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Dr Sathish Periyasamy

Academic Title - Research Fellow

Queensland Brain Institute
s.periyasamy@qcmhr.uq.edu.au

Overview

Dr Sathish Periyasamy is a Research Fellow at a Queensland Brain Institute and Senior Scientist at Queensland Centre for Mental Health Research. He is currently building and focusing on Systems/Genomic Medicine and conducting research in the interface of systems genetics and psychiatry. He is involved in studying the mechanisms of (patho-)physiological processes in psychiatric disorders using a unique combination of educational experience coupled with over twenty-five years of computer programming and eleven years of computational biology experience in biomedicine. Over the past 20 years, his experience working in chemical, biological and medical domains has enabled him to focus on the interface of basic and clinical research and contribute to translational research. From 2011 to 2014, he was involved in cancer genetics research at King Abdullah International Medical Research Centre, KSA. As the bioinformatics lead, with interdisciplinary skills and expertise at the interface of computational intelligence, systems biology, and quantitative/psychiatric genetics, He has been contributing to psychiatric genetics research since 2014 in Professor Bryan Mowry’s lab.

His current research areas include:

  • Bioinformatics, Systems Biology and Statistical Genetics - Developing and applying GWAS, post-GWAS bioinformatics, cross-population genetic association and systems genetics approaches.
  • Psychiatric Genomics
    • Common and rare variant association studies in schizophrenia using data generated from DNA microarray and whole-exome/whole-genome sequencing technologies.
    • Post-GWAS bioinformatics approaches to characterise risk variants discovered in schizophrenia GWAS.
    • Cross-population genetic association approaches in schizophrenia.
  • Computational Intelligence – Developing conventional and visible deep learning models for biomedicine.
  • Developing genetic resources for Indigenous Oceanic populations

Research Interests

  • Biological Complexity
    Studying the emergent properties of biological systems.

Qualifications

  • Doctor of Philosophy of Bioinformatics (Advanced), Cardiff University
  • Masters (Coursework) of Information Technology, Keele University

Publications

  • Journal Article: Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes

    Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan J. (2024). Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes. Frontiers in Genetics, 14 1301150, 1301150. doi: 10.3389/fgene.2023.1301150

  • Journal Article: Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

    Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051

  • Journal Article: Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study

    Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335

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Grants

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Publications

Featured Publications

  • Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

    Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051

  • Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study

    Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335

Book Chapter

Journal Article

  • Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes

    Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan J. (2024). Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes. Frontiers in Genetics, 14 1301150, 1301150. doi: 10.3389/fgene.2023.1301150

  • W93. INVESTIGATING THE GENETIC INTERACTIONS OF SCHIZOPHRENIA USING GENE-BASED STATISTICAL EPISTASIS

    Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan (2023). W93. INVESTIGATING THE GENETIC INTERACTIONS OF SCHIZOPHRENIA USING GENE-BASED STATISTICAL EPISTASIS. European Neuropsychopharmacology, 75, S154-S155. doi: 10.1016/j.euroneuro.2023.08.280

  • Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

    Liu, Dongjing, Meyer, Dara, Fennessy, Brian, Feng, Claudia, Cheng, Esther, Johnson, Jessica S., Park, You Jeong, Rieder, Marysia-Kolbe, Ascolillo, Steven, de Pins, Agathe, Dobbyn, Amanda, Lebovitch, Dannielle, Moya, Emily, Nguyen, Tan-Hoang, Wilkins, Lillian, Hassan, Arsalan, Burdick, Katherine E., Buxbaum, Joseph D., Domenici, Enrico, Frangou, Sophia, Hartmann, Annette M., Laurent-Levinson, Claudine, Malhotra, Dheeraj, Pato, Carlos N., Pato, Michele T., Ressler, Kerry, Roussos, Panos, Rujescu, Dan, Arango, Celso ... Catts, Stan (2023). Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics, 55 (3), 369-376. doi: 10.1038/s41588-023-01305-1

  • Mapping genomic loci implicates genes and synaptic biology in schizophrenia

    Trubetskoy, Vassily, Pardiñas, Antonio F, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B, Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A, Hall, Lynsey S, Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C, Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G ... Schizophrenia Working Group of the Psychiatric Genomics Consortium (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604 (7906), 502-508. doi: 10.1038/s41586-022-04434-5

  • BrainDevo: spatio-temporal gene regulation repository of brain development

    Periyasamy, Sathish and Mowry, Bryan (2022). BrainDevo: spatio-temporal gene regulation repository of brain development. Frontiers in Molecular Neuroscience, 15 799801, 799801. doi: 10.3389/fnmol.2022.799801

  • Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia

    Pardiñas, Antonio F., Smart, Sophie E., Willcocks, Isabella R., Holmans, Peter A., Dennison, Charlotte A., Lynham, Amy J., Legge, Sophie E., Baune, Bernhard T., Bigdeli, Tim B., Cairns, Murray J., Corvin, Aiden, Fanous, Ayman H., Frank, Josef, Kelly, Brian, McQuillin, Andrew, Melle, Ingrid, Mortensen, Preben B., Mowry, Bryan J., Pato, Carlos N., Periyasamy, Sathish, Rietschel, Marcella, Rujescu, Dan, Simonsen, Carmen, St Clair, David, Tooney, Paul, Wu, Jing Qin, Andreassen, Ole A., Kowalec, Kaarina, Sullivan, Patrick F. ... Vázquez-Bourgon, Javier (2022). Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia. JAMA Psychiatry, 79 (3) 20213799, 260-269. doi: 10.1001/jamapsychiatry.2021.3799

  • Genetic architecture of schizophrenia: a review of major advancements

    Legge, Sophie E., Santoro, Marcos L., Periyasamy, Sathish, Okewole, Adeniran, Arsalan, Arsalan and Kowalec, Kaarina (2021). Genetic architecture of schizophrenia: a review of major advancements. Psychological Medicine, 51 (13), 1-10. doi: 10.1017/s0033291720005334

  • Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

    Blokland, Gabriëlla A.M., Grove, Jakob, Chen, Chia-Yen, Cotsapas, Chris, Tobet, Stuart, Handa, Robert, Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B. ... iPSYCH (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry, 91 (1), 102-117. doi: 10.1016/j.biopsych.2021.02.972

  • Comparative genetic architectures of schizophrenia in East Asian and European populations

    Lam, Max, Chen, Chia-Yen, Li, Zhiqiang, Martin, Alicia R., Bryois, Julien, Ma, Xixian, Gaspar, Helena, Ikeda, Masashi, Benyamin, Beben, Brown, Brielin C., Liu, Ruize, Zhou, Wei, Guan, Lili, Kamatani, Yoichiro, Kim, Sung-Wan, Kubo, Michiaki, Kusumawardhani, Agung A. A. A., Liu, Chih-Min, Ma, Hong, Periyasamy, Sathish, Takahashi, Atsushi, Xu, Zhida, Yu, Hao, Zhu, Feng, Chen, Wei J., Faraone, Stephen, Glatt, Stephen J., He, Lin, Hyman, Steven E. ... Huang, Hailiang (2019). Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics, 51 (12), 1670-1678. doi: 10.1038/s41588-019-0512-x

  • Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

    Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051

  • Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study

    Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335

  • Association between schizophrenia polygenic risk and neural correlates of emotion perception

    Dzafic, Ilvana, Burianová, Hana, Periyasamy, Sathish and Mowry, Bryan (2018). Association between schizophrenia polygenic risk and neural correlates of emotion perception. Psychiatry research: Neuroimaging, 276, 33-40. doi: 10.1016/j.pscychresns.2018.04.005

  • Correction: Integrated exon level expression analysis of driver genes explain their role in colorectal cancer

    Aziz, M. A., Periyasamy, S., Al Yousef, Z., AlAbdulkarim, I., Al Otaibi, M., AlFahed, AbdulAziz and Alasiri, Glowi (2015). Correction: Integrated exon level expression analysis of driver genes explain their role in colorectal cancer. PLoS ONE, 10 (3) e0122532, e0122532. doi: 10.1371/journal.pone.0122532

  • Colorectal cancer driver genes identified by patient specific comparison of cytogenetic microarray

    Aziz, Mohammad Azhar, Periyasamy, Sathish, Yousef, Zeyad, Deeb, Ahmad and Alotaibi, Majed (2014). Colorectal cancer driver genes identified by patient specific comparison of cytogenetic microarray. Genomics Data, 2, 29-31. doi: 10.1016/j.gdata.2014.02.004

  • Integrated exon level expression analysis of driver genes explain their role in colorectal cancer

    Aziz, Mohammad Azhar, Periyasamy, Sathish, Al Yousef, Zeyad, Al Abdulkarim, Ibrahim, Al Otaibi, Majed, Alfahed, Abdulaziz and Alasiri, Glowi (2014). Integrated exon level expression analysis of driver genes explain their role in colorectal cancer. PLoS ONE, 9 (10) e110134, e110134. doi: 10.1371/journal.pone.0110134

  • Correction: Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner

    Eldai, Hisham, Periyasamy, Sathish, Al Qarni, Saeed, Al Rodayyan, Maha, Muhammed Mustafa, Sabeena, Deeb, Ahmad, Al Sheikh, Ebthehal, Afzal Khan, Mohammed, Johani, Mishal, Yousef, Zeyad and Aziz, Mohammad Azhar (2013). Correction: Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner. PLoS ONE, 8 (12). doi: 10.1371/annotation/3f97e271-6926-4766-8430-1b4a009e80c6

  • Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner

    Eldai, Hisham, Periyasamy, Sathish, Al Qarni, Saeed, Al Rodayyan, Maha, Muhammed Mustafa, Sabeena, Deeb, Ahmad, Al Sheikh, Ebthehal, Afzal Khan, Mohammed, Johani, Mishal, Yousef, Zeyad and Aziz, Mohammad Azhar (2013). Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner. PLoS ONE, 8 (10), e76251. doi: 10.1371/journal.pone.0076251

  • The bottom–up approach to defining life: deciphering the functional organization of biological cells via multi-objective representation of biological complexity from molecules to cells

    Periyasamy, Sathish, Gray, Alex and Kille, Peter (2013). The bottom–up approach to defining life: deciphering the functional organization of biological cells via multi-objective representation of biological complexity from molecules to cells. Frontiers in Physiology, 4 Article 369. doi: 10.3389/fphys.2013.00369

Conference Publication

Other Outputs

  • Schizophrenia genetic interaction

    Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan (2023). Schizophrenia genetic interaction. The University of Queensland. (Dataset) doi: 10.48610/24c3e5e

  • BrainDevo

    Periyasamy, Sathish (2021). BrainDevo. The University of Queensland. (Dataset) doi: 10.48610/5f24ed4

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ORCID: 0000-0002-8132-5717

Scopus ID: 56305257300

Google Scholar ID: eWYFii8AAAAJ

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