Dr. Li Lin spent 4 years involved in skin-related research and the set-up of clinical-testing facilities at Procter & Gamble Singapore from 2005. She moved to Queensland in 2009 to pursue higher education and has graduated with a PhD in biomedical engineering from The University of Queensland, supervised by A/Prof Tarl Prow (Deputy Director of Dermatology Research Centre and Prof H. Peter Soyer (Director of Dermatology Research Centre and Chair of Dermatology Department at Princess Alexandra Hospital). Her PhD training was focused on the development of a new micro-sized skin biopsy device for molecular diagnosis of skin diseases. She is currently a NHMRC Peter Doherty ECR Fellow at The University of Queensland whose research interest is to develop new technologies with focus on drug delivery, diagnostics and imaging in the context of dermatology.
Journal Article: Phase 1 safety, pharmacokinetics, and fluorescence imaging study of Tozuleristide (BLZ-100) in adults with newly diagnosed or recurrent gliomas
Patil, Chirag G., Walker, David G., Miller, Dennis M., Butte, Pramod, Morrison, Beth, Kittle, David S, Hansen, Stacey J, Nufer, Kaitlin L, Byrnes-Blake, Kelly A, Yamada, Miko, Lin, Lynlee L, Pham, Kim, Perry, Jeff, Parrish-Novak, Julia, Ishak, Laura, Prow, Tarl, Black, Keith and Mamelak, Adam N (2019) Phase 1 safety, pharmacokinetics, and fluorescence imaging study of Tozuleristide (BLZ-100) in adults with newly diagnosed or recurrent gliomas. Neurosurgery, . doi:10.1093/neuros/nyz125
Journal Article: A high-resolution study of in situ surface-enhanced Raman scattering nanotag behavior in biological systems
Wang, Jing, Anderson, Will, Li, Junrong, Lin, Lynlee L., Wang, Yuling and Trau, Matt (2019) A high-resolution study of in situ surface-enhanced Raman scattering nanotag behavior in biological systems. Journal of Colloid and Interface Science, 537 536-546. doi:10.1016/j.jcis.2018.11.035
Journal Article: Absorbent microbiopsy sampling and RNA extraction for minimally invasive, simultaneous blood and skin analysis
Lei, Benson U. W., Yamada, Miko, Hoang, Van L. T., Belt, Paul J., Moore, Mark H., Lin, Lynlee L., Flewell-Smith, Ross, Dang, Nhung, Tomihara, Shoko and Prow, Tarl W. (2019) Absorbent microbiopsy sampling and RNA extraction for minimally invasive, simultaneous blood and skin analysis. Journal of Visualized Experiments, 144: . doi:10.3791/58614
(2018–2020) TRI Spore Grants
Novel microdevices for controlled blood and skin extraction
(2016–2021) NHMRC Early Career Fellowships
Efficacy study of beauty sleep power peel
(2016) UniQuest Pty Ltd
Classification of naevus distribution patterns in the Brisbane naevus morphology study
(2019) Master Philosophy
Advances of Skin Microbiopsy for Blood and Skin Sampling with Streamlined Handling and Fabrication Settings
Doctor Philosophy
Real-time monitoring of circulating tumor cells phenotypic evolution
Doctor Philosophy
Reflectance confocal microscopy-guided microbiopsies for targeted molecular analysis
Ardigò, Marco, Agozzino, Marina, Lynlee, Lin and Prow, Tarl W. (2017). Reflectance confocal microscopy-guided microbiopsies for targeted molecular analysis. In Reflectance confocal microscopy of cutaneous tumors, Second Edition (pp. 53-58) Boca Raton, FL, United States: CRC Press. doi:10.1201/9781315113722
Reflectance confocal microscopy-guided microbiopsies for targeted molecular analysis
Ardigo, Marco, Agozzino, Marina, Lin, Lynlee L. and Prow, Tarl W. (2017). Reflectance confocal microscopy-guided microbiopsies for targeted molecular analysis. In Reflectance Confocal Microscopy of Cutaneous Tumors (pp. 52-57) Boca Raton, Florida, United States: CRC Press.
Imaging nanoparticle skin penetration in humans
Lin, L. L., Yamada, M. and Prow, T. W. (2016). Imaging nanoparticle skin penetration in humans. In Michael R. Hamblin, Pinar Avci and Tarl Prow (Ed.), Nanoscience in dermatology (pp. 353-366) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-802926-8.00027-6
Multiphoton microscopy applications in biology
Yamada, Miko, Lin, Lynlee L. and Prow, Tarl W. (2014). Multiphoton microscopy applications in biology. In Cornea, Anda and Conn, P. Michael (Ed.), Fluorescence microscopy: Super-resolution and other novel techniques (pp. 185-197) Amsterdam, The Netherlands: Elsevier. doi:10.1016/B978-0-12-409513-7.00013-0
Patil, Chirag G., Walker, David G., Miller, Dennis M., Butte, Pramod, Morrison, Beth, Kittle, David S, Hansen, Stacey J, Nufer, Kaitlin L, Byrnes-Blake, Kelly A, Yamada, Miko, Lin, Lynlee L, Pham, Kim, Perry, Jeff, Parrish-Novak, Julia, Ishak, Laura, Prow, Tarl, Black, Keith and Mamelak, Adam N (2019) Phase 1 safety, pharmacokinetics, and fluorescence imaging study of Tozuleristide (BLZ-100) in adults with newly diagnosed or recurrent gliomas. Neurosurgery, . doi:10.1093/neuros/nyz125
Wang, Jing, Anderson, Will, Li, Junrong, Lin, Lynlee L., Wang, Yuling and Trau, Matt (2019) A high-resolution study of in situ surface-enhanced Raman scattering nanotag behavior in biological systems. Journal of Colloid and Interface Science, 537 536-546. doi:10.1016/j.jcis.2018.11.035
Lei, Benson U. W., Yamada, Miko, Hoang, Van L. T., Belt, Paul J., Moore, Mark H., Lin, Lynlee L., Flewell-Smith, Ross, Dang, Nhung, Tomihara, Shoko and Prow, Tarl W. (2019) Absorbent microbiopsy sampling and RNA extraction for minimally invasive, simultaneous blood and skin analysis. Journal of Visualized Experiments, 144: . doi:10.3791/58614
Banzhaf, Christina A., Lin, Lynlee L., Dang, Nhung, Freeman, Michael, Haedersdal, Merete and Prow, Tarl W. (2017) The fractional laser-induced coagulation zone characterized over time by laser scanning confocal microscopy-A proof of concept study. Lasers in Surgery and Medicine, 50 1: 70-77. doi:10.1002/lsm.22758
Hoang, Van L. T., Tom, Lisa N., Quek, Xiu-Cheng, Tan, Jean-Marie, Payne, Elizabeth J., Lin, Lynlee L., Sinnya, Sudipta, Raphael, Anthony P., Lambie, Duncan, Frazer, Ian H., Dinger, Marcel E., Soyer, H. Peter and Prow, Tarl W. (2017) RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers. Peerj, 2017 8: e3631. doi:10.7717/peerj.3631
Novel microdevices for controlled blood and skin extraction, NHMRC
Li, Lynlee L. and Prow, Tarl W. (2017) Novel microdevices for controlled blood and skin extraction, NHMRC. Impact, 2017 6: 58-60.
Kirstein, Oscar David, Abbasi, Ibrahim, Horwitz, Ben Zion, Skrip, Laura, Hailu, Asrat, Jaffe, Charles, Li, Lynlee L., Prow, Tarl W. and Warburg, Alon (2017) Minimally invasive microbiopsies: a novel sampling method for identifying asymptomatic, potentially infectious carriers of Leishmania donovani. International Journal for Parasitology, 47 10-11: 609-616. doi:10.1016/j.ijpara.2017.02.005
Skin microbiopsy for HPV DNA detection in cutaneous warts
Tom, L. N., Dix, C. F., Hoang, V. L., Lin, L. L., Nufer, K. L., Tomihara, S., Prow, N. A., Soyer, H. P., Prow, T. W. and Ardigo, M. (2016) Skin microbiopsy for HPV DNA detection in cutaneous warts. Journal of the European Academy of Dermatology and Venereology, 30 12: E216-E217. doi:10.1111/jdv.13548.
Non-invasive nanoparticle imaging technologies for cosmetic and skin care products
Lin, Lynlee L., Nufer, Kaitlin L., Tomihara, Shoko and Prow, Tarl W. (2015) Non-invasive nanoparticle imaging technologies for cosmetic and skin care products. Cosmetics, 2 3: 196-210. doi:10.3390/cosmetics2030196
BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus
Tan, Jean-Marie, Lin, Lynlee L., Lambie, Duncan, Flewell-Smith, Ross, Jagirdar, Kasturee, Schaider, Helmut, Sturm, Richard A., Prow, Tari W. and Soyer, H. Peter (2015) BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus. JAMA Dermatology, 151 4: 417-421. doi:10.1001/jamadermatol.2014.3775
Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin
Mohammed, Yousuf H., Yamada, Miko, Lin, Lynlee L., Grice, Jeffrey E., Roberts, Michael S., Raphael, Anthony P., Benson, Heather A. E. and Prow, Tarl W. (2014) Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin. PLoS One, 9 7: e101956.1-e101956.9. doi:10.1371/journal.pone.0101956
High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers
Raphael, Anthony P., Primiero, Clare A., Lin, Lynlee L., Smith, Ross Flewell, Dyer, Philip, Soyer, H. Peter and Prow, Tarl W. (2014) High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers. Advanced Healthcare Materials, 3 6: 860-866. doi:10.1002/adhm.201300517
McClenahan, Phil, Lin, Lynlee L., Tan, Jean-Marie, Flewell-Smith, Ross, Schaider, Helmut, Jagirdar, Kasturee, Atkinson, Victoria, Lambie, Duncan, Prow, Tarl W., Sturm, Richard A. and Soyer, Peter (2014) BRAFV600E Mutation Status of Involuting and Stable Nevi in Dabrafenib Therapy with or without Trametinib. JAMA Dermatology, 150 10: 1079-1082. doi:10.1001/jamadermatol.2014.436
Noninvasive methods for the assessment of photoageing
Wheller, Laura, Lin, Lynlee L., Chai, Eric, Sinnya, Sudipta, Soyer, H. Peter and Prow, Tarl W. (2013) Noninvasive methods for the assessment of photoageing. Australasian Journal of Dermatology, 54 4: 290-295. doi:10.1111/ajd.12030
A plea for biobanking of all equivocal melanocytic proliferations
Soyer, H. Peter, Lin, Lynlee L. and Prow, Tarl W. (2013) A plea for biobanking of all equivocal melanocytic proliferations. JAMA Dermatology, 149 9: 1023-1024. doi:10.1001/jamadermatol.2013.4478
Effects of ex vivo skin microbiopsy on histopathologic diagnosis in melanocytic skin lesions
Banan, Parastoo, Lin, Lynlee L., Lambie, Duncan, Prow, Tarl and Soyer, H. Peter (2013) Effects of ex vivo skin microbiopsy on histopathologic diagnosis in melanocytic skin lesions. JAMA Dermatology, 149 9: 1107-1109. doi:10.1001/jamadermatol.2013.5020
The opportunity for microbiopsies for skin cancer
Prow, Tarl W., Lin, Lynlee L. and Soyer, H. Peter (2013) The opportunity for microbiopsies for skin cancer. Future Oncology, 9 9: 1241-1243. doi:10.2217/fon.13.88
Microbiopsy engineered for minimally invasive and suture-free sub-millimetre skin sampling
Lin, Lynlee L., Prow, Tarl W., Raphael, Anthony P., Harrold, Robert L., Primiero, Clare A., Ansaldo, Alexander B. and Soyer, H. Peter (2013) Microbiopsy engineered for minimally invasive and suture-free sub-millimetre skin sampling. F1000Research, 2 120. doi:10.12688/f1000research.2-120.v2
Wurm, Elisabeth M.T., Lin, Lynlee L., Ferguson, Blake, Lambie, Duncan, Prow, Tarl W., Walker, Graeme J. and Soyer, H. Peter (2012) A blueprint for staging of murine melanocytic lesions based on the Cdk4 R24C/R24C :: Tyr- NRAS Q 61K model. Experimental Dermatology, 21 9: 676-681. doi:10.1111/j.1600-0625.2012.01543.x
Butler, Margaret K., Prow, Tarl W., Guo, Ya-Nan, Lin, Lynlee L., Webb, Richard I. and Martin, Darren J. (2012) High pressure freezing/freeze substitution and TEM for the characterisation of metal oxide nanoparticles within sunscreens. Nanomedicine, 7 4: 541-551. doi:10.2217/NNM.11.149
Lin, Lynlee L., Grice, Jeffrey E., Butler, Margaret K., Zvyagin, Andrei V., Becker, Wolfgang, Robertson, Thomas A., Soyer, H. Peter, Roberts, Michael S. and Prow, Tarl W. (2011) Time-correlated single photon counting for simultaneous monitoring Of zinc oxide nanoparticles and NAD(P)H in intact and barrier-disrupted volunteer skin. Pharmaceutical Research, 28 11: 2920-2930. doi:10.1007/s11095-011-0515-5
Gold nanoparticle penetration and reduced metabolism in human skin by toluene
Labouta, H. I., Liu, D. C., Lin, L. L., Butler, M. K., Grice, J. E., Raphael, A. P., Kraus, T., El-Khordagui, L. K., Soyer, H. P., Roberts, M. S., Schneider, M. and Prow, T. W. (2011) Gold nanoparticle penetration and reduced metabolism in human skin by toluene. Pharmaceutical Research, 28 11: 2931-2944. doi:10.1007/s11095-011-0561-z
Nanoparticles and microparticles for skin drug delivery
Prow, Tarl W., Grice, Jeffrey E., Lin, Lynlee L., Faye, Rokhaya, Butler, Margaret, Becker, Wolfgang, Wurm, Elisabeth M. T., Yoong, Corinne, Robertson, Thomas A., Soyer, H. Peter and Roberts, Michael S. (2011) Nanoparticles and microparticles for skin drug delivery. Advanced Drug Delivery Reviews, 63 6: 470-491. doi:10.1016/j.addr.2011.01.012
König, Karsten, Raphael, Anthony P., Lin, Li, Grice, Jeffrey E., Soyer, H. Peter, Breunig, H. Georg, Roberts, Michael S. and Prow, Tarl W. (2011) Applications of multiphoton tomographs and femtosecond laser nanoprocessing microscopes in drug delivery research. Advanced Drug Delivery Reviews, 63 4-5: 388-404. doi:10.1016/j.addr.2011.03.002
Roberts, Michael S., Dancik, Yuri, Prow, Tarl W., Thorling, Camilla A., Lin, Lynlee L., Grice, Jeffrey E., Robertson, Thomas A., Koenig, Karsten and Becker, Wolfgang (2011) Non-invasive imaging of skin physiology and percutaneous penetration using fluorescence spectral and lifetime imaging with multiphoton and confocal microscopy. European Journal of Pharmaceutics and Biopharmaceutics, 77 3: 469-488. doi:10.1016/j.ejpb.2010.12.023
Microscopic evaluation of ZnO sunscreens in vivo
Lin, Lynlee L., Van Hoang, Nufer, Kaitlin L., Tomihara, Shoko, Pham, Kim and Prow, Tarl W. (2017). Microscopic evaluation of ZnO sunscreens in vivo. In: Annual Meeting of the American-Academy-of-Dermatology, Orlando, Fl, United States, (AB170-AB170). 3-7 March 2017.
The coagulation zone acts as a reservoir for sodium fluorescein
Banzhaf, Christina, Lin, Lynlee, Dang, Nhung, Yamada, Miko, Belt, Paul, Soyer, Peter, Freeman, Michael, Haedersdal, Merete and Prow, Tarl (2017). The coagulation zone acts as a reservoir for sodium fluorescein. In: Annual Meeting of the American-Society-for-Laser-Medicine-and-Surgery (ASLMS), San Diego, CA, United States, (3-4). 5-9 April 2017.
Microbiopsy biomarker profiling in a case of melanoma resembling a pigmented basal cell carcinoma
Sobarun, P., Hoang, V. L., Yamada, M., Lin, L., Tomihara, S., Lambie, D., Soyer, H. P. and Prow, T. (2016). Microbiopsy biomarker profiling in a case of melanoma resembling a pigmented basal cell carcinoma. In: *, *, (39-39). *.
Dermoscopy targeted skin microbiopsy is useful for RNA sampling in non-melanoma skin cancer lesions
Lin, L., Tan, J., Soyer, H. and Prow, T. (2015). Dermoscopy targeted skin microbiopsy is useful for RNA sampling in non-melanoma skin cancer lesions. In: Abstracts of the 45th Annual Meeting of the European Society for Dermatological Research. 45th Annual Meeting of the European Society for Dermatological Research, Rotterdam, The Netherlands, (S24-S24). 9-12 September 2015. doi:10.1038/jid.2015.267
Feasibility of genotyping melanocytic lesions by microsampling
Tan, Jean-Marie, Lin, Lynlee L., Lambie, Duncan, Ong, Natalie, Flewell-Smith, Ross, Jagirdar, Kasturee, Schaider, Helmut, Sturm, Richard A., Prow, Tarl W. and Soyer, H. Peter (2015). Feasibility of genotyping melanocytic lesions by microsampling. In: Poster Abstracts, American Academy of Dermatology 73rd Annual Meeting. 73rd Annual Meeting of the American Academy of Dermatology, San Francisco, California, (AB168-AB168). 20–24 March 2015.
Hang, Lydia Y. T., Lin, Lynlee L., Yamada, Miko, Soyer, H. Peter, Raphael, Anthony P. and Prow, Tarl W. (2015). Microbiopsy skin sampling in volunteers reveals no oxidative stress detected after topically applying sunscreen with zinc oxide nanoparticles. In: Poster Abstracts, American Academy of Dermatology 73rd Annual Meeting. 73rd Annual Meeting of the American Academy of Dermatology, San Francisco, California, (AB210-AB210). 20–24 March 2015.
Molecular profiles of reticular and globular naevus patterns: a pilot study
Ong, N., Duffy, D., Leikvold, A., Lee, K., Jagirdar, K., Lin, Lynlee L., Yamada, M., Sturm, R. A., Prow, T. W., Schaider, H. and Soyer, H. P. (2015). Molecular profiles of reticular and globular naevus patterns: a pilot study. In: Abstracts of the Australasian College of Dermatologists 48th Annual Scientific Meeting. 48th Annual Scientific Meeting of the Australasian College of Dermatologists, Adelaide SA, Australia, (58-58). 16 May 2015. doi:10.1111/ajd.12337
BRAF mutations in an involuting and non-involuting naevus upon BRAF +/- MEK treatment
McClenahan, P., Lin, L., Tan, J. M., Smith, R. Flewell, Schaider, H., Jagirdar, K., Lambie, D., Prow, T. W., Sturm, R. A. and Soyer, H. P. (2014). BRAF mutations in an involuting and non-involuting naevus upon BRAF +/- MEK treatment. In: The Australasian College of Dermatologists 47th Annual Scientific Meeting, Melbourne Australia, (40-40). 18–21 May 2014. doi:10.1111/ajd.12174
Skin microbiopsy effects on histopathological diagnosis of pigmented lesions
Banan, P., Lin, L., Lambie, D., Prow, T. and Soyer, H. P. (2013). Skin microbiopsy effects on histopathological diagnosis of pigmented lesions. In: Special Issue: The Australasian College of Dermatologists 46th Annual Scientific Meeting. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, Australia, (31-31). 19–22 May 2013. doi:10.1111/ajd.12051
Microparticle and microneedle drug delivery in human skin
Lin, L. L., Prow, T. W., Raphael, A. P., Ansaldo, A. B., Mohammed, Y., Primiero, C. A. and Soyer, H. (2012). Microparticle and microneedle drug delivery in human skin. In: Conjoint 3rd Australasian Wound & Tissue Repair Society and 9th Australasian Society for Dermatology Research Conference, Sydney, NSW, Australia, (A73-A73). 22-24 May 2012. doi:10.1111/j.1524-475X.2012.00835.x
Removing nanoparticles from human skin
Lin, L. L., Sundh, D., Raphael, A. P., Roberts, M. S., Soyer, H. and Prow, T. W. (2012). Removing nanoparticles from human skin. In: Conjoint 3rd Australasian Wound & Tissue Repair Society and 9th Australasian Society for Dermatology Research Conference, Sydney, NSW, Australia, (A64-A64). 22-24 May 2012. doi:10.1111/j.1524-475X.2012.00835.x
Non-invasive assessment of skin ageing
Baillie, L., Prow, T., Lin, L., Sim, P., Chai, E. and Soyer, H.P. (2011). Non-invasive assessment of skin ageing. In: x, x, (8-8). x.
Prow, TW, Liu, D, Faye, R, Lin, LL, Grice, JE, Soyer, HP and Roberts, MS (2011). Simultaneous imaging of metal nanoparticle penetration and metabolic changes in human skin using fluorescence lifetime imaging. In: Experimental Dermatology. 38th Annual Meeting of the Society-for-Cutaneous-Ultrastructure-Research, Brisbane Australia, (E873-E874). May 30-31, 2011.
Lin, Li (2015). The skin microbiopsy PhD Thesis, School of Medicine, The University of Queensland. doi:10.14264/uql.2015.848
(2018–2020) TRI Spore Grants
Novel microdevices for controlled blood and skin extraction
(2016–2021) NHMRC Early Career Fellowships
Efficacy study of beauty sleep power peel
(2016) UniQuest Pty Ltd
Minimally invasive microdevices for controlled blood and skin extraction
(2016) UQ Early Career Researcher
Advances of Skin Microbiopsy for Blood and Skin Sampling with Streamlined Handling and Fabrication Settings
Doctor Philosophy — Associate Advisor
Real-time monitoring of circulating tumor cells phenotypic evolution
Doctor Philosophy — Associate Advisor
Other advisors:
Characterisation of inflammatory signatures to enable rapid diagnosis of suspicious skin rashes
Master Philosophy — Associate Advisor
Other advisors:
Classification of naevus distribution patterns in the Brisbane naevus morphology study
(2019) Master Philosophy — Associate Advisor
Other advisors: