Journal Article: The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro
Nixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019) The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270 40-46. doi:10.1016/j.vetpar.2019.05.008
Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019) The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163 381-390. doi:10.1016/j.bcp.2019.03.004
Journal Article: Versatile spider venom peptides and their medical and agricultural applications
Saez, Natalie J. and Herzig, Volker (2019) Versatile spider venom peptides and their medical and agricultural applications. Toxicon, 158 109-126. doi:10.1016/j.toxicon.2018.11.298
(2019–2022) NHMRC Project Grant
High-throughput production of oxidized animal toxins in Escherichia coli
Duhoo, Yoan, Sequeira, Ana Filipa, Saez, Natalie J, Turchetto, Jeremy, Ramond, Laurie, Peysson, Fanny, Brás, Joana L A, Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M G A and Vincentelli, Renaud (2019). High-throughput production of oxidized animal toxins in Escherichia coli. In Renaud Vincentelli (Ed.), High-Throughput Protein Production and Purification (pp. 165-190) New York, NY, United States: Humana. doi:10.1007/978-1-4939-9624-7_7
A Strategy for production of correctly folded disulfide-rich peptides in the periplasm of E. coli
Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra and King, Glenn F. (2017). A Strategy for production of correctly folded disulfide-rich peptides in the periplasm of E. coli. In Heterologous Gene Expression in E. coli Methods and Protocols (pp. 155-180) New York, NY United States: Humana Press. doi:10.1007/978-1-4939-6887-9_10
High-throughput expression screening and purification of recombinant proteins in E-coli
Saez, Natalie J. and Vincentelli, Renaud (2014). High-throughput expression screening and purification of recombinant proteins in E-coli. In Yu Wai Chen (Ed.), Structural genomics: General applications (pp. 33-53) New York United States: Humana Press. doi:10.1007/978-1-62703-691-7_3
Nixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019) The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270 40-46. doi:10.1016/j.vetpar.2019.05.008
Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019) The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163 381-390. doi:10.1016/j.bcp.2019.03.004
Versatile spider venom peptides and their medical and agricultural applications
Saez, Natalie J. and Herzig, Volker (2019) Versatile spider venom peptides and their medical and agricultural applications. Toxicon, 158 109-126. doi:10.1016/j.toxicon.2018.11.298
Lee, Jia Yu Peppermint, Saez, Natalie J, Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F, Smith, Maree T and Rash, Lachlan D (2018) Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British journal of pharmacology, 175 12: 2204-2218. doi:10.1111/bph.14089
Pineda, Sandy S., Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W. C., Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique and King, Glenn F. (2017) ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins. Bioinformatics, 34 6: 1074-1076. doi:10.1093/bioinformatics/btx661
Sequeira, Ana Filipa, Turchetto, Jeremy, Saez, Natalie J., Peysson, Fanny, Ramond, Laurie, Duhoo, Yoan, Blemont, Marilyne, Fernandes, Vânia O., Gama, Luís T., Ferreira, Luís M. A., Guerreiro, Catarina I. P. I., Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M. G. A. and Vincentelli, Renaud (2017) Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli. Microbial Cell Factories, 16 1: 4. doi:10.1186/s12934-016-0618-0
Turchetto, Jeremy, Sequeira, Ana Filipa, Ramond, Laurie, Peysson, Fanny, Bras, Joana L. A., Saez, Natalie J., Duhoo, Yoan, Blemont, Marilyne, Guerreiro, Catarina I. P. D., Quinton, Loic, Pauw, Edwin de, Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M. G. A. and Vincentelli, Renaud (2017) High-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discovery. Microbial Cell Factories, 16 1: 6. doi:10.1186/s12934-016-0617-1
Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015) Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 20: 4985-4995. doi:10.1111/bph.13267
Saez, Natalie J., Nozach, Herve, Blemont, Marilyne and Vincentelli, Renaud (2014) High throughput quantitative expression screening and purification applied to recombinant disulfide-rich venom proteins produced in E. coli. Journal of Visualized Experiments, 1091 89: 33-53. doi:10.3791/51464
Klint, Julie K., Senff, Sebastian, Saez, Natalie J., Seshadri, Radha, Lau, Ho Yee, Bende, Nira J., Undheim, Eivind A. B., Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2013) Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS One, 8 5: e63865.1-e63865.12. doi:10.1371/journal.pone.0063865
Nozach, Hervé, Fruchart-Gaillard, Carole, Fenaille, François, Beau, Fabrice, Ramos, Oscar Henrique Pereira, Douzi, Badreddine, Saez, Natalie J., Moutiez, Mireille, Servent, Denis, Gondry, Muriel, Thaï, Robert, Cuniasse, Philippe, Vincentelli, Renaud and Dive, Vincent (2013) High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli. Microbial Cell Factories, 12 37: 1-16. doi:10.1186/1475-2859-12-37
Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011) A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 5: 796-808. doi:10.1124/mol.111.072207
Hu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M. and Martin, Jennifer L. (2011) Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America, 108 3: 1040-1045. doi:10.1073/pnas.0914906108
Spider-venom peptides as therapeutics
Seaz, Natalie J., Senff, Sebastian, Jensen, Jonas E., Er, Sing Yan, Herzig, Volker, Rash, Lachlan D. and King, Glenn F. (2010) Spider-venom peptides as therapeutics. Toxins, 2 12: 2851-2871. doi:10.3390/toxins2122851
Saez, Natalie Jose (2013). Characterising the molecular basis of the interaction between the putative drug target ASIC1a and π-TRTX-Pc1a PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.
(2019–2022) NHMRC Project Grant