Lecturer
Overview
In 2000, I received a BSc in Genetics from the University of Otago, then completed a Postgraduate Diploma in Health Sciences (Bioethics) and Masters in Health Sciences (Philosophy) in 2001 and 2003, respectively. My Master's thesis title was "Genetic modification and the facts: an ethical analysis of the GM debate". Library details here and was undertaken with supervision by Dr. Neil Pickering at the University of Otago. In 2003, I began studies in Pharmacy at the University of Otago from Second year, then transferred to the University of Auckland in 2004 (Third year) and in 2005, received my BPharm(Hons) and undertook my internship at Middlemore Hospital (2006), and was then employed as a clinical pharmacist in general surgery during 2007. Later in 2007, I was awarded with the Technology for Industry Fellowship (TIF) from the New Zealand Foundation for Research, Science & Technology (FRST) with joint funding from Pharmaceutical Compounding New Zealand (PCNZ) to complete a PhD in Pharmaceutical Sciences – Pharmacy at the University of Auckland. The PhD project title was “Development of a transdermal delivery for progesterone using supercritical carbon dioxide”. The PhD research was supervised by Dr. Jingyuan Wen and Prof. Raid Alany.
During the PhD, we developed a unique supercritical fluid (SCF) method as a preparation alternative to solvent evaporation, co-melting, and physical mixing techniques. In order to characterize the resulting dispersion systems, an in vitro dissolution method was employed to compare conventional diffusion and erosion processes to dual-first order release, also using Raman and infrared spectroscopy, x-ray diffraction, scannine electron microscopy, and birefringence. Moreover, I developed a linear and non-linear experimental design to determine significant processing factors and optmise the manufactured SCF prepared dispersion systems. Finally, we developed an ex vivo permeability study using mouse and porcine skin which was used as a simple tool to assess the transfer of progesterone across the skin.
Research Interests
- Supercritical fluid technology
- Solid state of drugs and dosage forms
- Quantitative analysis using Raman and IR spectroscopy and chemometrics
- Non-linear release modelling such as dual first order
- In situ gelling systems for systemic drug delivery
- Synthesis and characterization of bioactive polymorphic transformations
- SCF preparation of advnaced delivery systems such as liposomes and solid lipid particles
- Spray jet behaviour during SCF rapid exapnsion using in situ spectroscopy
- SCF extraction of bioactive molecules from indigenous plants
Qualifications
- Doctor of Philosophy, The University of Auckland
- Postgraduate Diploma in Health Sciences, University of Otago
- Bachelor of Pharmacy, The University of Auckland
- Bachelor of Science, University of Otago
Publications
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Journal Article: Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology
Maqbool, Faheem, Moyle, Peter M., Thurecht, Kristofer J. and Falconer, James R. (2019) Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. International Journal of Pharmaceutics, 563 174-183. doi:10.1016/j.ijpharm.2019.03.053
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Journal Article: Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice
Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas, Nguyen, Thao T. T., Pandey, Saurabh, Thurecht, Kristofer J. and Falconer, James Robert (2019) Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice. Scientific Reports, 9 1: 1716. doi:10.1038/s41598-018-37171-9
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Journal Article: Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing
Maqbool, Faheem, Moyle, Peter M., Tan, Madeleine S. A., Thurecht, Kristofer J. and Falconer, James R. (2019) Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing. Artificial Cells, Nanomedicine, and Biotechnology, . doi:10.1080/21691401.2018.1536059
Grants
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Novel oral delivery for meropenem nanoparticles prepared using supercritical fluid technology
(2017) UQ Early Career Researcher
Supervision
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Formation, encapsulation and release behaviour of nanoparticles of a hydrophilic drug using supercritical carbon dioxide
Doctor Philosophy
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Development of an advanced delivery system for difficult to formulate medicines using novel preparation technologies.
Doctor Philosophy
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Novel extraction and evaluation of papaya leaf for chemotherapeutic molecules
Doctor Philosophy
Publications
Journal Article
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Maqbool, Faheem, Moyle, Peter M., Thurecht, Kristofer J. and Falconer, James R. (2019) Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. International Journal of Pharmaceutics, 563 174-183. doi:10.1016/j.ijpharm.2019.03.053
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Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas, Nguyen, Thao T. T., Pandey, Saurabh, Thurecht, Kristofer J. and Falconer, James Robert (2019) Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice. Scientific Reports, 9 1: 1716. doi:10.1038/s41598-018-37171-9
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Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing
Maqbool, Faheem, Moyle, Peter M., Tan, Madeleine S. A., Thurecht, Kristofer J. and Falconer, James R. (2019) Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing. Artificial Cells, Nanomedicine, and Biotechnology, . doi:10.1080/21691401.2018.1536059
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Solid nanoparticles for oral antimicrobial drug delivery: a review
Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Maqbool, Faheem, Roberts, Jason A. and Falconer, James Robert (2019) Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discovery Today, . doi:10.1016/j.drudis.2019.01.004
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Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas and Falconer, James Robert (2017) Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules, 22 7: 1186. doi:10.3390/molecules22071186
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Extemporaneously compounded medicines (vol 40, pg 5, 2017)
Falconer, James R. and Steadman, Kathryn J. (2017) Extemporaneously compounded medicines (vol 40, pg 5, 2017). Australian Prescriber, 40 3: 119-119. doi:10.18773/austprescr.2017.042
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Extemporaneously compounded medicines
Falconer , James R. and Steadman, Kathryn J. (2017) Extemporaneously compounded medicines. Australian Prescriber, 40 1: 5-8. doi:10.18773/austprescr.2017.001
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Improving drug retention in liposomes by aging with the aid of glucose.
