A novel role for saturated fatty acids in learning and memory (2019–2022)
Learning and memory are thought to result from long-lasting changes in synaptic strength. Whereas the role of polyunsaturated fatty acids in these functions is well known, recent findings suggest an unprecedented role for the generation of saturated free fatty acids by phospholipase A1-enzyme. Using innovative imaging technologies, molecular assays and lipidomics, this Project aims to characterize the novel role of the phospholipase A1 pathway in neurotransmission, generating new knowledge on how the saturated fatty acid changes in neurons affect the mobility of neurotransmitter receptors and synaptic vesicles. The expected outcomes of this Project will provide novel conceptual insights into learning, memory and brain capacity.