Dr. Chun Xu received his Ph.D. in Biomedical Engineering and Nanotechnology at The University of Queensland, Australia in 2016. Before that, he got a M.D.S. in Oral and Maxillofacial Surgery and a B.D.S. in Dentistry from Wuhan University, China. He is currently a NHMRC Senior Research Officer and C.J. Martin fellow at The University of Queensland. He has published over 36 peer-reviewed scientific papers in top journals and hold 3 patents. He also serves as review editor on the editorial board of Nanoscience, Frontiers in Chemistry. He is a member of ISO experts committee for Nanoscience and Nanotechnologies. His reseach interests include the application of nanomaterials for biomedical applications.
Journal Article: Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles
Tasia, Winda, Lei, Chang, Cao, Yuxue, Ye, Qingsong, He, Yan and Xu, Chun (2020) Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles. Nanoscale, . doi:10.1039/c9nr08467c
Journal Article: Non-antibiotic Antimicrobial Agents to Combat Biofilm-forming Bacteria
Cao, Yuxue, Naseri, Mahdi, He, Yan, Xu, Chun, Walsh, Laurence J. and Ziora, Zyta M. (2019) Non-antibiotic Antimicrobial Agents to Combat Biofilm-forming Bacteria. Journal of Global Antimicrobial Resistance, . doi:10.1016/j.jgar.2019.11.012
Journal Article: Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2
Li, Huimin, Guo, Huilin, Lei, Chang, Liu, Li, Xu, Liqin, Feng, Yaping, Ke, Jin, Fang, Wei, Song, Hao, Xu, Chun, Yu, Chengzhong and Long, Xing (2019) Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Advanced Materials, 1904535. doi:10.1002/adma.201904535
(2019) Australian Dental Research Fund Inc
Functional nano-cement scaffolds for the treatment of osteoporotic bone defects
(2018–2021) NHMRC Early Career Fellowships
(2018) Australian Dental Research Fund Inc
A new generation of multifunctional nano-structured bone repair materials
Master Philosophy
The potential application of anti- stromal derived factor-1 (SDF-1) antibody and anti-vascular endothelial growth factor (VEGF) antibody for bone regeneration
Doctor Philosophy
Tasia, Winda, Lei, Chang, Cao, Yuxue, Ye, Qingsong, He, Yan and Xu, Chun (2020) Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles. Nanoscale, . doi:10.1039/c9nr08467c
Non-antibiotic Antimicrobial Agents to Combat Biofilm-forming Bacteria
Cao, Yuxue, Naseri, Mahdi, He, Yan, Xu, Chun, Walsh, Laurence J. and Ziora, Zyta M. (2019) Non-antibiotic Antimicrobial Agents to Combat Biofilm-forming Bacteria. Journal of Global Antimicrobial Resistance, . doi:10.1016/j.jgar.2019.11.012
Li, Huimin, Guo, Huilin, Lei, Chang, Liu, Li, Xu, Liqin, Feng, Yaping, Ke, Jin, Fang, Wei, Song, Hao, Xu, Chun, Yu, Chengzhong and Long, Xing (2019) Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Advanced Materials, 1904535. doi:10.1002/adma.201904535
Electrospinning of silica nanoparticles-entrapped nanofibers for sustained gentamicin release
Chen, Xiaobo, Xu, Chun and He, Hong (2019) Electrospinning of silica nanoparticles-entrapped nanofibers for sustained gentamicin release. Biochemical and Biophysical Research Communications, 516 4: 1085-1089. doi:10.1016/j.bbrc.2019.06.163
Cao, Yuxue, Xiao, Lan, Cao, Yanfan, Ashwin, Nanda, Xu, Chun and Ye, Qingsong (2019) 3D printed b-TCP scaffold with sphingosine 1-phosphate coating promotes osteogenesis and inhibits inflammation. Biochemical and Biophysical Research Communications, . doi:10.1016/j.bbrc.2019.03.132
Lowe, Baboucarr, Ottensmeyer, Mark.P., Xu, Chun, He, Yan, Ye, Qingsong and Troulis, Maria (2019) The regenerative applicability of bioactive glass and beta-tricalcium phosphate in bone tissue engineering: a transformation perspective. Journal of Functional Biomaterials, 10 1: . doi:10.3390/jfb10010016
Dargusch, Matthew, Dehghan-Manshadi, Ali, Shahbazi, Mahboobeth, Venezuela, Jeffrey, Tran, Xuan, Song, Jing, Liu, Na, Xu, Chun, Ye, Qingsong and Wen, Cuie (2019) Exploring the role of manganese on the microstructure, mechanical properties, biodegradability and biocompatibility of porous iron-based scaffolds. ACS Biomaterials Science & Engineering, . doi:10.1021/acsbiomaterials.8b01497
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
Ashammakhi, N., Ahadian, S., Xu, C., Montazerian, H., Ko, H., Nasiri, R., Barros, N. and Khademhosseini, A. (2019) Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs. Materials Today Bio, 1 100008. doi:10.1016/j.mtbio.2019.100008
Mesoporous silica nanoparticles for protein protection and delivery
Xu, Chun, Lei, Chang and Yu, Chengzhong (2019) Mesoporous silica nanoparticles for protein protection and delivery. Frontiers in Chemistry, 7 APR: 290. doi:10.3389/fchem.2019.00290
Xie, Huixu, Gu, Zhipeng, He, Yan, Xu, Jia, Xu, Chun, Li, Longjiang and Ye, Qingsong (2018) Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium. Journal of Materials Chemistry B, 6 15: 2332-2339. doi:10.1039/c8tb00306h
Xu, Chun, He, Yan, Li, Zhihao, Ahmad Nor, Yusilawati and Ye, Qingsong (2018) Nanoengineered hollow mesoporous silica nanoparticles for the delivery of antimicrobial proteins into biofilms. Journal of Materials Chemistry B, 6 13: 1899-1902. doi:10.1039/c7tb03201c
Double-layered microsphere based dual growth factor delivery system for guided bone regeneration
Xu, Chun, Xu, Jia, Xiao, Lan, Li, Zhihao, Xiao, Yin, Dargusch, Matthew, Lei, Chang, He, Yan and Ye, Qingsong (2018) Double-layered microsphere based dual growth factor delivery system for guided bone regeneration. RSC Advances, 8 30: 16503-16512. doi:10.1039/c8ra02072h
Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018) Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 24: 4089-4095. doi:10.1039/c8tb00544c
Xu, Chun, Lei, Chang, Huang, Lili, Zhang, Jun, Zhang, Hongwei, Song, Hao, Yu, Meihua, Wu, Yeda, Chen, Chen and Yu, Chengzhong (2017) Glucose-responsive nanosystem mimicking the physiological insulin secretion via an enzyme-polymer layer-by-layer coating strategy. Chemistry of Materials, 29 18: 7725-7732. doi:10.1021/acs.chemmater.7b01804
Dendritic mesoporous silica-titania nanospheres with enhanced photocatalytic activities
Lin, Chun Xiang Cynthia, Xu, Chun, Yang, Yannan, Lei, Chang, Zhang, Haijiao and Yu, Chengzhong (2017) Dendritic mesoporous silica-titania nanospheres with enhanced photocatalytic activities. New Journal of Chemistry, 41 17: 8754-8760. doi:10.1039/c7nj00713b
Abbaraju, Prasanna Lakshmi, Yang, Yannan, Yu, Meihua, Fu, Jianye, Xu, Chun and Yu, Chengzhong (2017) Core-shell-structured dendritic mesoporous silica nanoparticles for combined photodynamic therapy and antibody delivery. Chemistry - An Asian Journal, 12 13: 1465-1469. doi:10.1002/asia.201700392
Poly(lactic-co-glycolic acid): applications and future prospects for periodontal tissue regeneration
Sun, Xiaoyu, Xu, Chun, Wu, Gang, Ye, Qingsong and Wang, Changning (2017) Poly(lactic-co-glycolic acid): applications and future prospects for periodontal tissue regeneration. Polymers, 9 6: 189. doi:10.3390/polym9060189
Abbaraju, Prasanna Lakshmi, Meka, Anand Kumar, Song, Hao, Yang, Yannan, Jambhrunkar, Manasi, Zhang, Jun, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2017) Asymmetric silica nanoparticles with tunable head-tail structures enhance hemocompatibility and maturation of immune cells. Journal of the American Chemical Society, 139 18: 6321-6328. doi:10.1021/jacs.6b12622
Kalantari, Mohammad, Yu, Meihua, Noonan, Owen, Song, Hao, Xu, Chun, Huang, Xiaodan, Xiang, Feixiang, Wang, Xiaolin and Yu, Chengzhong (2017) Rattle-type magnetic mesoporous hollow carbon as a high-performance and reusable adsorbent for water treatment. Chemosphere, 166 109-117. doi:10.1016/j.chemosphere.2016.09.083
The effect of mesoporous bioglass on osteogenesis and adipogenesis of osteoporotic BMSCs
Wu, Tao, Cheng, Ning, Xu, Chun, Sun, Wei, Yu, Chengzhong and Shi, Bin (2016) The effect of mesoporous bioglass on osteogenesis and adipogenesis of osteoporotic BMSCs. Journal of Biomedical Materials Research Part A, 104 12: 3004-3014. doi:10.1002/jbm.a.35841
Liu, Yang, Zhang, Hongwei, Noonan, Owen, Xu, Chun, Niu, Yuting, Yang, Yannan, Zhou, Liang, Huang, Xiaodan and Yu, Chengzhong (2016) Kinetically controlled assembly of nitrogen-doped invaginated carbon nanospheres with tunable mesopores. Chemistry - A European Journal, 22 42: 14962-14967. doi:10.1002/chem.201602672
Meka, Anand Kumar, Abbaraju, Prasanna Lakshmi, Song, Hao, Xu, Chun, Zhang, Jun, Zhang, Hongwei, Yu, Meihua and Yu, Chengzhong (2016) A vesicle supra-assembly approach to synthesize amine-functionalized hollow dendritic mesoporous silica nanospheres for protein delivery. Small, 12 37: 5169-5177. doi:10.1002/smll.201602052
Binder-free TiO2 monolith-packed pipette tips for the enrichment of phosphorylated peptides
Lei, Chang, Zhou, Liang, Xu, Chun, Sun, Xiaoran, Nouwens, Amanda and Yu, Chengzhong (2016) Binder-free TiO2 monolith-packed pipette tips for the enrichment of phosphorylated peptides. Australian Journal of Chemistry, 69 12: 1396-1401. doi:10.1071/CH16443
Nor, Yusilawati Ahmad, Zhou, Liang, Meka, Anand Kumar, Xu, Chun, Niu, Yuting, Zhang, Hongwei, Mitter, Neena, Mahony, Donna and Yu, Chengzhong (2016) Engineering Iron Oxide Hollow Nanospheres to Enhance Antimicrobial Property: Understanding the Cytotoxic Origin in Organic Rich Environment. Advanced Functional Materials, 26 30: 5408-5418. doi:10.1002/adfm.201601459
Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles
Lei, Chang, Xu, Chun, Nouwens, Amanda and Yu, Chengzhong (2016) Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles. Journal of Materials Chemistry B, 4 29: 4975-4979. doi:10.1039/c6tb01023g
Noonan, Owen, Zhang, Hongwei, Song, Hao, Xu, Chun, Huang, Xiaodan and Yu, Chengzhong (2016) In situ Stöber templating: facile synthesis of hollow mesoporous carbon spheres from silica-polymer composites for ultra-high level in-cavity adsorption. Journal of Materials Chemistry A, 4 23: 9063-9071. doi:10.1039/c6ta02265k
Silica nanopollens enhance adhesion for long-term bacterial inhibition
Song, Hao, Ahmad Nor, Yusilawati, Yu, Meihua, Yang, Yannan, Zhang, Jun, Zhang, Hongwei, Xu, Chun, Mitter, Neena and Yu, Chengzhong (2016) Silica nanopollens enhance adhesion for long-term bacterial inhibition. Journal of the Americal Chemical Society, 138 20: 6455-6462. doi:10.1021/jacs.6b00243
Surfactant-free assembly of mesoporous carbon hollow spheres with large tunable pore sizes
Zhang, Hongwei, Noonan, Owen, Huang, Xiaodan, Yang, Yannan, Xu, Chun, Zhou, Liang and Yu, Chengzhong (2016) Surfactant-free assembly of mesoporous carbon hollow spheres with large tunable pore sizes. ACS Nano, 10 4: 4579-4586. doi:10.1021/acsnano.6b00723
Wang, Yue, Nor, Yusilawati Ahmad, Song, Hao, Yang, Yannan, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2016) Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery. Journal of Materials Chemistry B, 4 15: 2646-2653. doi:10.1039/c6tb00053c
Chang, Ting, Xu, Chun, Wang, Cong-Yi, Fang, Wei, Li, Ying-Jie, Dai, Lin and Long, Xing (2016) The effect of TNF-alpha on the development of degenerative changes in anterior disc displacement of the temporomandibular joint. International Journal of Clinical and Experimental Medicine, 9 3: 5813-5820.
Xu, Chun, Yu, Meihua, Noonan, Owen, Zhang, Jun, Song, Hao, Zhang, Hongwei, Lei, Chang, Niu, Yuting, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2015) Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery. Small, 11 44: 5949-5955. doi:10.1002/smll.201501449
Niu, Yuting, Yu, Meihua, Zhang, Jun, Yang, Yannan, Xu, Chun, Yeh, Michael, Taran, Elena, Hou, Jeff Jia Cheng, Gray, Peter P. and Yu, Chengzhong (2015) Synthesis of silica nanoparticles with controllable surface roughness for therapeutic protein delivery. Journal of Materials Chemistry B, 3 43: 8477-8485. doi:10.1039/c5tb01405k
Ahmad Nor, Yusilawati, Niu, Yuting, Karmakar, Surajit, Zhou, Liang, Xu, Chun, Zhang, Jun, Zhang, Hongwei, Yu, Meihua, Mahony, Donna, Mitter, Neena, Cooper, Matthew and Yu, Cheng Zhong (2015) Shaping nanoparticles with hydrophilic compositions and hydrophobic properties as nanocarriers for antibiotic delivery. ACS Central Science, 1 6: 328-334. doi:10.1021/acscentsci.5b00199
Lei, Chang, Xu, Chun, Noonan, Owen, Meka, Anand Kumar, Zhang, Long, Nouwens, Amanda and Yu, Chengzhong (2015) Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum. Chemical Communications, 51 71: 13642-13645. doi:10.1039/c5cc04458h
Yang, Yannan, Niu, Yuting, Zhang, Jun, Meka, Anand Kumar, Zhang, Hongwei, Xu, Chun, Lin, Chun Xiang Cynthia, Yu, Meihua and Yu, Chengzhong (2015) Biphasic synthesis of large-pore and well-dispersed benzene bridged mesoporous organosilica nanoparticles for intracellular protein delivery. Small, 11 23: 2743-2749. doi:10.1002/smll.201402779
Li, Chunyan, Meng, Gang, Su, Lei, Chen, Aiping, Xia, Mao, Xu, Chun, Yu, Decai, Jiang, Aiqin and Wei, Jiwu (2015) Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma. Oncotarget, 6 3: 1544-1555. doi:10.18632/oncotarget.2838
Floating tablets from mesoporous silica nanoparticles
Abbaraju, Prasanna Lakshmi, Meka, Anand kumar, Jambhrunkar, Siddharth, Zhang, Jun, Xu, Chun, Popat, Amirali and Yu, Chengzhong (2014) Floating tablets from mesoporous silica nanoparticles. Journal of Materials Chemistry B, 2 47: 8298-8302. doi:10.1039/c4tb01337a
Jambhrunkar, Siddharth, Qu, Zhi, Popat, Amirali, Karmakar, Surajit, Xu, Chun and Yu, Chengzhong (2014) Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles. Journal of Colloid and Interface Science, 434 218-225. doi:10.1016/j.jcis.2014.08.019
Sensitive detection of human insulin using a designed combined pore approach
Lei, Chang, Noonan, Owen, Jambhrunkar, Siddharth, Qian, Kun, Xu, Chun, Zhang, Jun, Nouwens, Amanda and Yu, Chengzhong (2014) Sensitive detection of human insulin using a designed combined pore approach. Small, 10 12: 2413-2418. doi:10.1002/smll.201303748
Popat, Amirali, Karmakar, Surajit, Jambhrunkar, Siddharth, Xu, Chun and Yu, Chengzhong (2014) Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids and Surfaces B: Biointerfaces, 117 520-527. doi:10.1016/j.colsurfb.2014.03.005
Rod-like mesoporous silica nanoparticles with rough surfaces for enhanced cellular delivery
Xu, Chun, Niu, Yuting, Popat, Amirali, Jambhrunkar, Siddharth, Karmakar, Surajit and Yu, Chengzhong (2014) Rod-like mesoporous silica nanoparticles with rough surfaces for enhanced cellular delivery. Journal of Materials Chemistry B, 2 3: 253-256. doi:10.1039/c3tb21431a
Chitosan as a barrier membrane material in periodontal tissue regeneration
Xu, Chun, Lei, Chang, Meng, Liuyan, Wang, Changning and Song, Yaling (2012) Chitosan as a barrier membrane material in periodontal tissue regeneration. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100 B 5: 1435-1443. doi:10.1002/jbm.b.32662
Design of Mesoporous Silica Nanoparticles as Drug Carriers
Xu, Chun (2016). Design of Mesoporous Silica Nanoparticles as Drug Carriers PhD Thesis, Aust Institute for Bioengineering & Nanotechnology, The University of Queensland. doi:10.14264/uql.2016.818
Developing sensitive detection nanotechnology to better identify insulin in serum
Lei, Chang, Xu, Chun, Noonan, Owen, Meka, Anand Kumar, Zhang, Long, Nouwens, Amanda and Yu, Chengzhong (2015): Developing sensitive detection nanotechnology to better identify insulin in serum. The Royal Society of Chemistry. Dataset. doi:10.14264/uql.2016.842
(2019) Australian Dental Research Fund Inc
Functional nano-cement scaffolds for the treatment of osteoporotic bone defects
(2018–2021) NHMRC Early Career Fellowships
(2018) Australian Dental Research Fund Inc
Three-Dimensional Printing of Functional Mesoporous Bioceramics for Craniofacial Regeneration
(2017) UQ Early Career Researcher
A new generation of multifunctional nano-structured bone repair materials
Master Philosophy — Associate Advisor
Other advisors:
The potential application of anti- stromal derived factor-1 (SDF-1) antibody and anti-vascular endothelial growth factor (VEGF) antibody for bone regeneration
Doctor Philosophy — Associate Advisor
Other advisors: