The University of Queensland

Nonuniform sampling in biomolecular NMR

Miljenovic, Tomas Marko, Jia, Xinying and Mobli, Mehdi (2018). Nonuniform sampling in biomolecular NMR. Modern Magnetic Resonance. (pp. 2035-2054) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-28388-3_118

Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1

Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009

Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Sun, Chenghai, Luo, Zhenyao, Zhang, Wenlu, Tian, Wenya, Peng, Haidong, Lin, Zhi, Deng, Zixin, Kobe, Bostjan, Jia, Xinying and Qu, Xudong (2020). Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines. Nature Communications, 11 (1) 6251, 1-10. doi: 10.1038/s41467-020-20022-5

Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor

Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148

A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins

Jia, Xinying, Crawford, Theo, Zhang, Alan H. and Mobli, Mehdi (2019). A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins. Protein Expression and Purification, 161, 1-7. doi: 10.1016/j.pep.2019.04.004

Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs

Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Brinson, Robert G., Marino, John P., Delaglio, Frank, Arbogast, Luke W., Evans, Ryan M., Kearsley, Anthony, Gingras, Geneviève, Ghasriani, Houman, Aubin, Yves, Pierens, Gregory K., Jia, Xinying, Mobli, Mehdi, Grant, Hamish G., Keizer, David W., Schweimer, Kristian, Ståhle, Jonas, Widmalm, Göran, Zartler, Edward R., Lawrence, Chad W., Reardon, Patrick N., Cort, John R., Xu, Ping, Ni, Feng, Yanaka, Saeko, Kato, Koichi, Parnham, Stuart R., Tsao, Desiree, Blomgren, Andreas, Rundlöf, Torgny ... Wikström, Mats (2019). Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. mAbs, 11 (1), 94-105. doi: 10.1080/19420862.2018.1544454

Insights into the functionalization of the methylsalicyclic moiety during the biosynthesis of chlorothricin by comparative kinetic assays of the activities of two KAS III-like acyltransferases

Yi, Xuan, Zhao, Qunfei, Tian, Zhenhua, Jia, Xinying, Cao, Weiguo, Liu, Wen and He, Qing-Li (2019). Insights into the functionalization of the methylsalicyclic moiety during the biosynthesis of chlorothricin by comparative kinetic assays of the activities of two KAS III-like acyltransferases. Chinese Journal of Chemistry, 37 (8), 821-826. doi: 10.1002/cjoc.201900134

Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Tian, Wenya, Sun, Chenghai, Zheng, Mei, Harmer, Jeffrey R., Yu, Mingjia, Zhang, Yanan, Peng, Haidong, Zhu, Dongqing, Deng, Zixin, Chen, Shi-Lu, Mobli, Mehdi, Jia, Xinying and Qu, Xudong (2018). Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications, 9 (1) 4428, 4428. doi: 10.1038/s41467-018-06528-z

A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors

Zhang, Alan H., Sharma, Gagan, Undheim, Eivind A. B., Jia, Xinying and Mobli, Mehdi (2018). A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors. Neuroscience Letters, 679, 35-47. doi: 10.1016/j.neulet.2018.04.030

Role of CysI–CysIII disulfide bond on the structure and activity of α-conotoxins at human neuronal nicotinic acetylcholine receptors

Tabassum, Nargis, Tae, Han-Shen, Jia, Xinying, Kaas, Quentin, Jiang, Tao, Adams, David J. and Yu, Rilei (2017). Role of CysI–CysIII disulfide bond on the structure and activity of α-conotoxins at human neuronal nicotinic acetylcholine receptors. ACS Omega, 2 (8), 4621-4631. doi: 10.1021/acsomega.7b00639

Activation of natural products biosynthetic pathways via a protein modification level regulation

Zhang, Benyin, Tian, Wenya, Wang, Shuwen, Yan, Xiaoli, Jia, Xinying, Pierens, Gregory K., Chen, Wenqing, Ma, Hongmin, Deng, Zixin and Qu, Xudong (2017). Activation of natural products biosynthetic pathways via a protein modification level regulation. ACS Chemical Biology, 12 (7), 1732-1736. doi: 10.1021/acschembio.7b00225

A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma

Laohaviroj, Marut, Potriquet, Jeremy, Jia, Xinying, Suttiprapa, Sutas, Chamgramol, Yaovalux, Pairojkul, Chawalit , Sithithaworn, Paiboon, Mulvenna, Jason and Sripa, Banchob (2017). A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma. Tumor Biology, 39 (6), 1010428317705764. doi: 10.1177/1010428317705764

A non-uniform sampling approach enables studies of dilute and unstable proteins

Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z

Integrated transcriptomic-proteomic analysis using a proteogenomic workflow refines rat genome annotation

Kumar, Dhirendra, Yadav, Amit Kumar, Jia, Xinying, Mulvenna, Jason and Dash, Debasis (2016). Integrated transcriptomic-proteomic analysis using a proteogenomic workflow refines rat genome annotation. Molecular and Cellular Proteomics, 15 (1), 329-339. doi: 10.1074/mcp.M114.047126

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1

Yu, Rilei, Seymour, Victoria A. L., Berecki, Geza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin and Craik, David J. (2015). Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports, 5 (Art No.: 13264) 13264, 13264. doi: 10.1038/srep13264

Transcriptome and venom proteome of the box jellyfish Chironex fleckeri

Brinkman, Diane L., Jia, Xinying, Potriquet, Jeremy, Kumar, Dhirendra, Dash, Debasis, Kvaskoff, David and Mulvenna, Jason (2015). Transcriptome and venom proteome of the box jellyfish Chironex fleckeri. BMC Genomics, 16 (1) 407, 407-407. doi: 10.1186/s12864-015-1568-3

A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

Plieskatt, Jordan, Rinaldi, Gabriel, Feng, Yanjun, Peng, Jin, Easley, Samantha, Jia, Xinying, Potriquet, Jeremy, Pairojkul, Chawalit, Bhudhisawasdi, Vajarabhongsa, Sripa, Banchob, Brindley, Paul J, Bethony, Jeffrey and Mulvenna, Jason (2015). A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma. BMC Cancer, 15 (309) 309, 1-15. doi: 10.1186/s12885-015-1270-5

An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins

Tian, Zhenhua, Sun, Peng, Yan, Yan, Wu, Zhuhua, Zheng, Qingfei, Zhou, Shuaixiang, Zhang, Hua, Yu, Futao, Jia, Xinying, Chen, Dandan, Mandi, Attila, Kurtan, Tibor and Liu, Wen (2015). An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology, 11 (4), 259-265. doi: 10.1038/nchembio.1769

Bioclojure: a functional library for the manipulation of biological sequences

Plieskatt, Jordan, Rinaldi, Gabriel, Brindley, Paul J., Jia, Xinying, Potriquet, Jeremy, Bethony, Jeffrey and Mulvenna, Jason (2014). Bioclojure: a functional library for the manipulation of biological sequences. Bioinformatics, 30 (17), 2537-2539. doi: 10.1093/bioinformatics/btu311

Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni

Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558

Semienzymatic cyclization of disulfide-rich peptides using sortase A

Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262

Structural basis for 5′-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2

Jaudzems, Kristaps, Jia, Xinying, Yagi, Hiromasa, Zhulenkovs, Dmitry, Graham, Bim, Otting, Gottfried and Liepinsh, Edvards (2012). Structural basis for 5′-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2. Journal of Molecular Biology, 424 (1-2), 42-53. doi: 10.1016/j.jmb.2012.09.010

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra

Graham, Bim, Loh, Choy Theng, Swarbrick, James David, Ung, Phuc, Shin, James, Yagi, Hiromasa, Jia, Xinying, Chhabra, Sandeep, Barlow, Nicholas, Pintacuda, Guido, Huber, Thomas and Otting, Gottfried (2011). DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra. Bioconjugate Chemistry, 22 (10), 2118-2125. doi: 10.1021/bc200353c

Engineering [Ln(DPA)3]3- binding sites in proteins: a widely applicable method for tagging proteins with lanthanide ions

Jia, Xinying, Yagi, Hiromasa, Su, Xun-Cheng, Stanton-Cook, Mitchell, Huber, Thomas and Otting, Gottfried (2011). Engineering [Ln(DPA)3]3- binding sites in proteins: a widely applicable method for tagging proteins with lanthanide ions. Journal of Biomolecular NMR, 50 (4), 411-420. doi: 10.1007/s10858-011-9529-x

4,4′-dithiobisdipicolinic acid: a small and convenient lanthanide binding tag for protein NMR spectroscopy

Jia, Xinying, Maleckis, Ansis, Huber, Thomas and Otting, Gottfried (2011). 4,4′-dithiobisdipicolinic acid: a small and convenient lanthanide binding tag for protein NMR spectroscopy. Chemistry - A European Journal, 17 (24), 6830-6836. doi: 10.1002/chem.201003573

Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins

Jia, Xinying, Ozawa, Kiyoshi, Loscha, Karin and Otting, Gottfried (2009). Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins. Journal of Biomolecular NMR, 44 (2), 59-67. doi: 10.1007/s10858-009-9315-1

Dissection of two acyl-transfer reactions centered on acyl-s-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin

He, Qing-Li, Jia, Xin-Ying, Tang, Man-Cheng, Tian, Zhen-Hua, Tang, Gong-Li and Liu, Wen (2009). Dissection of two acyl-transfer reactions centered on acyl-s-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. ChemBioChem, 10 (5), 813-819. doi: 10.1002/cbic.200800714

Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL

Wu, Zuopeng, Jia, Xinying, de la Cruz, Laura, Su, Xun-Cheng, Marzolf, Bruz, Troisch, Pamela, Zak, Daniel, Hamilton, Adam, Whittle, Belinda, Yu, Di, Sheahan, Daniel, Bertram, Edward, Aderem, Alan, Otting, Gottfried, Goodnow, Christopher C. and Hoyne, Gerard F. (2008). Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity, 29 (6), 863-875. doi: 10.1016/j.immuni.2008.11.004

Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics

Fang, Jie, Zhang, Yiping, Huang, Lijuan, Jia, Xinying, Zhang, Qi, Zhang, Xu, Tang, Gongli and Liu, Wen (2008). Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. Journal of Bacteriology, 190 (17), 6014-6025. doi: 10.1128/JB.00533-08

Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase

Shao, L, Qu, XD, Jia, XY, Zhao, QF, Tian, ZH, Wang, M, Tang, GL and Liu, W (2006). Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochemical and Biophysical Research Communications, 345 (1), 133-139. doi: 10.1016/j.bbrc.2006.04.069

Genetic Characterization of the Chlorothricin Gene Cluster as a Model for Spirotetronate Antibiotic Biosynthesis

Jia, XY, Tian, ZH, Shao, L, Qu, XD, Zhao, QF, Tang, J, Tang, GL and Liu, W (2006). Genetic Characterization of the Chlorothricin Gene Cluster as a Model for Spirotetronate Antibiotic Biosynthesis. Chemistry and Biology, 13 (6), 575-585. doi: 10.1016/j.chembiol.2006.03.008