Professor Sunil Lakhani

Head, Discipline of Pathology

UQ Centre for Clinical Research
Faculty of Medicine
s.lakhani@uq.edu.au
+61 7 334 66052

Overview

Sunil Lakhani is Executive Director Research and Senior Staff Specialist, Pathology Queensland, and Head of the Molecular Breast Group at the University of Queensland Centre for Clinical Research (UQCCR) at the Royal Brisbane and Women’s Hospital.

Prior to his move to Australia in 2004, he was Professor of Breast Pathology at The Institute of Cancer Research and The Royal Marsden Hospital, London, UK

His current research interests include lobular carcinoma and its variants, normal and stem cells, tumours with a basal phenotype, familial breast cancer and biology and therapeutic development for brain and distant metastases.

He was series editor for the 4th Edition WHO Tumour Classification Books and volume editor for the 4th Ed WHO Classification of Tumours of the Breast (2012). He is currently Standing member of the Board for the 5th Ed WHO Tumour Classification Books. He is also on the editorial board of a number of pathology and experimental research journals.

Research Impacts

The recognition that ADH is biologically very similar to DCIS has led to a policy of excising all ADH lesions diagnosed on core biopsies at breast screening assessment

The demonstration that LCIS is a clonal neoplastic proliferation with the same molecular phenotype as invasive lobular carcinoma, and the subsequent dissemination of this knowledge through publication (Lakhani SR 2003, Lancet) and conference presentations has also changed the management of LCIS. It is accepted that it is a non-obligate precursor, rather than a hyperplastic lesion.

The recognition of the pleomorphic variant of lobular is now changing the way this proliferation is managed. Like other lobular lesions, it is multifocal/bilateral but a more aggressive variant. There is considerable ongoing discussion on the international stage regarding management and my work has played a role in this policy change.

We have also shown that columnar cell lesions, which are increasingly being diagnosed in the screening program, are clonal lesions with a progressive relationship to low grade DCIS (Simpson PT et al 2005 Am J Surg Pathol). We have shown that morphological atypia is associated with molecular profiles similar to that of DCIS and hence patients with atypical lesions on core biopsy are now subjected to further excision. It has been shown subsequently that many of these patients have worse pathology on further resection.

My expertise, in diagnostic and molecular biology of pre-invasive breast disease has also been acknowledged in being appointed Head of Breast Screen Pathology, North Brisbane as well as being a member of the Breast Screen Quality (‘Q’) group in Queensland.

My work as part of the BCLC has demonstrated that BRCA1-related breast cancers are high grade, highly proliferative tumours and occurred in young women. Hence there was an immediate impact on breast screening protocols. I was invited to many meetings to discuss the pathology in relation to the following: (i) should mammography be used in young women and how effective would it be in dense breasts? (ii) should another modality such as MRI be considered? (iii) irrespective of the modality, should the screening interval be shortened to reduce the risk that patients would present with interval cancers?

All these issues have been addressed subsequent to the publications – in particular, I was member of the steering group that published the experience of using MRI in young women at high risk of breast cancer (Leach et al 2005 MARIBS The Lancet). MRI is now used in many countries to screen high-risk women. The screening interval has been reduced to 1 year as many patients did present with interval cancers as predicted by the pathology.

In extending the original work on morphology, my group has also demonstrated that a large proportion of BRCA1associated cancers are ER negative and ‘basal-like’. This led us to propose that this phenotype could be used to improve the risk estimation and carrier probability of women seen in family cancer clinics (Lakhani et al 2005 Clin Can Res).

We have now published a number of papers supporting the use of pathology data to improve risk estimation as well as improving the likelihood of unclassified variants (UVs) being pathogenic. This work has been done with previous BCLC collaborators (Prof Doug Easton) as well as with Georgia Chenevix-Trench and Amanda Spurdle at QIMR (Chenevix-Trench et al 2006 Can Res, Lovelock et al 2007 Br Can Res, Spurdle et al 2008 JCO, Spurdle et al 2009 Hum Mut, Mavaddat et al 2010 Br Can Res) This approach is now being incorporated into the genetics clinics.

Qualifications

  • Fellow of Royal College of Pathologists
  • Doctor of Medicine, University of London
  • Bachelor of Medicine Bachelor of Surgery, University of London
  • Bachelor of Science (hons), University of London

Publications

  • Abdel-Fatah, Tarek M. A., Ball, Graham R., Thangavelu, Pulari U., Reid, Lynne E., McCart Reed, Amy E., Saunus, Jodi M., Duijf, Pascal H. G., Simpson, Peter T., Lakhani, Sunil R., Pongor, Lorinc, Gyorffy, Balázs, Moseley, Paul M., Green, Andrew R., Pockley, Alan G., Caldas, Carlos, Ellis, Ian O. and Chan, Stephen Y. T. (2020). Association of sperm-associated antigen 5 and treatment response in patients with estrogen receptor-positive breast cancer. JAMA Network Open, 3 (7), e209486. doi: 10.1001/jamanetworkopen.2020.9486

  • Baker, Laura A., Holliday, Holly, Roden, Daniel, Krisp, Christoph, Wu, Sunny Z., Junankar, Simon, Serandour, Aurelien A., Mohammed, Hisham, Nair, Radhika, Sankaranarayanan, Geetha, Law, Andrew M. K., McFarland, Andrea, Simpson, Peter T., Lakhani, Sunil, Dodson, Eoin, Selinger, Christina, Anderson, Lyndal, Samimi, Goli, Hacker, Neville F., Lim, Elgene, Ormandy, Christopher J., Naylor, Matthew J., Simpson, Kaylene, Nikolic, Iva, O'Toole, Sandra, Kaplan, Warren, Cowley, Mark J., Carroll, Jason S., Molloy, Mark and Swarbrick, Alexander (2020). Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer. Breast Cancer Research , 22 (1) 63, 63. doi: 10.1186/s13058-020-01306-6

  • Zhang, Lin, Yao, Jun, Wei, Yongkun, Zhou, Zhifen, Li, Ping, Qu, Jingkun, Badu-Nkansah, Akosua, Yuan, Xiangliang, Huang, Yu-Wen, Fukumura, Kazutaka, Mao, Xizeng, Chang, Wei-Chao, Saunus, Jodi, Lakhani, Sunil, Huse, Jason T., Hung, Mien-Chie and Yu, Dihua (2020). Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases. Science Translational Medicine, 12 (545) eaaz5387, eaaz5387. doi: 10.1126/scitranslmed.aaz5387

View all Publications

Publications

Book

  • Lakhani, Sunil R., Dilly, Susan A., Finlayson, Caroline J. and Gandhi, Mitesh (2016). Basic Pathology: an introduction to the mechanisms of disease. 5th ed. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9781315381688

  • Sunil R. Lakhani and Stephen B. Fox eds. (2016). Molecular pathology in cancer research. New York, United States: Springer. doi: 10.1007/978-1-4939-6643-1

  • Sunil R. Lakhani, Ian O. Ellis, Stuart Schnitt, Puay Hoon Tan and Marc van de Vijver eds. (2012). WHO Classification of Tumours of the Breast. Lyon, France: IARC.

  • Keshtgar, Mohammad R. S., Waddington, Wendy A., Lakhani, Sunil R. and Ell, Peter J. (1999). The sentinel node in surgical oncology. Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/978-3-642-60038-8

Book Chapter

  • Kalinowski, Lauren, Saunus, Jodi M., McCart Reed, Amy E. and Lakhani, Sunil R. (2019). Breast cancer heterogeneity in primary and metastatic disease. Advances in Experimental Medicine and Biology. (pp. 75-104) Cham, Switzerland: Springer. doi: 10.1007/978-3-030-20301-6_6

  • McCart Reed, Amy Ellen, Kalaw, Emarene, Reid, Andrew Scott and Lakhani, Sunil R. (2018). Breast cancer - pathology and genetics. Encyclopedia of cancer. (pp. 170-183) edited by Paolo Boffetta and Pierre Hainaut. Cambridge, MA United States: Academic Press. doi: 10.1016/B978-0-12-801238-3.65263-7

  • Smith, Deborah, Reed, Amy McCart and Lakhani, Sunil R. (2016). Forgotten resources - The autopsy. Molecular Pathology in Cancer Research. (pp. 335-348) edited by Sunil R. Lakhani and Stephen B. Fox. New York, NY, U.S.A.: Springer New York. doi: 10.1007/978-1-4939-6643-1_15

  • Sim, Sarah Yen Mi, Simpson, Peter T., Cummings, Margaret C. and Lakhani, Sunil R. (2016). Future role of molecular profiling in small breast samples and personalized medicine. A comprehensive guide to core needle biopsies of the breast. (pp. 803-817) edited by Sandra J. Shin. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-26291-8

  • Fox, Stephen B. and Lakhani, Sunil R. (2016). Introduction: Setting the scene, morphology to molecular. Molecular pathology in cancer research. (pp. v-vi) edited by Sunil R. Lakhani and Stephen B. Fox. New York, United States: Springer.