Zhang, Wenli, Falconer, James R., Baguley, Bruce C., Shaw, John P., Kanamala, Manju, Xu, Hongtao, Wang, Guangji, Liu, Jianping and Wu, Zimei (2016) Improving drug retention in liposomes by aging with the aid of glucose.. International Journal of Pharmaceutics, 505 1-2: 194-203. doi:10.1016/j.ijpharm.2016.03.044
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Supercritical fluid technologies to fabricate proliposomes
Falconer, James R., Svirskis, Darren, Adil, Ali A. and Wu, Zimei (2015) Supercritical fluid technologies to fabricate proliposomes. Journal of Pharmacy and Pharmaceutical Sciences, 18 5: 747-764.
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Strategies to maximize liposomal drug loading for a poorly water-soluble anticancer drug
Zhang, Wenli, Wang, Guangji, Falconer, James R., Baguley, Bruce C., Shaw, John P., Liu, Jianping, Xu, Hongtao, See, Esther, Sun, Jianguo, Aa, Jiye and Wu, Zimei (2015) Strategies to maximize liposomal drug loading for a poorly water-soluble anticancer drug. Pharmaceutical Research, 32 4: 1451-1461. doi:10.1007/s11095-014-1551-8
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Falconer, James R., Wu, Zimei, Lau, Hugo, Suen, Joanna, Wang, Lucy, Pottinger, Sarah, Lee, Elaine, Alazawi, Nawar, Kallesen, Molly, Gargiulo, Derryn A., Swift, Simon and Svirskis, Darren (2014) An investigation into the stability and sterility of citric acid solutions used for cough reflex testing. Dysphagia, 29 5: 622-628. doi:10.1007/s00455-014-9558-1
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A study of microemulsions as prolonged-release injectables through in-situ phase transition
Wu, Zimei, Alany, Raid G., Tawfeek, Noor, Falconer, James, Zhang, Wenli, Hassan, Ibrahim M., Rutland, Michael and Svirskis, Darren (2014) A study of microemulsions as prolonged-release injectables through in-situ phase transition. Journal of Controlled Release, 174 1: 188-194. doi:10.1016/j.jconrel.2013.11.022
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Evaluation of progesterone permeability from supercritical fluid processed dispersion systems
Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Farid, Mohammed, El Maghraby, Gamal M. and Alany, Raid G. (2014) Evaluation of progesterone permeability from supercritical fluid processed dispersion systems. Pharmaceutical Development and Technology, 19 2: 238-246. doi:10.3109/10837450.2013.769570
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Preparation and characterization of progesterone dispersions using supercritical carbon dioxide
Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Farid, Mohammed, Tallon, Stephen J. and Alany, Raid G. (2014) Preparation and characterization of progesterone dispersions using supercritical carbon dioxide. Drug Development and Industrial Pharmacy, 40 4: 458-469. doi:10.3109/03639045.2013.768630
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Falconer, J. R., Wen, J., Zargar-Shoshtari, S., Chen, J. J., Farid, M., Young, S. and Alany, R. G. (2013) Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions. Journal of Drug Delivery Science and Technology, 23 5: 477-483. doi:10.1016/S1773-2247(13)50069-4
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Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Mohammed, Farid, Chan, Judy and Alany, Raid G. (2012) The effects of supercritical carbon dioxide processing on progesterone dispersion systems: a multivariate study. AAPS PharmSciTech, 13 4: 1255-1265. doi:10.1208/s12249-012-9850-z
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Meng, Dan, Falconer, James, Krauel-Goellner, Karen, Chen, John J. J. J., Farid, Mohammed and Alany, Raid G. (2008) Self-built supercritical CO2 anti-solvent unit design, construction and operation using Carbamazepine. AAPS PharmSciTech, 9 3: 944-952. doi:10.1208/s12249-008-9130-0
Other Outputs
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Batt, Laurie Robert, Win, Su, Davies, Keryn, Gill, David Anthony, Falconer, James Robert, Cleverly, Douglas Robert and Wu, Zimei (2016). Transdermal formulations. WO 2014132227 A1.
Grants (Administered at UQ)
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Novel oral delivery for meropenem nanoparticles prepared using supercritical fluid technology
(2017) UQ Early Career Researcher
PhD and MPhil Supervision
Current Supervision
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Formation, encapsulation and release behaviour of nanoparticles of a hydrophilic drug using supercritical carbon dioxide
Doctor Philosophy — Principal Advisor
Other advisors:
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Development of an advanced delivery system for difficult to formulate medicines using novel preparation technologies.
Doctor Philosophy — Principal Advisor
Other advisors:
-
Novel extraction and evaluation of papaya leaf for chemotherapeutic molecules
Doctor Philosophy — Principal Advisor
Other advisors:
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Development of a novel extraction method of a medicinal plant for manufacturing into an emulsion-based beverage
Doctor Philosophy — Principal Advisor
Other advisors:
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Can TLR4 active metabolites of drugs administered to cancer surgery patient improve long term cancer outcomes
Doctor Philosophy — Principal Advisor
Other advisors:
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Optimisation and preparation of drug delivery systems using a novel supercritial fluid technology for the purpose of targeting, stability enhancement and controlled release
Doctor Philosophy — Principal Advisor
Other advisors:
