Postdoctoral Research Fellow
Overview
Research Interests
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Innate Immune Responses of Macrophages in Cystic Fibrosis (CF)
Understanding the impaired immune responses of CF macrophages at cellular and molecular level.
Qualifications
- Bachelor of Science (Biochemistry) (Honours), University of Dhaka
- Master of Science(Biochemistry), University of Dhaka
- Master of Science (Infection & Immunity), Erasmus University Rotterdam
- Doctor of Philosophy, The University of Queensland
Publications
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Journal Article: Cytotoxic and bactericidal effects of inhalable ciprofloxacin-loaded poly(2-ethyl-2-oxazoline) nanoparticles with traces of zinc oxide
Sabuj, Mohammad Zaidur Rahman, Huygens, Flavia, Spann, Kirsten M., Tarique, Abdullah A., Dargaville, Tim R., Will, Geoffrey, Wahab, Md Abdul and Islam, Nazrul (2023). Cytotoxic and bactericidal effects of inhalable ciprofloxacin-loaded poly(2-ethyl-2-oxazoline) nanoparticles with traces of zinc oxide. International Journal of Molecular Sciences, 24 (5) 4532, 1-23. doi: 10.3390/ijms24054532
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Journal Article: Anti-inflammatory effects of lenabasum, a cannabinoid receptor type 2 agonist, on macrophages from cystic fibrosis
Tarique, Abdullah A., Evron, Tama, Zhang, George, Tepper, Mark A., Morshed, Mohammed M., Andersen, Isabella S.G., Begum, Nelufa, Sly, Peter D. and Fantino, Emmanuelle (2020). Anti-inflammatory effects of lenabasum, a cannabinoid receptor type 2 agonist, on macrophages from cystic fibrosis. Journal of Cystic Fibrosis, 19 (5), 823-829. doi: 10.1016/j.jcf.2020.03.015
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Conference Publication: Kinetic expression of genes and receptors during monocyte to macrophage differentiation in cystic fibrosis
Morshed, M., Tarique, A., Sly, P., Bell, S., Wainwright, C. and Fantino, E. (2019). Kinetic expression of genes and receptors during monocyte to macrophage differentiation in cystic fibrosis. TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Gold Coast, Australia, 29 March–2 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13492
Grants
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(2022–2024) Preclinical and Clinical Early Career Research
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Zinc supplementation to enhance bacterial killing ability of macrophages from cystic fibrosis (CF)
(2021–2022) Preclinical and Clinical Early Career Research
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(2020–2022) Australian Cystic Fibrosis Research Trust Innovation Grant
Supervision
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Investigating the molecular mechanisms of macrophage polarisation
(2022) Master Philosophy
Available Projects
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Developing CFTR knockout monocytic cell lines.
CF macrophages and monocytes (the precursor cells of macrophages) were functionally defective in CF in many aspects due to mutation(s) in CFTR gene. Inavailability of patient's specimen is scarce which creates a bar in CF macrophage research. This project aims to create a CFTR-KO human monocytic cell line using CRISPR-Cas9 technology. We anticipate that this CFTR-KO cell line will provide unlimited supply of CFTR-KO macrophages for research. The project will suit to honors students with strong interest in cell and molecular biology. Basic laboratory knowledge including cell culture, real-time PCR, western blot would be helpful.
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Improving bacteria killing ability of cystic fibrosis (CF) macrophages.
Bacteria killing ability of CF macrophages are known to be defective to extracellular bacteria. There is limited knowledge that how CF macrophages fight against intracellular bacteria. M. abscessus (MABS), an intracellular organism, is increasingly found in the CF lungs. Using MABS as a model pathogen, we aim to investigate how CF macrophages are defective in killing and clearance of intracellular bacteria and whether MABS killing ability can be enhanced by treating CF macrophages with a range of potential therapeutic agents. Basic laboratory knowledge including cell culture, bacterial culture, real-time PCR, western blot would be helpful.
-
Finding ways to improve mitochondrial dysfunctions in CF.
Mitochondria play crucial roles in killing and clearance of intracellular pathogens. Defective mitochondrial responses to respiratory bacteria had previously been observed in CFTR-KO zebrafish model and epithelial cells. This project aims to
- understand how CFTR mutation(s) downregulate mitochondrial responses in macrophages obtained from CF patients,
- test a number of potential therapeutic agents whether they could improve mitochondrial defence mechanism in CF macrophages.
Publications
Book Chapter
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Breeding rice for salinity tolerance using the Pokkali allele: Finding a linked DNA marker
Elahi, C. M. F., Seraj, Z. I., Rasul, N. M., Tarique, A. A., Das, K. C., Biswas, K., Salam, M. A., Gomosta, A. R., Tumimbang, E., Adorada, D., Gregori, G. and Bennett, J. (2004). Breeding rice for salinity tolerance using the Pokkali allele: Finding a linked DNA marker. In vitro culture transformation and molecular markers for crop improvement. (pp. 157-170) edited by A. S. Islam. Boca Raton, FL, United States: CRC Press.
Journal Article
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Sabuj, Mohammad Zaidur Rahman, Huygens, Flavia, Spann, Kirsten M., Tarique, Abdullah A., Dargaville, Tim R., Will, Geoffrey, Wahab, Md Abdul and Islam, Nazrul (2023). Cytotoxic and bactericidal effects of inhalable ciprofloxacin-loaded poly(2-ethyl-2-oxazoline) nanoparticles with traces of zinc oxide. International Journal of Molecular Sciences, 24 (5) 4532, 1-23. doi: 10.3390/ijms24054532
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Tarique, Abdullah A., Evron, Tama, Zhang, George, Tepper, Mark A., Morshed, Mohammed M., Andersen, Isabella S.G., Begum, Nelufa, Sly, Peter D. and Fantino, Emmanuelle (2020). Anti-inflammatory effects of lenabasum, a cannabinoid receptor type 2 agonist, on macrophages from cystic fibrosis. Journal of Cystic Fibrosis, 19 (5), 823-829. doi: 10.1016/j.jcf.2020.03.015
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TLR crosstalk activates LRP1 to recruit Rab8a and PI3Kγ for suppression of inflammatory responses
Luo, Lin, Wall, Adam A., Tong, Samuel J., Hung, Yu, Xiao, Zhijian, Tarique, Abdullah A., Sly, Peter D., Fantino, Emmanuelle, Marzolo, María-Paz and Stow, Jennifer L. (2018). TLR crosstalk activates LRP1 to recruit Rab8a and PI3Kγ for suppression of inflammatory responses. Cell Reports, 24 (11), 3033-3044. doi: 10.1016/j.celrep.2018.08.028
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Differential expression of genes and receptors in monocytes from patients with cystic fibrosis
Tarique, Abdullah A., Sly, Peter D., Cardenas, Diana G., Luo, Lin, Stow, Jennifer L., Bell, Scott C., Wainwright, Claire E. and Fantino, Emmanuelle (2018). Differential expression of genes and receptors in monocytes from patients with cystic fibrosis. Journal of Cystic Fibrosis, 18 (3), 342-348. doi: 10.1016/j.jcf.2018.07.012
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CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis
Tarique, Abdullah A., Sly, Peter D., Holt, Patrick G., Bosco, Anthony, Ware, Robert S., Logan, Jayden, Bell, Scott C., Wainwright, Claire E. and Fantino, Emmanuelle (2017). CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis. Journal of Cystic Fibrosis, 16 (4), 475-482. doi: 10.1016/j.jcf.2017.03.011
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Tarique, Abdullah A., Logan, Jayden, Thomas, Emma, Holt, Patrick G., Sly, Peter D. and Fantino, Emmanuelle (2015). Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages. American Journal of Respiratory Cell and Molecular Biology, 53 (5), 676-688. doi: 10.1165/rcmb.2015-0012OC
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Tarique, A. A., Kalsy, A., Arifuzzaman, M., Rollins, S. M., Charles, R. C., Leung, D. T., Harris, J. B., LaRocque, R. C., Sheikh, A., Bhuiyan, M. S., Saksena, R., Clements, J. D., Calderwood, S. B., Qadri, F., Kovac, P. and Ryan, E. T. (2012). Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice. Clinical and Vaccine Immunology, 19 (4), 594-602. doi: 10.1128/CVI.05689-11
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Bishop, Anne L., Tarique, Abdullah A., Patimalla, Bharathi, Calderwood, Stephen B., Qadri, Firdausi and Camilli, Andrew (2012). Immunization of mice with Vibrio cholerae outer-membrane vesicles protects against hyperinfectious challenge and blocks transmission. Journal of Infectious Diseases, 205 (3), 412-421. doi: 10.1093/infdis/jir756
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Matsuda, F., Chowdhury, M. I., Saha, A., Asahara, T., Nomoto, K., Tarique, A. A., Ahmed, T., Nishibuchi, M., Cravioto, A. and Qadri, F. (2011). Evaluation of a probiotics, Bifidobacterium breve BBG-01, for enhancement of immunogenicity of an oral inactivated cholera vaccine and safety: a randomized, double-blind, placebo-controlled trial in Bangladeshi children under 5 years of age. Vaccine, 29 (10), 1855-1858. doi: 10.1016/j.vaccine.2010.12.133
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Sheikh, Alaullah, Shamsuzzaman, Sohel, Ahmad, Shaikh Meshbahuddin, Nasrin, Dilruba, Nahar, Setarun, Alam, Mohammad Murshid, Al Tarique, Abdullah, Begum, Yasmin Ara, Qadri, Syed Saleheen, Chowdhury, Mohiul Islam, Saha, Amit, Larson, Charles P. and Qadri, Firdausi (2010). Zinc influences innate immune responses in children with enterotoxigenic Escherichia coli-induced diarrhea. Journal of Nutrition, 140 (5), 1049-1056. doi: 10.3945/jn.109.111492
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Kendall, Emily A., Tarique, Abdullah A., Hossain, Azim, Alam, Mohammad Murshid, Arifuzzaman, Mohammad, Akhtar, Nayeema, Chowdhury, Fahima, Khan, Ashraful I., LaRocque, Regina C., Harris, Jason B., Ryan, Edward T., Qadri, Firdausi and Calderwood, Stephen B. (2010). Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh. Infection and Immunity, 78 (1), 253-259. doi: 10.1128/IAI.00868-09
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Memory T-cell responses to Vibrio cholerae O1 infection
Weil, Ana A., Arifuzzaman, Mohammad, Bhuiyan, Taufiqur R., LaRocque, Regina C., Harris, Aaron M., Kendall, Emily A., Hossain, Azim, Tarique, Abdullah A., Sheikh, Alaullah, Chowdhury, Fahima, Khan, Ashraful I., Murshed, Farhan, Parker, Kenneth C., Banerjee, Kalyan K., Ryan, Edward T., Harris, Jason B., Qadri, Firdausi and Calderwood, Stephen B. (2009). Memory T-cell responses to Vibrio cholerae O1 infection. Infection and Immunity, 77 (11), 5090-5096. doi: 10.1128/IAI.00793-09
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Charles, Richelle C., Harris, Jason B., Chase, Michael R., Lebrun, Lauren M., Sheikh, Alaullah, LaRocque, Regina C., Logvinenko, Tanya, Rollins, Sean M., Tarique, Abdullah, Hohmann, Elizabeth L., Rosenberg, Ian, Krastins, Bryan, Sarracino, David A., Qadri, Firdausi, Calderwood, Stephen B. and Ryan, Edward T. (2009). Comparative proteomic analysis of the PhoP regulon in Salmonella enterica Serovar Typhi versus Typhimurium. Plos One, 4 (9) e6994, e6994. doi: 10.1371/journal.pone.0006994
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Ahmed, Tanvir, Svennerholm, Ann-Mari, Tarique, Abdullah Al, Sultana, Gazi N.N. and Qadri, Firdausi (2009). Enhanced immunogenicity of an oral inactivated cholera vaccine in infants in Bangladesh obtained by zinc supplementation and by temporary withholding breast-feeding. Vaccine, 27 (9), 1433-1439. doi: 10.1016/j.vaccine.2008.12.036
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Qadri, Firdausi, Saha, Amit, Ahmed, Tanvir, Al Tarique, Abdullah, Begum, Yasmin Ara and Svennerholm, Ann-Mari (2007). Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh. Infection and Immunity, 75 (8), 3961-3968. doi: 10.1128/IAI.00459-07
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Qadri, Firdausi, Chowdhury, Mohiul I., Faruque, Shah M., Salam, Mohammed A., Ahmed, Tanvir, Begum, Yasmin A., Saha, Amit, Al Tarique, Abdullah, Seidlein, Lorenz V., Park, Eunsik, Killeen, Kevin P., Mekalanos, John J., Clemens, John D. and Sack, David A. (2007). Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants. Vaccine, 25 (2), 231-238. doi: 10.1016/j.vaccine.2006.08.031
Conference Publication
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Morshed, M., Tarique, A., Sly, P., Bell, S., Wainwright, C. and Fantino, E. (2019). Kinetic expression of genes and receptors during monocyte to macrophage differentiation in cystic fibrosis. TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Gold Coast, Australia, 29 March–2 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13492
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Wainwright, C., Tarique, A., Sly, P., Bell, S. and Fantino, E. (2019). Modulation of macrophage polarization and function in patients with cystic fibrosis by mutation-independent immunomodulatory compounds. TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Gold Coast, Australia, 29 March–2 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13492
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Macrophages - the forgotten cells in cystic fibrosis
Tarique, Abdullah A. (2018). Macrophages - the forgotten cells in cystic fibrosis. The 32nd Annual North American Cystic Fibrosis Conference, Denver, Colorado, United States, October 18–20, 2018. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/ppul.24151
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CFTR-dependent deficiency in alternatively-activated macrophages in cystic fibrosis
Tarique, Abdullah, Sly, Peter, Holt, Patrick, Bosco, Anthony, Ware, Robert, Logan, Jayden, Bell, Scott, Wainwright, Claire and Fantino, Emmanuelle (2016). CFTR-dependent deficiency in alternatively-activated macrophages in cystic fibrosis. ERS Lung Science Conference 2016, Estoril, Portugal, 10 - 13 March 2016. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2016.PA4856
Other Outputs
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Macrophage Polarization and Function in Cystic Fibrosis
Al Tarique, Abdullah (2016). Macrophage Polarization and Function in Cystic Fibrosis. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2016.680
Grants (Administered at UQ)
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(2022–2024) Preclinical and Clinical Early Career Research
-
Zinc supplementation to enhance bacterial killing ability of macrophages from cystic fibrosis (CF)
(2021–2022) Preclinical and Clinical Early Career Research
-
(2020–2022) Australian Cystic Fibrosis Research Trust Innovation Grant
-
Improving the ability of CF macrophages to handle mycobacterium abscessus (MABS)
(2020–2022) Vertex Innovation Awards
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Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMAT)
(2019–2022) Cystic Fibrosis Foundation USA
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Molecular mechanism of defective anti-inflammatory responses by macrophages in cystic fibrosis (CF)
(2017) Australian Cystic Fibrosis Research Trust
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Linking childhood asthma and obesity through macrophages
(2016–2017) RL Cooper Medical Research Foundation Limited
PhD and MPhil Supervision
Completed Supervision
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Investigating the molecular mechanisms of macrophage polarisation
(2022) Master Philosophy — Associate Advisor
Other advisors:
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
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Developing CFTR knockout monocytic cell lines.
CF macrophages and monocytes (the precursor cells of macrophages) were functionally defective in CF in many aspects due to mutation(s) in CFTR gene. Inavailability of patient's specimen is scarce which creates a bar in CF macrophage research. This project aims to create a CFTR-KO human monocytic cell line using CRISPR-Cas9 technology. We anticipate that this CFTR-KO cell line will provide unlimited supply of CFTR-KO macrophages for research. The project will suit to honors students with strong interest in cell and molecular biology. Basic laboratory knowledge including cell culture, real-time PCR, western blot would be helpful.
-
Improving bacteria killing ability of cystic fibrosis (CF) macrophages.
Bacteria killing ability of CF macrophages are known to be defective to extracellular bacteria. There is limited knowledge that how CF macrophages fight against intracellular bacteria. M. abscessus (MABS), an intracellular organism, is increasingly found in the CF lungs. Using MABS as a model pathogen, we aim to investigate how CF macrophages are defective in killing and clearance of intracellular bacteria and whether MABS killing ability can be enhanced by treating CF macrophages with a range of potential therapeutic agents. Basic laboratory knowledge including cell culture, bacterial culture, real-time PCR, western blot would be helpful.
-
Finding ways to improve mitochondrial dysfunctions in CF.
Mitochondria play crucial roles in killing and clearance of intracellular pathogens. Defective mitochondrial responses to respiratory bacteria had previously been observed in CFTR-KO zebrafish model and epithelial cells. This project aims to
- understand how CFTR mutation(s) downregulate mitochondrial responses in macrophages obtained from CF patients,
- test a number of potential therapeutic agents whether they could improve mitochondrial defence mechanism in CF macrophages.
