The University of Queensland

In vivo recordings at the Caenorhabditis elegans neuromuscular junction

Gao, Shangbang and Hu, Zhitao (2018). In vivo recordings at the Caenorhabditis elegans neuromuscular junction. Extracellular Recording Approaches. (pp. 143-156) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-7549-5_8

Protocols for electrophysiological recordings and electron microscopy at C. elegans neuromuscular junction

Liu, Haowen, Li, Lei, Krout, Mia, Sheoran, Seema, Zhao, Qihong, Chen, Jingyi, Liu, Huisheng, Richmond, Janet E. and Hu, Zhitao (2021). Protocols for electrophysiological recordings and electron microscopy at C. elegans neuromuscular junction. STAR Protocols, 2 (3) 100749, 1-21. doi: 10.1016/j.xpro.2021.100749

The Role of Calmodulin vs. Synaptotagmin in Exocytosis

Xue, Renhao, Meng, Hao, Yin, Jiaxiang, Xia, Jingyao, Hu, Zhitao and Liu, Huisheng (2021). The Role of Calmodulin vs. Synaptotagmin in Exocytosis. Frontiers in Molecular Neuroscience, 14 691363, 1-12. doi: 10.3389/fnmol.2021.691363

The M domain in UNC-13 regulates the probability of neurotransmitter release

Liu, Haowen, Li, Lei, Sheoran, Seema, Yu, Yi, Richmond, Janet E., Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). The M domain in UNC-13 regulates the probability of neurotransmitter release. Cell Reports, 34 (10) 108828. doi: 10.1016/j.celrep.2021.108828

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming

Padmanarayana, Murugesh, Liu, Haowen, Michelassi, Francesco, Li, Lei, Betensky, Daniel, Dominguez, Matthew J., Sutton, R. Bryan, Hu, Zhitao and Dittman, Jeremy S. (2021). A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming. Proceedings of the National Academy of Sciences, 118 (11) e2016276118, e2016276118. doi: 10.1073/pnas.2016276118

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

Qian, Kang-Ying, Zeng, Wan-Xin, Hao, Yue, Zeng, Xian-Ting, Liu, Haowen, Li, Lei, Chen, Lili, Tian, Fu-min, Chang, Cindy, Hall, Qi, Song, Chun-Xue, Gao, Shangbang, Hu, Zhi-Tao, Kaplan, Joshua M., Li, Qian and Tong, Xia-Jing (2021). Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner. eLife, 10 e67170, 1-29. doi: 10.7554/eLife.67170

A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release

Li, Lei, Liu, Haowen, Krout, Mia, Richmond, Janet E., Wang, Yu, Bai, Jihong, Weeratunga, Saroja, Collins, Brett M., Ventimiglia, Donovan, Yu, Yi, Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release. Journal of Cell Biology, 220 (4) e202008121, 1-24. doi: 10.1083/jcb.202008121

A hyperactive form of unc-13 enhances Ca2+ sensitivity and synaptic vesicle release probability in C. elegans

Li, Lei, Liu, Haowen, Hall, Qi, Wang, Wei, Yu, Yi, Kaplan, Joshua M. and Hu, Zhitao (2019). A hyperactive form of unc-13 enhances Ca2+ sensitivity and synaptic vesicle release probability in C. elegans. Cell Reports, 28 (11), 2979-2995.e4. doi: 10.1016/j.celrep.2019.08.018

mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction

Snieckute, Goda, Baltaci, Oguzhan, Liu, Haowen, Li, Lei, Hu, Zhitao and Pocock, Roger (2019). mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction. Molecular and Cellular Neuroscience, 98, 70-81. doi: 10.1016/j.mcn.2019.06.001

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M. and Hu, Zhitao (2019). Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans. eLife, 8 e40585. doi: 10.7554/eLife.40585

The Claudin-like protein HPO-30 is required to maintain LAChRs at the C. elegans neuromuscular junction

Sharma, Pallavi, Li, Lei, Liu, Haowen, Tikiyani, Vina, Hu, Zhitao and Babu, Kavita (2018). The Claudin-like protein HPO-30 is required to maintain LAChRs at the C. elegans neuromuscular junction. The Journal of Neuroscience, 38 (32), 7072-7087. doi: 10.1523/JNEUROSCI.3487-17.2018

SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans

Li, Lei, Liu, Haowen, Wang, Wei, Chandra, Mintu, Collins, Brett M. and Hu, Zhitao (2018). SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans. The Journal of Neuroscience, 38 (23), 5313-5324. doi: 10.1523/JNEUROSCI.3097-17.2018

Spontaneous vesicle fusion is differentially regulated at cholinergic and GABAergic synapses

Liu, Haowen, Li, Lei, Wang, Wei, Gong, Jihong, Yang, Xiaofei and Hu, Zhitao (2018). Spontaneous vesicle fusion is differentially regulated at cholinergic and GABAergic synapses. Cell reports, 22 (9), 2334-2345. doi: 10.1016/j.celrep.2018.02.023

Wnt secretion is regulated by the tetraspan protein HIC-1 through its interaction with Neurabin/NAB-1

Tikiyani, Vina, Li, Lei, Sharma, Pallavi, Liu, Haowen, Hu, Zhitao and Babu, Kavita (2018). Wnt secretion is regulated by the tetraspan protein HIC-1 through its interaction with Neurabin/NAB-1. Cell Reports, 25 (7), 1856-1871.e6. doi: 10.1016/j.celrep.2018.10.053

A C1-C2 module in Munc13 inhibits calcium-dependent neurotransmitter release

Michelassi, Francesco, Liu, Haowen , Hu, Zhitao and Dittman, Jeremy S. (2017). A C1-C2 module in Munc13 inhibits calcium-dependent neurotransmitter release. Neuron, 95 (3), 577-590. doi: 10.1016/j.neuron.2017.07.015

