Journal Article: Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing
Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786
Journal Article: Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1
Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003
Journal Article: SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009
How analgesic peptides inhibit voltage gated ion channels in a complex membrane environment
(2019) UQ Early Career Researcher
Structural basis of the function of peptide inhibitors targeting voltage-gated sodium channel
(2021) Doctor Philosophy
The application of phospholipid nanodiscs to study peptide-lipid binding interactions
(2020) Doctor Philosophy
Nonuniform sampling in biomolecular NMR
Miljenovic, Tomas Marko, Jia, Xinying and Mobli, Mehdi (2018). Nonuniform sampling in biomolecular NMR. Modern Magnetic Resonance. (pp. 2035-2054) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-28388-3_118
Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786
Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009
Sun, Chenghai, Luo, Zhenyao, Zhang, Wenlu, Tian, Wenya, Peng, Haidong, Lin, Zhi, Deng, Zixin, Kobe, Bostjan, Jia, Xinying and Qu, Xudong (2020). Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines. Nature Communications, 11 (1) 6251, 1-10. doi: 10.1038/s41467-020-20022-5
Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148
Jia, Xinying, Crawford, Theo, Zhang, Alan H. and Mobli, Mehdi (2019). A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins. Protein Expression and Purification, 161, 1-7. doi: 10.1016/j.pep.2019.04.004
Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs
Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238
Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y
Brinson, Robert G., Marino, John P., Delaglio, Frank, Arbogast, Luke W., Evans, Ryan M., Kearsley, Anthony, Gingras, Geneviève, Ghasriani, Houman, Aubin, Yves, Pierens, Gregory K., Jia, Xinying, Mobli, Mehdi, Grant, Hamish G., Keizer, David W., Schweimer, Kristian, Ståhle, Jonas, Widmalm, Göran, Zartler, Edward R., Lawrence, Chad W., Reardon, Patrick N., Cort, John R., Xu, Ping, Ni, Feng, Yanaka, Saeko, Kato, Koichi, Parnham, Stuart R., Tsao, Desiree, Blomgren, Andreas, Rundlöf, Torgny ... Wikström, Mats (2019). Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. mAbs, 11 (1), 94-105. doi: 10.1080/19420862.2018.1544454
Yi, Xuan, Zhao, Qunfei, Tian, Zhenhua, Jia, Xinying, Cao, Weiguo, Liu, Wen and He, Qing-Li (2019). Insights into the functionalization of the methylsalicyclic moiety during the biosynthesis of chlorothricin by comparative kinetic assays of the activities of two KAS III-like acyltransferases. Chinese Journal of Chemistry, 37 (8), 821-826. doi: 10.1002/cjoc.201900134
Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
Tian, Wenya, Sun, Chenghai, Zheng, Mei, Harmer, Jeffrey R., Yu, Mingjia, Zhang, Yanan, Peng, Haidong, Zhu, Dongqing, Deng, Zixin, Chen, Shi-Lu, Mobli, Mehdi, Jia, Xinying and Qu, Xudong (2018). Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications, 9 (1) 4428, 4428. doi: 10.1038/s41467-018-06528-z
A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors
Zhang, Alan H., Sharma, Gagan, Undheim, Eivind A. B., Jia, Xinying and Mobli, Mehdi (2018). A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors. Neuroscience Letters, 679, 35-47. doi: 10.1016/j.neulet.2018.04.030
Tabassum, Nargis, Tae, Han-Shen, Jia, Xinying, Kaas, Quentin, Jiang, Tao, Adams, David J. and Yu, Rilei (2017). Role of CysI–CysIII disulfide bond on the structure and activity of α-conotoxins at human neuronal nicotinic acetylcholine receptors. ACS Omega, 2 (8), 4621-4631. doi: 10.1021/acsomega.7b00639
Activation of natural products biosynthetic pathways via a protein modification level regulation
Zhang, Benyin, Tian, Wenya, Wang, Shuwen, Yan, Xiaoli, Jia, Xinying, Pierens, Gregory K., Chen, Wenqing, Ma, Hongmin, Deng, Zixin and Qu, Xudong (2017). Activation of natural products biosynthetic pathways via a protein modification level regulation. ACS Chemical Biology, 12 (7), 1732-1736. doi: 10.1021/acschembio.7b00225
A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma
Laohaviroj, Marut, Potriquet, Jeremy, Jia, Xinying, Suttiprapa, Sutas, Chamgramol, Yaovalux, Pairojkul, Chawalit , Sithithaworn, Paiboon, Mulvenna, Jason and Sripa, Banchob (2017). A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma. Tumor Biology, 39 (6), 1010428317705764. doi: 10.1177/1010428317705764
A non-uniform sampling approach enables studies of dilute and unstable proteins
Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z
Kumar, Dhirendra, Yadav, Amit Kumar, Jia, Xinying, Mulvenna, Jason and Dash, Debasis (2016). Integrated transcriptomic-proteomic analysis using a proteogenomic workflow refines rat genome annotation. Molecular and Cellular Proteomics, 15 (1), 329-339. doi: 10.1074/mcp.M114.047126
Yu, Rilei, Seymour, Victoria A. L., Berecki, Geza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin and Craik, David J. (2015). Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports, 5 (Art No.: 13264) 13264, 13264. doi: 10.1038/srep13264
Transcriptome and venom proteome of the box jellyfish Chironex fleckeri
Brinkman, Diane L., Jia, Xinying, Potriquet, Jeremy, Kumar, Dhirendra, Dash, Debasis, Kvaskoff, David and Mulvenna, Jason (2015). Transcriptome and venom proteome of the box jellyfish Chironex fleckeri. BMC Genomics, 16 (1) 407, 407-407. doi: 10.1186/s12864-015-1568-3
Plieskatt, Jordan, Rinaldi, Gabriel, Feng, Yanjun, Peng, Jin, Easley, Samantha, Jia, Xinying, Potriquet, Jeremy, Pairojkul, Chawalit, Bhudhisawasdi, Vajarabhongsa, Sripa, Banchob, Brindley, Paul J, Bethony, Jeffrey and Mulvenna, Jason (2015). A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma. BMC Cancer, 15 (309) 309, 1-15. doi: 10.1186/s12885-015-1270-5
An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins
Tian, Zhenhua, Sun, Peng, Yan, Yan, Wu, Zhuhua, Zheng, Qingfei, Zhou, Shuaixiang, Zhang, Hua, Yu, Futao, Jia, Xinying, Chen, Dandan, Mandi, Attila, Kurtan, Tibor and Liu, Wen (2015). An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology, 11 (4), 259-265. doi: 10.1038/nchembio.1769
Bioclojure: a functional library for the manipulation of biological sequences
Plieskatt, Jordan, Rinaldi, Gabriel, Brindley, Paul J., Jia, Xinying, Potriquet, Jeremy, Bethony, Jeffrey and Mulvenna, Jason (2014). Bioclojure: a functional library for the manipulation of biological sequences. Bioinformatics, 30 (17), 2537-2539. doi: 10.1093/bioinformatics/btu311
Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558
Semienzymatic cyclization of disulfide-rich peptides using sortase A
Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262
Jaudzems, Kristaps, Jia, Xinying, Yagi, Hiromasa, Zhulenkovs, Dmitry, Graham, Bim, Otting, Gottfried and Liepinsh, Edvards (2012). Structural basis for 5′-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2. Journal of Molecular Biology, 424 (1-2), 42-53. doi: 10.1016/j.jmb.2012.09.010
DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra
Graham, Bim, Loh, Choy Theng, Swarbrick, James David, Ung, Phuc, Shin, James, Yagi, Hiromasa, Jia, Xinying, Chhabra, Sandeep, Barlow, Nicholas, Pintacuda, Guido, Huber, Thomas and Otting, Gottfried (2011). DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra. Bioconjugate Chemistry, 22 (10), 2118-2125. doi: 10.1021/bc200353c
Jia, Xinying, Yagi, Hiromasa, Su, Xun-Cheng, Stanton-Cook, Mitchell, Huber, Thomas and Otting, Gottfried (2011). Engineering [Ln(DPA)3]3- binding sites in proteins: a widely applicable method for tagging proteins with lanthanide ions. Journal of Biomolecular NMR, 50 (4), 411-420. doi: 10.1007/s10858-011-9529-x
Jia, Xinying, Maleckis, Ansis, Huber, Thomas and Otting, Gottfried (2011). 4,4′-dithiobisdipicolinic acid: a small and convenient lanthanide binding tag for protein NMR spectroscopy. Chemistry - A European Journal, 17 (24), 6830-6836. doi: 10.1002/chem.201003573
Jia, Xinying, Ozawa, Kiyoshi, Loscha, Karin and Otting, Gottfried (2009). Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins. Journal of Biomolecular NMR, 44 (2), 59-67. doi: 10.1007/s10858-009-9315-1
He, Qing-Li, Jia, Xin-Ying, Tang, Man-Cheng, Tian, Zhen-Hua, Tang, Gong-Li and Liu, Wen (2009). Dissection of two acyl-transfer reactions centered on acyl-s-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. ChemBioChem, 10 (5), 813-819. doi: 10.1002/cbic.200800714
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL
Wu, Zuopeng, Jia, Xinying, de la Cruz, Laura, Su, Xun-Cheng, Marzolf, Bruz, Troisch, Pamela, Zak, Daniel, Hamilton, Adam, Whittle, Belinda, Yu, Di, Sheahan, Daniel, Bertram, Edward, Aderem, Alan, Otting, Gottfried, Goodnow, Christopher C. and Hoyne, Gerard F. (2008). Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity, 29 (6), 863-875. doi: 10.1016/j.immuni.2008.11.004
Fang, Jie, Zhang, Yiping, Huang, Lijuan, Jia, Xinying, Zhang, Qi, Zhang, Xu, Tang, Gongli and Liu, Wen (2008). Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. Journal of Bacteriology, 190 (17), 6014-6025. doi: 10.1128/JB.00533-08
Shao, L, Qu, XD, Jia, XY, Zhao, QF, Tian, ZH, Wang, M, Tang, GL and Liu, W (2006). Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochemical and Biophysical Research Communications, 345 (1), 133-139. doi: 10.1016/j.bbrc.2006.04.069
Jia, XY, Tian, ZH, Shao, L, Qu, XD, Zhao, QF, Tang, J, Tang, GL and Liu, W (2006). Genetic Characterization of the Chlorothricin Gene Cluster as a Model for Spirotetronate Antibiotic Biosynthesis. Chemistry and Biology, 13 (6), 575-585. doi: 10.1016/j.chembiol.2006.03.008
How analgesic peptides inhibit voltage gated ion channels in a complex membrane environment
(2019) UQ Early Career Researcher
Structural basis of the function of peptide inhibitors targeting voltage-gated sodium channel
(2021) Doctor Philosophy — Associate Advisor
Other advisors:
The application of phospholipid nanodiscs to study peptide-lipid binding interactions
(2020) Doctor Philosophy — Associate Advisor
Other advisors: