Mathematical models of 4D multicellular spheroids (ARC Discovery Project administered by Queensland University of Technology) (2020–2023)
Mathematical models have a long, successful history of providing biological insight, and new mathematical models
must be developed to keep pace with emerging technologies. Modern experimental procedures involve studying
3D multicellular spheroids with fluorescent labels to show both the location of cells and the cell cycle progression.
This 4D data (3D spatial information + cell cycle time) provides vast information. No mathematical models have
been specifically developed to interpret/predict 4D spheroids. This project will deliver the first high-fidelity
mathematical models to interpret/predict 4D spheroid experiments in real time, providing quantitative insight into
innate mechanisms and responses to various intervention treatments.