  • Schnitt, Stuart J. and Lakhani, Sunil S. (2014). Breast Cancer. World Cancer Report. (pp. 362-373) edited by Bernard W. Stewart and Christopher P. Wild. Lyon, France: IARC.

  • Saunus, Jodi M., McCart-Reed, Amy, Momeny, Majid, Cummings, Margaret and Lakhani, Sunil R. (2013). Breast cancer heterogeneity in primary and metastatic disease. Breast Cancer Metastasis and Drug Resistance: Challenges and Progress. (pp. 65-95) edited by Aamir Ahmad. New York, NY, USA: Springer. doi: 10.1007/978-1-4614-5647-6

  • Schnitt, S., Collins, L., Lakhani, S. R. and Simpson, P. T. (2012). Flat epithelial atypia. WHO Classification of Tumours of the Breast. (pp. 87-87) Lyon, France: IARC Press.

  • Lakhani, S. R., Rakha, E. and Simpson, P. T. (2012). Invasive lobular carcinoma. WHO classification of tumours of the breast. (pp. 40-42) Lyon, France: IARC Press.

  • Lakhani, S. R., Schnitt, S., O’Malley, F., van de Vijver, M., Simpson, P. T. and Palacios, J. (2012). Lobular neoplasia. WHO classification of tumours of the breast. (pp. 77-80) Lyon, France: IARC Press.

  • Smart, Chanel, Simpson, Peter T., Vargas, Ana Cristina and Lakhani, Sunil R. (2011). Genetic alterations in normal and malignant breast tissue. Breast cancer, a lobar disease. (pp. 53-66) edited by Tot, Tibor. London, United Kingdom: Springer. doi: 10.1007/978-1-84996-314-5_4

  • Smart, Chanel E., Furnival, Colin M. and Lakhani, Sunil R. (2010). High-risk lesions: ALH/LCIS/ADH. Kuerer's breast surgical oncology. (pp. 179-187) edited by Henry Mark Kuerer. New York, U.S.A.: McGraw-Hill Medical.

  • Da Silva, Leonard, Simpson, Peter T. and Lakhani, Sunil R. (2010). Lobular carcinoma in situ. Management of breast diseases. (pp. 181-199) edited by Ismail Jatoi and M. Kaufmann. Heidelberg: Springer. doi: 10.1007/978-3-540-69743-5_11

  • Simpson, Peter T., Reis-Filho, Jorge S. and Lakhani, Sunil R. (2010). Lobular carcinoma in situ : Biology and pathology. Diseases of the breast. (pp. 333-340) edited by Jay R. Harris, Marc E. Lippman, C. Kent Osborne and Monica Morrow. Philadelphia: Lippencott, Williams & Wilkins.

  • Penault-Llorca, F. and Lakhani, S. R. (2007). Pathology of ovarian tumors in mutation carriers. Hereditary Breast Cancer. (pp. 333-343) edited by Isaacs, C. and Rebbeck, T. R.. New York, U.S.A.: Informa Healthcare.

  • Jones, Chris, Simpson, Peter, Mackay, Alan and Lakhani, Sunil R. (2006). Expression profiling using cDNA microarrays. Breast cancer research protocols. (pp. 403-414) edited by Susan A. Brooks and Adrian Harris. Totowa, NJ, U.S.A.: Humana Press. doi: 10.1385/1-59259-969-9:403

  • Simpson, Peter, Jones, Chris, Mackay, Alan and Lakhani, Sunil R. (2006). Gene expression analysis using filter cDNA microarrays. Breast cancer research protocols. (pp. 415-424) edited by Susan A. Brooks and Adrian Harris. Totowa, USA: Humana Press.

  • Reis-Filho, J.S. and Lakhani, S.R. (2006). Molecular genetics of ADH/DCIS and ALH/LCIS. Breast Pathology. (pp. 185-189) edited by Goldblum, J.R.. Philadelphia, U.S.A.: Churchill Livingstone. doi: 10.1016/B978-0-443-06680-1.50023-5

  • Jones, Chris and Lakhani , Sunil R. (2006). Molecular investigation of breast disease. Early breast cancer: From screening to multidisciplinary management. (pp. 319-327) edited by G. Querci della Rovere, R. Warren and John R. Benson. London, U.K. ; New York, U.S.A.: Informa Healthcare.

  • Fulford, Laura G., Reis-Filho, Jorge S. and Lakhani, Sunni R. (2004). Lobular carcinoma in situ: Biology and pathology. Diseases of the breast. (pp. 489-495) edited by Jay R. Harris, Marc E. Lippman, Monica Morrow and C. Kent Osborne. Philadelphia, U.S.A.: Lippincott Williams & Wilkins.

  • Lakhani, Sunil and Dogan, A. (2004). Wound Healing. Clinical surgery in general : RCS course manual. (pp. 322-330) edited by Kirk, R.M. and Ribbans, W. J.. Edinburgh; New York: Churchill Livingstone.

  • Keshtgar, Mohammad R. S., Waddington, Wendy A., Lakhani, Sunil R. and Ell, Peter J. (1999). Clinical case material. The sentinel node in surgical oncology. (pp. 119-169) Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/978-3-642-60038-8_11

  • Keshtgar, Mohammad R. S., Waddington, Wendy A., Lakhani, Sunil R. and Ell, Peter J. (1999). Surgical techniques. The sentinel node in surgical oncology. (pp. 79-89) Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/978-3-642-60038-8_7

Journal Article

Conference Publication

  • Sadras, Francisco, Stewart, Teneale A., Robitaille, Melanie, Peters, Amelia A., Kalita-de Croft, Priyakshi, Soon, Patsy, Saunus, Jodi M., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2020). Remodelling of calcium influx pathways in breast cancer associated fibroblasts. 2019 San Antonio Breast Cancer Symposium, San Antonio, TX United States, 10-14 December 2019. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs19-p6-06-15

  • Lim, Darren Z. R. , Chalmers, Silke B. , Robitaille, Melanie , Saunus, Jodi M. , Lakhani, Sunil R. , Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2019). Assessment of Ca2+ channels and pumps in brain-seeking breast cancer cell lines. ASCEPT-PAGANZ Joint Scientific Meeting, Queenstown, New Zealand, 25-29 November 2019. Hamilton Central, QLD, Australia: ASCEPT.

  • Saunus, J. M., Lim, M., Puttick, S., Croft, P. Kalita-de, Houston, Z. H., Jones, M. L., Latter, M. J., Campbell, L. C., Thomas, P., Jeffree, R. L., Rose, S. E., Mahler, S. M., Thurecht, K. J., Scott, A. M. and Lakhani, S. R. (2019). Innovation in diagnosis and treatment of brain metastases using multifunctional nanomedicines. San Antonio Breast Cancer Symposium, San Antonio, Texas, 4-8 December 2018. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS18-P1-19-02

  • McCart Reed, Amy E., Lal, Samir, Kutasovic, Jamie R., Wockner, Leesa, Robertson, Alan, de Croft, Priyakshi Kalıta, Dalley, Andrew, Coorey, Craig P., Kuo, Luyu, Ferguson, Kaltin, Niland, Colleen, Miller, Gregory, Johnson, Julie, Reid, Lynne E., Males, Renique, Saunus, Jodi M., Chenevix-Trench, Georgia, Coin, Lachlan, Lakhani, Sunil R. and Simpson, Peter T. (2019). LobSig, a prognostic signature for Invasive Lobular Carcinoma. 7th International PacRim Breast and Prostate Cancer Meeting, Barossa Novotel, South Australia, Australia, 17-20 March 2019.

  • Monteith, Greg, Sadras, Francisco, Stewart, Teneale, Robitaille, Melanie, Kalita-de Croft, Priyakshi, Soon, Patsy, Saunus, Jodi, Lakhani, Sunil and Roberts-Thomson, Sarah (2019). Remodeling of calcium influx pathways in models of cancer associated fibroblasts in breast cancer. AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, Atlanta, GA, United States, 29 March -3 April 2019. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS18-99

  • Simpson, P., Nones, K., Johnson, J., Newell, F., Patch, A-M, Thorne, H., Kazakoff, S., De Luca, X., Parsons, M., Ferguson, K., Reid, L., Reed, A. McCart, Srihari, S., Lakis, V., Davidson, A., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., Beasley, J., Degasperi, A., Nik-Zainal, S., Ragan, M., Spurdle, A., Khanna, K. K., Lakhani, S., Pearson, J., Chenevix-Trench, G. and Waddell, N. (2019). Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology. San Antonio Breast Cancer Symposium, San Antonio, TX United States, 4-8 December 2018. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS18-P5-10-01

  • Coorey, Craig, Lal, Samir, Kutasovic, Jamie, Niland, Colleen, Ferguson, Kaltin, Kuo, Lu Yu, Reid, Lynne, Evans, Elizabeth, Porter, Alan, Lakhani, Sunil, McCart Reed, Amy and Simpson, Peter (2018). Expression of ARGLU and FBXL3 is highly prognostic for invasive lobular carcinoma. Unknown, Unknown, Unknown. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1016/j.pathol.2017.12.166

  • Kalita de Croft, Priyakshi , Straube, Jasmin , Al-Ejeh, Fares , M Saunus,Jodi and R Lakhani, Sunil (2018). Proteomic analysis of the mouse brain stromal microenvironment: a milieu intérieur of metabolic reprogramming. 30th Lorne Cancer Conference 2018, Lorne, Victoria, Australia, 8th-11th February, 2018.

  • Lal, S., Reed, A. McCart, Nones, K., Wockner, L., Song, S., Lakhani, S. and Simpson, P. (2017). An integrated molecular analysis of invasive lobular carcinoma. 39th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, 6-10 December 2016. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS16-P1-05-16

  • Anderson, Robin L., Swarbrick, Alex, Johnstone, Ricky, Chua, Boon, Gill, Anthony, Saunders, Christobel, Lakhani, Sunil, Lim, Elgene, Loi, Sherene, O'Toole, Sandra A., Khanna, Kum Kum, Devereux, Lisa, Harvey, Kate and Reed, Amy McCart (2017). Brocade: The National Breast Cancer Foundation Repository of Primary Tumours and Metastases from Breast Cancer Patients. COSA's 44th Annual Scientific Meeting: Immunotherapy: Molecules and Moutains, Darling Harbour, Sydney, NSW, 13–15 November 2017. Hoboken, NJ United States: Wiley.

  • Fielding, D., Dalley, A., Bashirzadeh, F., Singh, M., Nandakumar, L., Reed, McCart A., Black, D., Waddell, N., Kazakoff, Stephen, Nones, Katia, Pearson, John, Lakhani, S. and Simpson, P. (2017). Diffquik Stained Cytology Smears Provide Improved Malignant Cell Dna Yields From Lymph Nodes At Endobronchial Ultrasound Transbronchial Needle Aspiration (Ebus-Tbna). ANZSRS/TSANZ Annual Scientific Meeting , Canberra, Australia, 24-28 March 2017. Richmond, VIC, Australia: Wiley-Blackwell.

  • Dedina, Liana, Kutasovic, Jamie R., McCart Reed, Amy E., Simpson, Peter T. and Lakhani, Sunil R. (2017). Immunohistochemical evaluation of FOXA1 expression and its correlation with breast cancer-specific survival: queensland follow up cohort. Pathology Update 2017, Sydney Australia, 24 - 26 February 2017. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1016/j.pathol.2016.12.174

  • Reed, A. E. McCart, Kutasovic, J. R., Nones, K., da Silva, L., Melville, L., Jayanthan, J., Vargas, A. C., Reid, L. E., Saunus, J. M., Cummings, M. M., Porter, A., Evans, E., Waddell, N., Lakhani, S. R. and Simpson, P. T. (2017). Mixed ductal-lobular carcinomas of the breast: Abrogated cell adhesion in the clonal evolution from ductal to lobular morphology. San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 6-10 December 2016. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS16-P1-07-08

  • Northwood, K., Saunus, J., Milevskiy, M., Lakhani, S. and Brown, M. (2017). RNA immunoprecipitation reveals lncRNA-protein interactions in basal-like breast cancer. San Antonio Breast Cancer Symposium, San Antonio TX, United States, 6-10 December 2016. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS16-P1-04-05

  • Kutasovic, J. R., Rozali, E., Miranda, M., Lakhani, S. R. and Al-Ejeh, F. (2017). The development of personalized diagnostic tests and therapeutic strategies in breast cancer. San Antonio Breast Cancer Symposium, San Antonio, TX United States, 06-10 December 2016. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS16-P6-09-47

  • Lakhani, Sunil R. (2016). Targeting Her Receptors in Brain Metastases.

  • Norris, S., Anderson, K., Jack, B., Milch, V., Lakhani, S. and Zorbas, H. (2016). Clinical Guidance for Management of Lobular Carcinoma in Situ.

  • Lal, Samir, McCart Reed, Amy E, Nones, Katia, Wockner Leesa, Song, Sarah, Waddell, Nic, Lakhani, Sunil and Simpson, Peter t (2016). An integrative analysis of invasive lobular breast cancer. Lorne Cancer Conference, Lorne VIC, Australia, February 11-13th 2016.

  • Saunus, Jodi M., Kalita-de Croft, Priyakshi, Lee, F. T., Al-Ejeh, Fares, Lim, Malcolm, Ensbey, Kathleen, Niland, Colleen, Jeffree, Rosalind L., Thomas, Paul, Day, Bryan W., Rose, Stephen, Scott, Andrew M. and Lakhani, Sunil R. (2016). Investigating the Her2-3 dimer as a theranostic target in brain metastases. COSA's 43 and ANZBCTG's 38 Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD Australia, 15-17 November 2016. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12646

  • Fielding, D., Bashirzadeh, F., Singh, M., Nandakumar, L., Reed, Mccart A., Black, D., Dalley, A., Pearson, J., Nones, K., Waddell, N., Simpson, P. and Lakhani, S. (2016). Next Generation Sequencing On Endobronchial Ultrasound Transbronchial Needle Aspirate Lymph Node Specimens in Lung Cancer Shows a High Incidence of Mutations and Consistency with Single Gene Testing. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1–6 April 2016. Wiley. doi: 10.1111/resp.12754_12

  • Kutasovic, Jamie R., Rozali, Esdy, Miranda, Mariska, Lakhani, Sunil R. and Al-Ejeh, Fares (2016). The development of personalized diagnostic tests and therapeutic strategies in breast cancer. COSA's 43rd and ANZBCTG's 38th Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD Australia, 15-17 November 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

  • Kutasovic, Jamie, Reed, Amy McCart, Sim, Sarah, Cummings, Margaret, Lakhani, Sunil and Simpson, Peter (2015). Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

  • Miranda, Mariska Sauzine, Al Ejeh, Fares, Shi, Wei, Simpson, Peter, Lakhani, Sunil and Khanna, Kum Kum (2015). Erk5 as a therapeutic target in triple negative breast cancer (TNBC). 37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 9-13 December 2014. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS14-P6-03-11

  • Saunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Reid, Lynne, Holland, Jane D., Birchmeier, Walter, Jat, Parmjit, Brandner, Sebastian, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2015). Exploring the HER3 tyrosine kinase as a therapeutic target for treatment of brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, 28 June - 01 July 2014. Dordrecht, Netherlands: Springer. doi: 10.1007/s10585-015-9708-3

  • Koteeswaran, Raja, Deborah Smith, Ekta Bhutada, Simpson, Peter T., Emma Bartle, Julie Elizabeth Ayre, Galea, Melanie, Joanne Lester, Bowker, Shari and Lakhani, Sunil (2015). Flipping pathology and its impact on learning in second year medical students at University of Queensland, School of Medicine, Australia. The 2015 AAMC Medical Education Meeting, Baltimore, Maryland, USA, 10-12 November 2015.

  • Saunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Cloonan, N., Nones, K., Miller, D., Mariasegaram, M., Lau, Q., Jeffree, L., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. and Lakhani, S. R. (2015). Genomic and transcriptomic landscapes of human brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

  • Nair, Radhika, Teo, Wee Siang, Ye, Sunny, McFarland, Andrea, Harvey, Kate, Roden, Daniel, Junankar, Simon, Baker, Laura, Yang, Jessica, Fluke, Nicola, Millar, Ewan, Mellick, Albert, Naylor, Matthew, Ormandy, Christopher, Lakhani, Sunil, O'Toole, Sandra and Swarbrick, Alexander (2015). The inhibitor of differentiation proteins mediate tumour-initiating properties and metastasis in breast cancer. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

  • Reed, McCart A. E., Kutasovic, J. R., Vargas, A. C., Da Silva, L., Jayanthan, J., Al-Murrani, A., Reid, L. E., Evans, E., Porter, A., Lakhani, S. R. and Simpson, P. T. (2015). The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

  • Junankar, Simon, Baker, Laura, Roden, Daniel, Nair, Radhika, Elsworth, Ben, Lakhani, Sunil, Simpson, Peter, Ormandy C, Chris, O'Toole, Sandra and Swarbrick, Alexander (2014). Id4 Controls Mammary Stem Cells and Marks Breast Cancers with a Stem Cell Like Phenotype. Sydney Cancer Conference 2014, University of Sydney, NSW Australia, 26 November 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12282

  • Lakhani, Sunil R. (2014). Update on WHO breast classification: 2 years on. IAP 2014: 30th Congress of the International Academy of Pathology 2014, Bangkok, Thailand, 5-10 October, 2014. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.PAT.0000454053.47289.16

  • Da Silva, Leonard, McCart Reed, Amy E., Kutasovic, Jamie R., Vargas, Ana Cristina, Jayanthan, Janani, Reid, Lynne, Fritz, Brian, Cummings, Margaret C., Porter, Alan, Evans, Elizabeth, Lakhani, Sunil R. and Simpson, Peter T. (2012). Abrogated cell-cell adhesion in the phenotypic drift from ductal to lobular breast cancer types. 24th Lorne Cancer Conference 2012, Lorne, VIC, Australia, 9-11 February 2012.

  • Peters, A. A., Simpson, P. T., Bassett, J. J., Lee, J. M., Song, S., Parat, M. O., Lakhani, S. R., Kenny, P. A., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)72328-6

  • Teo, W., Nair, R., McFarland, A., Ye, S., Mellick, A., Lakhani, S. and Swarbrick, A. (2012). Dissecting the role of the inhibitor of differentiation 1 in breast cancer metastasis and characterization of pathways controlling breast cancer stem cell phenotype. 22nd Biennial Congress of the European Association for Cancer Research, Barcelona Spain, 07-10 July 2012. Oxford, United Kingdom: Pergamon.

  • Peters, Amelia, Lee, Wei C., Smart, Chanel E., Reid, Lynne, da Silva, Leonard, Lakhani, Sunil, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Immunohistochemical analysis of PMCA2 expression in normal and malignant human breast tissues. Joint ASCEPT-APSA 2012 Conference, Medication Safety, Sydney, Australia, 2-5 December 2012.

  • Saunus, Jodi M., Da Silva, Leonard, Momeny, Majid, Morrison, Brian, Lane, Annette, Smart, Chanel, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2012). Role of HER3 in brain metastases from primary breast cancer. 24th Lorne Cancer Conference, Lorne, VIC, Australia, 9-12 February 2012.

  • Saunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Vargas, Ana Cristina, Al-Ejeh, Fares, Morrison, Brian, Khanna, Kum Kum, Grimmond, Sean, Chenevix-Trench, Georgia, Jeffree, Rosalind L., Waddell, Nicola, Simpson, Peter T. and Lakhani, Sunil R. (2012). Uncovering molecular mechanisms involved in metastasis to the brain. 14th International Biennial Congress of the Metastasis Research Society, Brisbane, QLD, Australia, 2-5 September 2012.

  • Lee, W. C., Reid, L., Smart, Chanel, Simpson, P. T., Da Silva, L., Peters, Amelia, Lakhani, Sunil, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Expression of the calcium pump PMCA2 in lactating breast and breast cancer. ComBio 2011, Cairns, Australia, 25-29 September 2011.

  • Vargas, Ana Cristina, Simpson, Peter, McCart Reed, Amy, Lane, Annette, Smart, Chanel, Da Silva, Leonard and Lakhani, Sunil (2011). The Role of Type XI and Type XVII Collagen in Breast Cancer Progression. 100th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, United States, February 6 - March 4 2011. London, United Kingdom: Nature Publishing Group.

  • Vargas, Ana Cristina, Simpson, Peter T., McCart Reed, Amy E., Smart, Chanel, Waddell, Nic, Lane, Annette and Lakhani, Sunil (2011). The role of Type XI Collagen in Breast Cancer Progression. LICR Translational Oncology Conference, Melbourne, Australia, 24-26 October 2011.

  • Peters, Amelia, Simpson, Peter T., Bassett, Johnathon, Lakhani, Sunil, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). The transient receptor potential V6 (TRPV6) calcium channel in breast cancer cell lines and clinical breast cancer tissues. American Association for Cancer Research 102nd Annual Meeting, Orlando, United States, 2 - 6 April 2011. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2011-2954

  • Rosty, Christophe, Walsh, Michael, Cummings, Margaret, Buchanan, Daniel, Arnold, Sven, McKeone, Diane, Walters, Rhiannon, Hopper, John, Jenkins, Mark, Spurdle, Amanda, McGuckin, Michael, Lakhani, Sunil and Young, Joanne (2010). Lynch syndrome-associated breast cancers: Clinicopathological characteristics of a case series from the Colon CFR. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM10-32

  • Lakhani, SR and Simpson, PT (2010). Distinct pathological characteristics of lobular carcinoma. European Breast Cancer Conference, Barcelona Spain, Mar 24, 2010. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(10)70242-1

  • Vargas, A. C., Simpson, P., Jayanthan, J., Lane, A., Reid, L., Evans, E., Porter, A. and Lakhani, S. (2010). Role of breast screening for characterising the heterogeneity of invasive lobular carcinomas of the breast. 28th International Congress of the International-Academy-of-Pathology, Sao Paulo, Brazil, 10-15 October 2010. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

  • Smart, Chanel E., Saunus, Jodi M., Keith, Patricia, Vargas, Ana Cristina, Malik, Neelam, Clarke, Catherine, Simpson, Peter T. and Lakhani, Sunil R. (2010). Shifting phenotypes in primary human mammary epithelial culture. Sixth International Conference on Hormonal Oncogenesis, Tokyo, Japan, 12-16 September 2010.

  • Shin, S. J., Simpson, P. T., Da Silva, L., Mahalinga-Iyer, J., Lakhani, S. R. and Rosen, P. P. (2008). Is there molecular evidence for progression of microglandular adenosis to carcinoma: Results of comparative genomic hybridization (CGH) on microdissected lesions. 97th Annual Meeting of the United States and Canadian Academy of Pathology, Denver, CO, United States, 1-7 March 2008. Nature Publishing Group.

  • Da Silva, L., Parry, S., Keith, P., Lakhani, S. R. and Simpson, P. (2007). Evidence of evolution and intrinsic molecular relationship in a spectrum of morphological variants of invasive lobular carcinoma with variable E-cadherin status. United States and Canadian Academy of Pathology 2007 Annual Meeting, San Diego, California, 24-30 March, 2007. Baltimore, MD: Nature Publishing.

  • Brewster, Brooke, Brooke, Kelly, Brown, Melissa Anne, Clarke, C., Fleming, J. S., French, J. D., Hetherington, Rehan, Lakhani, Sunil, Raghavendra, Ashwini, Rothnagel, Joseph, Smart, Chanel and Wainwright, Brandon (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. kConFab Familial Breast Cancer Conference, Couran Cove, Queensland, 21-24 August 2007.

  • Brewster, Brooke, Brooks, Kelly, Brown, Melissa Anne, Clarke, C., Fleming, J. S., French, J. D., Hetherington, Rehan, Lakhani, Sunil, Raghavendra, Ashwini, Rothnagel, Joseph, Smart, Chanel and Wainwright, Brandon (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Gordon Research Conference: Mammary Gland Biology, Newport, RI, 10-15 June 2007.

  • Smart, C. E., Clarke, C., Brooks, K. M., Raghavendra, A., Brewster, B. L., French, J. D., Hetherington, R., Fleming, J. S., Rothnagel, J. A., Wainwright, B., Lakhani, S. R. and Brown, M. A. (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Australian Breast Cancer Conference, Melbourne, Australia, 2007.

  • Reis, JS, Pinheiro, C, Lambros, MBK, Milanezi, F, Carvalho, S, Savage, K, Simpson, PT, Jones, C, Swift, S, Mackay, A, Reis, RM, Hornick, JL, Pereira, EM, Baltazar, F, Fletcher, CDM, Ashworth, A, Lakhani, SR and Schmitt, FC (2006). EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. 190th Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, Manchester England, Jul 04-07, 2006.

  • Chenevix-Trench, G., Healey, S. C., Lakhani, S., Brinkworth, R. I., KConFab, K. C. F., Marsh, A., Brown, M. A., Easton, D. F., Tavtigian, S., Goldgar, D. E. and Spurdle, A. B. (2005). Genetic and immunohistopathological evaluation of BRCA1 and BRCA2 unclassified variants. Familial Cancer 2005: Research and Practice, Couran Cove, Queensland, 30 August - 3 September, 2005.

  • Lakhani, S. R. (1997). Is there a benign to malignant progression?. 2nd International Meeting on Current Topics in Breast Cancer Research, Cambridge, England, Sep, 1996. Bristol, United Kingdom: BioScientifica.

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Joint Principal Advisor

  • Doctor Philosophy — Joint Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Master Philosophy — Associate Advisor

Completed Supervision