Dr Priyakshi Kalita de Croft

Postdoctoral Research Officer

UQ Centre for Clinical Research
Faculty of Medicine
p.kalita@uq.edu.au
+61 7 334 66048

Overview

I am a postdoctoral researcher and the winner of the prestigious Rose-Anne Kelso Commemorative Award 2019. This highly competitive cash award is given to one female scientist each year within Queensland for her dedication and passion for science and enables her to strengthen her research profile and collaborations. I am working towards an enhanced understanding of metastasis to the brain, specialising in assessing disease biomarkers in formalin-fixed tissues and development and use of preclinical disease models.

Research Interests

  • Breast Cancer Metastases
    My research objectives are aimed towards understanding and developing therapeutic interventions for breast cancer and metastases. My program of work comprises of two main interests; brain metastasis and triple-negative breast cancer. I am interested in understanding the influence of the unique tumour/tissue microenvironment (TME) in metastases including immune markers. I am working on elucidating the immune landscape of breast cancer brain metastasis in patient samples using multiplex immunofluorescence. Another branch of my work consists of targeting calcium channels in brain metastasis.To achieve my objectives I have established brain metastatic tumours from the breast using intra-cranial preclinical model along with molecular biology, genomic and proteomic tools. I also routinely analyse archival patient tumour tissues to identify novel biomarkers for breast cancer and brain metastasis. In triple-negative breast cancer I am understanding the biology of cancer-associated fibroblasts and their role in breast density and the immune microenvironment using various Pathology tools such as histology and multiplex Immunofluorescence. I also use a variety of statistical algorithms and clinical data analysis tools to achieve this.

Qualifications

  • Doctor of Philosophy, University of Otago

Publications

  • Adwal, Alaknanda, Kalita-de Croft, Priyakshi, Shakya, Reshma, Lim, Malcolm, Kalaw, Emarene, Taege, Lucinda D., McCart Reed, Amy E., Lakhani, Sunil R., Callen, David F. and Saunus, Jodi M. (2020). Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life Science Alliance, 3 (7), e201900562. doi: 10.26508/lsa.201900562

  • Raninga, Prahlad, Lee, Andy, Sinha, Debottam, Dong, Lan-feng, Datta, Keshava, Lu, Xue, Kalita-de Croft, Priyakshi, Dutt, Mriga, Hill, Michelle M., Pouliot, Normand M., Gowda, Harsha, Kalimutho, Murugan, Neuzil, Jiri and Khanna, Kum Kum (2020). Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition. Theranostics, 10 (12), 5259-5275. doi: 10.7150/thno.42705

  • Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016). 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 (6), 356-367. doi: 10.1097/PAP.0000000000000128

View all Publications

Available Projects

  • This project will be investigating the unique immune microenvironmental adaptations that take place in an organ when it is invaded by tumour cells. It will be employing molcular biology techniques such as gene knockdown, histology, protein expression and pathway analysis.

View all Available Projects

Publications

Featured Publications

  • Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016). 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 (6), 356-367. doi: 10.1097/PAP.0000000000000128

Journal Article

  • Adwal, Alaknanda, Kalita-de Croft, Priyakshi, Shakya, Reshma, Lim, Malcolm, Kalaw, Emarene, Taege, Lucinda D., McCart Reed, Amy E., Lakhani, Sunil R., Callen, David F. and Saunus, Jodi M. (2020). Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life Science Alliance, 3 (7), e201900562. doi: 10.26508/lsa.201900562

  • Raninga, Prahlad, Lee, Andy, Sinha, Debottam, Dong, Lan-feng, Datta, Keshava, Lu, Xue, Kalita-de Croft, Priyakshi, Dutt, Mriga, Hill, Michelle M., Pouliot, Normand M., Gowda, Harsha, Kalimutho, Murugan, Neuzil, Jiri and Khanna, Kum Kum (2020). Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition. Theranostics, 10 (12), 5259-5275. doi: 10.7150/thno.42705

  • McCart Reed, Amy E., Lal, Samir, Kutasovic, Jamie R., Wockner, Leesa, Robertson, Alan, de Luca, Xavier M., Kalita-de Croft, Priyakshi, Dalley, Andrew J., Coorey, Craig P., Kuo, Luyu, Ferguson, Kaltin, Niland, Colleen, Miller, Gregory, Johnson, Julie, Reid, Lynne E., Males, Renique, Saunus, Jodi M., Chenevix-Trench, Georgia, Coin, Lachlan, Lakhani, Sunil R. and Simpson, Peter T. (2019). LobSig is a multigene predictor of outcome in invasive lobular carcinoma. npj Breast Cancer, 5 (1) 18, 18. doi: 10.1038/s41523-019-0113-y

  • Kalita-de Croft, Priyakshi, Straube, Jasmin, Lim, Malcolm, Al-Ejeh, Fares, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Proteomic analysis of the breast cancer brain metastasis microenvironment. International Journal of Molecular Sciences, 20 (10) 2524, 2524. doi: 10.3390/ijms20102524

  • Lim, Malcolm, Puttick, Simon, Houston, Zachary H., Thurecht, Kristofer J., Kalita-de Croft, Priyakshi, Mahler, Stephen, Rose, Stephen E., Jeffree, Rosalind L., Mazzieri, Roberta, Dolcetti, Riccardo, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Innovative therapeutic strategies for effective treatment of brain metastases. International Journal of Molecular Sciences, 20 (6) 1280, 1280. doi: 10.3390/ijms20061280

  • McCart Reed, Amy E, Kalita-de Croft, Priyakshi, Kutasovic, Jamie, Saunus, Jodi M and Lakhani, Sunil R (2018). Recent advances in breast cancer research impacting clinical diagnostic practice : Breast cancer research - where are we now?. The Journal of Pathology, 247 (5), 552-562. doi: 10.1002/path.5199

  • Raghavendra, Ashwini, Kalita-de Croft, Priyakshi, Vargas, Ana Cristina, Smart, Chanel E., Simpson, Peter T., Saunus, Jodi M. and Lakhani, Sunil R. (2018). Expression of MAGE-A and NY-ESO-1 cancer-testis antigens is enriched in triple-negative invasive breast cancers. Histopathology, 73 (1), 68-80. doi: 10.1111/his.13498

  • Pozniak, Katarzyna N., Pearen, Michael A., Pereira, Tamara N., Kramer, Cynthia S. M., Kalita-De Croft, Priyakshi, Nawaratna, Sujeevi K., Fernandez-Rojo, Manuel A., Gobert, Geoffrey N., Tirnitz-Parker, Janina E. E., Olynyk, John K., Shepherd, Ross W., Lewindon, Peter J. and Ramm, Grant A. (2017). Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease. The American Journal of Pathology, 187 (12), 2744-2757. doi: 10.1016/j.ajpath.2017.08.024

  • Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017). Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, 167 (1), 1-13. doi: 10.1007/s10549-017-4496-x

  • Saunus, J. M., Croft, P. K.-D., Lee, F. T., Al-Ejeh, F., Lim, M., Ensbey, K., Niland, C., Jeffree, R. L., Thomas, P., Day, B. W., Rose, S., Scott, A. M. and Lakhani, S. R. (2017). Investigating the HER2-3 dimer as a theranostic target in brain metastases. Clinical and Experimental Metastasis, 34 (3-4), 224-224. doi: 10.1007/s10585-017-9843-0

  • Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016). 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 (6), 356-367. doi: 10.1097/PAP.0000000000000128

  • Kalita-de Croft, Priyakshi, Bedford, Jennifer, Leader, John P. and Walker, Robert J. (2016). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23 (1), 20-30. doi: 10.1111/nep.12929

  • Dias, George Jayantha, Mahoney, Patricia, Hung, Noelyn Anne, Sharma, Lavanya Ajay, Kalita, Priyakshi, Smith, Robert Allen, Kelly, Robert James and Ali, Azam (2016). Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 105 (7), 2034-2044. doi: 10.1002/jbm.b.33735

  • Weiner, I. David, Leader, John P., Bedford, Jennifer J., Verlander, Jill W., Ellis, Gaye, Kalita, Priyakshi, Vos, Frederiek, de Jong, Sylvia and Walker, Robert J. (2014). Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reserach, 2 (12) e12242, e12242.1-e12242.15. doi: 10.14814/phy2.12242

Conference Publication

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • This project will be investigating the unique immune microenvironmental adaptations that take place in an organ when it is invaded by tumour cells. It will be employing molcular biology techniques such as gene knockdown, histology, protein expression and pathway analysis.