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New antiparasitics to protect Australian livestock (2021–2025)

Abstract:
There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
Grant type:
ARC Linkage Projects
Researchers:

  • Professor Rob Capon

    Professorial Research Fellow - GL
    Institute for Molecular Bioscience
    Affiliate Professorial Res Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Dr Zeinab Khalil

    ARC Research Fellow
    Institute for Molecular Bioscience
Funded by:
Australian Research Council