Academic Title - Research Fellow
Overview
Dr Sathish Periyasamy is a Research Fellow at a Queensland Brain Institute and Senior Scientist at Queensland Centre for Mental Health Research. He is currently building and focusing on Systems/Genomic Medicine and conducting research in the interface of systems genetics and psychiatry. He is involved in studying the mechanisms of (patho-)physiological processes in psychiatric disorders using a unique combination of educational experience coupled with over twenty-five years of computer programming and eleven years of computational biology experience in biomedicine. Over the past 20 years, his experience working in chemical, biological and medical domains has enabled him to focus on the interface of basic and clinical research and contribute to translational research. From 2011 to 2014, he was involved in cancer genetics research at King Abdullah International Medical Research Centre, KSA. As the bioinformatics lead, with interdisciplinary skills and expertise at the interface of computational intelligence, systems biology, and quantitative/psychiatric genetics, He has been contributing to psychiatric genetics research since 2014 in Professor Bryan Mowry’s lab.
His current research areas include:
- Bioinformatics, Systems Biology and Statistical Genetics - Developing and applying GWAS, post-GWAS bioinformatics, cross-population genetic association and systems genetics approaches.
- Psychiatric Genomics
- Common and rare variant association studies in schizophrenia using data generated from DNA microarray and whole-exome/whole-genome sequencing technologies.
- Post-GWAS bioinformatics approaches to characterise risk variants discovered in schizophrenia GWAS.
- Cross-population genetic association approaches in schizophrenia.
- Computational Intelligence – Developing conventional and visible deep learning models for biomedicine.
- Developing genetic resources for Indigenous Oceanic populations
Research Interests
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Biological Complexity
Studying the emergent properties of biological systems.
Qualifications
- Master of Information Technology, Keele University
- Doctor of Philosophy, Cardiff University
Publications
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Journal Article: Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
Liu, Dongjing, Meyer, Dara, Fennessy, Brian, Feng, Claudia, Cheng, Esther, Johnson, Jessica S., Park, You Jeong, Rieder, Marysia-Kolbe, Ascolillo, Steven, de Pins, Agathe, Dobbyn, Amanda, Lebovitch, Dannielle, Moya, Emily, Nguyen, Tan-Hoang, Wilkins, Lillian, Hassan, Arsalan, Burdick, Katherine E., Buxbaum, Joseph D., Domenici, Enrico, Frangou, Sophia, Hartmann, Annette M., Laurent-Levinson, Claudine, Malhotra, Dheeraj, Pato, Carlos N., Pato, Michele T., Ressler, Kerry, Roussos, Panos, Rujescu, Dan, Arango, Celso ... Catts, Stan (2023). Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics, 55 (3), 369-376. doi: 10.1038/s41588-023-01305-1
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Journal Article: Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations
Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051
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Journal Article: Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study
Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335
Grants
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(2022) NHMRC IDEAS Grants
Publications
Featured Publications
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Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051
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Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335
Book Chapter
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Genome-wide association studies in schizophrenia
Mowry, Bryan J. and Periyasamy, Sathish (2022). Genome-wide association studies in schizophrenia. eLS. (pp. 1-14) Hoboken, NJ USA: John Wiley & Sons. doi: 10.1002/9780470015902.a0025337
Journal Article
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Liu, Dongjing, Meyer, Dara, Fennessy, Brian, Feng, Claudia, Cheng, Esther, Johnson, Jessica S., Park, You Jeong, Rieder, Marysia-Kolbe, Ascolillo, Steven, de Pins, Agathe, Dobbyn, Amanda, Lebovitch, Dannielle, Moya, Emily, Nguyen, Tan-Hoang, Wilkins, Lillian, Hassan, Arsalan, Burdick, Katherine E., Buxbaum, Joseph D., Domenici, Enrico, Frangou, Sophia, Hartmann, Annette M., Laurent-Levinson, Claudine, Malhotra, Dheeraj, Pato, Carlos N., Pato, Michele T., Ressler, Kerry, Roussos, Panos, Rujescu, Dan, Arango, Celso ... Catts, Stan (2023). Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics, 55 (3), 369-376. doi: 10.1038/s41588-023-01305-1
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Trubetskoy, Vassily, Pardiñas, Antonio F, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B, Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A, Hall, Lynsey S, Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C, Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G ... Schizophrenia Working Group of the Psychiatric Genomics Consortium (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604 (7906), 502-508. doi: 10.1038/s41586-022-04434-5
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BrainDevo: spatio-temporal gene regulation repository of brain development
Periyasamy, Sathish and Mowry, Bryan (2022). BrainDevo: spatio-temporal gene regulation repository of brain development. Frontiers in Molecular Neuroscience, 15 799801, 799801. doi: 10.3389/fnmol.2022.799801
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Pardiñas, Antonio F., Smart, Sophie E., Willcocks, Isabella R., Holmans, Peter A., Dennison, Charlotte A., Lynham, Amy J., Legge, Sophie E., Baune, Bernhard T., Bigdeli, Tim B., Cairns, Murray J., Corvin, Aiden, Fanous, Ayman H., Frank, Josef, Kelly, Brian, McQuillin, Andrew, Melle, Ingrid, Mortensen, Preben B., Mowry, Bryan J., Pato, Carlos N., Periyasamy, Sathish, Rietschel, Marcella, Rujescu, Dan, Simonsen, Carmen, St Clair, David, Tooney, Paul, Wu, Jing Qin, Andreassen, Ole A., Kowalec, Kaarina, Sullivan, Patrick F. ... Vázquez-Bourgon, Javier (2022). Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia. JAMA Psychiatry, 79 (3) 20213799, 260-269. doi: 10.1001/jamapsychiatry.2021.3799
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Genetic architecture of schizophrenia: a review of major advancements
Legge, Sophie E., Santoro, Marcos L., Periyasamy, Sathish, Okewole, Adeniran, Arsalan, Arsalan and Kowalec, Kaarina (2021). Genetic architecture of schizophrenia: a review of major advancements. Psychological Medicine, 51 (13), 1-10. doi: 10.1017/s0033291720005334
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
Blokland, Gabriëlla A.M., Grove, Jakob, Chen, Chia-Yen, Cotsapas, Chris, Tobet, Stuart, Handa, Robert, Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B. ... iPSYCH (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry, 91 (1), 102-117. doi: 10.1016/j.biopsych.2021.02.972
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Comparative genetic architectures of schizophrenia in East Asian and European populations
Lam, Max, Chen, Chia-Yen, Li, Zhiqiang, Martin, Alicia R., Bryois, Julien, Ma, Xixian, Gaspar, Helena, Ikeda, Masashi, Benyamin, Beben, Brown, Brielin C., Liu, Ruize, Zhou, Wei, Guan, Lili, Kamatani, Yoichiro, Kim, Sung-Wan, Kubo, Michiaki, Kusumawardhani, Agung A. A. A., Liu, Chih-Min, Ma, Hong, Periyasamy, Sathish, Takahashi, Atsushi, Xu, Zhida, Yu, Hao, Zhu, Feng, Chen, Wei J., Faraone, Stephen, Glatt, Stephen J., He, Lin, Hyman, Steven E. ... Huang, Hailiang (2019). Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics, 51 (12), 1670-1678. doi: 10.1038/s41588-019-0512-x
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Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051
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Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335
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Association between schizophrenia polygenic risk and neural correlates of emotion perception
Dzafic, Ilvana, Burianová, Hana, Periyasamy, Sathish and Mowry, Bryan (2018). Association between schizophrenia polygenic risk and neural correlates of emotion perception. Psychiatry research: Neuroimaging, 276, 33-40. doi: 10.1016/j.pscychresns.2018.04.005
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Aziz, M. A., Periyasamy, S., Al Yousef, Z., AlAbdulkarim, I., Al Otaibi, M., AlFahed, AbdulAziz and Alasiri, Glowi (2015). Correction: Integrated exon level expression analysis of driver genes explain their role in colorectal cancer. PLoS ONE, 10 (3) e0122532, e0122532. doi: 10.1371/journal.pone.0122532
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Colorectal cancer driver genes identified by patient specific comparison of cytogenetic microarray
Aziz, Mohammad Azhar, Periyasamy, Sathish, Yousef, Zeyad, Deeb, Ahmad and Alotaibi, Majed (2014). Colorectal cancer driver genes identified by patient specific comparison of cytogenetic microarray. Genomics Data, 2, 29-31. doi: 10.1016/j.gdata.2014.02.004
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Integrated exon level expression analysis of driver genes explain their role in colorectal cancer
Aziz, Mohammad Azhar, Periyasamy, Sathish, Al Yousef, Zeyad, Al Abdulkarim, Ibrahim, Al Otaibi, Majed, Alfahed, Abdulaziz and Alasiri, Glowi (2014). Integrated exon level expression analysis of driver genes explain their role in colorectal cancer. PLoS ONE, 9 (10) e110134, e110134. doi: 10.1371/journal.pone.0110134
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Eldai, Hisham, Periyasamy, Sathish, Al Qarni, Saeed, Al Rodayyan, Maha, Muhammed Mustafa, Sabeena, Deeb, Ahmad, Al Sheikh, Ebthehal, Afzal Khan, Mohammed, Johani, Mishal, Yousef, Zeyad and Aziz, Mohammad Azhar (2013). Correction: Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner. PLoS ONE, 8 (12). doi: 10.1371/annotation/3f97e271-6926-4766-8430-1b4a009e80c6
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Eldai, Hisham, Periyasamy, Sathish, Al Qarni, Saeed, Al Rodayyan, Maha, Muhammed Mustafa, Sabeena, Deeb, Ahmad, Al Sheikh, Ebthehal, Afzal Khan, Mohammed, Johani, Mishal, Yousef, Zeyad and Aziz, Mohammad Azhar (2013). Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner. PLoS ONE, 8 (10), e76251. doi: 10.1371/journal.pone.0076251
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Periyasamy, Sathish, Gray, Alex and Kille, Peter (2013). The bottom–up approach to defining life: deciphering the functional organization of biological cells via multi-objective representation of biological complexity from molecules to cells. Frontiers in Physiology, 4 Article 369. doi: 10.3389/fphys.2013.00369
Conference Publication
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Investigating brain development using tissue and single-cell gene expression data
Periyasamy, Sathish , Youssef, Pierre and Mowry, Bryan (2022). Investigating brain development using tissue and single-cell gene expression data. The 21st International Conference on Systems Biology, Berlin, Germany, 8-12 October 2022.
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Periyasamy, Sathish and Mowry, Bryan (2019). A novel approach for the generation of disease-specific genetic interaction data using gene-based statistical epistasis. International Conference on Systems Biology, Okinawa, Japan, 1-5 November 2019. Okinawa:
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Mowry, Bryan and Periyasamy, Sathish (2019). Prioritising causal variants in schizophrenia GWAS by investigating the regulatory impact of non-coding variants using differential binding and brain EQTL data. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA USA, 26-31 October 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.08.288
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Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Holliday, Elizabeth, Bakshi, Andrew, Jorde, Lynn, Brown, Matthew, Wray, Naomi, Suetani, Rachel, Giacomotto, Jean, Thara, Rangaswamy and Mowry, Bryan (2019). First genome-wide association study of schizophrenia in an Indian population reveals a novel susceptibility locus. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2018.08.017
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Periyasamy, Sathish and Mowry, Bryan (2019). Modelling the impact of schizophrenia gwas loci during human brain development using spatio-temporal gene expression data. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.489
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Vinkhuyzen, Anna, John, Sujit, Periyasamy, Sathish, Wray, Naomi, Thara, Rangaswamy and Mowry, Bryan (2017). Genome-wide association study in an Indian population reveals genetic overlap for schizophrenia with Europeans. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier.
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Periyasamy, Sathish, Barrett, Robert, Yue, Weihua, Gratten, Jacob, Nertney, Deborah, McLean, Duncan, Smith, Heather, Filippich, Cheryl, Loa, Peter, Zhang, Dai, Yolken, Robert and Mowry, Bryan (2017). Genome-wide association study of schizophrenia in the Iban of Sarawak reveals genetic overlap with Han Chinese and, to a lesser extent, Europeans. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier .
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Integrated analysis reveals association of ATP8B1 gene with colorectal cancer
Aziz, Mohammad A., Ali, Rizwan, Rasool, Mahmood, Jamal, Mohammad S., Samman, Nusaibah, Abdussami, Ghufrana, Periyasamy, Sathish, Warsi, Mohiuddin K., Aldress, Mohammed, Majed Al Otaibi, , Zeyad Al Yousef, , Mohamed Boudjelal, , Abdelbasit Buhmeida, , Mohammed H Al-Qahtani, and AlAbdulkarim, Ibrahim (2016). Integrated analysis reveals association of ATP8B1 gene with colorectal cancer. 3rd International Genomic Medicine Conference (3rd IGMC 2015), Jeddah, Saudi Arabia, 30 November - 1 December 2015. London, United Kingdom: BioMed Central. doi: 10.1186/s12864-016-2858-0
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Somatic Acquired Uniparental Disomy at 1q21.3-q22 Affects MUC1 in a Colorectal Cancer Patient
Azhar Aziz, Mohammad, Periyasamy, Sathish, Al Otaibi, Majed, I, Al Abdul Karim and Al Balwi, Mohammed (2013). Somatic Acquired Uniparental Disomy at 1q21.3-q22 Affects MUC1 in a Colorectal Cancer Patient. EMBL Conference on Cancer Genomics, Heidelberg, Germany, 3-5 November 2013.
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Modelling Intracellular Collective Dynamics
Periyasamy, Sathish, Kille, Peter and Gray, Alex (2012). Modelling Intracellular Collective Dynamics. International Conference on Systems Biology, Toronto, Canada, 19-23 August 2012. Toronto:
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Multi-scale Adaptive Dynamics from Molecules to Cells
Periyasamy, Sathish, Kille, Peter and Gray, Alex (2009). Multi-scale Adaptive Dynamics from Molecules to Cells. Foundations of Systems Biology in Engineering, Denver, CO United States, 9-12 August 2009. Denver, CO United States: Omnipress.
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Periyasamy, Sathish, Gray, Alex and Kille, Peter (2008). The Epigenetic Algorithm. IEEE. doi: 10.1109/cec.2008.4631235
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Biological Complexity in the Agent World.
Periyasamy, Sathish, Kille, Peter and Gray, Alex (2008). Biological Complexity in the Agent World.. IADIS International Conference on Applied Computing, Algarve, Portugal, 10-13 April 2008.
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A Collective Intelligence approach to modelling intelligent cellular organisation
Periyasamy, Sathish, Gray, Alex and Kille, Peter (2008). A Collective Intelligence approach to modelling intelligent cellular organisation. International Conference on Systems Biology, Gothenburg, Sweden, 23-27 August 2008.
Other Outputs
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Periyasamy, Sathish (2021). BrainDevo. The University of Queensland. (Dataset) doi: 10.48610/5f24ed4
