Dr Parker's fundamental research interest is the improved healthcare of infants and children through evidence-based drug dosing. Dr Parker is a bioanalyst with 20 years of experience designing methods to measure drugs in biological fluids, positioning her to develop kinder, less-invasive sampling methods that can improve the feasibility of clinical dosing studies. Dr Parker’s research career has furthered these laboratory skills into a translational framework: by applying innovation in microsampling her research will define evidence-based antibiotic dosing regimens.
To advance her research program, in 2016 Dr Parker established the Clinical Microsampling Group. Her research and experience is cross-disciplinary - based in infectious diseases, pharmacokinetic modelling and bioanalysis
Dr Parker has a series of important publications culminating in the characterization of fosfomycin, an antibiotic vital for the treatment of multi-drug resistant pathogens. This provided crucial evidence for effective dosing of this antibiotic in critically ill patients and advanced change in clinical practice. Dr Parker’s research has also produced world-first evidence essential for the implementation of microsampling in a clinical environment. Dr Parker has developed population pharmacokinetic models for clinical collaborators to describe dosing of drugs in challenging patient groups.
Parker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2019) A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study. Analytical and Bioanalytical Chemistry, . doi:10.1007/s00216-019-02184-4
Pandey, Saurabh, Dhanani, Jayesh, Lipman, Jeffrey, Roberts, Jason A., Wallis, Steve C. and Parker, Suzanne L. (2019) Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study. Clinical Chemistry and Laboratory Medicine, . doi:10.1515/cclm-2019-0780
Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2019) A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration. Antimicrobial Agents and Chemotherapy, . doi:10.1128/aac.01655-19
(2020) The Children's Hospital Foundation
(2019–2020) Metro North Hospital and Health Service
Translating a Drop of Blood into Effective Antibiotic Dosing in Infants and Children
(2018–2021) NHMRC Early Career Fellowships
Translating microsampling techniques into better antibiotic dosing for critically ill children
Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Doctor Philosophy
The microbiological effects of antimicrobial de-escalation: An in-vitro evaluation in a dynamic infection model
Doctor Philosophy
Parker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2019) A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study. Analytical and Bioanalytical Chemistry, . doi:10.1007/s00216-019-02184-4
Pandey, Saurabh, Dhanani, Jayesh, Lipman, Jeffrey, Roberts, Jason A., Wallis, Steve C. and Parker, Suzanne L. (2019) Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study. Clinical Chemistry and Laboratory Medicine, . doi:10.1515/cclm-2019-0780
Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2019) A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration. Antimicrobial Agents and Chemotherapy, . doi:10.1128/aac.01655-19
Gurunathan, Usha, Parker, Suzanne L., Maguire, Richard, Ramdath, Dale, Bijoor, Manu, Wallis, Steven C. and Roberts, Jason A. (2019) Population pharmacokinetics of periarticular ketorolac in adult patients undergoing total hip or total knee replacement surgery. Anesthesia and Analgesia, 129 3: 701-708. doi:10.1213/ANE.0000000000003377
Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2019) Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction. Antimicrobial Agents and Chemotherapy, 63 10: . doi:10.1128/aac.01265-19
Sime, Fekade B., Byrn, Catherine J., Parker, Suzanne, Stuart, Janine, Butler, Jenie, Starr, Therese, Pandey, Saurabh, Wallis, Steven C., Lipman, Jeffery and Roberts, Jason A. (2019) Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients. Critical Care, . doi:10.1186/s13054-019-2483-9
Guerra Valero, Yarmarly C., Roberts, Jason A., Lipman, Jeffrey, Fourie, Cheryl, Starr, Therese, Wallis, Steven C. and Parker, Suzanne L. (2019) Analysis of capillary microsamples obtained from a skin-prick to measure vancomycin concentrations as a valid alternative to conventional sampling: a bridging study. Journal of Pharmaceutical and Biomedical Analysis, 169 288-292. doi:10.1016/j.jpba.2019.03.018
Dhanani, Jayesh A., Diab, Sara, Chaudhary, Jivesh, Cohen, Jeremy, Parker, Suzanne L., Wallis, Steven C., Boidin, Clément, Barnett, Adrian, Chew, Michelle, Roberts, Jason A. and Fraser, John F. (2019) Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model. Anesthesiology, 131 2: 1-355. doi:10.1097/ALN.0000000000002752
Dimopoulos, George, Koulenti, Despoina, Parker, Suzanne L, Roberts, Jason A, Arvaniti, Kostoula and Poulakou, Garyphalia (2019) Intravenous fosfomycin for the treatment of multidrug resistant pathogens: what is the evidence on dosing regimens?. Expert Review of Anti-infective Therapy, 17 3: 201-210. doi:10.1080/14787210.2019.1573669
Sime, Fekade B., Pandey, Saurabh, Karamujic, Nermin, Parker, Suzanne, Alexander, Elizabeth, Loutit, Jeffery, Durso, Stephanie, Griffith, David, Lipman, Jeffrey, Wallis, Steven C. and Roberts, Jason A. (2018) Ex vivo characterization of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam. Antimicrobial Agents and Chemotherapy, 62 10: . doi:10.1128/AAC.01306-18
Sime, Fekade B., Pandey, Saurabh, Karamujic, Nermin, Parker, Suzanne, Alexander, Elizabeth, Loutit, Jeffery, Durso, Stephanie, Griffith, David, Lipman, Jeffrey, Wallis, Steven C. and Roberts, Jason A. (2018) Ex vivo characterisation of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam. Antimicrobial Agents and Chemotherapy, 62 10: AAC.01306-18. doi:10.1128/AAC.01306-18
Dhanani, Jayesh A., Cohen, Jeremy, Parker, Suzanne L., Chan, Hak-Kim, Tang, Patricia, Ahern, Benjamin J., Khan, Adeel, Bhatt, Manoj, Goodman, Steven, Diab, Sara, Chaudhary, Jivesh, Lipman, Jeffrey, Wallis, Steven C., Barnett, Adrian, Chew, Michelle, Fraser, John F. and Roberts, Jason A. (2018) A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models. Intensive Care Medicine Experimental, 6 1: 17. doi:10.1186/s40635-018-0180-7
Dhanani, Jayesh A., Parker, Suzanne L., Lipman, Jeffrey, Wallis, Steven C., Cohen, Jeremy, Fraser, John, Barnett, Adrian, Chew, Michelle and Roberts, Jason A. (2018) Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions. Journal of Pharmaceutical Analysis, . doi:10.1016/j.jpha.2018.07.003
Parker, Suzanne L, Saxena, Manoj, Gowardman, John, Lipman, Jeffrey, Myburgh, John and Roberts, Jason A. (2018) Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. Journal of Critical Care, 47 15-20. doi:10.1016/j.jcrc.2018.05.016
Gurunathan, Usha, Parker, Suzanne L., Maguire, Richard, Ramdath, Dale, Bijoor, Manu, Wallis, Steven C. and Roberts, Jason A. (2018) Population pharmacokinetics of periarticular ketorolac in adult patients undergoing total hip or total knee replacement surgery. Anesthesia and Analgesia, 1. doi:10.1213/ANE.0000000000003377
Dhanani, Jayesh A., Tang, Patrician, Wallis, Steven C., Parker, Suzanne L., Pandey, Preeti, Fraser, John F., Cohen, Jeremy, Barnett, Adrian, Roberts, Jason R. and Chan, Hak-Kim (2018) Characterisation of 40 mg/ml and 100 mg/ml tobramycin formulations for aerosol therapy with adult mechanical ventilation. Pulmonary Pharmacology and Therapeutics, 50 93-99. doi:10.1016/j.pupt.2018.04.006
Guerra Valero, Yarmarly C., Wallis, Steven C., Lipman, Jeffrey, Stove, Christophe, Roberts, Jason A. and Parker, Suzanne L. (2018) Clinical application of microsampling versus conventional sampling techniques in the quantitative bioanalysis of antibiotics: a systematic review. Bioanalysis, 10 6: 407-423. doi:10.4155/bio-2017-0269
Naicker, Saiyuri, Guerra Valero, Yarmarly C., Ordenez Meija, Jenny L., Lipman, Jeffrey, Roberts, Jason A., Wallis, Steven C. and Parker, Suzanne L. (2018) A UHPLC–MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent. Journal of Pharmaceutical and Biomedical Analysis, 148 324-333. doi:10.1016/j.jpba.2017.10.023
Parker, Suzanne L., Guerra Valero, Yarmarly C., Lipman, Jeffrey, Weiss, Steven, Smith, Camilla, Russell, Lyndal, Smith, Paul, Roberts, Jason A and Wallis, Steven C (2017) A validated UHPLC-MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples. Biomedical Chromatography, 31 12: e4030. doi:10.1002/bmc.4030
Parker, Suzanne L., Valero, Yarmarly C. Guerra, Mejia, Jenny L. Ordonez, Roger, Claire, Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2017) An LC-MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent. Bioanalysis, 9 12: 911-924. doi:10.4155/bio-2017-0019
Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin
Parker, Suzanne L., Guerra Valero, Yarmarly C., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2016) Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin. Bioanalysis, 8 21: 2235-2242. doi:10.4155/bio-2016-0159
Dorofaeff, Tavey, Bandini, Rossella M., Lipman, Jeffrey, Ballot, Daynia E., Roberts, Jason A. and Parker, Suzanne L. (2016) Uncertainty in antibiotic dosing in critically ill neonate and pediatric patients: can microsampling provide the answers?. Clinical Therapeutics, 38 9: 1961-1975. doi:10.1016/j.clinthera.2016.07.093
Parker, Suzanne L., Guerra Valero, Yarmarly C., Roberts, Darren M., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2016) Determination of cefalothin and cefazolin in human plasma, urine and peritoneal dialysate by UHPLC-MS/MS: application to a pilot pharmacokinetic study in humans. Biomedical Chromatography, 30 6: 872-879. doi:10.1002/bmc.3622
Is there a role for microsampling in antibiotic pharmacokinetic studies?
Parker, Suzanne L., Dorofaeff, Tavey, Lipman, Jeffrey, Ballot, Daynia E., Bandini, Rossella M., Wallis, Steven C. and Roberts, Jason A. (2016) Is there a role for microsampling in antibiotic pharmacokinetic studies?. Expert Opinion on Drug Metabolism and Toxicology, 12 6: 601-614. doi:10.1080/17425255.2016.1178238
The use and risks of antibiotics in critically ill patients
Denny, Kerina J., Cotta, Menino O., Parker, Suzanne L., Roberts, Jason A. and Lipman, Jeffrey (2016) The use and risks of antibiotics in critically ill patients. Expert Opinion on Drug Safety, 15 5: 667-678. doi:10.1517/14740338.2016.1164690
Parker, Suzanne L., Lipman, Jeffrey, Dimopoulos, George, Roberts, Jason A. and Wallis, Steven C. (2015) A validated method for the quantification of fosfomycin on dried plasma spots by HPLC-MS/MS: application to a pilot pharmacokinetic study in humans. Journal of Pharmaceutical and Biomedical Analysis, 115 509-514. doi:10.1016/j.jpba.2015.07.013
Population pharmacokinetics of fosfomycin in critically ill patients
Parker, Suzanne L., Frantzeskaki, Frantzeska, Wallis, Steven C., Diakaki, Chryssa, Giamarellou, Helen, Koulenti, Despoina, Karaiskos, Ilias, Lipman, Jeffrey, Dimopoulos, George and Roberts, Jason A. (2015) Population pharmacokinetics of fosfomycin in critically ill patients. Antimicrobial Agents and Chemotherapy, 59 10: 6471-6476. doi:10.1128/AAC.01321-15
Parker, Suzanne L., Roberts, Jason A., Lipman, Jeffrey and Wallis, Steven C. (2015) Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling. Bioanalysis, 7 19: 2585-2595. doi:10.4155/bio.15.173
Optimizing dosing of antibiotics in critically ill patients
Parker, Suzanne L., Sime, Fekade B. and Roberts, Jason A. (2015) Optimizing dosing of antibiotics in critically ill patients. Current Opinion in Infectious Diseases, 28 6: 497-504. doi:10.1097/QCO.0000000000000206
Parker, Suzanne L., Adnan, Syamhanin, Meija, Jenny L. Ordonez, Paterson, David L., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2015) An UHPLC-MS/MS method for the simultaneous determination of ampicillin and sulbactam in human plasma and urine. Bioanalysis, 7 18: 2311-2319. doi:10.4155/bio.15.143
Parker S.L., Lipman J., Roberts J.A. and Wallis S.C. (2015) A simple LC-MS/MS method using HILIC chromatography for the determination of fosfomycin in plasma and urine: Application to a pilot pharmacokinetic study in humans. Journal of Pharmaceutical and Biomedical Analysis, 105 39-45. doi:10.1016/j.jpba.2014.11.042
Parker, Suzanne, Lipman, Jeffrey, Koulenti, Despoina, Dimopoulos, George and Roberts, Jason A. (2013) What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review. International Journal of Antimicrobial Agents, 42 4: 289-293. doi:10.1016/j.ijantimicag.2013.05.018
Steady-state dispositions of valproate and diflunisal alone and coadministered to healthy volunteers
Addison, RS, Parker-Scott, SL, Eadie, MJ, Hooper, WD and Dickinson, RG (2000) Steady-state dispositions of valproate and diflunisal alone and coadministered to healthy volunteers. European Journal of Clinical Pharmacology, 56 9-10: 715-721. doi:10.1007/s002280000211
Valproate metabolism during valproate-associated hepatotoxicity in a surviving adult patient
McLaughlin, DB, Eadie, MJ, Parker-Scott, SL, Addison, RS, Henderson, RD, Hooper, WD and Dickinson, RG (2000) Valproate metabolism during valproate-associated hepatotoxicity in a surviving adult patient. Epilepsy Research, 41 3: 259-268. doi:10.1016/S0920-1211(00)00151-0
Effect of naproxen co-administration on valproate disposition
Addison, RS, Parker-Scott, SL, Hooper, WD, Eadie, MJ and Dickinson, RG (2000) Effect of naproxen co-administration on valproate disposition. Biopharmaceutics & Drug Disposition, 21 6: 235-242. doi:10.1002/bdd.235
Collaborations with Junior Colleagues for Building Research Capacity in the Public Sector
Siskind, D., Kisely, S. and Parker, S. (2017). Collaborations with Junior Colleagues for Building Research Capacity in the Public Sector. In: Australian and New Zealand Journal of Psychiatry. , , (23-23). . doi:10.1177/0004867417702054
How to do qualitative research?
Parker, S. (2017). How to do qualitative research?. In: RANZCP 2017 Congress, Adelaide, Australia, (53-54). 30 April - 4 May 2017.
Aspects of time- and concentration-related of valproate in humans
Addison, R. S., Dickinson, R. G., Eadie, M., Hooper, W. D., Parker-Scott, S. L. and Reith, D. (2000). Aspects of time- and concentration-related of valproate in humans. In: Proceedings of ASCEPT. Annual Scientifc Meeting of ASCEPT, Newcastle, Australia, (121-121). 03-06 Dec, 2000.
Effect of naproxen co-administration on valproate disposition
Addison, R. S., Dickinson, R. G., Hooper, W. D. and Parker-Scott, S. L. (2000). Effect of naproxen co-administration on valproate disposition. In: Drug Metabolism Reviews. DMW/ISSX 2000 Meeting, St Andrews, Scotland, (29-29). 11-16 Jun, 2000.
Interplay between b-oxidation and glucuronidation of valproate in humans
Addison, R. S., Dickinson, R. G., Hooper, W. D. and Parker-Scott, S. L. (2000). Interplay between b-oxidation and glucuronidation of valproate in humans. In: Drug Metabolism Reviews. DMW/ISSX 2000 Meeting, St Andrews, Scotland, (62-62). 11-16 Jun, 2000.
The renal handling of valproate and several metabolites in humans
Addison, R. S., Dickinson, R. G., Eadie, M., Hooper, W. D. and Parker-Scott, S. L. (2000). The renal handling of valproate and several metabolites in humans. In: Proceedings of ASCEPT. Annual Scientific Meeting of ASCEPT, Newcastle, Australia, (121-121). 03-06 Dec, 2000.
Effect of Naproxen co-administration on Valproate disposition
Addison, R. S., Dickinson, R. G., Hooper, W. D. and Parker-Scott, S. L. (1999). Effect of Naproxen co-administration on Valproate disposition. In: Abstracts of the Scientific Meeting of ASCEPT. 33rd Annual Scientific Meeting of ASCEPT, Sydney Convention & Exhibition Cen., Darling Harbour, (136-136). 4 - 8 Dec, 1999.
Steady state dispositions of Valproate and Diflunisal alone and coadministered to healthy volunteers
Addison, R. S., Dickinson, R. G., Eadie, M. J., Hooper, W. D. and Parker-Scott, S. L. (1999). Steady state dispositions of Valproate and Diflunisal alone and coadministered to healthy volunteers. In: Proceedings of ASCEPT 33rd Annual Scienctific Meeting. ASCEPT, Sydney Convention & Exhibition Cen., Darling Harbour, (146). 4 - 8 Dec, 1999.
Parker, Suzanne (2016). Translating innovative pharmacokinetic sampling techniques into improved antibiotic dosing regimens in critically ill patients PhD Thesis, School of Medicine, The University of Queensland. doi:10.14264/uql.2016.70
(2020) The Children's Hospital Foundation
(2019–2020) Metro North Hospital and Health Service
Translating a Drop of Blood into Effective Antibiotic Dosing in Infants and Children
(2018–2021) NHMRC Early Career Fellowships
(2018–2020) The Children's Hospital Foundation
(2018–2019) The Children's Hospital Foundation
(2018–2019) UQ Early Career Researcher
(2018–2019) Metro North Hospital and Health Service
(2017) Royal Brisbane and Women's Hospital Foundation
Using a drop of blood to personalise antibiotic dosing in children and prevent antibiotic resistance
(2016–2018) Ian Potter Foundation
Translating microsampling techniques into better antibiotic dosing for critically ill children
Doctor Philosophy — Principal Advisor
Other advisors:
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Doctor Philosophy — Principal Advisor
The microbiological effects of antimicrobial de-escalation: An in-vitro evaluation in a dynamic infection model
Doctor Philosophy — Associate Advisor
Other advisors: