My research focuses on liver biology and pharmacology and I am a research team leader of the joint liver cancer research program of Frazer Institute and Gallipoli Medical Research Foundation from 2019. My long-term goal is to direct a research group exploring strategies to improve liver cancer outcomes in patients, working closely with clinicians to enable bench-to-bedside translation.
I developed an intravital imaging platform for visualising and characterising the spatial distribution of activated hepatic stellate cells and metabolic status in liver cancer. This imaging platform and physiologically based kinetics modelling was applied for the first time to investigate the sub-organ disposition and clearance of therapeutic agents in the liver. By expanding the initial work, I further led studies on assessment and monitoring of cellular oxidative stress, microcirculation, and drug response in the specific liver microenvironment for early prediction of treatment efficacy in liver diseases.
Journal Article: Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis
Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 108163. doi: 10.1016/j.pharmthera.2022.108163
Butcher, Daniel A., Brandis, Kelli J., Wang, Haolu, Spannenburg, Liam, Bridle, Kim R., Crawford, Darrell HG. and Liang, Xiaowen (2022). Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis. European Journal of Surgical Oncology, 48 (3), 621-631. doi: 10.1016/j.ejso.2021.09.017
Book Chapter: Theranostic nanoparticles for imaging and targeted drug delivery to the liver
Wang, Haolu, Yang, Haotian, Ruan, Qi, Roberts, Michael S. and Liang, Xiaowen (2022). Theranostic nanoparticles for imaging and targeted drug delivery to the liver. Fundamentals of drug delivery. (pp. 311-328) edited by Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams and Xiaowen Liang. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119769644.ch12
The role of EGFR-CDCP1 axis in the treatment of cholangiocarcinoma
(2024) Ferguson Foundation (Reginald Ferguson)
Therapeutic targeting of CDCP1 in the treatment of cholangiocarcinoma
(2022) Ferguson Foundation (Reginald Ferguson)
(2021–2023) United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
(2022) Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
(2023) Doctor Philosophy
Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver
Doctor Philosophy
Benson, Heather A. E., Roberts, Michael S., Williams, Adrian C. and Liang, Xiaowen eds. (2021). Fundamentals of Drug Delivery. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/9781119769644
Theranostic nanoparticles for imaging and targeted drug delivery to the liver
Wang, Haolu, Yang, Haotian, Ruan, Qi, Roberts, Michael S. and Liang, Xiaowen (2022). Theranostic nanoparticles for imaging and targeted drug delivery to the liver. Fundamentals of drug delivery. (pp. 311-328) edited by Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams and Xiaowen Liang. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119769644.ch12
Revealing interaction of dyes and nanomaterials by multiphoton imaging
Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020
Hepatic metabolism in liver health and disease
Liu, X., Wang, H., Liang, X. and Roberts, M. S. (2017). Hepatic metabolism in liver health and disease. Liver Pathophysiology: Therapies and Antioxidants. (pp. 391-400) edited by Pablo Muriel. Cambridge, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-804274-8.00030-8
Related topic: Safety evaluation of nanomaterials
Liang, Xiaowen, Wang, Haolu, Liu, Xin, Grice, Jeffrey, Xu, Zhi Ping and Roberts, Michael S. (2017). Related topic: Safety evaluation of nanomaterials. Skin permeation and disposition of therapeutic and cosmeceutical compounds. (pp. 313-322) edited by Kenji Sugibayashi. Tokyo, Japan: Springer Japan. doi: 10.1007/978-4-431-56526-0_28
Thorling, Camilla A., Holmes, Amy, Studier, Hauke, Liu, David, Liang, Xiaowen and Roberts, Michael S. (2016). Multiphoton and fluorescence lifetime imaging microscopy in studying nanoparticle pharmacokinetics in skin and liver. Multiphoton and fluorescence lifetime imaging microscopy in studying nanoparticle pharmacokinetics in skin and liver. (pp. 107-123) edited by Stefan G. Stanciu. Rijeka, Croatia: InTech. doi: 10.5772/63452
Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 108163. doi: 10.1016/j.pharmthera.2022.108163
Butcher, Daniel A., Brandis, Kelli J., Wang, Haolu, Spannenburg, Liam, Bridle, Kim R., Crawford, Darrell HG. and Liang, Xiaowen (2022). Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis. European Journal of Surgical Oncology, 48 (3), 621-631. doi: 10.1016/j.ejso.2021.09.017
Xin, Kai, Li, Xinxing, Guo, Yinghua, Zhong, Youhuan, Wang, Jungang, Yang, Haotian, Zhao, Jie, Guo, Chunlei, Huang, Yunxia, Lei, Zuhai, Ying, Yi-Lun, Luo, Xiao, Wang, Haolu, Qian, Xuhong, Yang, Wen, Liang, Xiaowen and Yang, Youjun (2021). A monochromophoric approach to succinct ratiometric fluorescent probes without probe-product crosstalk. CCS Chemistry, 3 (8), 2307-2315. doi: 10.31635/ccschem.020.202000480
Liver organoid as a 3D in vitro model for drug validation and toxicity assessment
Brooks, Anastasia, Liang, Xiaowen, Zhang, Yonglong, Zhao, Chun-Xia, Roberts, Michael S., Wang, Haolu, Zhang, Lei and Crawford, Darrell H.G. (2021). Liver organoid as a 3D in vitro model for drug validation and toxicity assessment. Pharmacological Research, 169 105608, 105608. doi: 10.1016/j.phrs.2021.105608
Zhang, Yonglong, Wang, Hui, Chen, Tao, Wang, Haolu, Liang, Xiaowen, Zhang, Yuchen, Duan, Jinlin, Qian, Shenjiao, Qiao, Ke, Zhang, Lei, Liu, Yanfeng and Wang, Jian (2021). C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation. Hepatology, 73 (2), 692-712. doi: 10.1002/hep.31304
Deng, Zheng, Xuan, Yan, Li, Xinxing, Crawford, William J., Yuan, Zhiqing, Chen, Zhoukan, Brooks, Anastasia, Song, Yanyan, Wang, Haolu, Liang, Xiaowen and Chen, Tao (2021). Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions. Journal of Cancer, 12 (5), 1531-1537. doi: 10.7150/JCA.54617
Benson, Heather A. E., Roberts, Michael S., Williams, Adrian C. and Liang, Xiaowen (2021). Preface. Fundamentals of Drug Delivery, xvii-xviii. doi: 10.1002/9781119769644.fmatter
Yang, Jingxing, Hou, Mengfei, Sun, Wenshe, Wu, Qinghe, Xu, Jia, Xiong, Liqin, Chai, Yimin, Liu, Yuxin, Yu, Meihua, Wang, Haolu, Xu, Zhi Ping, Liang, Xiaowen and Zhang, Chunfu (2020). Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse. Advanced Science, 7 (16) 2001088, 2001088. doi: 10.1002/advs.202001088
Barkauskas, Deborah S., Medley, Gregory, Liang, Xiaowen, Mohammed, Yousuf H., Thorling, Camilla A., Wang, Haolu and Roberts, Michael S. (2020). Using in vivo multiphoton fluorescence lifetime imaging to unravel disease-specific changes in the liver redox state. Methods and Applications in Fluorescence, 8 (3) 034003, 034003. doi: 10.1088/2050-6120/ab93de
Spannenburg, Liam J., Sanchez Gonzalez, Mariana, Brooks, Anastasia, Wei, Shujun, Li, Xinxing, Liang, Xiaowen, Gao, Wenchao and Wang, Haolu (2020). Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials. European Journal of Surgical Oncology, 46 (8), 1404-1414. doi: 10.1016/j.ejso.2020.04.052
Computer-aided diagnosis of gallbladder polyps based on high resolution ultrasonography
Chen, Tao, Tu, Shaoxiong, Wang, Haolu, Liu, Xuesong, Li, Fenghua, Jin, Wang, Liang, Xiaowen, Zhang, Xiaoqun and Wang, Jian (2020). Computer-aided diagnosis of gallbladder polyps based on high resolution ultrasonography. Computer Methods and Programs in Biomedicine, 185 105118, 105118. doi: 10.1016/j.cmpb.2019.105118
Hepatic artery classification based on three-dimensional CT
Yan, J., Feng, H., Wang, H., Yuan, F., Yang, C., Liang, X., Chen, W. and Wang, J. (2020). Hepatic artery classification based on three-dimensional CT. British Journal of Surgery, 107 (7), 906-916. doi: 10.1002/bjs.11458
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Ruan, Qi, Wang, Haolu, Burke, Leslie J., Bridle, Kim R., Li, Xinxing, Zhao, Chun-Xia, Crawford, Darrell H. G., Roberts, Michael S. and Liang, Xiaowen (2020). Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma. International Journal of Cancer, 147 (6) ijc.32899, 1519-1527. doi: 10.1002/ijc.32899
Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury
Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900
Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2019). Erratum: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT (Oncotarget (2017) 8 (47052–47063) DOI: 10.18632/oncotarget.16789). OncoTarget, 10 (60), 6540-6540. doi: 10.18632/oncotarget.27299
Wei, Shuxun, Chen, Jinshui, Huang, Yu, Sun, Qiang, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2019). Identification of hub genes and construction of transcriptional regulatory network for the progression of colon adenocarcinoma hub genes and TF regulatory network of colon adenocarcinoma. Journal of Cellular Physiology, 235 (3) jcp.29067, 2037-2048. doi: 10.1002/jcp.29067
Nastiti, Christofori M.R.R., Mohammed, Yousuf, Telaprolu, Krishna C., Liang, Xiaowen, Grice, Jeffrey E., Roberts, Michael S. and Benson, Heather A.E. (2019). Evaluation of quantum dot skin penetration in porcine skin: effect of age and anatomical site of topical application. Skin Pharmacology and Physiology, 32 (4), 1-10. doi: 10.1159/000499435
Yang, Chengcheng, Mi, Xuan, Su, Huilan, Yang, Jingxing, Gu, Yiyun, Zhang, Lu, Sun, Wenshe, Liang, Xiaowen and Zhang, Chunfu (2019). GE11-PDA-Pt@USPIOs nano-formulation for relief of tumor hypoxia and MRI/PAI-guided tumor radio-chemotherapy. Biomaterials Science, 7 (5), 2076-2090. doi: 10.1039/c8bm01492b
Zhang, Lu, Su, Huilan, Wang, Haolu, Li, Qian, Li, Xiao, Zhou, Chuanqing, Xu, Jia, Chai, Yimin, Liang, Xiaowen, Xiong, Liqin and Zhang, Chunfu (2019). Tumor chemo-radiotherapy with rod-shaped and spherical gold nano probes: shape and active targeting both matter. Theranostics, 9 (7), 1893-1908. doi: 10.7150/thno.30523
Designer artificial membrane binding proteins to direct stem cells to the myocardium
Xiao, Wenjin, Green, Thomas I. P., Liang, Xiaowen, Delint, Rosalia Cuahtecontzi, Perry, Guillaume, Roberts, Michael S., Le Vay, Kristian, Back, Catherine R., Ascione, Raimomdo, Wang, Haolu, Race, Paul R. and Perriman, Adam W. (2019). Designer artificial membrane binding proteins to direct stem cells to the myocardium. Chemical Science, 10 (32), 7610-7618. doi: 10.1039/c9sc02650a
Impact of Tumor Site on Lymph Node Status and Survival in Colon Cancer
Xie, Yayun, Huang, Yu, Ruan, Qi, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2019). Impact of Tumor Site on Lymph Node Status and Survival in Colon Cancer. Journal of Cancer, 10 (11), 2376-2383. doi: 10.7150/jca.32038
Impact of age on risk of lymph node positivity in patients with colon cancer
Wang, Haolu, Lu, Hao, Yang, Haotian, Zhang, Xianwen, Thompson, Erik W., Roberts, Michael S., Hu, Zhigian, Liang, Xiaowen and Li, Xinxing (2019). Impact of age on risk of lymph node positivity in patients with colon cancer. Journal of Cancer, 10 (9), 2102-2108. doi: 10.7150/jca.28377
Anionic long-circulating quantum dots for long-term intravital vascular imaging
Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244
The role of cellular reactive oxygen species in cancer chemotherapy
Yang, Haotian, Villani, Rehan M., Wang, Haolu, Simpson, Matthew J., Roberts, Michael S., Tang, Min and Liang, Xiaowen (2018). The role of cellular reactive oxygen species in cancer chemotherapy. Journal of Experimental and Clinical Cancer Research, 37 (1) 266, 266. doi: 10.1186/s13046-018-0909-x
He, Haihong, Liu, Yuxin, Zhou, Zhongneng, Guo, Chunlei, Wang, Hong-Yin, Wang, Zhuang, Wang, Xueli, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications. Free Radical Biology and Medicine, 123, 1-7. doi: 10.1016/j.freeradbiomed.2018.04.563
Luo, Xiao, Yang, Haotian, Wang, Haolu, Ye, Zhiwei, Zhou, Zhongneng, Gu, Luyan, Chen, Jinquan, Xiao, Yi, Liang, Xiaowen, Qian, Xuhong and Yang, Youjun (2018). Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells. Analytical Chemistry, 90 (9), 5803-5809. doi: 10.1021/acs.analchem.8b00218
He, Haihong, Xia, Yang, Qi, Yingxue, Wang, Hong-Yin, Wang, Zhuang, Bao, Jianming, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry, 29 (4), 1194-1198. doi: 10.1021/acs.bioconjchem.7b00821
Indocyanine green-incorporating nanoparticles for cancer theranostics
Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872
Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072
Lu, Hao, Guo, Rong, Yang, Haotian, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2017). The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery. Oncotarget, 9 (2), 2810-2818. doi: 10.18632/oncotarget.23596
Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209
Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells
Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39
Li, Xinxing, Wang, Weijun, Ruan, Canping, Wang, Yi, Wang, Haolu, Liang, Xiaowen, Sun, Yanping and Hu, Zhiqian (2017). Age-specific impact on the survival of gastric cancer patients with distant metastasis: an analysis of SEER database. Oncotarget, 8 (57), 97090-97100. doi: 10.18632/oncotarget.21350
The influence of marital status on survival of gallbladder cancer patients: a population-based study
Li, Xinxing, Liu, Ye, Wang, Yi, Ruan, Canping, Wang, Haolu, Liang, Xiaowen, Sun, Yanping and Hu, Zhiqian (2017). The influence of marital status on survival of gallbladder cancer patients: a population-based study. Scientific Reports, 7 (1) 5322, 5322. doi: 10.1038/s41598-017-05545-0
Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway
Zhou, Ling-ling, Zhou, Cong, Liang, Xiao-wen, Feng, Zhe, Liu, Zhang-pu, Wang, Hao-lu and Zhou, Xue-ping (2017). Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway. Chinese Journal of Integrative Medicine, 23 (12), 929-936. doi: 10.1007/s11655-017-2546-6
Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. OncoTarget, 8 (29), 47052-47063. doi: 10.18632/oncotarget.16789
Multiphoton imaging for assessing renal disposition in acute kidney injury
Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964
Li, Xinxing, Lu, Hao, Xu, Kai, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy. BMC Cancer, 17 (1) 227, 227. doi: 10.1186/s12885-017-3222-8
Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374, 45374. doi: 10.1038/srep45374
Li, Xinxing, Zhang, Weigang, Zhang, Xianwen, Wang, Haolu, Xu, Kai, Yao, Houshan, Yao, Jun, Liang, Xiaowen and Hu, Zhiqian (2017). The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy. Oncotarget, 8 (29), 46946-46954. doi: 10.18632/oncotarget.14943
Zhang, Feiyue, Liang, Xiaowen, Zhang, Wenzhu, Wang, Yong-Lei, Wang, Haolu, Mohammed, Yousuf H., Song, Bo, Zhang, Run and Yuan, Jingli (2017). A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors and Bioelectronics, 87, 1005-1011. doi: 10.1016/j.bios.2016.09.067
Teng, Shifeng, Xu, Kai, Yao, Jun, Zhang, Xianwen, Li, Mingming, Zhang, Yanyan, Zhang, Weigang, Wang, Haolu, Liang, Xiaowen, Li, Xinxing and Hu, Zhiqian (2017). Exploration of the optimal lymph node count retrieved for patients with node-negative colonic mucinous cancer. International Journal of Clinical and Experimental Medicine, 10 (12), 16625-16631.
MDCT assessment of resectability in hilar cholangiocarcinoma
Ni, Qihong, Wang, Haolu, Zhang, Yunhe, Qian, Lijun, Chi, Jiachang, Liang, Xiaowen, Chen, Tao and Wang, Jian (2016). MDCT assessment of resectability in hilar cholangiocarcinoma. Abdominal Radiology, 42 (3), 1-10. doi: 10.1007/s00261-016-0943-0
Li, Xinxing, Wang, Haolu, Wang, Juan, Chen, Yuying, Yin, Xiaobin, Shi, Guiying, Li, Hui, Hu, Zhiqian and Liang, Xiaowen (2016). Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. Bmc Cancer, 16 (1) 578, 578. doi: 10.1186/s12885-016-2640-3
Allosteric regulation of fibronectin/α5 β1 interaction by fibronectin-binding MSCRAMMs
Liang, Xiaowen, Garcia, Brandon L., Visai, Livia, Prabhakaran, Sabitha, Meenan, Nicola A. G., Potts, Jennifer R., Humphries, Martin J. and Höök, Magnus (2016). Allosteric regulation of fibronectin/α5 β1 interaction by fibronectin-binding MSCRAMMs. PLoS ONE, 11 (7) e0159118, e0159118. doi: 10.1371/journal.pone.0159118
Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy
Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083
Ni, Qihong, Wang, Haolu, Liang, Xiaowen, Zhang, Yunhe, Chen, Wei and Wang, Jian (2016). Successful parenchyma-sparing anatomical surgery by 3-dimensional reconstruction of hilar cholangiocarcinoma combined with anatomic variation. Journal of the College of Physicians and Surgeons Pakistan, 26 (S1), S13-S15.
Wang, Haolu, Liang, Xiaowen, Xu, Zhi Ping, Crawford, Darrell H. G, Liu, Xin and Roberts, Michael S. (2016). A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports, 6 (1) 22293, e22293.1-e22293.12. doi: 10.1038/srep22293
Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles
Liang, Xiaowen, Wang, Haolu, Grice, Jeffrey E., Li, Li, Liu, Xin, Xu, Zhi Ping and Roberts, Michael S. (2016). Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles. Nano Letters, 16 (2), 939-945. doi: 10.1021/acs.nanolett.5b03854
Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney
Liang, Xiaowen, Wang, Haolu, Zhu, Yian, Zhang, Run, Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Grice, Jeffrey E. and Roberts, Michael S. (2016). Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney. Acs Nano, 10 (1), 387-395. doi: 10.1021/acsnano.5b05066
Jin, Yue, Wang, Haolu, Ma, Xiaowei, Liang, Xiaowen, Liu, Xin and Wang, Yu (2015). Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects. PLoS ONE, 10 (5) e0127229, e0127229. doi: 10.1371/journal.pone.0127229
Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging
Wang, Haolu, Liang, Xiaowen, Mohammed, Yousuf H., Thomas, James A., Bridle, Kim R., Thorling, Camilla A., Grice, Jeffrey E., Xu, Zhi Ping, Liu, Xin, Crawford, Darrell H. G. and Roberts, Michael S. (2015). Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express, 6 (3), 780-792. doi: 10.1364/BOE.6.000780
Diagnostic imaging and therapeutic application of nanoparticles targeting the liver
Wang, Haolu, Thorling, Camilla A., Liang, Xiaowen, Bridle, Kim R., Grice, Jeffrey E., Zhu, Yian, Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2015). Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. Journal of Materials Chemistry B, 3 (6), 939-958. doi: 10.1039/C4TB01611D
Jin, Yue, Wang, Haolu, Liang, Xiaowen, Ma, Jun and Wang, Yu (2014). Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis. Tumor Biology, 35 (8), 8149-8159. doi: 10.1007/s13277-014-2059-x
Wang, Hui, Wang, Haolu, Chen, Tao, Liang, Xiaowen, Song, Yanyan and Wang, Jian (2014). Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma. World Journal of Surgical Oncology, 12 (1) 191. doi: 10.1186/1477-7819-12-191
Yang, L., Wang, H., Liang, X., Chen, T., Chen, W., Song, Y. and Wang, J. (2014). Bacteria in hernia sac: an important risk fact for surgical site infection after incarcerated hernia repair. Hernia, 19 (2), 279-283. doi: 10.1007/s10029-014-1275-z
Liang X., Grice J.E., Zhu Y., Liu D., Sanchez W.Y., Li Z., Crawford D.H.G., Le Couteur D.G., Cogger V.C., Liu X., Xu Z.P. and Roberts M.S. (2014). Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small, 11 (14), 1711-1720. doi: 10.1002/smll.201402698
Penetration of Nanoparticles into Human Skin
Liang, Xiao Wen, Xu, Zhi Ping, Grice, Jeffrey, Zvyagin, Andrei V., Roberts, Michael S. and Liu, Xin (2013). Penetration of Nanoparticles into Human Skin. Current Pharmaceutical Design, 19 (35), 6353-6366. doi: 10.2174/1381612811319350011
Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes
Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058
Wang, H., Liang, X., Weijs, L., Brooks, A., Liu, X., Roberts, M. S. and Crawford, D. H. G. (2017). Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, Queensland, 20–22 Aug 2017. Hoboken, NJ United States: Wiley.
Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978
Non-invasive assessment of the liver using imaging
Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883
Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity
Liang, X., Wang, H., Liu, X., Touraud, M., Chouane, J. B., Tse, B. and Roberts, M. S. (2017). Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, , Gold Coast, Queensland, Australia, 20–22 Aug 2017. Richmond, VIC Australia: Wiley.
Quantitative optical imaging of paracetamol-induced metabolism changes in the liver
Liang, Xiaowen, Wang, Haolu, Liu, Xin and Roberts, Michael (2017). Quantitative optical imaging of paracetamol-induced metabolism changes in the liver. SPIE BioPhotonics Australasia, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242962
Wang, H., Liang, X., Endo-Munoz, L., Weijs, L., Liu, X., Crawford, D. and Roberts, M. (2015). A blood-flow limited physiologically based kinetic model to characterize and predict the biological fate of mesenchymal stem cells in vivo. Gastro 2015 GESA‐AGW And WGO International Congress, Gastroenterological Society Of Australia Australian Gastroenterology Week 2015 - World Congress Of Gastroenterology, , Brisbane, Queensland, Australia, 28 September‐2 October 2015. Richmond, VIC Australia: Wiley.
Wang, H., Liang, X., Thorling, C., Xu, Z. P., Crawford, D., Liu, X. and Roberts, M. (2015). A physiologically based kinetic model to characterize and predict the biological fate of circulating tumor cells in vivo. European Cancer Congress, Vienna, Austria, 2015. Hoboken, NJ United States: Wiley. doi: 10.1016/S0959-8049(15)30013-7
Early diagnosis of hepatocellular carcinoma by in vivo imaging
Liang, X., Wang, H., Zhu, Y., Grice, J., Liu, X., Xu, Z. and Roberts, M. (2015). Early diagnosis of hepatocellular carcinoma by in vivo imaging. European Cancer Congress, Vienna, Austria, 2015. Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(16)30378-1
Biodistribution of newly developed water-dispersible CdTe/CdS quantum dots for in vivo imaging
Liang, Xiaowen (2015). Biodistribution of newly developed water-dispersible CdTe/CdS quantum dots for in vivo imaging. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2015.503
The role of EGFR-CDCP1 axis in the treatment of cholangiocarcinoma
(2024) Ferguson Foundation (Reginald Ferguson)
Therapeutic targeting of CDCP1 in the treatment of cholangiocarcinoma
(2022) Ferguson Foundation (Reginald Ferguson)
(2021–2023) United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
Early prediction of chemotherapy efficacy in liver cancer by a novel nanoplatform
(2018–2021) UQ Development Fellowships
(2018) University of Sydney
(2017–2019) NHMRC Project Grant
(2017–2018) University of Sydney
Visualisation and early prediction of chemotherapy efficacy in liver cancer by a novel nanoplatform
(2017) UQ Early Career Researcher
(2016–2017) University of Sydney
Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver
Doctor Philosophy — Associate Advisor
Other advisors:
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Doctor Philosophy — Associate Advisor
Other advisors:
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
(2022) Doctor Philosophy — Principal Advisor
Other advisors:
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
(2023) Doctor Philosophy — Associate Advisor
(2022) Doctor Philosophy — Associate Advisor
Other advisors: