Dr Lachlan Rash

Senior Lecturer

School of Biomedical Sciences
Faculty of Medicine
l.rash@uq.edu.au
+61 7 336 52745

Overview

Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.

Qualifications

  • Bachelor of Science, Monash University
  • Doctor of Philosophy, Monash University

Publications

  • Schendel, , Rash, , Jenner, and Undheim, (2019) The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution. Toxins, 11 11: 666. doi:10.3390/toxins11110666

  • Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W, Becirovic, Elvir, Biel, Martin, Catterall, William A, Conner, Alex C, Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, George, Chandy, Goldstein, Steve AN, Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike, Jensen, Anders A, Kaczmarek, Leonard K, Kellenberger, Stephan, Kennedy, Charles, King, Brian, Lynch, Joseph W, Perez-Reyes, Edward, Plant, Leigh D, Rash, Lachlan D, Ren, Dejian, Sivilotti, Lucia G, Smart, Trevor G, Snutch, Terrance P, Tian, Jinbin, Van den Eynde, Charlotte, Vriens, Joris, Wei, Aguan D, Winn, Brenda T, Wulff, Heike, Xu, Haoxing, Yue, Lixia, Zhang, Xiaoli, Zhu, Michael and , (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels. British Journal of Pharmacology, 176 S1: . doi:10.1111/bph.14749

  • Kellenberger, Stephan, Rash, Lachlan D. and Schild, Laurent (2019) Acid-sensing (proton-gated) ion channels (ASICs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 4: . doi:10.2218/gtopdb/f118/2019.4

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Rash, Lachlan D. (2017). Acid-sensing ion channel pharmacology, past, present, and future …. In Dominic P. Geraghty and Lachlan D. Rash (Ed.), Ion Channels DownUnder (pp. 35-66) Maryland Heights, MO, United States: Academic Press. doi:10.1016/bs.apha.2017.02.001

  • Mobli, Mehdi, Undheim, Eivind A. B. and Rash, Lachlan D. (2017). Modulation of ion channels by cysteine-rich peptides: from sequence to structure. In Dominic P. Geraghty and Lachlan D. Rash (Ed.), Ion channels downunder (pp. 199-223) Cambridge, MA, United States: Academic Press. doi:10.1016/bs.apha.2017.03.001

  • Geraghty, Dominic P. and Rash, Lachlan D. (2017). Preface. In Dominic P. Geraghty and Lachlan D. Rash (Ed.), Ion Channels DownUnder (pp. xi-xii) Cambridge, MA, United States: Academic Press. doi:10.1016/S1054-3589(17)30052-2

  • Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D., Reeks, T. and Sunagar, K. (2015). Research methods. In Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery (pp. 153-214) New York, NY, United States: Oxford University Press.

  • Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. In Glenn F. King (Ed.), Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics (pp. 221-244) Cambridge, United Kingdom: Royal Society of Chemistry.. doi:10.1039/9781849737876-00221

Journal Article

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision