Dr Lauren Aoude

UQ Amplify Fellow

The University of Queensland Diamantina Institute
Faculty of Medicine
l.aoude@uq.edu.au
+61 7 344 38027

Overview

Dr Lauren Aoude was awarded a PhD in melanoma genetics from the University of Queensland in 2014. Her research focused on large scale genetic sequencing projects that described novel melanoma predisposition genes. In 2016, Dr Aoude was awarded an NHMRC Early Career Fellowship to investigate precision medicine for the treatment of metastatic melanoma.

Currently, Dr Aoude is a UQ Amplify Fellow in the Surgical Oncology Group at the University of Queensland Diamantina Institute. Her research primarily focuses on ways to better predict treatment responses and outcomes for patients with cancer, particularly melanoma and oesophageal adenocarcinoma. Her research integrates genomic sequencing data from both tumours and circulating tumour DNA with clinical, pathological and imaging information. The results of her research will inform treatment decisions and improve health outcomes for patients through the integration of genomics into the clinic.

Qualifications

  • Bachelor of Arts, The University of Queensland
  • Bachelor of Engineering, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Publications

  • Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors acssensors.1c00358. doi: 10.1021/acssensors.1c00358

  • Aoude, Lauren G., Wong, Bernadette, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B., Koufariotis, Lambros T., Naeini, Marjan M., Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J., Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B. Mark, Waddell, Nicola, Miles, Kenneth and Barbour, Andrew P. (2021). Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients. Molecular Cancer Research, 19 (6) molcanres.1038.2020, 950-956. doi: 10.1158/1541-7786.mcr-20-1038

  • Tiffen, Jessamy, Gallagher, Stuart, Filipp, Fabian, Gunatilake, Dilini, Al Emran, Abdullah, Cullinane, Carleen, Dutton-Register, Ken, Aoude, Lauren, Hayward, Nick, Chatterjee, Aniruddha, Rodger, Euan J., Eccles, Michael R. and Hersey, Peter (2020). EZH2 cooperates with DNA methylation to downregulate key tumour suppressors and interferon gene signatures in melanoma. The Journal of Investigative Dermatology, 140 (12), 2442-2454.e5. doi: 10.1016/j.jid.2020.02.042

View all Publications

Grants

View all Grants

Publications

Journal Article

  • Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors acssensors.1c00358. doi: 10.1021/acssensors.1c00358

  • Aoude, Lauren G., Wong, Bernadette, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B., Koufariotis, Lambros T., Naeini, Marjan M., Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J., Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B. Mark, Waddell, Nicola, Miles, Kenneth and Barbour, Andrew P. (2021). Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients. Molecular Cancer Research, 19 (6) molcanres.1038.2020, 950-956. doi: 10.1158/1541-7786.mcr-20-1038

  • Tiffen, Jessamy, Gallagher, Stuart, Filipp, Fabian, Gunatilake, Dilini, Al Emran, Abdullah, Cullinane, Carleen, Dutton-Register, Ken, Aoude, Lauren, Hayward, Nick, Chatterjee, Aniruddha, Rodger, Euan J., Eccles, Michael R. and Hersey, Peter (2020). EZH2 cooperates with DNA methylation to downregulate key tumour suppressors and interferon gene signatures in melanoma. The Journal of Investigative Dermatology, 140 (12), 2442-2454.e5. doi: 10.1016/j.jid.2020.02.042

  • Aoude, Lauren G., Bonazzi, Vanessa F., Brosda, Sandra, Patel, Kalpana, Koufariotis, Lambros T., Oey, Harald, Nones, Katia, Wood, Scott, Pearson, John V., Lonie, James M., Arneil, Melissa, Atkinson, Victoria, Smithers, B. Mark, Waddell, Nicola and Barbour, Andrew P. (2020). Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients. Scientific Reports, 10 (1) 17687, 17687. doi: 10.1038/s41598-020-74956-3

  • Law, Matthew H., Aoude, Lauren G., Duffy, David L., Long, Georgina V., Johansson, Peter A., Pritchard, Antonia L., Khosrotehrani, Kiarash, Mann, Graham J., Montgomery, Grant W., Iles, Mark M., Cust, Anne E., Palmer, Jane M., Melanoma GWAS Consortium, Shannon, Kerwin F., Spillane, Andrew J., Stretch, Jonathan R., Thompson, John F., Saw, Robyn P. M., Scolyer, Richard A., Martin, Nicholas G., Hayward, Nicholas K. and MacGregor, Stuart (2020). Multiplex melanoma families are enriched for polygenic risk. Human Molecular Genetics, 29 (17), 2976-2985. doi: 10.1093/hmg/ddaa156

  • Newell, Felicity, Patel, Kalpana, Gartside, Michael, Krause, Lutz, Brosda, Sandra, Aoude, Lauren G., Loffler, Kelly A., Bonazzi, Vanessa F., Patch, Ann-Marie, Kazakoff, Stephen H., Holmes, Oliver, Xu, Qinying, Wood, Scott, Leonard, Conrad, Lampe, Guy, Lord, Reginald V., Whiteman, David C., Pearson, John V., Nones, Katia, Waddell, Nicola and Barbour, Andrew P. (2019). Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples. BMC Medical Genomics, 12 (1) 31, 31. doi: 10.1186/s12920-019-0476-9

  • Johansson, Peter, Aoude, Lauren G., Wadt, Karin, Glasson, William J., Warrier, Sunil K., Hewitt, Alex W., Kiilgaard, Jens Folke, Heegaard, Steffen, Isaacs, Tim, Franchina, Maria, Ingvar, Christian, Vermeulen, Tersia, Whitehead, Kevin J., Schmidt, Christopher W., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2016). Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. Oncotarget, 7 (4), 4624-4631. doi: 10.18632/oncotarget.6614

  • Harland, Mark, Petljak, Mia, Robles-Espinoza, Carla Daniela, Ding, Zhihao, Gruis, Nelleke A., van Doorn, Remco, Pooley, Karen A., Dunning, Alison M., Aoude, Lauren G., Wadt, Karin A. W., Gerdes, Anne-Marie, Brown, Kevin M., Hayward, Nicholas K., Newton-Bishop, Julia A., Adams, David J. and Bishop, D. Timothy (2016). Germline TERT promoter mutations are rare in familial melanoma. Familial Cancer, 15 (1), 139-144. doi: 10.1007/s10689-015-9841-9

  • Wadt, K. A. W., Aoude, L. G., Johansson, P., Solinas, A., Pritchard, A., Crainic, O., Andersen, M. T., Kiilgaard, J. F., Heegaard, S., Sunde, L., Federspiel, B., Madore, J., Thompson, J. F., Mccarthy, S. W., Goodwin, A., Tsao, H., Jonsson, G., Busam, K., Gupta, R., Trent, J. M., Gerdes, A. -M., Brown, K. M., Scolyer, R. A. and Hayward, N. K. (2015). A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clinical Genetics, 88 (3), 267-272. doi: 10.1111/cge.12501

  • Aoude, Lauren G., Heitzer, Ellen, Johansson, Peter, Gartside, Michael, Wadt, Karin, Pritchard, Antonia L., Palmer, Jane M., Symmons, Judith, Gerdes, Anne-Marie, Montgomery, Grant W., Martin, Nicholas G., Tomlinson, Ian, Kearsey, Stephen and Hayward, Nicholas K. (2015). POLE mutations in families predisposed to cutaneous melanoma. Familial Cancer, 14 (4), 621-628. doi: 10.1007/s10689-015-9826-8

  • Wadt, Karin A. W., Aoude, Lauren G., Golmard, Lisa, Hansen, Thomas V. O., Sastre-Garau, Xavier, Hayward, Nicholas K. and Gerdes, Anne-Marie (2015). Germline RAD51B truncating mutation in a family with cutaneous melanoma. Familial Cancer, 14 (2), 337-340. doi: 10.1007/s10689-015-9781-4

  • Aoude, Lauren G., Gartside, Michael, Johansson, Peter, Palmer, Jane M., Symmons, Judith, Martin, Nicholas G., Montgomery, Grant W. and Hayward, Nicholas K. (2015). Prevalence of germline BAP1, CDKN2A, and CDK4 mutations in an australian population-based sample of cutaneous melanoma cases. Twin Research and Human Genetics, 18 (2), 126-133. doi: 10.1017/thg.2015.12

  • Aoude, Lauren G, Wadt, A.W, Pritchard, Antonia L and Hayward, Nicholas K (2015). Genetics of familial melanoma: 20 years after CDKN2A. Pigment Cell and Melanoma Research, 28 (2), 148-160. doi: 10.1111/pcmr.12333

  • Wadt, Karin A. W., Aoude, Lauren G., Krogh, Lotte, Sunde, Lone, Bojesen, Anders, Gronskov, Karen, Wartacz, Nine, Ek, Jakob, Tolstrup-Andersen, Morten, Klarskov-Andersen, Mette, Borg, Ake, Heegaard, Steffen, Kiilgaard, Jens F., Hansen, Thomas V. O., Klein, Kerenaftali, Jonsson, Goran, Drzewiecki, Krzysztof T., Duno, Morten, Hayward, Nicholas K. and Gerdes, Anne-Marie (2015). Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition. PLoS One, 10 (3) e0122662, e0122662.1-e0122662.16. doi: 10.1371/journal.pone.0122662

  • Aoude, Lauren G., Pritchard, Antonia L., Robles-Espinoza, Carla Daniela, Wadt, Karin, Harland, Mark, Choi, Jiyeon, Gartside, Michael, Quesada, Victor, Johansson, Peter, Palmer, Jane M., Ramsay, Andrew J., Zhang, Xijun, Jones, Kristine, Symmons, Judith, Holland, Elizabeth A., Schmid, Helen, Bonazzi, Vanessa, Woods, Susan, Dutton-Regester, Ken, Stark, Mitchell S., Snowden, Helen, van Doom, Remco, Montgomery, Grant W., Martin, Nicholas G., Keane, Thomas M., Lopez-Otin, Carlos, Gerdes, Anne-Marie, Olsson, Hakan, Ingvar, Christian ... Hayward, Nicholas K. (2015). Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. Journal of the National Cancer Institute, 107 (2) dju408, 1-7. doi: 10.1093/jnci/dju408

  • Aoude, Lauren G., Xu, Mai, Zhao, Zhen Zhen, Kovacs, Michael, Palmer, Jane M., Johansson, Peter, Symmons, Judith, Trent, Jeffrey M., Martin, Nicholas G., Montgomery, Grant W., Brown, Kevin M. and Hayward, Nicholas K. (2014). Assessment of PALB2 as a candidate melanoma susceptibility gene. PLoS One, 9 (6) e100683, e100683.1-e100683.7. doi: 10.1371/journal.pone.0100683

  • Robles-Espinoza, Carla Daniela, Harland, Mark, Ramsay, Andrew J, Aoude, Lauren G, Quesada, Víctor, Ding, Zhihao, Pooley, Karen A, Pritchard, Antonia L, Tiffen, Jessamy C, Petljak, Mia, Palmer, Jane M, Symmons, Judith, Johansson, Peter, Stark, Mitchell S., Gartside, Michael G, Snowden, Helen, Montgomery, Grant W, Martin, Nicholas G, Liu, Jimmy Z, Choi, Jiyeon, Makowski, Matthew, Brown, Kevin M, Dunning, Alison M, Keane, Thomas M, Lopez-Otin, Carlos, Gruis, Nelleke A, Hayward, Nicholas K, Bishop, D Timothy, Newton-Bishop, Julia A and Adams, David J (2014). POT1 loss-of-function variants predispose to familial melanoma. Nature Genetics, 46 (5), 478-481. doi: 10.1038/ng.2947

  • Dutton-Regester, K., Kakavand, H., Aoude, L.G., Stark, M.S., Gartside, M.G., Johansson, P., O'Connor, L., Lanagan, C., Tembe, V., Pupo, G.M., Haydu, L.E., Schmidt, C.W., Mann, G.J., Thompson, J.F., Scolyer, R.A. and Hayward, N.K. (2013). Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma. Pigment Cell and Melanoma Research, 26 (6), 852-860. doi: 10.1111/pcmr.12153

  • Cronin, J.C., Watkins-Chow, D.E., Incao, A., Hasskamp, J.H., Schonewolf, N., Aoude, L.G., Hayward, N.K., Bastian, B.C., Dummer, R., Loftus, S.K. and Pavan, W.J. (2013). SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Research, 73 (18), 5709-5718. doi: 10.1158/0008-5472.CAN-12-4620

  • Aoude, Lauren G., Wadt, Karin, Bojesen, Anders, Cruger, Dorthe, Borg, Ake, Trent, Jeffrey M., Brown, Kevin M., Gerdes, Anne-Marie, Jonsson, Goran and Hayward, Nicholas K. (2013). A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers. PloS One, 8 (8) e72144, e72144. doi: 10.1371/journal.pone.0072144

  • Aoude, Lauren G., Vajdic, Claire M., Kricker, Anne, Armstrong, Bruce and Hayward, Nicholas K. (2013). Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases. Pigment Cell and Melanoma Research, 26 (2), 1-3. doi: 10.1111/pcmr.12046

  • Dutton-Regester, Ken, Aoude, Lauren G., Nancarrow, Derek J., Stark, Mitchell S., O'Connor, Linda, Lanagan, Cathy, Pupo, Gulietta M., Tembe, Varsha, Carter, Candace D., O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012). Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. Genes Chromosomes and Cancer, 51 (5), 452-461. doi: 10.1002/gcc.21932

  • Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 2: 165-169. doi:10.1038/ng.1041

  • Dutton-Regester, Ken, Irwin, Darryl, Hunt, Priscilla, Aoude, Lauren G., Tembe, Varsha, Pupo, Gulietta M., Lanagan, Cathy, Carter, Candace D., O'Connor, Linda, O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012). A high-throughput panel for identifying clinically relevant mutation profiles in melanoma. Molecular Cancer Therapeutics, 11 (4), 888-897. doi: 10.1158/1535-7163.MCT-11-0676

  • Yokoyama, Satoru, Woods, Susan L., Boyle, Glen M., Aoude, Lauren G., MacGregor, Stuart, Zismann, Victoria, Gartside, Michael, Cust, Anne E., Haq, Rizwan, Harland, Mark, Taylor, John C., Duffy, David L., Holohan, Kelly, Dutton-Regester, Ken, Palmer, Jane M., Bonazzi, Vanessa, Stark, Mitchell S., Symmons, Judith, Law, Matthew H., Schmidt, Christopher, Lanagan, Cathy, O'Connor, Linda, Holland, Elizabeth A., Schmid, Helen, Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Jenkins, Mark A., Kefford, Richard F. ... Brown, Kevin M. (2011). A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature, 480 (7375), 99-103. doi: 10.1038/nature10630

  • Bonazzi, Vanessa F., Nancarrow, Derek J., Stark, Mitchell S., Moser, Ralf J., Boyle, Glen M., Aoude, Lauren G., Schmidt, Christopher and Hayward, Nicholas K. (2011). Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. PLoS One, 6 (10) e26121, 1-9. doi: 10.1371/journal.pone.0026121

  • Boyle, Glen M., Woods, Susan L., Bonazzi, Vanessa F., Stark, Mitchell S., Hacker, Elke, Aoude, Lauren G., Dutton-Regester, Ken, Cook, Anthony L., Sturm, Richard A. and Hayward, Nicholas K. (2011). Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell and Melanoma Research, 24 (3), 525-537. doi: 10.1111/j.1755-148X.2011.00849.x

  • Whiteman, D.C., Parmar, P., Fahey, P., Moore, S.P., Stark, M., Zhao, Z.Z., Montgomery, G.W., Green, A.C., Hayward, N.K., Webb, P.M., Australian Cancer Study and Aoude, Lauren (2010). Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers. Gastroenterology, 139 (1), 73-83. doi: 10.1053/j.gastro.2010.04.009

Conference Publication

  • Hayward, N., Pritchard, A., Johansson, P., Aoude, L., Jonsson, G., Hoiom, V. and Wadt, K. (2017). Novel germline variants in cutaneous and uveal melanoma families. 13th Congress of the European Association of Dermato‐Oncology (EADO), Athens, Greece, 3–6 May 2017. Hoboken, NJ United States: Wiley.

  • Hayward, N., Pritchard, A., Johansson, P., Aoude, L., Jonsson, G., Hoiom, V., Wadt, K. and Adams, D. (2017). Novel high risk genes of melanoma. 13th Congress of the European Association of Dermato‐Oncology (EADO), Athens, Greece, 3–6 May 2017. Hoboken, NJ United States: Wiley.

  • Aoude, L., Ferguson, B., Gordon, V., Johns, J., Maslovskaya, L., Parsons, P., Pierce, C., Reddell, P., Savchenko, A. and Williams, C. (2008). Cell culture-based assays identify edible rainforest fruits with potential for chemoprevention of cancer. 4th Australian Health and Medical Research Congress, Brisbane, Australia, 16-21 November 2008. Sydney, Australia: AHMRC.

Other Outputs

Grants (Administered at UQ)