Retrograde synaptic inhibition is mediated by α-neurexin binding to the α2δ subunits of n-type calcium channels

Tong, Xia-Jing, Lopez-Soto, Eduardo Javier, Li, Lei, Liu, Haowen, Nedelcu, Daniel, Lipscombe, Diane, Hu, Zhitao and Kaplan, Joshua M. (2017). Retrograde synaptic inhibition is mediated by α-neurexin binding to the α2δ subunits of n-type calcium channels. Neuron, 95 (2), 326-+. doi: 10.1016/j.neuron.2017.06.018

Protective effect of Aster tataricus extract on retinal damage on the virtue of its antioxidant and anti-inflammatory effect in diabetic rat

Du, Hao, Zhang, Meng, Yao, Kejun and Hu, Zhitao (2017). Protective effect of Aster tataricus extract on retinal damage on the virtue of its antioxidant and anti-inflammatory effect in diabetic rat. Biomedicine and Pharmacotherapy, 89, 617-622. doi: 10.1016/j.biopha.2017.01.179

A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

Tong, Xia-Jing, Hu, Zhitao, Liu, Yu, Anderson, Dorian and Kaplan, Joshua M. (2015). A network of autism linked genes stabilizes two pools of synaptic GABAA receptors. eLife, 4 (e09648) e09648. doi: 10.7554/eLife.09648

Sensory neurons arouse C. elegans locomotion via both glutamate and neuropeptide release

Choi, Seungwon, Taylor, Kelsey P., Chatzigeorgiou, Marios, Hu, Zhitao, Schafer, William R. and Kaplan, Joshua M. (2015). Sensory neurons arouse C. elegans locomotion via both glutamate and neuropeptide release. PloS Genetics, 11 (7), e1005359. doi: 10.1371/journal.pgen.1005359

NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release

Hu, Zhitao, Vashlishan-Murray, Amy B. and Kaplan, Joshua M. (2015). NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release. Journal of Neuroscience, 35 (3), 1038-1042. doi: 10.1523/JNEUROSCI.2825-14.2015

UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans

Hu, Zhitao, Tong, Xia-Jing and Kaplan, Joshua M. (2013). UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans. eLife, 2013 (2) e00967. doi: 10.7554/eLife.00967

The F-Box Protein MEC-15 (FBXW9) Promotes Synaptic Transmission in GABAergic Motor Neurons in C. elegans

Sun, Yu, Hu, Zhitao, Goeb, Yannick and Dreier, Lars (2013). The F-Box Protein MEC-15 (FBXW9) Promotes Synaptic Transmission in GABAergic Motor Neurons in C. elegans. PloS One, 8 (3), e59132. doi: 10.1371/journal.pone.0059132

Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans

Hu, Zhitao, Hom, Sabrina, Kudze, Tambudzai, Tong, Xia-Jing, Choi, Seungwon, Aramuni, Gayane, Zhang, Weiqi and Kaplan, Joshua M. (2012). Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science, 337 (6097), 980-984. doi: 10.1126/science.1224896

Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release

Chan, Jason P., Hu, Zhitao and Sieburth, Derek (2012). Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release. Genes & Development, 26 (10), 1070-1085. doi: 10.1101/gad.188003.112

HBL-1 patterns synaptic remodeling in C. elegans

Thompson-Peer, Katherine L., Bai, Jihong, Hu, Zhitao and Kaplan, Joshua M. (2012). HBL-1 patterns synaptic remodeling in C. elegans. Neuron, 73 (3), 453-465. doi: 10.1016/j.neuron.2011.11.025

RIC-7 promotes neuropeptide secretion

Hao, Yingsong, Hu, Zhitao, Sieburth, Derek and Kaplan, Joshua M. (2012). RIC-7 promotes neuropeptide secretion. PloS Genetics, 8 (1) e1002464, e1002464. doi: 10.1371/journal.pgen.1002464

A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release

Hu, Zhitao, Pym, Edward C. G., Babu, Kavita, Murray, Amy B. Vashlishan and Kaplan, Joshua M. (2011). A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Neuron, 71 (1), 92-102. doi: 10.1016/j.neuron.2011.04.021

The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling

Babu, Kavita, Hu, Zhitao, Chien, Shih-Chieh, Garriga, Gian and Kaplan, Joshua M. (2011). The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling. Neuron, 71 (1), 103-116. doi: 10.1016/j.neuron.2011.05.034

Complexin has opposite effects on two modes of synaptic vesicle fusion

Martin, Jesse A., Hu, Zhitao, Fenz, Katherine M., Fernandez, Joel and Dittman, Jeremy S. (2011). Complexin has opposite effects on two modes of synaptic vesicle fusion. Current Biology, 21 (2), 97-105. doi: 10.1016/j.cub.2010.12.014

The C2C-MCT Domain of Munc13 is Essential for Priming Synaptic Vesicles

Narayanappa, Murugesh, Liu, Haowen, Li, Lei, Michelassi, Francesco, Hu, Zhitao and Dittman, Jeremy (2020). The C2C-MCT Domain of Munc13 is Essential for Priming Synaptic Vesicles. 64th Annual Meeting of the Biophysical-Society, San Diego Ca, Feb 15-19, 2020. CAMBRIDGE: CELL PRESS.

A C1-C2 Module in MUNC13 Inhibits Calcium-Dependent Neurotransmitter Release

Dittman, Jeremy, Michelassi, Francesco, Liu, Haowen and Hu, Zhitao (2017). A C1-C2 Module in MUNC13 Inhibits Calcium-Dependent Neurotransmitter Release. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2016.11.2145