Professor Minchin received his PhD from the Department of Pharmacology at the University of Western Australia before undertaking post-doctoral studies at the National Cancer Institute in Washington DC. His major work was on pulmonary toxicology of anti-cancer drugs and chemical carcinogenesis. He returned as a QEII Fellow to the University of New South Wales to investigate polyamine transport in the lung. Eventually, he returned to the University of Western Australia as a teaching and research academic where his interest in arylamine N-acetyltransferases and gene therapy developed. Currently, Professor Minchin is the Chair of Molecular Pharmacology at the University of Queensland and is Head, Laboratory for Moleculkar and Cellular Pharmacology in the School of Biomedical Sciences
The Laboratory for Molecular and Cellular Pharmacology investigates the effects that drugs and other chemicals exert in human health and disease. Our research aims to identify biochemical pathways and cellular processes that may be targets for novel drug development and use. The Laboratory focuses on several cellular proteins (arylamine N-acetyltransferases and cytosolic sulfotransferases) that have a central role in cancer initiation and progression as well as neurological diseases such as Parkinsons. We also investigate the interaction of nanoparticles and nanomaterials with proteins and cells in order to better understand their potential future pharmacological applications.
Journal Article: Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-α
Li, Pengcheng, Butcher, Neville J. and Minchin, Rod (2019) Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-α. Molecular Pharmacology, 96 5: 573-579. doi:10.1124/mol.119.117432
Journal Article: Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases
Wang, Lili, Subasic, Christopher, Minchin, Rodney F. and Kaminskas, Lisa M. (2019) Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases. Nanomedicine, 14 12: 1605-1621. doi:10.2217/nnm-2018-0478
Journal Article: Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex
Wang, Lili, Minchin, Rodney F., Essebier, Patricia J. and Butcher, Neville J. (2019) Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex. The International Journal of Biochemistry & Cell Biology, . doi:10.1016/j.biocel.2019.03.002
The Queensland Drug Repurposing Initiative
(2017–2021) Queensland Government Advance Queensland Innovation Partnerships
Fusion of Digital Microscopy and Plain Text Reports for Automated Analysis
(2017–2020) ARC Linkage Projects
The pharmacology of sulfotransferase 4A1
(2016–2019) NHMRC Project Grant
ROLE OF HUMAN NAT1 IN BREAST CANCER INVASION
Doctor Philosophy
The regulation of NAT1 mRNA by alterations in polyadenylation site usage.
Doctor Philosophy
NAT1 and cancer cell metabolism
(2018) Doctor Philosophy
Unravelling risks in Parkinsons disease - Pharmacogenetics of brain sulfotransferases involved in dopamine metabolism.
Transcriptional regulation of sulfotransferases implicated in neurodegenerative disease.
Arylamine N-acetyltransferases are central to cancer cell survival via protein acetylation/deacetylation homeostasis.
Human Arylamine N-Acetyltransferase Type 1
Butcher, Neville J., Li, Pengcheng, Wang, Lili and Minchin, Rodney F. (2018). Human Arylamine N-Acetyltransferase Type 1. In Arylamine N-acetyltransferases in Health and Disease (pp. 91-107) Singapore: World Scientific Publishing. doi:10.1142/9789813232013_0004
Nanotoxicology and nanovaccines
Mortimer, G. M. and Minchin, R. F. (2016). Nanotoxicology and nanovaccines. In Mariusz Skwarczynski and Istvan Toth (Ed.), Micro and nanotechnology in vaccine development (pp. 373-392) Oxford, United Kingdom: Elsevier . doi:10.1016/B978-0-323-39981-4.00020-8
Toxicity and regulatory perspectives of carbon nanotubes
Martin, D., Minchin, R. F., Belkina, M., Milev, A. and Kannangara, G. S. Kamali (2011). Toxicity and regulatory perspectives of carbon nanotubes. In Tony McNally and Petra Pötschke (Ed.), Polymer-carbon nanotube composites : Preparation, properties and applications (pp. 621-653) Cambridge, U.K.: Woodhead Publishing. doi:10.1533/9780857091390.2.621
Arylamine N-Acetyltransferases
Butcher, Neville J. and Minchin, Rodney F. (2008). Arylamine N-Acetyltransferases. In Manfred Schwab (Ed.), Encyclopedia of cancer 2nd ed. (pp. 255-257) Berlin, Germany: Springer Verlag.
Arylamine N-Acetyltransferase Gene Polymorphism
Butcher, N. J. and Minchin, R. F. (2005). Arylamine N-Acetyltransferase Gene Polymorphism. In Jurgen Fuchs and Maurizio Podda (Ed.), Encyclopedia of Medical Genomics and Proteomics (pp. 79-83) New York: Marcel Dekker.
Li, Pengcheng, Butcher, Neville J. and Minchin, Rod (2019) Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-α. Molecular Pharmacology, 96 5: 573-579. doi:10.1124/mol.119.117432
Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases
Wang, Lili, Subasic, Christopher, Minchin, Rodney F. and Kaminskas, Lisa M. (2019) Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases. Nanomedicine, 14 12: 1605-1621. doi:10.2217/nnm-2018-0478
Wang, Lili, Minchin, Rodney F., Essebier, Patricia J. and Butcher, Neville J. (2019) Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex. The International Journal of Biochemistry & Cell Biology, . doi:10.1016/j.biocel.2019.03.002
Idris, Misgana, Butcher, Neville J and Minchin, Rodney F (2019) The MBNL/CELF splicing factors regulate cytosolic sulfotransferase 4A1 protein expression during cell differentiation. Drug Metabolism and Disposition, 47 3: 314-319. doi:10.1124/dmd.118.085290
Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate
Minchin, Rodney F., Rosengren, K. Johan, Burow, Rachel and Butcher, Neville J. (2018) Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochemical Pharmacology, 158 153-160. doi:10.1016/j.bcp.2018.10.013
Minchin, Rodney F. and Butcher, Neville J. (2018) Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance. BMC Genomics, 19 1: 513. doi:10.1186/s12864-018-4894-4
Wang, LiLi, Minchin, Rodney F and Butcher, Neville J (2018) Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. PLoS One, 13 3: e0193560. doi:10.1371/journal.pone.0193560
Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease
Butcher, N. J., Horne, M. K., Mellick, G. D., Fowler, C. J., Masters, C. L. and Minchin, R. F. (2017) Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease. Pharmacogenomics Journal, 18 2: 209-214. doi:10.1038/tpj.2017.4
Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway
Witham, Katey L., Minchin, Rodney F. and Butcher, Neville J. (2017) Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochemical Pharmacology, 125 93-100. doi:10.1016/j.bcp.2016.11.015
Cryptic epitopes and functional diversity in extracellular proteins
Mortimer, Gysell M. and Minchin, Rodney F. (2016) Cryptic epitopes and functional diversity in extracellular proteins. International Journal of Biochemistry and Cell Biology, 81 Part A: 112-120. doi:10.1016/j.biocel.2016.10.020
Zhang, Jing, Woodruff, Trent M., Clark, Richard J., Martin, Darren J. and Minchin, Rodney F. (2016) Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition. Acta Biomaterialia, 41 264-272. doi:10.1016/j.actbio.2016.05.034
Stable non-covalent labeling of layered silicate nanoparticles for biological imaging
Mortimer, Gysell M., Jack, Kevin S., Musumeci, Anthony W., Martin, Darren J. and Minchin, Rodney F. (2016) Stable non-covalent labeling of layered silicate nanoparticles for biological imaging. Materials Science and Engineering C, 61 674-680. doi:10.1016/j.msec.2015.12.047
Shaw, Catherine A., Mortimer, Gysell M., Deng, Zhou J., Carter, Edwin S., Connell, Shea P., Miller, Mark R., Duffin, Rodger, Newby, David E., Hadoke, Patrick W. F. and Minchin, Rodney F. (2016) Protein corona formation in bronchoalveolar fluid enhances diesel exhaust nanoparticle uptake and pro-inflammatory responses in macrophages. Nanotoxicology, 10 7: 981-991. doi:10.3109/17435390.2016.1155672
Drug delivery: unravelling the stealth effect
Butcher, Neville J., Mortimer, Gysell M. and Minchin, Rodney F. (2016) Drug delivery: unravelling the stealth effect. Nature Nanotechnology, 11 4: 310-311. doi:10.1038/nnano.2016.6
A bag of cells approach for antinuclear antibodies HEp-2 image classification
Wiliem, Arnold, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2015) A bag of cells approach for antinuclear antibodies HEp-2 image classification. Cytometry. Part A, 87 6: 549-557. doi:10.1002/cyto.a.22597
Tiang, Jacky M., Butcher, Neville J. and Minchin, Rodney F. (2015) Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines. Cancer Medicine, 4 4: 565-574. doi:10.1002/cam4.415
Minchin, Rodney F and Butcher, Neville J (2015) The role of lysine100 in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: Implications for other acetyltransferases. Biochemical Pharmacology, 94 3: 195-202. doi:10.1016/j.bcp.2015.01.015
Tirtaatmadja, Nicolin, Mortimer, Gysell, Ng, Eng-Poh, Ahmad, Hacan Ali, Mintova, Svetlana, Serpooshan, Vahid, Minchin, Rodney F and Mahmoudi, Morteza (2015) Nanoparticles-induced inflammatory cytokines in human plasma concentration manner: An ignored factor at the nanobio-interface. Journal of the Iranian Chemical Society, 12 2: 317-323. doi:10.1007/s13738-014-0486-7
Fluoromica nanoparticle cytotoxicity in macrophages decreases with size and extent of uptake
Tee, Nicolin, Zhu, Yingdong, Mortimer, Gysell M., Martin, Darren J. and Minchin, Rodney F. (2015) Fluoromica nanoparticle cytotoxicity in macrophages decreases with size and extent of uptake. International Journal of Nanomedicine, 10 2363-2375. doi:10.2147/IJN.S80655
Sidharthan, Neelima P., Butcher, Neville J., Mitchell, Deanne J. and Minchin, Rodney F. (2014) Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination. PLoS One, 9 7: e101520.1-e101520.8. doi:10.1371/journal.pone.0101520
Stephenson, Rachel, Varamini, Pegah, Butcher, Neville, Minchin, Rodney and Toth, Istvan (2014) Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro. Nanomedicine: Nanotechnology, Biology and Medicine, 10 8: 1799-1808. doi:10.1016/j.nano.2014.06.015
Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials
Mortimer, Gysell M., Butcher, Neville J., Musumeci, Anthony W., Deng, Zhou J., Martin, Darren J. and Minchin, Rodney F. (2014) Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials. ACS Nano, 8 4: 3357-3366. doi:10.1021/nn405830g
Implementation of a Virtual Laboratory Practical Class (VLPC) module in pharmacology education
Cheesman, Matthew J., Chen, Steven, Manchadi, Mary-Louise, Jacob, Teague, Minchin, Rodney F. and Tregloan, Peter A. (2014) Implementation of a Virtual Laboratory Practical Class (VLPC) module in pharmacology education. Pharmacognosy Communications, 4 1: 2-10. doi:10.5530/pc.2014.1.2
Wiliem, Arnold, Sanderson, Conrad, Wong, Yongkang, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2014) Automatic classification of Human Epithelial type 2 cell Indirect Immunofluorescence images using Cell Pyramid Matching. Pattern Recognition, 47 7: 2315-2324. doi:10.1016/j.patcog.2013.10.014
Zhang, Jing, Martin, Darren J., Taran, Elena, Thurecht, Kristofer J. and Minchin, Rodney F. (2014) Effect of supercritical carbon dioxide on the loading and release of model drugs from polyurethane films: comparison with solvent casting. Macromolecular Chemistry and Physics, 215 1: 54-64. doi:10.1002/macp.201300492
Interaction of human arylamine n-acetyltransferase 1 with different nanomaterials
Deng, Zhou J., Butcher, Neville J., Mortimer, Gysell M., Jia, Zhongfan, Monteiro, Michael J., Martin, Darren J. and Minchin, Rodney F. (2014) Interaction of human arylamine n-acetyltransferase 1 with different nanomaterials. Drug Metabolism and Disposition, 42 3: 377-383. doi:10.1124/dmd.113.055988
Sidharthan, Neelima P., Minchin, Rodney F. and Butcher, Neville J. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: Role of D1 receptor-n-methyl-d-aspartate receptor coupling. Journal of Biological Chemistry, 288 48: 34364-34374. doi:10.1074/jbc.M113.493239
Witham, Katey L., Butcher, Neville J., Sugamori, Kim S., Brenneman, Debbie, Grant, Denis M. and Minchin, Rodney F. (2013) 5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. PLoS One, 8 10: e77923.1-e77923.7. doi:10.1371/journal.pone.0077923
Deng, Zhou J., Liang, Mingtao, Toth, Istvan, Monteiro, Michael and Minchin, Rodney F. (2013) Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses. Nanotoxicology, 7 3: 314-322. doi:10.3109/17435390.2012.655342
Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity
Sakhtianchi, Ramom, Minchin, Rodney F., Lee, Ki-Bum, Alkilany, Alaaldin M., Serpooshan, Vahid and Mahmoudi, Morteza (2013) Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity. Advances in Colloid and Interface Science, 201-202 18-29. doi:10.1016/j.cis.2013.10.013
Arylamine N-acetyltransferase 1: A novel drug target in cancer development
Butcher, Neville J. and Minchin, Rodney F. (2012) Arylamine N-acetyltransferase 1: A novel drug target in cancer development. Pharmacological Reviews, 64 1: 147-165. doi:10.1124/pr.110.004275
Molecular interaction of poly(acrylic acid) gold nanoparticles with human fibrinogen
Deng, Zhou J., Liang, Mingtao, Toth, Istvan, Monteiro, Michael J. and Minchin, Rodney F. (2012) Molecular interaction of poly(acrylic acid) gold nanoparticles with human fibrinogen. ACS Nano, 6 10: 8962-8969. doi:10.1021/nn3029953
Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives
Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012) Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 8: 675-684. doi:10.1002/emmm.201101131
Tiang, JM, Butcher, NJ, Cullinane, C, Humbert, PO and Minchin, RF (2011) RNAi-mediated knock-down of Arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. PLoS One, 6 2: 1-10. doi:10.1371/journal.pone.0017031
Paterson, S, Sin, KL, Tiang, JM, Minchin, RF and Butcher, NJ (2011) Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. Drug Metabolism and Disposition, 39 1: 77-82. doi:10.1124/dmd.110.036202
Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation
Deng, Zhou J., Liang, Mingtao, Monteiro, Michael, Toth, Istvan and Minchin, Rodney F. (2011) Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nature Nanotechnology, 6 1: 39-44. doi:10.1038/NNANO.2010.250
Phosphorylation/dephosphorylation of human SULT4A1: Role of Erk1 and PP2A
Mitchell, Deanne J., Butcher, Neville J. and Minchin, Rodney F. (2011) Phosphorylation/dephosphorylation of human SULT4A1: Role of Erk1 and PP2A. Biochimica et Biophysica Acta - Molecular Cell Research, 1813 1: 231-237. doi:10.1016/j.bbamcr.2010.09.011
Butcher, Neville J., Mitchell, Deanne J., Burow, Rachel and Minchin, Rodney F. (2010) Regulation of Mouse Brain-Selective Sulfotransferase Sult4a1 by cAMP Response Element-Binding Protein and Activating Transcription Factor-2. Molecular Pharmacology, 78 3: 503-510. doi:10.1124/mol.110.063404
Butcher, Neville J. and Minchin, Rodney F. (2010) Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis, 31 5: 820-826. doi:10.1093/carcin/bgq042
Endosomal disruptors in non-viral gene delivery
Minchin, Rodney F. and Yang, Shu (2010) Endosomal disruptors in non-viral gene delivery. Expert Opinion On Drug Delivery, 7 3: 331-339. doi:10.1517/17425240903512931
Fluorescent layered double hydroxide nanoparticles for biological studies
Musumeci, Anthony W., Mortimer, Gysell M., Butler, Margaret K., Xu, Zhi Ping, Minchin, Rodney M. and Martin, Darren J. (2010) Fluorescent layered double hydroxide nanoparticles for biological studies. Applied Clay Science, 48 1-2: 271-279. doi:10.1016/j.clay.2009.11.008
Tiang, Jacky M., Butcher, Neville J. and Minchin, Rodney F. (2010) Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells. Biochemical and Biophysical Research Communications, 393 1: 95-100. doi:10.1016/j.bbrc.2010.01.087
Minireview: Nanoparticles for molecular imaging - an overview
Minchin, Rodney F and Martin, Darren J (2010) Minireview: Nanoparticles for molecular imaging - an overview. Endocrinology, 151 2: 474-481. doi:10.1210/en.2009-1012
Cellular uptake of densely packed polymer coatings on gold nanoparticles
Liang, Mingtao, Lin, I-Chun, Whittaker, Michael R., Minchin, Rodney F., Monteiro, Michael J. and Toth, Istvan (2010) Cellular uptake of densely packed polymer coatings on gold nanoparticles. ACS Nano, 4 1: 403-413. doi:10.1021/nn9011237
Musumeci, Anthony W., Schiller, Tara L., Xu, Zhi Ping, Minchin, Rodney F., Martin, Darren J. and Smith, Suzanne V. (2010) Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces, 114 2: 734-740. doi:10.1021/jp905347x
Musumeci, Anthony W, Xu, Zhi Ping, Smith, Suzanne V, Minchin, Rodney F and Martin, Darren J (2010) Layered double hydroxide nanoparticles incorporating terbium: applicability as a fluorescent probe and morphology modifier. Journal of Nanoparticle Research, 12 1: 111-120. doi:10.1007/s11051-008-9583-9
Differential plasma protein binding to metal oxide nanoparticles
Deng, Zhou J., Mortimer, Gysell, Schiller, Tara, Musumeci, Anthony, Martin, Darren and Minchin, Rodney F. (2009) Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology, 20 45: 455101.1-455101.9. doi:10.1088/0957-4484/20/45/455101
Cytosolic Aryl Sulfotransferase 4A1 Interacts with the Peptidyl Prolyl Cis-Trans Isomerase Pin1
Mitchell, Deanne J. and Minchin, Rodney F. (2009) Cytosolic Aryl Sulfotransferase 4A1 Interacts with the Peptidyl Prolyl Cis-Trans Isomerase Pin1. Molecular Pharmacology, 76 2: 388-395. doi:10.1124/mol.109.055442
Lack of exonic sulflotransferase 4A1 mutations in controls and schizophrenia cases
Lewis, Aaron G. and Minchin, Rodney F. (2009) Lack of exonic sulflotransferase 4A1 mutations in controls and schizophrenia cases. Psychiatric Genetics, 19 1: 53-55. doi:10.1097/YPG.0b013e3283118776
Yang, Shu, Coles, David J., Esposito, Anna, Mitchell, Deanne J., Toth, Istvan and Minchin, Rodney F. (2009) Cellular uptake of self-assembled cationic peptide-DNA complexes: Multifunctional role of the enhancer chloroquine. Journal of controlled release, 135 2: 159-165. doi:10.1016/j.jconrel.2008.12.015
Regulation of arylamine N-acetyltransferases
Butcher, Neville J., Tiang, Jacky and Minchin, Rodney F. (2008) Regulation of arylamine N-acetyltransferases. Current Drug Metabolism, 9 6: 498-504. doi:10.2174/138920008784892128
Coles, Daniel J., Yang, Shu, Minchin, Rodney F. and Toth, Istvan (2008) The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry. Biopolymers, 90 5: 651-654. doi:10.1002/bip.21019
Changes in consensus arylamine N-acetyltransferase gene nomenclature
Hein, David W., Boukouvala, Sotiriab, Grant, Denis M., Minchin, Rodney F. and Sim, Edith (2008) Changes in consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics and Genomics, 18 4: 367-368. doi:10.1097/FPC.0b013e3282f60db0
Mitchell, D. J. and Minchin, R. F. (2008) E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2. Cancer Gene Therapy, 15 11: 758-764. doi:10.1038/cgt.2008.47
Nanomedicine: Sizing up targets with nanoparticles
Minchin, Rod (2008) Nanomedicine: Sizing up targets with nanoparticles. Nature Nanotechnology, 3 1: 12-13. doi:10.1038/nnano.2007.433
Minchin, Rodney F., Lewis, Aaron, Mitchell, Deanne, Kadlubar, Fred F. and McManus, Michael E. (2008) Sulfotransferase 4A1. The International Journal of Biochemistry & Cell Biology, 40 12: 2686-2691. doi:10.1016/j.biocel.2007.11.010
The synthesis and characterisation of a novel dendritic system for gene delivery
Coles, Daniel J., Yang, Shu, Esposito, Anna, Mitchell, Deanne, Minchin, Rodney F. and Toth, Istvan (2007) The synthesis and characterisation of a novel dendritic system for gene delivery. Tetrahedron, 63 49: 12207-12214. doi:10.1016/j.tet.2007.09.048
Polyamine-dependent regulation of spermidine-spermine N-1-acetyltransferase mRNA translation
Butcher, Neville J., Broadhurst, Gysell M. and Minchin, Rodney F. (2007) Polyamine-dependent regulation of spermidine-spermine N-1-acetyltransferase mRNA translation. Journal of Biological Chemistry, 282 39: 28530-28539. doi:10.1074/jbc.M701265200
Arylamine N-acetyltransferase I
Minchin, RF, Hanna, PE, Dupret, JM, Wagner, CR, Rodrigues-Lima, F and Butcher, NJ (2007) Arylamine N-acetyltransferase I. International Journal of Biochemistry & Cell Biology, 39 11: 1999-2005. doi:10.1016/j.biocel.2006.12.006
Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells
Butcher, Neville J., Tetlow, Natasha L., Cheung, Catherine, Broadhurst, Gysell M. and Minchin, Rodney F. (2007) Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Research, 67 1: 85-92. doi:10.1158/0008-5472.CAN-06-2635
Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery
Khoshnejad, M., Young, P. R., Toth, I. and Minchin, R. F. (2007) Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery. Current Medicinal Chemistry, 14 29: 3152-3156. doi:10.2174/092986707782793989
Concentration dependent effects of N1,N11-diethylnorspermine on melanoma cell proliferation
Minchin, Rodney F., Knight, Samuel, Arulpragasam, Ajanthy and Fogel-Petrovic, Mirjana (2006) Concentration dependent effects of N1,N11-diethylnorspermine on melanoma cell proliferation. International Journal of Cancer, 118 2: 509-512. doi:10.1002/ijc.21359
Butcher, N. J., Arulpragasam, A., Goh, H. L., Davey, Tamara and Minchin, Rodney F. (2005) Genomic organization of human arylamine N-acetyltransferase Type I reveals alternative promoters that generate different 5'-UTR splice variants with altered translational activities. Biochemical Journal, 387 1: 119-127. doi:10.1042/BJ20040903
HIV LTR-dependent expression of Bax selectively induces apoptosis in Tat-positive cells
McCoubrie, J. E., Kendrick, T. S. and Minchin, R. F. (2004) HIV LTR-dependent expression of Bax selectively induces apoptosis in Tat-positive cells. Biochemical and Biophysical Research Communications, 325 4: 1459-1464. doi:10.1016/j.bbrc.2004.10.195
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70
Carrello, A, Allan, RK, Morgan, SL, Owen, BAL, Mok, D, Ward, BK, Minchin, RF, Toft, DO and Ratajczak, T (2004) Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress & Chaperones, 9 2: 167-181. doi:10.1379/CSC-26R.1
Minchin, R. F. and McCoubrie, J. E. (2004) Mutational analysis of the large periplasmic loop 7-8 of the putrescine transporter PotE in Escherichia coli. International Journal of Biochemistry & Cell Biology, 36 2: 271-280. doi:10.1016/S1357-2725(03)00245-0
Butcher, Neville J., Arulpragasam, Ajanthy and Minchin, Rodney F. (2004) Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine - A mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. Journal of Biological Chemistry, 279 21: 22131-22137. doi:10.1074/jbc.M312858200
Immunophilin chaperones in steroid receptor signalling
Ratajczak, T., Ward, B. K. and Minchin, R. F. (2003) Immunophilin chaperones in steroid receptor signalling. Current Topics in Medicinal Chemistry, 3 12: 1348-1357. doi:10.2174/1568026033451934
Butcher, NJ, Arulpragasam, A, Pope, C and Minchin, RF (2003) Identification of a minimal promoter sequence for the human N-acetyltransferase Type I gene that binds AP-1 (activator protein 1) and YY-1 (Yin and Yang 1). Biochemical Journal, 376 441-448. doi:10.1042/BJ20030650
ATP-dependent kinase-catalyzed activation of N-hydroxy hetero-cyclic amines
Kadlubar, FF, Minchin, RF, Teitel, CH, Turesky, RJ and Ilett, KF (2002) ATP-dependent kinase-catalyzed activation of N-hydroxy hetero-cyclic amines. Drug Metabolism Reviews, 34 27-27.
Pharmacogenetics of the arylamine N-acetyltransferases
Butcher, N. J., Boukouvala, S., Sim, E. and Minchin, R. F. (2002) Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics Journal, 2 1: 30-42.
Griese, Ernst-Ulricha, Ilett, Kenneth F., Kitteringham, Neil R., Eichelbaum, Michela, Powell, Helend, Spargo, Randolph M., LeSouef, Peter N., Musk, A. William and Minchin, Rodney F. (2001) Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in Aborigines from Western Australia. Pharmacogenetics, 11 1: 69-76. doi:10.1097/00008571-200102000-00008
Allelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas
Ward, BK, Kumar, P, Turbett, GR, Edmondston, JE, Papadimitriou, JM, Laing, NG, Ingram, DM, Minchin, RF and Ratajczak, T (2001) Allelic loss of cyclophilin 40, an estrogen receptor-associated immunophilin, in breast carcinomas. Journal of Cancer Research And Clinical Oncology, 127 2: 109-115. doi:10.1007/s004320000182
Kumar, P, Mark, PJ, Ward, BK, Minchin, RF and Ratajczak, T (2001) Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells. Biochemical And Biophysical Research Communications, 284 1: 219-225. doi:10.1006/bbrc.2001.4952
Mark, PJ, Ward, BK, Kumar, P, Lahooti, H, Minchin, RF and Ratajczak, T (2001) Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. Cell Stress & Chaperones, 6 1: 59-70. doi:10.1379/1466-1268(2001)006<0059:HCIAHS>2.0.CO;2
Minchin, RF, Carpenter, D and Orr, RJ (2001) Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA. Journal of Pharmacology And Experimental Therapeutics, 296 3: 1006-1012.
Kumar, P, Ward, BK, Minchin, RF and Ratajczak, T (2001) Regulation of the Hsp90-binding immunophilin, cyclophilin 40, is mediated by multiple sites for CA-binding protein (GABP). Cell Stress & Chaperones, 6 1: 78-91. doi:10.1379/1466-1268(2001)006<0078:ROTHBI>2.0.CO;2
Two structures of cyclophilin 40: Folding and fidelity in the TPR domains
Taylor, Paul, Dornan, Jacqueline, Carrello, Amerigo, Minchin, Rodney F., Ratajczak, Thomas and Walkinshaw, Malcolm D. (2001) Two structures of cyclophilin 40: Folding and fidelity in the TPR domains. Structure, 9 5: 431-438. doi:10.1016/S0969-2126(01)00603-7
Sim, E, Payton, M, Noble, M and Minchin, R (2000) An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes. Human Molecular Genetics, 9 16: 2435-2441. doi:10.1093/hmg/9.16.2435
Agus, C, Ilett, KF, Kadlubar, FF and Minchin, RF (2000) Characterization of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis, 21 6: 1213-1219. doi:10.1093/carcin/21.6.1213
Genetic polymorphisms in glutathione S-transferase M1 and T1 in an Australian Aborigine population
Ilett, KF, McCormick, N, Carpenter, DS, Spargo, RM, Le Souef, PN, Musk, AW and Minchin, RF (2000) Genetic polymorphisms in glutathione S-transferase M1 and T1 in an Australian Aborigine population. Pharmacogenetics, 10 5: 477-480. doi:10.1097/00008571-200007000-00011
Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid
Butcher, NJ, Ilett, KF and Minchin, RF (2000) Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid. Biochemical Pharmacology, 60 12: 1829-1836. doi:10.1016/S0006-2952(00)00501-3
Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells
Butcher, NJ, Ilett, KF and Minchin, RF (2000) Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. Molecular Pharmacology, 57 3: 468-473.
The pharmacology of gene therapy
Minchin, Rodney F., Orr, Rebecca J., Cronin, Andrew S. and Puls, Rebecca L. (1999) The pharmacology of gene therapy. Croatian Medical Journal, 40 3: 381-391.
Ward, BK, Mark, PJ, Ingram, DM, Minchin, RF and Ratajczak, T (1999) Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. Breast Cancer Research And Treatment, 58 3: 267-280.
Gene transfer and expression of a non-viral polycation-based vector in CD4(+) cells
Puls, R. L. and Minchin, R. F. (1999) Gene transfer and expression of a non-viral polycation-based vector in CD4(+) cells. Gene Therapy, 6 10: 1774-1778. doi:10.1038/sj.gt.3301022
Purification,characterization and crystallization in two crystal forms of bovine cyclophilin 40
Dornan, A, Taylor, P, Carrello, A, Minchin, RF, Ratajczak, T and Walkinshaw, MD (1999) Purification,characterization and crystallization in two crystal forms of bovine cyclophilin 40. Acta Crystallographica Section D: Biological Crystallography, 55 5: 1079-1082. doi:10.1107/S0907444999003017
Carrello, A, Ingley, E, Minchin, RF, Tsai, S and Ratajczak, T (1999) The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and Hop is located in the dimerization domain of hsp90. Journal of Biological Chemistry, 274 5: 2682-2689. doi:10.1074/jbc.274.5.2682
Butcher, NJ, Ilett, KF and Minchin, RF (1998) Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by (CT)-T-190 and G(560)A mutations. Pharmacogenetics, 8 1: 67-72. doi:10.1097/00008571-199802000-00009
Targeting of a cholecystokinin-DNA complex to pancreatic cells in vitro and in vivo
Carpenter, D. S. and Minchin, R. F. (1998) Targeting of a cholecystokinin-DNA complex to pancreatic cells in vitro and in vivo. Gene Therapy, 5 6: 848-854. doi:10.1038/sj.gt.3300657
Hase, CC, Minchin, RF, Kloda, A and Martinac, B (1997) Cross-linking studies and membrane localization and assembly of radiolabelled large mechanosensitive ion channel (MscL) of Escherichia coli. Biochemical And Biophysical Research Communications, 232 3: 777-782. doi:10.1006/bbrc.1997.6370
Cyclophilin 40 (PPID) gene - Map position 4q31.3
Ratajczak, T, Woollatt, E, Kumar, P, Ward, BK, Minchin, RF and Baker, E (1997) Cyclophilin 40 (PPID) gene - Map position 4q31.3. Chromosome Research, 5 2: 151-151.
Estimate of the pore size of the large mechanosensitive ion channel (MscL) of Escherichia coli.
Cruickshank, C, Minchin, RF, LeDain, AC and Martinac, B (1997) Estimate of the pore size of the large mechanosensitive ion channel (MscL) of Escherichia coli.. Biophysical Journal, 72 2: MPO63-MPO63.
Cruickshank, CC, Minchin, RF, LeDain, AC and Martinac, B (1997) Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. Biophysical Journal, 73 4: 1925-1931.
Extracellular calcium stimulates Na+-dependent putrescine uptake in B16 melanoma cells
Minchin, RF and Martin, RL (1997) Extracellular calcium stimulates Na+-dependent putrescine uptake in B16 melanoma cells. International Journal of Biochemistry & Cell Biology, 29 3: 447-454. doi:10.1016/S1357-2725(96)00145-8
Metabolic activation of aromatic amines by human pancreas
Anderson, KE, Hammons, GJ, Kadlubar, FF, Potter, JD, Kaderlik, KR, Ilett, KF, Minchin, RF, Teitel, CH, Chou, HC, Martin, MV, Guengerich, FP, Barone, GW, Lang, NP and Peterson, LA (1997) Metabolic activation of aromatic amines by human pancreas. Carcinogenesis, 18 5: 1085-1092. doi:10.1093/carcin/18.5.1085
Butcher, N.J., Minchin, R.F., Kadlubar, F.F. and llett , K.F. (1996) Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its N-hydroxy metabolite into rat pancreatic acini and hepatocytes in vitro. Carcinogenesis, 17 4: 889-992. doi:10.1093/carcin/17.4.889
Wong, WS and Minchin, RF (1996) Binding and internalization of the melanocyte stimulating hormone receptor ligand [Nle(4), D-Phe(7)]alpha-MSH in B16 melanoma cells. International Journal of Biochemistry & Cell Biology, 28 11: 1223-1232. doi:10.1016/S1357-2725(96)00074-X
Localization of Spermidine Uptake in Rabbit Lung Slices
Saunders, NA, McGeachie, JK, Ilett, KF and Minchin, RF (1989) Localization of Spermidine Uptake in Rabbit Lung Slices. American Journal of Physiology, 257 3: C579-C587.
Pulmonary Alveolar Macrophages Express a Polyamine Transport-System
Saunders, NA, Ilett, KF and Minchin, RF (1989) Pulmonary Alveolar Macrophages Express a Polyamine Transport-System. Journal of Cellular Physiology, 139 3: 624-631. doi:10.1002/jcp.1041390324
Autoradiographic Localization of Putrescine Uptake to Type-Ii Pneumocytes of Rabbit Lung Slices
Saunders, NA, Rigby, PJ, Ilett, KF and Minchin, RF (1988) Autoradiographic Localization of Putrescine Uptake to Type-Ii Pneumocytes of Rabbit Lung Slices. Laboratory Investigation, 59 3: 380-386.
Uptake, efflux and metabolism of the polyamine putrescine in rabbit lung slices
Saunders, NA, Ilett, KF and Minchin, RF (1987) Uptake, efflux and metabolism of the polyamine putrescine in rabbit lung slices. BBA - Molecular Cell Research, 927 2: 170-176. doi:10.1016/0167-4889(87)90131-5
Targeting the Arylamine N-Acetyltransferases in Cancer
Minchin, Rodney F. and Butcher, Neville J. (2014). Targeting the Arylamine N-Acetyltransferases in Cancer. In: Abstracts from the 10th International ISSX Meeting. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, (2-2). 29 September - 03 October 2013.
Wiliem, Arnold, Hobson, Peter, Minchin, Rodney F. and Lovell, Brian C. (2011). An automatic image based single dilution method for end point titre quantitation of antinuclear antibodies tests using HEp-2 cells. In: Proceedings of the 2011 International Conference on Digital Image Computing: Techniques and Applications. 2011 International Conference on Digital Image Computing: Techniques and Applications (DICTA 2011), Noosa, QLD, Australia, (1-6). 6 - 8 December 2011. doi:10.1109/DICTA.2011.9
Radiolabeled clay nanoparticles for toxicological investigations
Musumeci, Anthony, Broadhurst, Gysell, Smith, Suzanne, Xu, Zhi P., Minchin, Rodney F. and Martin, Darren J. (2009). Radiolabeled clay nanoparticles for toxicological investigations. In: Proceedings of the 8th World Biomaterials Congress. 8th World Biomaterials Conference, Amsterdam, The Netherlands, (). 28 May 2008 - 1 June, 2008.
The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry
Coles, D., Yang, S., Esposito, A., Mitchell, D., Minchin, R. and Toth, I. (2007). The Characterisation of Novel Dendritic Carriers with DNA by Isothermal Titration Calorimetry. In: Wilce, J., Proceedings of the 4th International Peptide Symposium in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 2007. 4th International Peptide Symposium, Cairns, (). 21-25 October 2007.
Modified influenza virosomes for gene delivery
Khoshnejad, M., Toth, I., Young, P. R. and Minchin, R. F. (2006). Modified influenza virosomes for gene delivery. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, Qld, (Abstract). 24 Nov 2006.
The synthesis of a novel dendritic system for gene delivery
Coles, D. J., Yang, S., Esposito, A., Mitchell, D. J., Minchin, R. F. and Toth, I. (2006). The synthesis of a novel dendritic system for gene delivery. In: Proceedings of: Annual Conference of the Australasian Pharmaceutical Science Association. Annual Conference of the Australasian Pharmaceutical Science Association, Adelaide, Australia, (). 3-5 December, 2006.
The synthesis of a novel dendritic system for gene delivery
Coles, D. J., Yang, S, Esposito, A., Mitchell, D J, Minchin, R F and Toth, I (2006). The synthesis of a novel dendritic system for gene delivery. In: Brisbane Biological & Organic Chemistry Symposium. Brisbane Biological & Organic Chemistry Symposium, Brisbane, (Abstract). 24 November 2006.
Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells
Yang, S, Coles, D. J., Esposito, A., Mitchell, D J, Toth, I and Minchin, R F (2006). Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells. In: Annual Conference of the Australasian Pharmaceutical Science Assn. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, (Poster). 3-5 December, 2006.
Arylamine N-acetyltransferase - from xenobiotic metabolising enzyme to regulation of transcription
Minchin, Ron (2004). Arylamine N-acetyltransferase - from xenobiotic metabolising enzyme to regulation of transcription. In: C. J. Waterfield, Proceedings of the British Toxicology Society Annual Congress. The British Toxicology Society Annual Congress 2003, Nottingham, UK, (33-33). 1st - 4th September, 2003. doi:10.1016/j.tox.2004.06.030
Kendrick, T., Mus, A. M., Minchin, R., Leedman, P. and Klinken, P. (2004). The chromatin remodeller ATRX is a thyroid hormone responsive gene with a potential role as a repressor of erythropoiesis. In: Faseb: Annual Meeting of the American Society for Biochemistry and Molecular Biology/8th Congress of the International Union for Biochemistry and Molecular Biology. Annual Meeting of the American Society for Biochemistry and Molecular Biology/8th Congress of the International Union for Biochemistry and Molecular Biology, Boston, MA, (C195-C196). 12-16 Jun 2004.
The Queensland Drug Repurposing Initiative
(2017–2021) Queensland Government Advance Queensland Innovation Partnerships
Fusion of Digital Microscopy and Plain Text Reports for Automated Analysis
(2017–2020) ARC Linkage Projects
The pharmacology of sulfotransferase 4A1
(2016–2019) NHMRC Project Grant
Role of sirtuins in the regulation of the carcinogen metabolising arylamine N-acetyltransferases
(2015–2017) NHMRC Project Grant
Establishment of a small animal surgical suite for integrative physiology.
(2014)
(2014) UQ Major Equipment and Infrastructure
(2013–2017) ARC Linkage Projects
Role of the drug metabolising enzyme arylamine N-acetyltransferase 1 in breast cancer
(2012–2015) NHMRC Project Grant
The putative drug metabolising enzyme SULT4A1 is a sulfotransferase inhibitor
(2011–2013) NHMRC Project Grant
Refurbishment of Entox's molecular biology laboratory
(2011–2012) UQ Major Equipment and Infrastructure
A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
(2011) NHMRC Equipment Grant
Building UQ's analytical capacity in biomedical sciences
(2011) UQ Major Equipment and Infrastructure
Establishment of a centralised live animal imaging fluorescence/bio-luminescence suite
(2010) UQ Major Equipment and Infrastructure
The Toxicology of Nanomaterials
(2009–2014) NHMRC Project Grant
Pharmacological Targeting of Arylamine N-Acetyltransferase I
(2009–2012) NHMRC Project Grant
Function of sulfotransferase SULT4A1 - transcriptional and post-transcriptional regulation
(2008–2010) NHMRC Project Grant
Synthesis, Biological Interactions and Toxicity Studies of Precisely Engineered Nanoparticles
(2008–2010) ARC Discovery Projects
(2008) NHMRC Equipment Grant
(2007–2008) ARC Linkage Infrastructure, Equipment and Facilities
Regulation of human arylamine N-acetyltransferase transcription, translation and protein stability
(2006–2008) NHMRC Project Grant
Biomolecular discovery and analysis facility
(2006) ARC Linkage Infrastructure, Equipment and Facilities
Nanotoxicology Feasibility Study
(2005–2008) Queensland Government Smart State Partnership Alliances Facilitation Program
Role of heterocyclic amine carcinogens in prostate cancer - a pharmacogenetic analysis
(2004–2007) Department of Veterans' Affairs
Human arylamine N-acetyltransferase regulation and function - effect of genetic poymorphisms
(2004) NHMRC Project Grant
ROLE OF HUMAN NAT1 IN BREAST CANCER INVASION
Doctor Philosophy — Principal Advisor
Other advisors:
The regulation of NAT1 mRNA by alterations in polyadenylation site usage.
Doctor Philosophy — Principal Advisor
Other advisors:
Modulation of the drug metabolising enzyme arylamine N-acetyltransferase 1 regulates the response to chemotherapy in cancer.
Doctor Philosophy — Principal Advisor
Other advisors:
Understanding the basis of interindividual pharmacokinetic variability of nanomedicines
Doctor Philosophy — Associate Advisor
Other advisors:
NAT1 and cancer cell metabolism
(2018) Doctor Philosophy — Principal Advisor
Other advisors:
Splicing Regulation and Function of the Cytosolic Sulfotransferase SULT4A1
(2018) Doctor Philosophy — Principal Advisor
Other advisors:
Arylamine N-acetyltransferase 1 : Pursuit of an endogenous role
(2015) Doctor Philosophy — Principal Advisor
Other advisors:
Delivery of therapeutic peptides from thermoplastic polyurethane films
(2015) Doctor Philosophy — Principal Advisor
Other advisors:
Mechanism of interaction of nanoparticles with plasma proteins
(2011) Doctor Philosophy — Principal Advisor
Other advisors:
The Interaction of Synthetic Nanoparticles with Biological Systems
(2011) Doctor Philosophy — Principal Advisor
Other advisors:
NAT1 and Cancer Biology: The Effects of NAT1 Silencing
(2010) Doctor Philosophy — Principal Advisor
Other advisors:
Multi-component peptide-based carriers for gene delivery
(2009) Doctor Philosophy — Principal Advisor
Other advisors:
(2013) Doctor Philosophy — Associate Advisor
Other advisors:
Tailored nanoparticles for nanotoxicological investigations
(2010) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Unravelling risks in Parkinsons disease - Pharmacogenetics of brain sulfotransferases involved in dopamine metabolism.
Transcriptional regulation of sulfotransferases implicated in neurodegenerative disease.
Arylamine N-acetyltransferases are central to cancer cell survival via protein acetylation/deacetylation homeostasis.
Metabolic profiling of cancer cells following arylamine N-acetyltransferase inhibition pathways to cell growth and survival.
Transcytosis of nanoparticles across cell barriers role of receptor binding and internalisation.
Mapping the binding of intracellular proteins to engineered nanoparticles.