The University of Queensland

Emerging lipoprotein-related therapeutics for patients with diabetes

Little, Peter J., Chait, Alan, Januszewski, Andrzej S., Bobik, Alex, O'Neal, David and Jenkins, Alicia J. (2014). Emerging lipoprotein-related therapeutics for patients with diabetes. In Alicia J. Jenkins, Peter P. Toth and Timothy J. Lyons (Ed.), Lipoproteins in diabetes mellitus (pp. 435-453) New York, United States: Springer. doi:10.1007/978-1-4614-7554-5_23

Lipid: extracellular matrix interactions as therapeutic targets in the atherosclerosis of diabetes

Osman, Narin and Little, Peter J. (2014). Lipid: extracellular matrix interactions as therapeutic targets in the atherosclerosis of diabetes. In Alicia J. Jenkins, Peter P. Toth and Timothy J. Lyons (Ed.), Lipoproteins in diabetes mellitus (pp. 215-229) New York, United States: Springer. doi:10.1007/978-1-4614-7554-5_11

Peroxisome Proliferator-Activated Receptors and diabetic vasculature

Little, P. J., Topliss, D. J., Mudaliar, S. and Law, R. E. (2004). Peroxisome Proliferator-Activated Receptors and diabetic vasculature. In Diabetes and Cardiovascular Disease: Integrating Science and Clinical Medicine (pp. 75-91) Philadelphia USA: LWW.

Role of Na-H exchange in vascular remodelling in diabetes. Diabetes and Vascular Disease

Little, P. J. and Dilley, R. J. (2003). Role of Na-H exchange in vascular remodelling in diabetes. Diabetes and Vascular Disease. In The sodium-hydrogen exchanger: from molecule to its role in disease (pp. 160-175) New York: Springer US.

Vascular derived growth factors: potential role in the development of the tumour vasculature

Bobik, A., Agrotis, A. and Little, P. J. (1997). Vascular derived growth factors: potential role in the development of the tumour vasculature. In Tumour Angiogenesis (pp. 169-180) England: Oxford University Press.

Disturbances of vascular smooth muscle cation transport and the pathogenesis of hypertension

Bobik, A., Agrotis, A. and Little, P. J. (1994). Disturbances of vascular smooth muscle cation transport and the pathogenesis of hypertension. In Textbook of hypertension (pp. 175-187) UK: Blackwell Scientific Publications.

Na+/H+ exchange in an excitable tissue (Chapter 7)

Little, P. J. (1992). Na+/H+ exchange in an excitable tissue (Chapter 7). In Amiloride and its Analogues: Unique Cation Transport Inhibitors (pp. 97-120) New York: VCH Press.

Different inositol phosphate responses to angiotensin II and Vasopressin in rat adrenal glomerulosa cells

Woodcock, E. A., Caroccia, L., McLeod, J. K. and Little, P. J. (1990). Different inositol phosphate responses to angiotensin II and Vasopressin in rat adrenal glomerulosa cells. In Advances in Second Messenger and Phosphoprotein Research. The Biology and Medicine of Signal Transduction V. 24 (pp. 134-139) New York: Raven Press.

Ionic mechanisms of cytoplasmic pH regulation in vascular smooth muscle

Bobik, A., Little, P. J., Weissberg, P. L. and Grinpukel, S. (1988). Ionic mechanisms of cytoplasmic pH regulation in vascular smooth muscle. In Vascular Neuroeffector Mechanisms (pp. 209-216) England: Oxford University Press.

Mechanisms influencing Na+ entry in cultured vascular smooth muscle

Little, P. J., Weissberg, P. L., Cragoe, E. J. and Bobik, A. (1988). Mechanisms influencing Na+ entry in cultured vascular smooth muscle. In Progress in Biochemical Pharmacology (pp. 142-149) Basel: Karger.

In vitro and in vivo metabolism of benzo(a)pyrene by selected marine crustacean species

Bend, J. R., James, M. O., Little, P. J. and Foureman, G. L. (1981). In vitro and in vivo metabolism of benzo(a)pyrene by selected marine crustacean species. In Phyletic Approaches to Cancer (pp. 179-194) Tokyo: Japan Scientific Societies Press.

Characterisation of cytochrome P-450 dependent mixed function oxidation in the spiny lobster, Panulirus argus

James, M. O. and Little, P. J. (1980). Characterisation of cytochrome P-450 dependent mixed function oxidation in the spiny lobster, Panulirus argus. In Biochemistry, Biophysics and Regulation of Cytochrome P-450 (pp. 113-120) Amsterdam North-Holland: Elsevier Biomedical Press.

Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1

Seif, Faezeh, Little, Peter J., Niayesh-Mehr, Reyhaneh, Zamanpour, Masoumeh and Babaahmadi-Rezaei, Hossein (2019) Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1. Journal of Pharmacy and Pharmacology, 71 6: 988-995. doi:10.1111/jphp.13081

Role of corticotropin releasing factor in the neuroimmune mechanisms of depression: Examination of current pharmaceutical and herbal therapies

Jiang, Yizhou, Peng, Tangming, Gaur, Uma, Silva, Marta, Little, Peter, Chen, Zhong, Qiu, Wei, Zhang, Yandong and Zheng, Wenhua (2019) Role of corticotropin releasing factor in the neuroimmune mechanisms of depression: Examination of current pharmaceutical and herbal therapies. Frontiers in Cellular Neuroscience, 13 . doi:10.3389/fncel.2019.00290

Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis

Yusof, Nur Nazifah Mohd, McCann, Andrew, Little, Peter J. and Ta, Hang T. (2019) Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis. Thrombosis Research, 177 161-171. doi:10.1016/j.thromres.2019.03.009

Treatment of atherosclerotic plaque: perspectives on theranostics

Zhang, Yicong, Koradia, Aayushi, Kamato, Danielle, Popat, Amirali, Little, Peter J. and Ta, Hang T. (2019) Treatment of atherosclerotic plaque: perspectives on theranostics. Journal of Pharmacy and Pharmacology, . doi:10.1111/jphp.13092

Targeting mechanosensitive transcription factors in atherosclerosis

Niu, Niu, Xu, Suowen, Xu, Yanni, Little, Peter J. and Jin, Zheng-Gen (2019) Targeting mechanosensitive transcription factors in atherosclerosis. Trends in Pharmacological Sciences, 40 4: 253-266. doi:10.1016/j.tips.2019.02.004

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes

Kamato, Danielle, Burch, Micah, Yang, Zhou, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin and Little, Peter J. (2018) Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cellular Signalling, 53 365-373. doi:10.1016/j.cellsig.2018.11.005

Danhong injection in cardiovascular and cerebrovascular diseases: cardiovascular actions, molecular mechanisms, and therapeutic potential

Feng, Xiaojun, Li, Yi, Wang, Yanan, Li, Lingli, Little, Peter J., Xu, Suo-wen and Liu, Sheng (2018) Danhong injection in cardiovascular and cerebrovascular diseases: cardiovascular actions, molecular mechanisms, and therapeutic potential. Pharmacological Research, 139 62-75. doi:10.1016/j.phrs.2018.11.006

Tanshinone IIA attenuates insulin like growth factor 1 -induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways

Wang, Haitao, Su, Xiaoying, Fang, Jiankang, Xin, Xingan, Zhao, Xia, Gaur, Uma, Wen, Qiang, Xu, Jiangping, Little, Peter and Zheng, Wenhua (2018) Tanshinone IIA attenuates insulin like growth factor 1 -induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways. International Journal of Molecular Sciences, 19 9: 2719. doi:10.3390/ijms19092719

Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases

Wu, Yuao, Yang, Yanchen, Zhao, Wei, Xu, Zhi Ping, Little, Peter J., Whittaker, Andrew K., Zhang, Run and Ta, Hang T. (2018) Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases. Journal of Materials Chemistry B: Materials for Biology and Medicine, 6 30: 4937-4951. doi:10.1039/c8tb00022k

Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis

Ta, Hang T., Arndt, Nina, Wu, Yuao, Lim, Hui Jean, Landeen, Shea, Zhang, Run, Kamato, Danielle, Little, Peter J., Whittaker, Andrew K. and Xu, Zhi Ping (2018) Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis. Nanoscale, 10 31: 15103-15115. doi:10.1039/c8nr05095c

Endothelial function and dysfunction: impact of metformin

Nafisa, Asma, Gray, Susan G., Cao, Yingnan, Wang, Tinghuai, Xu, Suowen, Wattoo, Feroza H., Barras, Michael, Cohen, Neale, Kamato, Danielle and Little, Peter J. (2018) Endothelial function and dysfunction: impact of metformin. Pharmacology and Therapeutics, . doi:10.1016/j.pharmthera.2018.07.007

Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2

Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018) Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 1: 156-164. doi:10.1124/jpet.117.244483

The changing environment of hyperglycaemia in pregnancy: gestational diabetes and diabetes mellitus in pregnancy

Gray, Susan G., Sweeting, Arianne N., Mcguire, Treasure M., Cohen, Neale, Ross, Glynis P. and Little, Peter J. (2018) The changing environment of hyperglycaemia in pregnancy: gestational diabetes and diabetes mellitus in pregnancy. Journal of Diabetes, 10 8: 633-640. doi:10.1111/1753-0407.12660

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation

Talati, Nirali, Kamato, Danielle, Piva, Terrence J, Little, Peter and Osman, Narin (2018) Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation. Cellular Signalling, 47 37-43. doi:10.1016/j.cellsig.2018.03.009

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of smad transcription factors

Dayati, Parisa, Rezaei, Hossein Babaahmadi, Sharifat, Narges, Kamato, Danielle and Little, Peter J (2018) G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of smad transcription factors. Life Sciences, 199 10-15. doi:10.1016/j.lfs.2018.03.004

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis

Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle and Little, Peter J. (2018) Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis. Pharmacology and Therapeutics, 187 88-97. doi:10.1016/j.pharmthera.2018.02.005

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects

Xu, Suowen, Xu, Yanni, Yin, Meimei, Zhang, Shuya, Liu, Peng, Koroleva, Marina, Si, Shuyi, Little, Peter J., Pelisek, Jaroslav and Jin, Zheng Gen (2018) Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics, 8 11: 3007-3021. doi:10.7150/thno.21966

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

Tian, Kunming, Ogura, Sayoko, Little, Peter J., Xu, Suo-wen and Sawamura, Tatsuya (2018) Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives. Annals of the New York Academy of Sciences, . doi:10.1111/nyas.13984

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

Xu, Suowen, Kamato, Danielle, Little, Peter J., Nakagawa, Shinichi, Pelisek, Jaroslav and Jin, Zheng Gen (2018) Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics. Pharmacology and Therapeutics, . doi:10.1016/j.pharmthera.2018.11.003

Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells

Mohamed, Raafat, Dayati, Parisa, Mehr, Reyhaneh Niayesh, Kamato, Danielle, Seif, Faezeh, Babaahmadi-Rezaei, Hossein and Little, Peter J. (2018) Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells. Journal of Cell Communication and Signaling, . doi:10.1007/s12079-018-0495-x

Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B

Yan, Fengxia, Liao, Rifang, Lin, Shaofen, Deng, Xianguo, Little, Peter J and Zheng, Wenhua (2017) Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Molecular medicine reports, 17 2: 3109-3114. doi:10.3892/mmr.2017.8215

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Kamato, Danielle, Vijayanand Bhaskarala, Venkata, Mantri, Nitin, Gyu Oh, Tae, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2017) RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One, 12 7: e0180842. doi:10.1371/journal.pone.0180842

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors

Chaplin, Rebecca, Thach, Lyna, Hollenberg, Morley D., Cao, Yingnan, Little, Peter J. and Kamato, Danielle (2017) Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors. Journal of Cell Communication and Signaling, 11 2: 117-125. doi:10.1007/s12079-017-0375-9

Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes

Asrafuzzaman, Md., Cao, Yingnan, Afroz, Rizwana, Kamato, Danielle, Gray, Susan and Little, Peter J. (2017) Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes. Biomedicine and Pharmacotherapy, 89 1242-1251. doi:10.1016/j.biopha.2017.03.010

Gaq proteins: molecular pharmacology and therapeutic potential

Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017) Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 8: 1379-1390. doi:10.1007/s00018-016-2405-9

The emerging role of metformin in gestational diabetes mellitus

Gray, Susan G. , Mcguire, Treasure M. , Cohen, Neale and Little, Peter J. (2017) The emerging role of metformin in gestational diabetes mellitus. Diabetes, Obesity and Metabolism, 19 6: 765-772. doi:10.1111/dom.12893

Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo

Wang, Rikang, Yan, Fengxia, Liao, Rifang, Wan, Pei, Little, Peter J. and Zheng, Wenhua (2017) Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Molecular and Cellular Endocrinology, 447 C: 71-78. doi:10.1016/j.mce.2017.02.040

IGF-1-mediated survival from induced death of human primary cultured retinal pigment epithelial cells is mediated by an Akt-dependent signaling pathway

Zheng, Wenhua, Meng, Qian, Wang, Haitao, Yan, Fengxia, Little, Peter J., Deng, Xinguo and Lin, Shaofen (2017) IGF-1-mediated survival from induced death of human primary cultured retinal pigment epithelial cells is mediated by an Akt-dependent signaling pathway. Molecular Neurobiology, 55 3: 1-13. doi:10.1007/s12035-017-0447-0

Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine Danshen

Fang, Jian, Little, Peter J. and Xu, Suowen (2017) Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine Danshen. Medicinal Research Reviews, 38 1: 201-228. doi:10.1002/med.21438

Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis

Sharifat, Narges, Mohammad Zadeh, Ghorban, Ghaffari, Mohammad-Ali, Dayati, Parisa, Kamato, Danielle, Little, Peter J. and Babaahmadi-Rezaei, Hossein (2017) Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis. Journal of Pharmacy and Pharmacology, 69 1: 66-72. doi:10.1111/jphp.12654

FOXO signaling pathways as therapeutic targets in cancer

Farhan, Mohd, Wang, Haitao, Gaur, Uma, Little, Peter J., Xu, Jiangping and Zheng, Wenhua (2017) FOXO signaling pathways as therapeutic targets in cancer. International Journal of Biological Sciences, 13 7: 815-827. doi:10.7150/ijbs.20052

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells

Fengxia, Yan, Rifang, Liao, Farhan, Mohd, Tinghuai, Wang, Jiashu, Chen, Wang, Zhong, Little, Peter J. and Wenhua, Zheng (2016) Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells. Biomedicine and Pharmacotherapy, 84 1538-1550. doi:10.1016/j.biopha.2016.11.027

Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway

Liao, Rifang, Yan, Fengxia, Zeng, Zhuanping, Farhan, Mohd, Little, Peter, Quirion, Remi, Srivastava, Lalit K. and Zheng, Wenhua (2016) Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway. Molecular Neurobiology, 54 9: 1-13. doi:10.1007/s12035-016-0211-x

An investigation of sodium fusidate and recombinant cytochrome P450 enzymes inhibition in-vitro

Mishriky, John, Balassone, Jacqueline, Bashour, Zenah, Kaur, Simranjit, Raman, Vini, Getachew, Robel, Osman, Narin, Guidone, Daniel, Chan, Vincent and Little, Peter J. (2016) An investigation of sodium fusidate and recombinant cytochrome P450 enzymes inhibition in-vitro. Drug Metabolism Letters, 10 3: 180-186. doi:10.2174/1872312810666160607015045

Is high-dose beta-lactam therapy associated with excessive drug toxicity in critically ill patients?

Mcdonald, Craig, Cotta, Menino O., Little, Peter J., Mcwhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2016) Is high-dose beta-lactam therapy associated with excessive drug toxicity in critically ill patients?. Minerva Anestesiologica, 82 9: 957-965.

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle

Rostam, Muhamad A., Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016) The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cellular Signalling, 28 8: 956-966. doi:10.1016/j.cellsig.2016.05.002

Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells

Al Gwairi, Othman, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Kamato, Danielle, Thach, Lyna and Little, Peter J. (2016) Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells. International Journal of Biological Sciences, 12 9: 1041-1051. doi:10.7150/ijbs.16134

Multidisciplinary involvement in completion of a hospital medication management plan in a tertiary hospital in Australia

Thrimawithana, Thilini, Abdelmalek, Sandra, Al-Maliki, Saja, Ali, Saabreen, Gupta, Arushi, Hassan, Nourhan, Little, Peter J. and Stuchbery, Peter (2016) Multidisciplinary involvement in completion of a hospital medication management plan in a tertiary hospital in Australia. Journal of Pharmacy Practice and Research, 46 2: 192-194. doi:10.1002/jppr.1146

The atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt/FoxO3a signaling pathway

Zeng, Zhiwen, Wang, Xue, Bhardwaj, Sanjeev K., Zhou, Xuanhe, Little, Peter J., Quirion, Remi, Srivastava, Lalit K. and Zheng, Wenhua (2016) The atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt/FoxO3a signaling pathway. Molecular Neurobiology, 54 5: 1-12. doi:10.1007/s12035-016-9904-4

SIRT6 protects against endothelial dysfunction and atherosclerosis in mice

Xu, Suowen, Yin, Meimei, Koroleva, Marina, Mastrangelo, Michael A., Zhang, Wenbo, Bai, Peter, Little, Peter J. and Jin, Zheng Gen (2016) SIRT6 protects against endothelial dysfunction and atherosclerosis in mice. Aging, 8 5: 1064-1078. doi:10.18632/aging.100975

SIRT6 protects against endothelial dysfunction and atherosclerosis in mice

Xu, Suowen, Yin, Meimei, Koroleva, Marina, Mastrangelo, Michael A., Zhang, Wenbo, Bai, Peter, Little, Peter J. and Jin, Zheng Gen (2016) SIRT6 protects against endothelial dysfunction and atherosclerosis in mice. Aging, 8 5: 1064-1082.

Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response

Bernard, Rebekah, Getachew R., Kamato, D., Thach L., Osman N., Chan V., Zheng W. and Little P.J. (2016) Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. Journal of Pharmacy and Pharmacology, 68 3: 368-378. doi:10.1111/jphp.12530

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling

Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016) Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 20: 2992-3000. doi:10.1111/bph.13398

Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans

Al Gwairi, Othman, Thach, Lyna, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2016) Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. Journal of Ophthalmology, 2016 2913612. doi:10.1155/2016/2913612

Honey-derived flavonoids: natural products for the prevention of atherosclerosis and cardiovascular diseases

Afroz, R., Tanvir, E and Little, P.J. (2016) Honey-derived flavonoids: natural products for the prevention of atherosclerosis and cardiovascular diseases. Clinical and Experimental Pharmacology, 6 3: . doi:10.4172/2161-1459.1000208

Molecular Pharmacology of Honey

Afroz, R, Tanvir, EM, Zheng, W and Little, PJ (2016) Molecular Pharmacology of Honey. Clinical and Experimental Pharmacology, 06 03: . doi:10.4172/2161-1459.1000212

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes

Kamato, Danielle, Thach, Lyna, Getachew, Robel, Burch, Micah, Hollenberg, Morley D., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016) Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling, 28 1: 110-119. doi:10.1016/j.cellsig.2015.11.003

Forkhead box O transcription factors as possible mediators in the development of major depression

Wang, Haitao, Quirion, Remi, Little, Peter J., Cheng, Yufang, Feng, Zhong-Ping, Sun, Hong-Shuo, Xu, Jiangping and Zheng, Wenhua (2015) Forkhead box O transcription factors as possible mediators in the development of major depression. Neuropharmacology, 99 527-537. doi:10.1016/j.neuropharm.2015.08.020

Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways

Zeng, Zhiwen, Wang, Haitao, Shang, Fu, Zhou, Lihua, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2015) Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways. Psychopharmacology, 233 5: 785-794. doi:10.1007/s00213-015-4168-7

Determination of dose enhancement caused by gold-nanoparticles irradiated with proton, X-rays (kV and MV) and electron beams, using alanine/EPR dosimeters

Smith, Clare L., Ackerly, Trevor, Best, Stephen P., Gagliardi, Frank, Kie, Katahira, Little, Peter J., McCorkell, Giulia, Sale, Charlotte A., Tsunei, Yusuke, Tominaga, Takahiro, Volaric, Sloe See and Geso, Moshi (2015) Determination of dose enhancement caused by gold-nanoparticles irradiated with proton, X-rays (kV and MV) and electron beams, using alanine/EPR dosimeters. Radiation Measurements, 82 122-128. doi:10.1016/j.radmeas.2015.09.008

Methotrexate Inhibits Proliferation but not Proteoglycan Synthesis or Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells

Little, Peter J., Getachew, Robel, Kamto, Danielle, Ashraf Rostam, Muhamad, Cohen, Neale, Chan, Vincent and Osman, Narin (2015) Methotrexate Inhibits Proliferation but not Proteoglycan Synthesis or Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells. Clinical & Experimental Pharmacology, 5 4: . doi:10.4172/2161-1459.1000181

Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins

Guidone, Daniel, Getachew, Robel, Osman, Narin, Ward, Michael, Chan, Vincent and Little, Peter J. (2015) Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins. Clinical and Experimental Pharmacology, 5 3: 1000174.1-1000174.4. doi:10.4172/2161-1459.1000174

IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprusside insult

Wang, Haitao, Liao, Sufen, Geng, Ruojun, Zheng, Yongxin, Liao, Rifang, Yan, Fengxia, Thrimawithana, Thilini, Little, Peter J., Feng, Zhong-Ping, Lazarovici, Philip and Zheng, Wenhua (2015) IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprusside insult. Journal of Molecular Neuroscience, 55 4: 931-940. doi:10.1007/s12031-014-0448-7

Structure, function, pharmacology, and therapeutic potential of the G protein, Gα/q,11

Kamato, Danielle, Thach, Lyna, Bernard, Rebekah, Chan, Vincent, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret, Osman, Narin and Little, Peter J. (2015) Structure, function, pharmacology, and therapeutic potential of the G protein, Gα/q,11. Frontiers in Cardiovascular Medicine, 2 . doi:10.3389/fcvm.2015.00014

Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats

Chen, Qian, Wang, Haitao, Liao, Sufen, Gao, Yang, Liao, Rifang, Little, Peter J., Xu, Jiangping, Feng, Zhong-Ping, Zheng, Yongxin and Zheng, Wenhua (2015) Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats. Growth Factors, 33 2: 149-159. doi:10.3109/08977194.2015.1010642

Total synthesis of the cyclic depsipeptide YM-280193, a platelet aggregation inhibitor

Kaur, Harveen, Harris, Paul W. R., Little, Peter J. and Brimblet, Margaret A. (2015) Total synthesis of the cyclic depsipeptide YM-280193, a platelet aggregation inhibitor. Organic Letters, 17 3: 492-495. doi:10.1021/ol503507g

Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease

Rostam, Muhamad A., Piva, Terrence J., Rezaei, Hossein B., Kamato, Danielle, Little, Peter J., Zheng, Wenhua and Osman, Narin (2015) Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease. Clinical and Experimental Pharmacology and Physiology, 42 2: 117-124. doi:10.1111/1440-1681.12335

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Kamato, Danielle, Rostam, Muhamad Ashraf, Bernard, Rebekah, Piva, Terrence J., Mantri, Nitin, Guidone, Daniel, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2015) The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier. Cellular and Molecular Life Sciences, 72 4: 799-808. doi:10.1007/s00018-014-1775-0

The status of radioimmunotherapy in CD20+ non-Hodgkin's lymphoma

Read, Evan D., Eu, Peter, Little, Peter J. and Piva, Terrence J. (2015) The status of radioimmunotherapy in CD20+ non-Hodgkin's lymphoma. Targeted Oncology, 10 1: 15-26. doi:10.1007/s11523-014-0324-y

Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells

Kamato, Danielle, Rostam, Muhamad Ashraf, Piva, Terence J., Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Bernard, Rebekah, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2014) Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. Journal of Pharmacy and Pharmacology, 66 12: 1722-1733. doi:10.1111/jphp.12298

Assessing the role of Gαq/11 in cellular responses: an analysis of investigative tools

Bernard, Rebekah, Thach, Lyna, Kamato, Danielle, Osman, Narin and Little, Peter J. (2014) Assessing the role of Gαq/11 in cellular responses: an analysis of investigative tools. Clinical and Experimental Pharmacology, 4 5: 1-4. doi:10.4172/2157-7420.1000164

Stereoselective reduction of 1-O-isopropyloxygenipin enhances its neuroprotective activity in neuronal cells from apoptosis induced by sodium nitroprusside

Wang, Rikang, Yang, Jian, Liao, Sufen, Xiao, Gaokeng, Luo, Jun, Zhang, Lang, Little, Peter J., Chen, Heru and Zheng, Wenhua (2014) Stereoselective reduction of 1-O-isopropyloxygenipin enhances its neuroprotective activity in neuronal cells from apoptosis induced by sodium nitroprusside. ChemMedChem, 9 7: 1397-1401. doi:10.1002/cmdc.201400051

Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications

Xu, Suowen, Bai, Peter, Little, Peter J. and Liu, Peiqing (2014) Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications. Medicinal Research Reviews, 34 3: 644-675. doi:10.1002/med.21300

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle

Al-aryahi, Sefaa, Kamato, Danielle, Getachew, Robel, Zheng, Wenhua, Potocnik, Simon J., Cohen, Neale, Guidone, Daniel, Osman, Narin and Little, Peter J. (2014) Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle. Cardiovascular Diabetology, 13 80: 1-15. doi:10.1186/1475-2840-13-80

Fixed-dose statins with no lipid targets: a new paradigm of dosing?

Guidone, Daniel M. and Little, Peter J. (2014) Fixed-dose statins with no lipid targets: a new paradigm of dosing?. Journal of Pharmacy Practice and Research, 44 1: . doi:10.1002/j.2055-2335.2014.tb00020.x

Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via akt phosphorylation

Osman, Narin, Getachew, Robel, Thach, Lyna, Wang, Haitao, Su, Xiaoying, Zheng, Wenhua and Little, Peter J. (2014) Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via akt phosphorylation. Cellular Signalling, 26 5: 912-916. doi:10.1016/j.cellsig.2014.01.019

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: Role of heme oxygenase-1

Liu, Zhiping, Wang, Jiaojiao, Huang, Erwen, Gao, Si, Li, Hong, Lu, Jing, Tian, Kunming, Little, Peter J., Shen, Xiaoyan, Xu, Suowen and Liu, Peiqing (2014) Tanshinone IIA suppresses cholesterol accumulation in human macrophages: Role of heme oxygenase-1. Journal of Lipid Research, 55 2: 201-213. doi:10.1194/jlr.M040394

The nerve growth factor signaling and its potential as therapeutic target for glaucoma

Wang, Haitao, Wang, Rikang, Thrimawithana, Thilini, Little, Peter J., Xu, Jiangping, Feng, Zhong-Ping and Zheng, Wenhua (2014) The nerve growth factor signaling and its potential as therapeutic target for glaucoma. Biomed Research International, 2014 . doi:10.1155/2014/759473

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation

Kamato, Danielle, Burch, Micah L., Piva, Terrence J., Rezaei, Hossein Babaahmadi, Rostam, Muhamad Ashraf, Xu, Suowen, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2013) Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cellular Signalling, 25 10: 2017-2024. doi:10.1016/j.cellsig.2013.06.001

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

Xu, Suowen, Ogura, Sayoko, Chen, Jiawei, Little, Peter J., Moss, Joel and Liu, Peiqing (2013) LOX-1 in atherosclerosis: biological functions and pharmacological modifiers. Cellular and Molecular Life Sciences, 70 16: 2859-2872. doi:10.1007/s00018-012-1194-z

(S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Kamato, Danielle, Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Guidone, Daniel, Osman, Narin, Roufogalis, Basil, Duke, Colin C., Van Hoan Tran, Zheng, Wenhua and Little, Peter J. (2013) (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 7: 1026-1036. doi:10.1111/jphp.12060

Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terrence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua and Osman, Narin (2013) Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 7: 1055-1063. doi:10.1111/jphp.12064

GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways

Little, Peter J. (2013) GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways. Life Sciences, 92 20-21: 951-956. doi:10.1016/j.lfs.2013.03.017

Siah2-deficient mice show impaired skin wound repair

Musyoka, James N., Liu, Mira C. P., Pouniotis, Dodie S., Wong, Christina S. F., Bowtell, David D., Little, Peter J., Getachew, Robel, Moeller, Andreas and Darby, Ian A. (2013) Siah2-deficient mice show impaired skin wound repair. Wound Repair and Regeneration, 21 3: 437-447. doi:10.1111/wrr.12045

Aortic Smooth Muscle Cells from ApoE(-/-) Mice Secrete Biglycan with Hyperelongated Glycosaminoglycan Chains

Osman, Narin, Getachew, Robel and Little, Peter J. (2013) Aortic Smooth Muscle Cells from ApoE(-/-) Mice Secrete Biglycan with Hyperelongated Glycosaminoglycan Chains. Clinical and Experimental Pharmacology, 3 3: . doi:10.4172/2161-1459.1000125

Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Kamato, Danielle, Burch, Micah L., Osman, Narin, Zheng, Wenhua and Little, Peter J. (2013) Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. Journal of Pharmacy and Pharmacology, 65 4: 465-473. doi:10.1111/j.2042-7158.2012.01577.x

Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells

Burch, Micah L., Getachew, Robel, Osman, Narin, Febbraio, Mark A. and Little, Peter J. (2013) Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells. Journal of Biological Chemistry, 288 10: 7410-7419. doi:10.1074/jbc.M112.400259

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans

Osman, Narin, Grande-Allen, K. Jane, Ballinger, Mandy L., Getachew, Robel, Marasco, Silvana, O'Brien, Kevin D. and Little, Peter J. (2013) Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovascular Pathology, 22 2: 146-155. doi:10.1016/j.carpath.2012.07.002

PDGF β-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL

Getachew, Robel, Ballinger, Mandy L., Burch, Micah L., Reid, Julianne J., Khachigian, Levon M., Wight, Thomas N., Little, Peter J. and Osman, Narin (2013) PDGF β-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology, 151 9: 4356-4367. doi:10.1210/en.2010-0027

The Growing Promiscuity of G Protein Coupled Receptors

Little, Peter J., Burch, Micah L. and Osman, Narin (2012) The Growing Promiscuity of G Protein Coupled Receptors. Clinical and Experimental Pharmacology, 2 3: 1000e110.1-1000e110.2. doi:10.4172/2161-1459.1000e110

Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation

Little, Peter J., Getachew, Robel, Rezaei, Hossein Babaahmadi, Sanchez-Guerrero, Estella, Khachigian, Levon M., Wang, Haitao, Liao, Sufen, Zheng, Wenhua, Ballinger, Mandy L. and Osman, Narin (2012) Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation. Archives of Biochemistry and Biophysics, 525 1: 25-31. doi:10.1016/j.abb.2012.05.025

The possible role of the Akt signaling pathway in schizophrenia

Zheng, Wenhua, Wang, Haitao, Zeng, Zhiwen, Lin, Jun, Little, Peter J., Srivastava, Lalit K. and Quirion, Remi (2012) The possible role of the Akt signaling pathway in schizophrenia. Brain Research, 1470 145-158. doi:10.1016/j.brainres.2012.06.032

Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle

Rezaei, Hossein B., Kamato, Danielle, Ansari, Ghazaleh, Osman, Narin and Little, Peter J. (2012) Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle. Clinical and Experimental Pharmacology and Physiology, 39 8: 661-667. doi:10.1111/j.1440-1681.2011.05592.x

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation

Xu, Suowen, Liu, Zhiping, Huang, Yan, Le, Kang, Tang, Futian, Huang, Heqing, Ogura, Sayoko, Little, Peter J., Shen, Xiaoyan and Liu, Peiqing (2012) Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation. Translational Research, 160 2: 114-124. doi:10.1016/j.trsl.2012.01.008

Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells

Wang, Haitao, Zhang, Qishan, Zhang, Lang, Little, Peter J., Xie, Xiaochun, Meng, Qian, Ren, Yannan, Zhou, Lihua, Gao, Guoquan, Quirion, Remi and Zheng, Wenhua (2012) Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells. Neuroscience Letters, 516 1: 105-109. doi:10.1016/j.neulet.2012.03.068

Forkhead family transcription factor FoxO and neural differentiation

Wen, Qiang, Wang, Haitao, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2012) Forkhead family transcription factor FoxO and neural differentiation. Neurogenetics, 13 2: 105-113. doi:10.1007/s10048-012-0320-2

G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors

Burch, Micah L., Osman, Narin, Getachew, Robel, Al-aryahi, Sefaa, Poronnik, Philip, Zheng, Wenhua, Hill, Michael A. and Little, Peter J. (2012) G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors. International Journal of Biochemistry and Cell Biology, 44 5: 722-727. doi:10.1016/j.biocel.2012.01.018

Corrigendum to: cardiovascular actions and therapeutic potential of tanshinone IIA [Atherosclerosis 220 (2012) 3-10]

Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing and Xu, Suowen (2012) Corrigendum to: cardiovascular actions and therapeutic potential of tanshinone IIA [Atherosclerosis 220 (2012) 3-10]. Atherosclerosis, 221 2: 604. doi:10.1016/j.atherosclerosis.2012.01.014

Cardiovascular actions and therapeutic potential of tanshinone IIA

Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing and Xu, Suowen (2012) Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis, 220 1: 3-10. doi:10.1016/j.atherosclerosis.2011.06.041

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet

Xu, Suowen, Little, Peter J., Lan, Tian, Huang, Yan, Le, Kang, Wu, Xiaoqian, Shen, Xiaoyan, Huang, Heqing, Cai, Yi, Tang, Futian, Wang, Hua and Liu, Peiqing (2011) Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet. Archives of Biochemistry and Biophysics, 515 1-2: 72-79. doi:10.1016/j.abb.2011.08.006

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

Little, Peter J., Chait, Alan and Bolbik, Alex (2011) Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis. Pharmacology and Therapeutics, 131 3: 255-268. doi:10.1016/j.pharmthera.2011.04.001

Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells

Wen, Qiang, Duan, Xiaolu, Liao, Rifang, Little, Peter, Gao, Guoquan, Jiang, Hao, Lalit, Srivastava, Quirion, Remi and Zheng, Wenhua (2011) Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells. Neuroscience Letters, 498 1: 31-36. doi:10.1016/j.neulet.2011.04.055

The paradigm of G protein receptor transactivation: a mechanistic definition and novel example

Little, Peter J., Burch, Micah L., Al-aryahi, Sefaa and Zheng, Wenhua (2011) The paradigm of G protein receptor transactivation: a mechanistic definition and novel example. The Scientific World Journal, 11 709-714. doi:10.1100/tsw.2011.75

Smad linker region phosphorylation in the regulation of extracellular matrix synthesis

Burch, Micah L., Zheng, Wenhua and Little, Peter J. (2011) Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cellular and Molecular Life Sciences, 68 1: 97-107. doi:10.1007/s00018-010-0514-4

TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle

Osman, Narin, Getachew, Robel, Burch, Micah, Lancaster, Graeme, Wang, Rikang, Wang, Haitau, Zheng, Wenhua and Little, Peter J. (2011) TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle. Growth Factors, 29 5: 203-210. doi:10.3109/08977194.2011.615747

Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes

Yang, Sundy N. Y., Burch, Micah L., Tannock, Lisa R., Evanko, Stephen, Osman, Narin and Little, Peter J. (2010) Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes. Journal of Diabetes, 2 4: 233-242. doi:10.1111/j.1753-0407.2010.00089.x

Zinc and cardiovascular disease

Little, Peter J., Bhattacharya, Runa, Moreyra, Abel E. and Korichneva, Irina L. (2010) Zinc and cardiovascular disease. Nutrition, 26 11-12: 1050-1057. doi:10.1016/j.nut.2010.03.007

Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-β type I receptor

Little, Peter J., Burch, Micah L., Getachew, Robel, Al-aryahi, Sefaa and Osman, Narin (2010) Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-β type I receptor. Journal of Cardiovascular Pharmacology, 56 4: 360-368. doi:10.1097/FJC.0b013e3181ee6811

Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor

Burch, Micah L., Ballinger, Mandy L., Yang, Sundy N. Y., Getachew, Robel, Itman, Catherine, Loveland, Kate, Osman, Narin and Little, Peter J. (2010) Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor. Journal of Biological Chemistry, 285 35: 26798-26805. doi:10.1074/jbc.M109.092767

Platelet-derived Growth Factor Differentially Regulates the Expression and Post-translational Modification of Versican by Arterial Smooth Muscle Cells through Distinct Protein Kinase C and Extracellular Signal-regulated Kinase Pathways

Cardoso, Luiz E. M., Little, Peter J., Ballinger, Mandy L., Chan, Christina K., Braun, Kathleen R., Potter-Perigo, Susan, Bornfeldt, Karin E., Kinsella, Michael G. and Wight, Thomas N. (2010) Platelet-derived Growth Factor Differentially Regulates the Expression and Post-translational Modification of Versican by Arterial Smooth Muscle Cells through Distinct Protein Kinase C and Extracellular Signal-regulated Kinase Pathways. Journal of Biological Chemistry, 285 10: 6987-6995. doi:10.1074/jbc.M109.088674

Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells

Getachew, Robel, Ballinger, Mandy L., Burch, Micah L., Little, Peter J. and Osman, Narin (2010) Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells. European Journal of Pharmacology, 626 2-3: 186-192. doi:10.1016/j.ejphar.2009.09.066

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

Ballinger, Mandy L., Osman, Narin, Hashimura, Kazuhiko, de Haan, Judy B., Jandeleit-Dahm, Karin, Allen, Terri, Tannock, Lisa R., Rutledge, John C. and Little, Peter J. (2010) Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo. Journal of Cellular and Molecular Medicine, 14 6 B: 1408-1418. doi:10.1111/j.1582-4934.2009.00902.x

TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

Burch, Micah L., Yang, Sundy N. Y., Ballinger, Mandy L., Getachew, Robel, Osman, Narin and Little, Peter J. (2010) TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2. Cellular and Molecular Life Sciences, 67 12: 2077-2090. doi:10.1007/s00018-010-0315-9

Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes

Ivey, Melanie E., Osman, Narin and Little, Peter J. (2009) Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes. Atherosclerosis, 206 2: 569-574. doi:10.1016/j.atherosclerosis.2009.03.006

Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL

Ballinger, M. L., Ivey, M. E., Osman, N., Thomas, W. G. and Little, P. J. (2009) Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. Atherosclerosis, 205 2: 451-457. doi:10.1016/j.atherosclerosis.2009.01.024

Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins

Yang, Sundy N. Y., Osman, Narin, Burch, Micah L. and Little, Peter J. (2009) Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins. Future Lipidology, 4 4: 479-492. doi:10.2217/CLP.09.37

Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation

Yang, Sundy N. Y., Burch, Micah L., Getachew, Robel, Ballinger, Mandy L., Osman, Narin and Little, Peter J. (2009) Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation. Archives of Physiology and Biochemistry, 115 3: 147-154. doi:10.1080/13813450903110754

Potential of small molecule protein tyrosine kinase inhibitors as immunomodulators and inhibitors of the development of diabetes

Little, Peter J., Cohen, Neale and Morahan, Grant (2009) Potential of small molecule protein tyrosine kinase inhibitors as immunomodulators and inhibitors of the development of diabetes. The Scientific World Journal, 9 224-228. doi:10.1100/tsw.2009.28

Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways

Ivey, Melanie E. and Little, Peter J. (2008) Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways. Thrombosis Research, 123 2: 288-297. doi:10.1016/j.thromres.2008.04.019

p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis

Osman, Narin, Ballinger, Mandy L., Dadlani, Harsha M., Getachew, Robel, Burch, Micah L. and Little, Peter J. (2008) p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis. Cardiovascular and Hematological Disorders - Drug Targets, 8 4: 287-292. doi:10.2174/187152908786786205

Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding

Ballinger, Mandy L., Osman, Narin, Wilks, Andrew F., Su, Stephen, Phd, Christopher J. Burns, Bu, Xianyong and Little, Peter J. (2008) Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding. Journal of Cardiovascular Pharmacology, 52 5: 403-412.

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

Little, Peter J., Osman, Narin and O'Brien, Kevin D. (2008) Hyperelongated biglycan: the surreptitious initiator of atherosclerosis. Current Opinion in Lipidology, 19 5: 448-454. doi:10.1097/MOL.0b013e32830dd7c4

Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis

Ivey, Melanie E., Osman, Narin and Little, Peter J. (2008) Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis. Atherosclerosis, 199 2: 237-247. doi:10.1016/j.atherosclerosis.2008.03.006

Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP

Little, Peter J., Drennon, Katherine D. and Tannock, Lisa R. (2008) Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP. Archives of Physiology and Biochemistry, 114 2: 120-126. doi:10.1080/13813450802033909

The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells

Nigro, Julie, Potter-Perigo, Susan, Ivey, Melanie E., De Dios, Stephanie T., Evanko, Stephen P., Wight, Thomas N. and Little, Peter J. (2008) The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells. Archives of Physiology and Biochemistry, 114 3: 171-177. doi:10.1080/13813450802181013

Calcific aortic valve disease and hypertension

Dadlani, Harsha, Osman, Narin, Ballinger, Mandy L., Marasco, Silvana and Little, Peter J. (2008) Calcific aortic valve disease and hypertension. Current Hypertension Reviews, 4 2: 107-113. doi:10.2174/157340208784245884

Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle

Dadlani, Harsha, Ballinger, Mandy L., Osman, Narin, Getachew, Robel and Little, Peter J. (2008) Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle. Journal of Biological Chemistry, 283 12: 7844-7852. doi:10.1074/jbc.M703125200

Another piece of cell biology in the puzzle of inflammation, glucose and diabetic vascular disease

Dilley, Rodney J. and Little, Peter J. (2008) Another piece of cell biology in the puzzle of inflammation, glucose and diabetic vascular disease. Journal of Hypertension, 26 3: 396-398.

Phosphorylated troglitazone activates PPAR gamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis

Little, Peter J., Ballinger, Mandy L., Survase, Soniya, Osman, Narin, Ogru, Esra, Geytenbeek, Stephen, Bruemmer, Dennis and Nigro, Julie (2008) Phosphorylated troglitazone activates PPAR gamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis. Journal of Cardiovascular Pharmacology, 51 3: 274-279.

Biosynthesis of natural and hyperelongated chondroitin sulfate glycosaminoglycans: new insights into an elusive process

Little, Peter J., Ballinger, Mandy L., Burch, Micah L. and Osman, Narin (2008) Biosynthesis of natural and hyperelongated chondroitin sulfate glycosaminoglycans: new insights into an elusive process. The Open Biochemistry Journal, 2 135-142. doi:10.2174/1874091X00802010135

Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis

Little, Peter J., Ivey, Melanie E. and Osman, Narin (2008) Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis. Current Vascular Pharmacology, 6 3: 195-203. doi:10.2174/157016108784911966

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

Little, Peter J., Osman, Narin, de Dios, Stephanie T., Cemerlang, Nelly, Ballinger, Mandy and Nigro, Julie (2007) Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions. Cardiovascular Diabetology, 6 . doi:10.1186/1475-2840-6-33

Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease

Grande-Allen, K. J., Osman, N., Ballinger, M. L., Dadlani, H., Marasco, S. and Little, P. J. (2007) Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease. Cardiovascular Research, 76 1: 19-28. doi:10.1016/j.cardiores.2007.05.014

Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis

Little, Peter J., Ballinger, Mandy L. and Osman, Narin (2007) Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis. Vascular Health and Risk Management, 3 1: 117-124.

Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents

de Dios, Stephanie T., Frontanilla, Karen V., Nigro, Julie, Ballinger, Mandy L., Ivey, Melanie E., Cawson, Elizabeth A. and Little, Peter J. (2007) Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents. Journal of Diabetes and its Complications, 21 2: 108-117. doi:10.1016/j.jdiacomp.2006.03.003

Clinical thiazolidinediones as PPARγ ligands with the potential for the prevention of cardiovascular disease in diabetes

de Dios, Stephanie T., O'Brien, Richard C. and Little, Peter J. (2006) Clinical thiazolidinediones as PPARγ ligands with the potential for the prevention of cardiovascular disease in diabetes. Current Diabetes Reviews, 2 2: 227-239. doi:10.2174/157339906776818622

Insulin resistance and atherosclerosis

Nigro, Julie, Osman, Narin, Dart, Anthony M. and Little, Peter J. (2006) Insulin resistance and atherosclerosis. Endocrine Reviews, 27 3: 242-259. doi:10.1210/er.2005-0007

Actions of calcium channel blockers on vascular proteoglycan synthesis: relationship to atherosclerosis

Survase, Soniya, Ivey, Melanie E, Nigro, Julie, Osman, Narin and Little, Peter J (2005) Actions of calcium channel blockers on vascular proteoglycan synthesis: relationship to atherosclerosis. Vascular health and risk management, 1 3: 199-208.

Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries

Dilley, Rodney J., Farrelly, Caroline A., Allen, Terri J., Jandeleit-Dahm, Karin, Cooper, Mark E., Morahan, Grant and Little, Peter J. (2005) Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries. Diabetes Research and Clinical Practice, 70 3: 201-208. doi:10.1016/j.diabres.2005.03.038

Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells

Ballinger, Mandy L., Thomas, Merlin C., Nigro, Julie, Ivey, Melanie E., Dilley, Rodney J. and Little, Peter J. (2005) Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells. Kidney International, 68 6: 2756-2765. doi:10.1111/j.1523-1755.2005.00746.x

Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis

Sudhir, Krishnankutty, Nigro, Julie, Osman, Narin and Little, Peter J. (2005) Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis. Thescientificworldjournal, 5 521-526. doi:10.1100/tsw.2005.75

New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix

Nigro, Julie, Ballinger, Mandy L., Survase, Soniya, Osman, Narin and Little, Peter J. (2005) New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix. Thescientificworldjournal, 5 2: 515-520. doi:10.1100/tsw.2005.69

Androgens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increase lipoprotein binding

Hashimura, Kazuhiko, Sudhir, Krishnankutty, Nigro, Julie, Ling, Shanhong, Williams, Maro R. I., Komesaroff, Paul A. and Little, Peter J. (2005) Androgens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increase lipoprotein binding. Endocrinology, 146 4: 2085-2090. doi:10.1210/en.2004-1242

Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding

Nigro, J, Ballinger, ML, Dilley, RJ, Jennings, GLR, Wight, T and Little, PJ (2004) Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding. Diabetologia, 47 12: 2105-2113. doi:10.1007/s00125-004-1588-z

Regulation of glycosaminoglycan structure and atherogenesis

Ballinger, M. L., Nigro, J., Frontanilla, K. V., Dart, A. M. and Little, P. J. (2004) Regulation of glycosaminoglycan structure and atherogenesis. Cellular and Molecular Life Sciences, 61 11: 1296-1306. doi:10.1007/s00018-004-3389-4

Thiazolidinedlones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans

Tannock, L. R., Little, P. J., Tsoi, C., Barrett, P. H. R., Wight, T. N. and Chait, A. (2004) Thiazolidinedlones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans. Diabetologia, 47 5: 837-843. doi:10.1007/s00125-004-1358-y

Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-γ ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation

de Dios, Stephanie T., Bruemmer, Dennis, Dilley, Rodney J., Ivey, Melanie E., Jennings, Garry L.R., Law, Ronald E. and Little, Peter J. (2003) Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-γ ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation, 107 20: 2548-2550. doi:10.1161/01.CIR.0000074040.31731.96

Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta

Hannan, Katherine M., Dilley, Rodney J., de Dios, Stephanie T. and Little, Peter J. (2003) Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta. Arteriosclerosis, Thrombosis, and Vascular Biology, 23 5: 762-768. doi:10.1161/01.ATV.0000069210.46539.0D

Impact of sleep apnea on sympathetic nervous system activity in heart failure

Solin, Peter, Kaye, David M., Little, Peter J., Bergin, Peter, Richardson, Meroula and Naughton, Matthew T (2003) Impact of sleep apnea on sympathetic nervous system activity in heart failure. Chest, 123 4: 1119-1126. doi:10.1378/chest.123.4.1119

High glucose potentiates mitogenic responses of cultured ovine coronary smooth muscle cells to platelet derived growth factor and transforming growth factor-β1

Little, Peter J., Allen, Terri J., Hashimura, Kazuhiko, Nigro, Julie, Farrelly, Caroline A. and Dilley, Rodney J. (2003) High glucose potentiates mitogenic responses of cultured ovine coronary smooth muscle cells to platelet derived growth factor and transforming growth factor-β1. Diabetes Research and Clinical Practice, 59 2: 93-101. doi:10.1016/S0168-8227(02)00201-2

Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells

Nigro, Julie, Dilley, Rodney J. and Little, Peter J. (2002) Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. Atherosclerosis, 162 1: 119-129. doi:10.1016/S0021-9150(01)00704-3

High glucose abolishes the antiproliferative effect of 17 beta-estradiol in human vascular smooth muscle cells

Ling, SH, Little, PJ, Williams, MRI, Dai, A, Hashimura, K, Liu, JP, Komesaroff, PA and Sudhir, K (2002) High glucose abolishes the antiproliferative effect of 17 beta-estradiol in human vascular smooth muscle cells. American Journal of Physiology-Endocrinology and Metabolism, 282 4: E746-E751. doi:10.1152/ajpendo.00111.2001

Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL

Tannock, LR, Little, PJ, Wight, TN and Chait, A (2002) Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL. Journal of Lipid Research, 43 1: 149-157.

Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-β1 exhibit increased binding to LDLs

Little, Peter J., Tannock, Lisa, Olin, Katherine L., Chait, Alan and Wight, Thomas N. (2002) Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-β1 exhibit increased binding to LDLs. Arteriosclerosis, Thrombosis, and Vascular Biology, 22 1: 55-60. doi:10.1161/hq0102.101100

Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor

Sudhir, Krishnankutty, Hashimura, Kazuhiko, Bobik, Alex, Dilley, Rodney J., Jennings, Garry L. and Little, Peter J. (2001) Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor. American Journal of Hypertension, 14 11: 1128-1134. doi:10.1016/S0895-7061(01)02189-6

Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells

de Dios, Stephanie T., Hannan, Katherine M., Dilley, Rodney J., Hill, Michael A. and Little, Peter J. (2001) Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells. Journal of Diabetes and its Complications, 15 3: 120-127. doi:10.1016/S1056-8727(01)00141-6

Diabetes-induced vascular hypertrophy is accompanied by activation of Na+-H+ exchange and prevented by Na+-H+ exchange inhibition

Jandeleit-Dahm, K, Hannan, KM, Farrelly, CA, Allen, TJ, Rumble, JR, Gilbert, RE, Cooper, ME and Little, PJ (2000) Diabetes-induced vascular hypertrophy is accompanied by activation of Na+-H+ exchange and prevented by Na+-H+ exchange inhibition. Circulation Research, 87 12: 1133-1140.

Effect of moderate alcohol upon obstructive sleep apnoea

Scanlan, MF, Roebuck, T, Little, PJ, Redman, JR and Naughton, MT (2000) Effect of moderate alcohol upon obstructive sleep apnoea. European Respiratory Journal, 16 5: 909-913. doi:10.1183/09031936.00.16590900

Overnight urinary noradrenaline and awake pulmonary capillary wedge pressure in heart failure with central sleep apnoea

Solin, P., Little, P. J., Roebuck, T., Richardson, M., Bergin, P., Kaye, D. M., Walters, E. H. and Naughton, M. T. (1999) Overnight urinary noradrenaline and awake pulmonary capillary wedge pressure in heart failure with central sleep apnoea. Respirology, 4 SUPPL. 1: .

Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses following endothelin-1 stimulation

Speed, CJ, Neylon, CB, Little, PJ and Mitchell, CA (1999) Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses following endothelin-1 stimulation. Journal of Cell Science, 112 5: 669-679.

Identification of a novel, inhibitory action of amiodarone on vesicular monoamine transport

Haikerwal, D, Dart, AM, Little, PJ and Kaye, DM (1999) Identification of a novel, inhibitory action of amiodarone on vesicular monoamine transport. Journal of Pharmacology and Experimental Therapeutics, 288 2: 834-837.

Rapid regulation of adrenomedullin in metabolically compromised vascular smooth muscle cells

Autelitano, DJ, Tang, F and Little, PJ (1999) Rapid regulation of adrenomedullin in metabolically compromised vascular smooth muscle cells. Journal of Hypertension, 17 3: 373-379. doi:10.1097/00004872-199917030-00010

Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms

Du, XJ, Woodcock, EA, Little, PJ, Esler, MD and Dart, AM (1998) Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. Journal of Cardiovascular Pharmacology, 32 4: 621-628. doi:10.1097/00005344-199810000-00015

Urokinase plasminogen activator induces smooth muscle cell migration: Key role of growth factor-like domain

Stepanova, V, Bobik, A, Bibilashvily, R, Belogurov, A, Rybalkin, I, Domogatsky, S, Little, PJ, Goncharova, E and Tkachuk, V (1997) Urokinase plasminogen activator induces smooth muscle cell migration: Key role of growth factor-like domain. FEBS Letters, 414 2: 471-474. doi:10.1016/S0014-5793(97)00993-9

Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes

Du, XJ, Bobik, A, Little, PJ, Esler, MD and Dart, AM (1997) Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes. Circulation Research, 80 2: 179-188.

Regulation and role of urokinase plasminogen activator in vascular remodelling

Tkachuk, V, Stepanova, V, Little, PJ and Bobik, A (1996) Regulation and role of urokinase plasminogen activator in vascular remodelling. Clinical and Experimental Pharmacology and Physiology, 23 9: 759-765. doi:10.1111/j.1440-1681.1996.tb01177.x

Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with cellular transformation

Speed, CJ, Little, PJ, Hayman, JA and Mitchell, CA (1996) Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with cellular transformation. Embo Journal, 15 18: 4852-4861.

Vascular localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme

Smith, RE, Little, PJ, Maguire, JA, SteinOakley, AN and Krozowski, ZS (1996) Vascular localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme. Clinical and Experimental Pharmacology and Physiology, 23 6-7: 549-551. doi:10.1111/j.1440-1681.1996.tb02776.x

Na+/H+ exchanger-1 alleles: Strain distribution and correlation with activity

McClive, PJ, Little, PJ and Morahan, G (1996) Na+/H+ exchanger-1 alleles: Strain distribution and correlation with activity. Immunogenetics, 43 3: 163-164.

Underexpression of the 43 KDA inositol polyphosphate 5-phosphatase is associated with cellular transformation

Speed, Caroline J., Little, Peter J., Hayman, John A. and Mitchell, Christina A. (1996) Underexpression of the 43 KDA inositol polyphosphate 5-phosphatase is associated with cellular transformation. Biochemical Society Transactions, 24 4: .

Do glycoproteins IIb/IIIa participate in activation of human platelet s by low density lipoproteins? Uchastvuiut li glikoproteidy IIb/IIIa v aktivatsii trombotsitov cheloveka lipoproteidami nizkoǐ plotnosti?

Bochkov, V. N., Sorokin, E. V., Byzova, T. V., Mazurov, A. V., Little, P., Bobik, A. and Tkachuk, V. A. (1995) Do glycoproteins IIb/IIIa participate in activation of human platelet s by low density lipoproteins? Uchastvuiut li glikoproteidy IIb/IIIa v aktivatsii trombotsitov cheloveka lipoproteidami nizkoǐ plotnosti?. Biokhimiya, 60 8: 1187-1194.

Glycoproteins Iib/iiia Involved in the Activation of Human Platelets by Low-Density Lipoproteins

Bochkov, VN, Sorokin, EV, Byzova, TV, Mazurov, AV, Little, P, Bobick, A and Tkachuk, VA (1995) Glycoproteins Iib/iiia Involved in the Activation of Human Platelets by Low-Density Lipoproteins. Biochemistry-Moscow, 60 8: 897-902.

Intracellular pH in vascular smooth muscle: Regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3- mechanisms

Little, P. J., Neylon, C. B., Farrelly, C. A., Weissberg, P. L., Cragoe Jr., E. J. and Bobik, A. (1995) Intracellular pH in vascular smooth muscle: Regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3- mechanisms. Cardiovascular Research, 29 2: 239-246. doi:10.1016/0008-6363(96)88576-2

Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity

Morahan, G, McClive, P, Huang, DX, Little, P and Baxter, A (1994) Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity. Proceedings of the National Academy of Sciences of the United States of America, 91 13: 5898-5902. doi:10.1073/pnas.91.13.5898

Intracellular pH in vascular smooth muscle: Regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3 mechanisms

Little, PJ, Neylon, CB, Farrelly, CA, Weissberg, PL, Cragoe, EJ and Bobik, A (1994) Intracellular pH in vascular smooth muscle: Regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3 mechanisms. Cardiovascular Research, 28 9: 239-246. doi:10.1016/S0008-6363(96)88576-2

Transforming growth factor-β1 regulates the expression of ryanodine-sensitive Ca2+ oscillations in cardiac myocytes

Neylon, CB, Bryant, SM, Little, PJ and Bobik, A (1994) Transforming growth factor-β1 regulates the expression of ryanodine-sensitive Ca2+ oscillations in cardiac myocytes. Biochemical and Biophysical Research Communications, 204 2: 678-684. doi:10.1006/bbrc.1994.2513

Leu143 in the Putative Fourth Membrane Spanning Domain Is Critical for Amiloride Inhibition of an Epithelial Na+/H+ Exchanger Isoform (NHE-2)

Yun, Chc, Little, PJ, Nath, SK, Levine, SA, Pouyssegur, J, Tse, CM and Donowitz, M (1993) Leu143 in the Putative Fourth Membrane Spanning Domain Is Critical for Amiloride Inhibition of an Epithelial Na+/H+ Exchanger Isoform (NHE-2). Biochemical and Biophysical Research Communications, 193 2: 532-539. doi:10.1006/bbrc.1993.1656

Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2)

Tse, Chung-Ming, Levine, Susan A., Yun, C. H. Chris, Montrose, Marshall H., Little, Peter J., Pouyssegur, Jacques and Donowitz, Mark (1993) Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). Journal of Biological Chemistry, 268 16: 11917-11924.

Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells

Agrotis, A, Little, PJ, Saltis, J and Bobik, A (1993) Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells. European Journal of Pharmacology: Molecular Pharmacology, 244 3: 269-275. doi:10.1016/0922-4106(93)90152-Y

Thrombin-induced Ca2+ mobilization in vascular smooth muscle utilizes a slowly ribosylating pertussis toxin-sensitive G protein: evidence for the involvement of a G protein in inositol trisphosphate-dependent Ca2+ release

Neylon, Craig B., Nickashin, Alex, Little, Peter J., Tkachuk, Vsevolod A. and Bobik, Alex (1992) Thrombin-induced Ca2+ mobilization in vascular smooth muscle utilizes a slowly ribosylating pertussis toxin-sensitive G protein: evidence for the involvement of a G protein in inositol trisphosphate-dependent Ca2+ release. Journal of Biological Chemistry, 267 11: 7295-7302.

Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle

Little, PJ, Neylon, CB, Tkachuk, VA and Bobik, A (1992) Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle. Biochemical and Biophysical Research Communications, 183 2: 694-700. doi:10.1016/0006-291X(92)90538-V

Multiple Growth Abnormalities in Vascular Smooth-Muscle From Spontaneously Hypertensive Rats

Saltis, J, Little, P and Bobik, A (1991) Multiple Growth Abnormalities in Vascular Smooth-Muscle From Spontaneously Hypertensive Rats. Clinical and Experimental Pharmacology and Physiology, 18 5: 319-322. doi:10.1111/j.1440-1681.1991.tb01454.x

Ethylisopropylamiloride-Sensitive Ph Control Mechanisms Modulate Vascular Smooth-Muscle Cell-Growth

Bobik, A, Grooms, A, Little, PJ, Cragoe, EJ and Grinpukel, S (1991) Ethylisopropylamiloride-Sensitive Ph Control Mechanisms Modulate Vascular Smooth-Muscle Cell-Growth. American Journal of Physiology, 260 3: C581-C588.

Ionic Mechanisms Regulating Sodium Entry Into Vascular Smooth-Muscle

Bobik, A, Little, PJ and Neylon, CB (1991) Ionic Mechanisms Regulating Sodium Entry Into Vascular Smooth-Muscle. Clinical and Experimental Pharmacology and Physiology, 18 2: 117-120. doi:10.1111/j.1440-1681.1991.tb01419.x

Inositol Phosphate Release and Steroidogenesis in Rat Adrenal Glomerulosa Cells - Comparison of the Effects of Endothelin, Angiotensin-Ii and Vasopressin

Woodcock, EA, Little, PJ and Tanner, JK (1990) Inositol Phosphate Release and Steroidogenesis in Rat Adrenal Glomerulosa Cells - Comparison of the Effects of Endothelin, Angiotensin-Ii and Vasopressin. Biochemical Journal, 271 3: 791-796.

Intracellular Ph in Human Arterial Smooth-Muscle - Regulation by Na+/h+ Exchange and a Novel 5-(N-Ethyl-N-Isopropyl)Amiloride-Sensitive Na+-Dependent and Hco3--Dependent Mechanism

Neylon, CB, Little, PJ, Cragoe, EJ and Bobik, A (1990) Intracellular Ph in Human Arterial Smooth-Muscle - Regulation by Na+/h+ Exchange and a Novel 5-(N-Ethyl-N-Isopropyl)Amiloride-Sensitive Na+-Dependent and Hco3--Dependent Mechanism. Circulation Research, 67 4: 814-825.

Mechanisms Involved in the Stimulation of Aldosterone Production by Angiotensin-Ii, Vasopressin and Endothelin

Woodcock, EA, Tanner, JK, Caroccia, LM and Little, PJ (1990) Mechanisms Involved in the Stimulation of Aldosterone Production by Angiotensin-Ii, Vasopressin and Endothelin. Clinical and Experimental Pharmacology and Physiology, 17 4: 263-267. doi:10.1111/j.1440-1681.1990.tb01318.x

Sodium-Dependent, Ethylisopropylamiloride-Sensitive Mechanisms Regulate Intracellular Ph in Human Vascular Smooth-Muscle

Bobik, A, Neylon, CB, Little, PJ, Cragoe, EJ and Weissberg, PL (1990) Sodium-Dependent, Ethylisopropylamiloride-Sensitive Mechanisms Regulate Intracellular Ph in Human Vascular Smooth-Muscle. Clinical and Experimental Pharmacology and Physiology, 17 4: 297-301. doi:10.1111/j.1440-1681.1990.tb01324.x

Angiotensin II and noradrenaline increase PDGF-BB receptors and potentiate PDGF-BB stimulated DNA synthesis in vascular smooth muscle

Bobik, A, Grinpukel, S, Little, PJ, Grooms, A and Jackman, G (1990) Angiotensin II and noradrenaline increase PDGF-BB receptors and potentiate PDGF-BB stimulated DNA synthesis in vascular smooth muscle. Biochemical and Biophysical Research Communications, 166 2: 580-588. doi:10.1016/0006-291X(90)90848-H

Different Inositol Phosphate Responses to Angiotensin-Ii and Vasopressin in Rat Adrenal Glomerulosa Cells

Woodcock, EA, Caroccia, L, McLeod, JK and Little, PJ (1990) Different Inositol Phosphate Responses to Angiotensin-Ii and Vasopressin in Rat Adrenal Glomerulosa Cells. Advances in Second Messenger and Phosphoprotein Research, 24 134-139.

Spontaneous Oscillations in Cytoplasmic Calcium-Concentration in Vascular Smooth-Muscle

Weissberg, PL, Little, PJ and Bobik, A (1989) Spontaneous Oscillations in Cytoplasmic Calcium-Concentration in Vascular Smooth-Muscle. American Journal of Physiology, 256 5: C951-C957.

The Ph of Spontaneously Beating Cultured Rat-Heart Cells Is Regulated by An Atp-Calmodulin-Dependent Na+/h+ Antiport

Weissberg, PL, Little, PJ, Cragoe, EJ and Bobik, A (1989) The Ph of Spontaneously Beating Cultured Rat-Heart Cells Is Regulated by An Atp-Calmodulin-Dependent Na+/h+ Antiport. Circulation Research, 64 4: 676-685.

The Effects of Alterations in Membrane Sodium-Transport On Rat Aortic Smooth-Muscle Proliferation

Bobik, A, Grooms, A, Grinpukel, S and Little, PJ (1988) The Effects of Alterations in Membrane Sodium-Transport On Rat Aortic Smooth-Muscle Proliferation. Journal of Hypertension, 6 S219-S221.

Dependence of Na+/H+ antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP: evidence for the involvement of calmodulin-dependent kinases

Little, Peter J., Weissberg, Peter L., Cragoe, Edward J. and Bobik, Alex (1988) Dependence of Na+/H+ antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP: evidence for the involvement of calmodulin-dependent kinases. Journal of Biological Chemistry, 263 32: 16780-16786.

Amiloride Analogs Cause Endothelium-Dependent Relaxation in the Canine Coronary-Artery Invitro - Possible Role of Na+/ca2+ Exchange

Cocks, TM, Little, PJ, Angus, JA and Cragoe, EJ (1988) Amiloride Analogs Cause Endothelium-Dependent Relaxation in the Canine Coronary-Artery Invitro - Possible Role of Na+/ca2+ Exchange. British Journal of Pharmacology, 95 1: 67-76.

Spontaneous Oscillations in Cytoplasmic Free Calcium-Concentration in Vascular Smooth-Muscle - a Potential Mechanism Associated with Myogenic Tone

Bobik, A, Weissberg, PL and Little, PJ (1988) Spontaneous Oscillations in Cytoplasmic Free Calcium-Concentration in Vascular Smooth-Muscle - a Potential Mechanism Associated with Myogenic Tone. Clinical and Experimental Pharmacology and Physiology, 15 4: 281-284. doi:10.1111/j.1440-1681.1988.tb01073.x

Circulating Digoxin-Like Immunoreactivity in Renal Hypertensive Rabbits - Lack of Modulation by Alterations in Dietary-Sodium Intake

Scott, PJ, Little, PJ and Bobik, A (1988) Circulating Digoxin-Like Immunoreactivity in Renal Hypertensive Rabbits - Lack of Modulation by Alterations in Dietary-Sodium Intake. Journal of Hypertension, 6 3: 205-209. doi:10.1097/00004872-198803000-00004

Mechanisms influencing sodium entry to cultured vascular smooth muscle

Little, P. J., Weissberg, P. L., Cragoe Jr., E. J. and Bobik, A. (1988) Mechanisms influencing sodium entry to cultured vascular smooth muscle. Progress in biochemical pharmacology, 23 142-149.

Na-H Antiport in Cultured Rat Aortic Smooth-Muscle - its Role in Cytoplasmic Ph Regulation

Weissberg, PL, Little, PJ, Cragoe, EJ and Bobik, A (1987) Na-H Antiport in Cultured Rat Aortic Smooth-Muscle - its Role in Cytoplasmic Ph Regulation. American Journal of Physiology, 253 2: C193-C198.

Regulation of Sodium Influx and Sodium, Potassium Pump Activity by a Sodium-Hydrogen Antiport in Rat Vascular Smooth-Muscle

Bobik, A, Weissberg, PL and Little, PJ (1987) Regulation of Sodium Influx and Sodium, Potassium Pump Activity by a Sodium-Hydrogen Antiport in Rat Vascular Smooth-Muscle. Clinical and Experimental Pharmacology and Physiology, 14 3: 191-195. doi:10.1111/j.1440-1681.1987.tb00374.x

Glimpses of the mechanisms of hypertension

Weissberg, P. L., Little, P. J. and Bobik, A. (1986) Glimpses of the mechanisms of hypertension. BMJ, 293 6559: 1436-1437. doi:10.1136/bmj.293.6559.1436-c

Na-H Exchange Is a Major Pathway for Na Influx in Rat Vascular Smooth-Muscle

Little, PJ, Cragoe, EJ and Bobik, A (1986) Na-H Exchange Is a Major Pathway for Na Influx in Rat Vascular Smooth-Muscle. American Journal of Physiology, 251 5: C707-C712.

The Relationship Between Coronary Pressure During Reperfusion and Myocardial Recovery After Hypothermic Cardioplegia

Rosenfeldt, FL, Rabinov, M, Little, P and Campbell, G (1986) The Relationship Between Coronary Pressure During Reperfusion and Myocardial Recovery After Hypothermic Cardioplegia. Journal of Thoracic and Cardiovascular Surgery, 92 3: 414-424.

1-C-14 N-Hexadecane Disposition in the Spiny Lobster, Panulirus-Argus and the American Lobster, Homarus-Americanus

Little, PJ, James, MO, Foureman, GL, Weatherby, RP and Bend, JR (1986) 1-C-14 N-Hexadecane Disposition in the Spiny Lobster, Panulirus-Argus and the American Lobster, Homarus-Americanus. Journal of Environmental Pathology Toxicology and Oncology, 6 5-6: 13-27.

1-14C-n-hexadecane disposition in the spiny lobster, Panulirus argus and the American lobster, Homarus americanus

Little, P. J., James, M. O. and Foureman, G. L. (1986) 1-14C-n-hexadecane disposition in the spiny lobster, Panulirus argus and the American lobster, Homarus americanus. Journal of Environmental Pathology, Toxicology and Oncology, 6 5-6: 13-27.

Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle

Little, PJ and Bobik, A (1985) Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle. Clinical and Experimental Hypertension, A7 11: 1563-1582. doi:10.3109/10641968509073610

TEMPERATURE-DEPENDENT DISPOSITION OF [C-14] BENZO(A)PYRENE IN THE SPINY LOBSTER, PANULIRUS-ARGUS

LITTLE, PJ, JAMES, MO, PRITCHARD, JB and BEND, (1985) TEMPERATURE-DEPENDENT DISPOSITION OF [C-14] BENZO(A)PYRENE IN THE SPINY LOBSTER, PANULIRUS-ARGUS. Toxicology and Applied Pharmacology, 77 2: 325-333. doi:10.1016/0041-008X(85)90332-1

Estimation of 'total' renal, cardiac and splanchnic sympathetic nervous tone in essential hypertension from measurements of noradrenaline release

Esler, M. D., Jennings, G. L., Johns, J., Burke, F., Little, P. J. and Leonard, P. (1984) Estimation of 'total' renal, cardiac and splanchnic sympathetic nervous tone in essential hypertension from measurements of noradrenaline release. Journal of Hypertension, 2 SUPPL. 3: 123-125.

2 Patients with Abnormalities of Regional Sympathetic Nervous Tone

Ohehir, R, Esler, M, Jennings, G, Leonard, P, Little, P, Johns, J and Panetta, F (1984) 2 Patients with Abnormalities of Regional Sympathetic Nervous Tone. Australian and New Zealand Journal of Medicine, 14 6: 855-859. doi:10.1111/j.1445-5994.1984.tb03789.x

3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene

James, MO and Little, PJ (1984) 3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene. Comparative Biochemistry and Physiology. Part C, Comparative, 78 1: 241-245. doi:10.1016/0742-8413(84)90076-8

Benzo(A)Pyrene Metabolism in Hepatic Microsomes From Feral and 3-Methycholanthrene-Treated Southern Flounder, Paralichthys-Lethostigma

Little, PJ, James, MO, Pritchard, JB and Bend, JR (1984) Benzo(A)Pyrene Metabolism in Hepatic Microsomes From Feral and 3-Methycholanthrene-Treated Southern Flounder, Paralichthys-Lethostigma. Journal of Environmental Pathology Toxicology and Oncology, 5 4-5: 309-320.

Desensitization of the Alpha1-Adrenoceptor System in Vascular Smooth-Muscle

Bobik, A, Campbell, JH and Little, PJ (1984) Desensitization of the Alpha1-Adrenoceptor System in Vascular Smooth-Muscle. Biochemical Pharmacology, 33 7: 1143-1145. doi:10.1016/0006-2952(84)90527-6

Mechanism of Isoprenaline Induced Desensitization of Rabbit Aortic Smooth-Muscle Beta-Adrenoceptor Responses

Little, PJ, Campbell, JH, Skews, H and Bobik, A (1984) Mechanism of Isoprenaline Induced Desensitization of Rabbit Aortic Smooth-Muscle Beta-Adrenoceptor Responses. Clinical and Experimental Pharmacology and Physiology, 11 5: 503-511.

Plasma noradrenaline kinetics in humans

Esler, M, Willett, I, Leonard, P, Hasking, G, Johns, J, Little, P and Jennings, G (1984) Plasma noradrenaline kinetics in humans. Journal of the Autonomic Nervous System, 11 2: 125-144. doi:10.1016/0165-1838(84)90071-7

Role of Cyclic-Amp in Cardiac Beta-Adrenoceptor Desensitization - Studies Using Prenalterol and Inhibitors of Phosphodiesterase

Bobik, A and Little, PJ (1984) Role of Cyclic-Amp in Cardiac Beta-Adrenoceptor Desensitization - Studies Using Prenalterol and Inhibitors of Phosphodiesterase. Journal of Cardiovascular Pharmacology, 6 5: 795-801. doi:10.1097/00005344-198409000-00009

Modification of Benzo(A)Pyrene Metabolism in Hepatic Microsomes From Untreated and Induced Rats by Imidazole Derivatives Which Inhibit Monooxygenase Activity and Enhance Epoxide Hydrolase Activity

James, MO and Little, PJ (1983) Modification of Benzo(A)Pyrene Metabolism in Hepatic Microsomes From Untreated and Induced Rats by Imidazole Derivatives Which Inhibit Monooxygenase Activity and Enhance Epoxide Hydrolase Activity. Drug Metabolism and Disposition, 11 4: 350-354.

The effects of endogenous phospholipase A2 activation on beta adrenoceptor function in cardiac cells

Bobik, A, Campbell, J, Snow, P and Little, PJ (1983) The effects of endogenous phospholipase A2 activation on beta adrenoceptor function in cardiac cells. Journal of Molecular and Cellular Cardiology, 15 11: 759-767. doi:10.1016/0022-2828(83)90335-8

Inhibitors of hepatic mixed function oxidases-V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives

Little, PJ and Ryan, AJ (1982) Inhibitors of hepatic mixed function oxidases-V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives. Biochemical Pharmacology, 31 9: 1795-1798. doi:10.1016/0006-2952(82)90690-6

Agonist-induced modulation of β-adrenoceptor responsiveness in cultured rabbit aorta smooth muscle cells

Little, P. J., Campbell, J. and Bobik, A. (1982) Agonist-induced modulation of β-adrenoceptor responsiveness in cultured rabbit aorta smooth muscle cells. Clinical and Experimental Pharmacology and Physiology, 9 4: .

Bioavailability of Dihydroergotamine in Man

Little, PJ, Jennings, GL, Skews, H and Bobik, A (1982) Bioavailability of Dihydroergotamine in Man. British Journal of Clinical Pharmacology, 13 6: 785-790.

Inhibition of Rat Hepatic-Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives - Quantitative Structure Activity Relationships

Murray, M, Ryan, AJ and Little, PJ (1982) Inhibition of Rat Hepatic-Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives - Quantitative Structure Activity Relationships. Journal of Medicinal Chemistry, 25 8: 887-892. doi:10.1021/jm00350a002

Inhibitors of Hepatic Mixed-Function Oxidases .4. Effects of Benzimidazole and Related-Compounds On Aryl-Hydrocarbon Hydroxylase-Activity From Phenobarbitone and 3-Methylcholanthrene Induced Rats

Little, PJ and Ryan, AJ (1982) Inhibitors of Hepatic Mixed-Function Oxidases .4. Effects of Benzimidazole and Related-Compounds On Aryl-Hydrocarbon Hydroxylase-Activity From Phenobarbitone and 3-Methylcholanthrene Induced Rats. Journal of Medicinal Chemistry, 25 6: 622-626. doi:10.1021/jm00348a003

Imidazole derivatives as inhibitors of cytochrome P-450-dependent oxidation and activators of epoxide hydrolase in hepatic microsomes from a marine fish

Little, PJ, James, MO, Bend, JR and Ryan, AJ (1981) Imidazole derivatives as inhibitors of cytochrome P-450-dependent oxidation and activators of epoxide hydrolase in hepatic microsomes from a marine fish. Biochemical Pharmacology, 30 20: 2876-2880. doi:10.1016/0006-2952(81)90432-9

Perturbation of benzo(a)pyrene (BP) metabolism in rat and fish hepatic microsomes by monooxygenase (MO) inhibitors which stimulate epoxide hydrolase (EH)

James, M. O. and Little, P. J. (1981) Perturbation of benzo(a)pyrene (BP) metabolism in rat and fish hepatic microsomes by monooxygenase (MO) inhibitors which stimulate epoxide hydrolase (EH). Federation Proceedings, 40 3 I: .

Polyhalogenated biphenyls and phenobarbital: Evaluation as inducers of drug metabolizing enzymes in the sheepshead, Archosargus probatocephalus

James, MO and Little, PJ (1981) Polyhalogenated biphenyls and phenobarbital: Evaluation as inducers of drug metabolizing enzymes in the sheepshead, Archosargus probatocephalus. Chemico-Biological Interactions, 36 2: 229-248. doi:10.1016/0009-2797(81)90022-3

14C-benzo(a)pyrene metabolism in hepatic microsomes from the marine fish sheepshead, Archosargus probatocephalus and southern flounder, Paralichthyes lethostigma

Little, P. J., James, M. O. and Bend, J. R. (1980) 14C-benzo(a)pyrene metabolism in hepatic microsomes from the marine fish sheepshead, Archosargus probatocephalus and southern flounder, Paralichthyes lethostigma. Pharmacologist, 22 3: .

The inhibition of aryl hydrocarbon hydroxylase activity in rat liver microsomes by a 2-n-alkylbenzimidazole homologous series

Ryan, A. J. and Little, P. J. (1979) The inhibition of aryl hydrocarbon hydroxylase activity in rat liver microsomes by a 2-n-alkylbenzimidazole homologous series. Clinical and Experimental Pharmacology and Physiology, 6 2: .

The inhibition of hepatic cytochrome-p-448 mediated aryl hydrocarbon hydroxylase

Stupans, I., Ryan, A. J. and Little, P. J. (1979) The inhibition of hepatic cytochrome-p-448 mediated aryl hydrocarbon hydroxylase. Australian Journal of Pharmaceutical Sciences, 8 1: .

Cefoxitin Sodium in Complicated Urinary-Tract Infection

Little, PJ, Peddie, BA and Pearson, S (1978) Cefoxitin Sodium in Complicated Urinary-Tract Infection. Journal of Antimicrobial Chemotherapy, 4 255-256.

Inhibitors of hepatic mixed function oxidases-II Some benzimidazole, benzoxazole and benzothiazole derivatives

Holder, GM, Little, PJ, Ryan, AJ and Watson, TR (1976) Inhibitors of hepatic mixed function oxidases-II Some benzimidazole, benzoxazole and benzothiazole derivatives. Biochemical Pharmacology, 25 24: 2747-2750. doi:10.1016/0006-2952(76)90267-7

Gpcr Signaling Via Dual Kinase Receptor Transactivation and Stimulation of Glycosaminoglycan Gene Expression in Cardiovascular Disease

Little, P. J. and Osman, N. (2013). Gpcr Signaling Via Dual Kinase Receptor Transactivation and Stimulation of Glycosaminoglycan Gene Expression in Cardiovascular Disease. In: Clinical and Experimental Pharmacology and Physiology. 4th Meeting of the Australia-Chinese-Association-for-Biomedical-Sciences-Inc (ACABS), Hangzhou Peoples R China, (7-8). Oct 10-13, 2013.

The Role of Nr2B and Neuronal Nitric Oxide Synthase in Glutamate Inhibitory Effect On Igf-1 Receptor Signaling

Zhang, L., Chen, Q., Han, C., Wang, R., Yan, F., Lai, Y., Liao, R., Little, P. and Zheng, W. (2013). The Role of Nr2B and Neuronal Nitric Oxide Synthase in Glutamate Inhibitory Effect On Igf-1 Receptor Signaling. In: Clinical and Experimental Pharmacology and Physiology. 4th Meeting of the Australia-Chinese-Association-for-Biomedical-Sciences-Inc (ACABS), Hangzhou Peoples R China, (3-3). Oct 10-13, 2013. doi:10.1111/1440-1681.12170_10

Vasoactive peptides stimulate atherogenic changes in vascular proteoglycans

Ivey, M. E. and Little, P. J. (2006). Vasoactive peptides stimulate atherogenic changes in vascular proteoglycans. In: Atherosclerosis Supplements. 14th Meeting of the International-Society-of-Atherosclerosis, Rome Italy, (242-242). Jun 18-22, 2006. doi:10.1016/S1567-5688(06)80966-9

Endothelin-1 stimulates atherogenic changes in vascular proteoglycans

Ivey, ME, Osman, N and Little, PJ (2005). Endothelin-1 stimulates atherogenic changes in vascular proteoglycans. In: Circulation. 78th Annual Scientific Session of the American-Heart-Association, Dallas Tx, (U257-U257). Nov 13-16, 2005.

AGE mediated atherosclerosis does not involve direct stimulation of vascular smooth muscle cells.

Ballinger, ML, Ivey, ME, Nigro, J and Little, PJ (2003). AGE mediated atherosclerosis does not involve direct stimulation of vascular smooth muscle cells.. In: Diabetologia. 18th Congress of the International-Diabetes-Federation, Paris France, (A405-A405). Aug 24-29, 2003.

Regulation of human vascular smooth muscle proteoglycan biosynthesis by biguanides, sulfonylureas and glitazones.

Little, PJ, Ivey, ME, De Dios, ST, Wong, WS, Nigro, J, Ballinger, ML and Frontanilla, K (2003). Regulation of human vascular smooth muscle proteoglycan biosynthesis by biguanides, sulfonylureas and glitazones.. In: Diabetologia. 18th Congress of the International-Diabetes-Federation, Paris France, (A52-A52). Aug 24-29, 2003.

Structural changes of glycosaminoglycans from human vascular smooth muscle, induced by the PPAR-alpha ligand, fenofibrate.

Nigro, J, Ivey, ME, Jennings, GL and Little, PJ (2003). Structural changes of glycosaminoglycans from human vascular smooth muscle, induced by the PPAR-alpha ligand, fenofibrate.. In: Diabetologia. 18th Congress of the International-Diabetes-Federation, Paris France, (A52-A52). Aug 24-29, 2003.

Vascular actions of anti-diabetic thiazolidinediones.

de Dios, ST, Jennings, GLR, Dilley, RJ and Little, PJ (2003). Vascular actions of anti-diabetic thiazolidinediones.. In: Diabetologia. 18th Congress of the International-Diabetes-Federation, Paris France, (A51-A51). Aug 24-29, 2003.

Regulation of proteoglycan metabolism by peroxisome proliferating activator receptor (PPAR) ligands

Little, PJ, De Dios, ST, Nigro, J, Ballinger, ML, Ivey, ME and Dilley, RJ (2003). Regulation of proteoglycan metabolism by peroxisome proliferating activator receptor (PPAR) ligands. In: Clinical and Experimental Pharmacology and Physiology. Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, Melbourne Australia, (A26-A27). Dec 27, 2002.

Versican synthesized in the presence of troglitazone is smaller and has reduced LDL binding

Tannock, LR, Little, PJ, Barrett, PHR, Wight, TN and Chait, A (2002). Versican synthesized in the presence of troglitazone is smaller and has reduced LDL binding. In: Arteriosclerosis Thrombosis and Vascular Biology. , , (A36-A36). .

TGF-beta 1 increases LDL retention by vascular proteoglycans

Tannock, LR, Little, PJ, Wight, TN and Chait, A (2001). TGF-beta 1 increases LDL retention by vascular proteoglycans. In: Arteriosclerosis Thrombosis and Vascular Biology. , , (678-678). .

Overnight urinary norepinephrine and awake pulmonary capillary wedge pressure in heart failure with central sleep apnea.

Solin, P, Little, PJ, Roebuck, T, Richardson, M, Bergin, P, Kaye, DM, Walters, EH and Naughton, MT (1999). Overnight urinary norepinephrine and awake pulmonary capillary wedge pressure in heart failure with central sleep apnea.. In: American Journal of Respiratory and Critical Care Medicine. , , (A529-A529). .

Mechanisms regulating the vascular smooth muscle Na/H exchanger (NHE-1) in diabetes

Hannan, KM and Little, PJ (1998). Mechanisms regulating the vascular smooth muscle Na/H exchanger (NHE-1) in diabetes. In: 8th Fisher Winternational Symposium of the Canadian-Society-of-Biochemistry-and-Molecular-and-Cellular-Biology on Membrane Proteins in Health and Disease, Banff Canada, (751-759). Apr 02-05, 1998. doi:10.1139/bcb-76-5-751

Metabolic ischemia in vascular smooth muscle causes adrenomedullin gene expression by a calcium dependent mechanism

Little, PJ and Autelitano, DJ (1997). Metabolic ischemia in vascular smooth muscle causes adrenomedullin gene expression by a calcium dependent mechanism. In: Circulation. , , (961-961). .

Hmg-Coa Reductase Inhibition by Simvastatin Depletes Membrane-Bound Heterotrimeric-G Proteins and Inhibits Proliferation of Vascular Smooth-Muscle Cells

Little, PJ, Dinatale, A, Neylon, CB and Bobik, A (1993). Hmg-Coa Reductase Inhibition by Simvastatin Depletes Membrane-Bound Heterotrimeric-G Proteins and Inhibits Proliferation of Vascular Smooth-Muscle Cells. In: Circulation. , , (3-3). .

Regulation of vascular smooth muscle cell growth by amiloride-sensitive pH(i) control mechanisms

Little, PJ, Grooms, A and Bobik, A (1990). Regulation of vascular smooth muscle cell growth by amiloride-sensitive pH(i) control mechanisms. In: , , (1280-1281). . doi:10.1016/0014-2999(90)94387-D

Spontaneous Calcium Transients May Regulate Vascular-Resistance

Weissberg, PL, Little, PJ and Bobik, A (1987). Spontaneous Calcium Transients May Regulate Vascular-Resistance. In: Journal of Hypertension. , , (761-761). . doi:10.1097/00004872-198712000-00022

Na-H Exchange Is a Major Determinant of Cellular Sodium Handling in Vascular Smooth-Muscle Cells

Weissberg, PL, Little, PJ, Cragoe, EJ and Bobik, A (1986). Na-H Exchange Is a Major Determinant of Cellular Sodium Handling in Vascular Smooth-Muscle Cells. In: Journal of Hypertension. , , (S710-S710). .

Effects of Partial Beta-Agonists and Phosphodiesterase Inhibition On Beta-Adrenoceptor Responsiveness of Cultured Cardiac-Cells

Bobik, A, Little, P, Campbell, J and Minasian, S (1983). Effects of Partial Beta-Agonists and Phosphodiesterase Inhibition On Beta-Adrenoceptor Responsiveness of Cultured Cardiac-Cells. In: Clinical and Experimental Pharmacology and Physiology. , , (660-660). .

Agonist-Induced Modulation of Beta-Adrenoceptor Responsiveness in Cultured Rabbit Aorta Smooth-Muscle Cells

Little, PJ, Campbell, J and Bobik, A (1982). Agonist-Induced Modulation of Beta-Adrenoceptor Responsiveness in Cultured Rabbit Aorta Smooth-Muscle Cells. In: Clinical and Experimental Pharmacology and Physiology. , , (405-405). .

Metabolism and Distribution of C-14 Benzo(A)Pyrene in the Spiny Lobster Panulirus-Argus

Little, PJ, James, MO and Bend, JR (1980). Metabolism and Distribution of C-14 Benzo(A)Pyrene in the Spiny Lobster Panulirus-Argus. In: Federation Proceedings. , , (538-538). .