Dr Rob Adam

Trials Medical Specialist

UQ Centre for Clinical Research
Faculty of Medicine

Overview

Dr. Robert James Adam MA(Cantab) MBBS (London) PhD(UCL) FRACP FRCP (London)

Behavioural neurologist with interests in cognition and movement disorders. Clinical lead for deep brain stimulation at The Royal Brisbane & Women's Hospital, Senior Lecturer and Clinical Trials Specialist at UQCCR.

Movement disorders and advanced Parkinson's clinics in addition to Statewide Huntington's Disease, Friedreich's Ataxia and Metro North Deep Brain Stimulation services https://metronorth.health.qld.gov.au/news/deep-brain-stimulation-parkinsons. Young onset dementia clinic at STARS https://metronorth.health.qld.gov.au/stars/.

Principal investigator in 2 Phase 1b/2a clinical trials of novel antisense oligonucleotides for Huntington's Disease, PRECISION-HD1 & 2 and their open label extensions. I am part of a nationwide and statewide effort to investigate drug repurposing - particularly in Parkinson's Disease. I collaborate widely in investigator led research with both clinical scientists, basic scientists and allied health practioners both at UQ and beyond. Former research officer in PISA (Prospective Imaging Study of Aging) https://www.qimrberghofer.edu.au/pisa/ and the clinical lead for ADNet in QLD. ADNet is an NHMRC funded project to screen and register patients with cognitive impairment https://www.australiandementianetwork.org.au/.

I was trained in the US (NYU Medical Centre), UK (National Hospital for Neurology & Neurosurgery in Queen Square, UCLH, Cambridge University Hospitals) and Australia (Royal North Shore and Westmead Hospitals, Sydney). My PhD (UCL 2014) Thesis, "Dopamine and Oculomotor Decisions In Health & Disease", investigated the use of eye movement recordings during behavioral tasks to monitor decision making in patients with focal lesions, Parkinson's disease, impulse control disorders and healthy volunteers both under the influence and without the effects of dopaminergic modulators. I teach both medical undergraduates and graduates, supervise higher degree candidates and have written chapters in medical textbooks.

Research Interests

  • Cognitive Neurology
  • Movement Disorders
  • Parkinson's Disease
  • Tremor
  • Dementia
  • Alzheimer's Disease
  • Huntington's Disease

Research Impacts

Research on biomarkers (PISA study & ADNet) may allow the early identification of "at risk" patients prior to the onset of neurodegenerative disease, thus provding a valuable "window" for intervention.

At the other end of the research spectrum, drug repurposing may discover new benefits of treatments (traditionally used in other disease entitities) for conditions that currently lack disease modifying therapies.

By engaging with community groups (e.g. HD QLD) and industry, we enable our patients to become involved in studies ranging from basic science and fundamental studies of brain function to pharmaceurtical trials of novel investigational agents.

Qualifications

  • Doctor of Philosophy, University College London
  • FRACP, Royal Australasian College of Physicians

Publications

  • Borne, Léonie, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir , Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen , Robinson, Gail A. and Breakspear, Michael (2022). A snapshot of brain and cognition in healthy mid-life and older adults. bioRxiv. doi: 10.1101/2022.01.20.476706

  • Zech, Michael, Kumar, Kishore R., Reining, Sophie, Reunert, Janine, Tchan, Michel, Riley, Lisa G., Drew, Alexander P., Adam, Robert J., Berutti, Riccardo, Biskup, Saskia, Derive, Nicolas, Bakhtiari, Somayeh, Sheng, Chih Jin, Kruer, Michael C., Bardakjian, Tanya, Gonzalez-Alegre, Pedro, Sarmiento, Ignacio J. Keller, Mencacci, Niccolo E., Lubbe, Steven J., Kurian, Manju A., Clot, Fabienne, Méneret, Aurélie, de Sainte Agathe, Jean-Madeleine, Fung, Victor S.C., Vidailhet, Marie, Baumann, Matthias, Marquardt, Thorsten, Winkelmann, Juliane and Boesch, Sylvia (2021). Biallelic AOPEP loss-of-function variants cause progressive dystonia with prominent limb involvement. Movement Disorders, 37 (1), 137-147. doi: 10.1002/mds.28804

  • Swayne, Andrew, Warren, Nicola, Prain, Kerri, Gillis, David, O'Gorman, Cullen, Tsang, Benjamin K-T., Muller, Claire, Broadley, Simon, Adam, Robert J., McCombe, Pamela, Wong, Richard C. and Blum, Stefan (2021). An Australian state-based cohort study of autoimmune encephalitis cases detailing clinical presentation, investigation results, and response to therapy. Frontiers in Neurology, 12 607773, 607773. doi: 10.3389/fneur.2021.607773

View all Publications

Publications

Book Chapter

  • Adam, Robert, Marshall, Charles and Birns, Jonathan (2020). Neurology. In Rupa Bessant, Jonathan Birns and Charlotte Ford (Ed.), Medicine for MRCP (pp. Unknown-Unknown) Oxford, United Kingdom: Oxford University Press.

Journal Article

  • Borne, Léonie, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir , Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen , Robinson, Gail A. and Breakspear, Michael (2022). A snapshot of brain and cognition in healthy mid-life and older adults. bioRxiv. doi: 10.1101/2022.01.20.476706

  • Zech, Michael, Kumar, Kishore R., Reining, Sophie, Reunert, Janine, Tchan, Michel, Riley, Lisa G., Drew, Alexander P., Adam, Robert J., Berutti, Riccardo, Biskup, Saskia, Derive, Nicolas, Bakhtiari, Somayeh, Sheng, Chih Jin, Kruer, Michael C., Bardakjian, Tanya, Gonzalez-Alegre, Pedro, Sarmiento, Ignacio J. Keller, Mencacci, Niccolo E., Lubbe, Steven J., Kurian, Manju A., Clot, Fabienne, Méneret, Aurélie, de Sainte Agathe, Jean-Madeleine, Fung, Victor S.C., Vidailhet, Marie, Baumann, Matthias, Marquardt, Thorsten, Winkelmann, Juliane and Boesch, Sylvia (2021). Biallelic AOPEP loss-of-function variants cause progressive dystonia with prominent limb involvement. Movement Disorders, 37 (1), 137-147. doi: 10.1002/mds.28804

  • Swayne, Andrew, Warren, Nicola, Prain, Kerri, Gillis, David, O'Gorman, Cullen, Tsang, Benjamin K-T., Muller, Claire, Broadley, Simon, Adam, Robert J., McCombe, Pamela, Wong, Richard C. and Blum, Stefan (2021). An Australian state-based cohort study of autoimmune encephalitis cases detailing clinical presentation, investigation results, and response to therapy. Frontiers in Neurology, 12 607773, 607773. doi: 10.3389/fneur.2021.607773

  • Lupton, Michelle K., Robinson, Gail A., Adam, Robert J, Rose, Stephen, Byrne, Gerard J., Salvado, Olivier, Pachana, Nancy A., Almeida, Osvaldo P., McAloney, Kerrie, Gordon, Scott D., Raniga, Parnesh, Fazlollahi, Amir, Xia, Ying, Ceslis, Amelia, Sonkusare, Saurabh, Zhang, Qing, Kholghi, Mahnoosh, Karunanithi, Mohan, Mosley, Philip E., Lv, Jinglei, Borne, Léonie, Adsett, Jessica, Garden, Natalie, Fripp, Jurgen, Martin, Nicholas G., Guo, Christine C. and Breakspear, Michael (2020). A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: genes, brain and behaviour (PISA). NeuroImage: Clinical, 29 102527, 102527. doi: 10.1016/j.nicl.2020.102527

  • Ketheesan, Sarangan, Bertram, Georgia, Adam, Robert, Stark, Anne and Scott, James G. (2020). Muddying the waters? A false positive case of autoimmune psychosis. Australasian Psychiatry, 29 (3), 1039856220965041-281. doi: 10.1177/1039856220965041

  • Tjokrowijoto, Priscilla, Ceslis, Amelia, O'Sullivan, John D., Adam, Robert, Mellick, George, Silburn, Peter and Robinson, Gail A. (2020). Differential patterns of internally generated responses in parkinsonian disorders. Neuropsychologia, 146 107569, 107569. doi: 10.1016/j.neuropsychologia.2020.107569

  • Barker, Megan S., Nelson, Nicole L., O'Sullivan, John D., Adam, Robert and Robinson, Gail A. (2018). Energization and spoken language production: evidence from progressive supranuclear palsy. Neuropsychologia, 119, 349-362. doi: 10.1016/j.neuropsychologia.2018.09.004

  • Heyes, Stephanie Burnett, Adam, Robert J., Urner, Maren, van der Leer, Leslie, Bahrami, Bahador, Bays, Paul M. and Husain, Masud (2017). Impulsivity and rapid decision-making for reward. Frontiers in Psychology, 3 (MAY) Article 153. doi: 10.3389/fpsyg.2012.00153

  • Tai, Yi-cheng, Yin, Yun Wo Katie, Ha, Ainhi D., Adam, Robert, Mahant, Neil, Sue, Carolyn M. and Fung, Victor S. C. (2016). Neurophysiological features Of Hemiballism. Movement Disorders Clinical Practice, 4 (1), 116-120. doi: 10.1002/mdc3.12356

  • Axinte, Laura T., Fiddes, Barnaby D., Donaghy, Alastair, Whyte, Adam, Allen, Chris, Sawcer, Stephen, Adam, Robert J. and Stacpoole, Sybil R. L. (2015). Experience from two decades of the Cambridge Rapid Access Neurology Clinic. Clinical Medicine, 15 (5), 437-441. doi: 10.7861/clinmedicine.15-5-437

  • Adam, Robert J., McLeod, Robert, Ha, Ainhi D., Colebatch, James G., Menzies, Graham, de Moore, Gregory, Mahant, Neil and Fung, Victor S. C. (2014). Resolution of Othello Syndrome after subthalamic nucleus deep brain stimulation in 3 patients with parkinson's disease. Movement Disorders Clinical Practice, 1 (4), 357-360. doi: 10.1002/mdc3.12084

  • Adam, Robert, Priglinger, Miriam, Harrington, Timothy, Gottlieb, David and Krause, Martin (2014). An unusual cause of cerebellar hemorrhage in a young patient: Essential thrombocythemia. Journal of Stroke and Cerebrovascular Diseases, 23 (5), E373-E374. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.013

  • Adam, R., Leff A., Sinha N., Turner C., Bays P., Draganski B. and Husain M. (2013). Dopamine reverses reward insensitivity in apathy following globus pallidus lesions. Cortex, 49 (5), 1292-1303. doi: 10.1016/j.cortex.2012.04.013

  • Adam, Robert, Bays, Paul M. and Husain, Masud (2012). Rapid decision-making under risk. Cognitive Neuroscience, 3 (1), 52-61. doi: 10.1080/17588928.2011.613988

  • Adam, Robert J. and Manohar, Sanjay G. (2007). Does reward modulate actions or bias attention?. Journal of Neuroscience, 27 (41), 10919-10921. doi: 10.1523/JNEUROSCI.2957-07.2007

Conference Publication

  • Dissanayaka, N., Byrne, G. J., Mitchell, L. K., O'Sullivan, J. D., Padmassini, A., White, E. X., Yang, J. H. J., Forbes, E., Thangavelu, K., Au, T., Lehn, A., Adam, R. and Pachana, N. A. (2020). Improving diagnosis and treatment of anxiety in Parkinson’s disease: IDATA-PD study update. Herston Health Precinct Symposium 2020, Brisbane, QLD Australia, 7-11 December 2020.

  • Pourzinal, D., Bakker, A., Byrne, G. J., McMahon, K., O'Sullivan, J., Adam, R., Copland, D., Yang, J. H. J., Au, T., Littleford, R., Chatfield, M., Pontone, G., Mari, Z. and Dissanayaka, N. (2020). Therapy to Reduce dementia risk In Parkinson’s disease (TRIP): proof-of-concept protocol. UQ Faculty of Medicine Higher Degree by Research Student Symposium, Brisbane, QLD Australia, 23-27 November 2020.

  • Pourzinal, D., Bakker, A., Byrne, G. J., McMahon, K., O'Sullivan, J., Adam, R., Copland, D., Yang, J. H. J., Au, T., Littleford, R., Chatfield, M., Pontone, G., Mari, G. and Dissanayaka, N. (2020). Therapy to reduce dementia risk in Parkinson’s disease (TRIP): proof-of-concept protocol. Herston Health Precinct Symposium 2020, Brisbane, QLD Australia, 7-11 December 2020.

  • Pourzinal, D., Bakker, A., Byrne, G., McMahon, K.L., O'Sullivan, J.D., Adam, R., Lehn, A., Copland, D., Yang, J.H., Au, T., Littleford, R., Chatfield, M., Pontone, G., Mari, Z. and Dissanayaka, N.N.W. (2020). Therapy to Reduce dementia risk In Parkinson’s disease (TRIP): Proof-of-concept protocol. Macquarie University BioNetwork 3rd Annual Research Symposium on Dementia, Online, 14-15 September 2020.

  • Yin, Y.W.K., Chang, F.C.F., Mahant, N., Fung, V.S.C., Tsui, D., Aldaajani, Z., Adam, R. and Hely, M. (2016). 2. Antecollis associated with Parkinson’s disease improved following apomorphine therapy. Proceedings of the 16th Biennial Clinical Neurophysiology Workshop of the Australian and New Zealand Association of Neurologists, Gold Coast, QLD, Australia, 27–30 September, 2015. Elsevier BV. doi: 10.1016/j.clinph.2015.11.022

  • Chang, F. C. F., Mahant, N., Fung, V. S. C., Tsui, D. S. Y., Aldaajani, Z., Adam, R. and Hely, M. A. (2015). Antecollis associated with Parkinson's disease improved following apomorphine therapy. 19th International Congress of Parkinson's Disease and Movement Disorders, San Diego, CA, United States, 14-18 June 2015. Hoboken, NJ, United States: John Wiley & Sons.

  • Fiddes, Barnaby, Adam, Robert, Donaghy, Alastair, Whyte, Adam and Allen, Chris (2013). The changing face of urgent neurology outpatient referrals. Annual Meeting of the Association-of-British-Neurologists, Glasgow, Scotland, 21-24 May 2013. London, United Kingdom: B M J Group. doi: 10.1136/jnnp-2013-306573.54

  • Adam, R. J., Bays, P. M., Singh-Curry, V., Bain, P. G. and Husain, M. (2009). Oculomotor Impulsivity in Parkinson'S Disease. ABN Joint Annual Meeting/Spanish-Society-of-Neurology, Liverpool England, Jun 22-26, 2009. B M J PUBLISHING GROUP. doi: 10.1136/jnnp.2009.191759r

  • Adam, R., Bays, P. M., Singh-Curry, V., Bain, P. and Husain, M. (2009). A novel task to probe impulsivity in Parkinson's disease. 13th International Congress of Parkinsons Disease and Movement Disorders, Paris, France, 7-11 June 2009. Hoboken, NJ, United States: John Wiley & Sons.

Grants (Administered at UQ)