable and furthermore, is not efficiently taken up by plants. For these reasons, topical application of dsRNA has thus far produced only modest induction of RNAi in plants. This project aims to identify the most effective form of dsRNA for inducing systemic RNAi in plants, and develop clay nanoparticles to facilitate the uptake and movement of dsRNA in plants for maximal systemic RNAi. The key outcome from the project will be robust strategies for nanoparticle-mediated non-transgenic trait modification, including improved crop protection and productivity.
Grant type:
ARC Discovery Projects
Researchers:
  • Snr Group Leader/VC Snr Res Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Principal Research Fellow
    Centre for Horticultural Science
    Queensland Alliance for Agriculture and Food Innovation
  • Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliated Professor
    Centre for Crop Science
    Queensland Alliance for Agriculture and Food Innovation
  • Centre Director
    Centre for Horticultural Science
    Queensland Alliance for Agriculture and Food Innovation
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council