The University of Queensland

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312

Fibrillin-1 and asprosin, novel players in metabolic syndrome

Summers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)

Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784

CSF1R as a therapeutic target in bone diseases: obvious but not so simple

Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4

Building a case for pancreas and liver targeted intereukin-22 therapy in fatty liver disease

Sajiir, Haressh, Wong, Kuan Yau, Mueller, Alexandra, Keshvari, Sahar, Wang, Ran, Wiid, Percival, Ramm, Grant, Macdonald, Graeme, Prins, John, McGuckin, Michael and Hasnain, Sumaira (2022). Building a case for pancreas and liver targeted intereukin-22 therapy in fatty liver disease. Journal of Hepatology, 77 (Supplement 1), S190-S191. doi: 10.1016/s0168-8278(22)00756-5

Editorial: Adipose Tissue in Obesity and Metabolic Disease

Keshvari, Sahar, Ceddia, Ryan P., Rajbhandari, Prashant, Chaurasia, Bhagirath and Bond, Simon T. (2022). Editorial: Adipose Tissue in Obesity and Metabolic Disease. Frontiers in Physiology, 13 898861. doi: 10.3389/fphys.2022.898861

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective

Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605

The mononuclear phagocyte system of the rat

Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136

Ex vivo glucocorticoid-induced secreted proteome approach for discovery of glucocorticoid-responsive proteins in human serum

Inder, Warrick J., Mohamed, Ahmed, Keshvari, Sahar, Barclay, Johanna L., Ruelcke, Jayde E., Stoll, Thomas, Nolan, Brendan J., Cesana-Nigro, Nicole and Hill, Michelle M. (2021). Ex vivo glucocorticoid-induced secreted proteome approach for discovery of glucocorticoid-responsive proteins in human serum. Proteomics - Clinical Applications, 15 (2-3) 2000078, 2000078. doi: 10.1002/prca.202000078

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268

The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans

Cesana-Nigro, Nicole, Keshvari, Sahar, Barclay, Johanna L., Sorbello, Jane, Upham, John W., Benham, Helen, Anderson, Stephen T., Steiger, Natasha, Prins, Johannes B. and Inder, Warrick J. (2019). The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans. Clinical Endocrinology, 91 (6) cen.14108, 728-736. doi: 10.1111/cen.14108

Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene

Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Borg, Danielle J., Yap, Felicia Y. T., Keshvari, Sahar, Simmons, David G., Gallo, Linda A., Fotheringham, Amelia K., Zhuang, Aowen, Slattery, Robyn M., Hasnain, Sumaira Z., Coughlan, Melinda T., Kantharidis, Phillip and Forbes, Josephine M. (2017). Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets, 10 (1), 10-24. doi: 10.1080/19382014.2017.1405189

Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins

Fercher, Christian, Keshvari, Sahar, McGuckin, Michael A and Barnard, Ross T (2017). Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental biology and medicine (Maywood, N.J.), 243 (2), 166-183. doi: 10.1177/1535370217748575

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects

Keshvari, Sahar, Henstridge, Darren C., Ng, Choaping, Febbraio, Mark A. and Whitehead, Jonathan P. (2017). Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects. Scientific Reports, 7 (1) 41792, 41792. doi: 10.1038/srep41792

Development of an enzyme-linked immunosorbent assay for thrombospondin-1 and comparison of human plasma and serum concentrations

Barclay, Johanna L., Keshvari, Sahar, Whitehead, Jonathan P. and Inder, Warrick J. (2016). Development of an enzyme-linked immunosorbent assay for thrombospondin-1 and comparison of human plasma and serum concentrations. Annals of Clinical Biochemistry, 53 (5), 606-610. doi: 10.1177/0004563216628891

Effects of delayed sample processing on determination of total and high molecular weight (HMW) adiponectin in serum and plasma: a pilot study

Ng, Choaping, Rose, Felicity J., Keshvari, Sahar, Reeves, Marina M., Dimeski, Goce, Hickman, Ingrid J. and Whitehead, Jonathan P. (2016). Effects of delayed sample processing on determination of total and high molecular weight (HMW) adiponectin in serum and plasma: a pilot study. International Journal of Chemistry, 8 (3), 19-24. doi: 10.5539/ijc.v8n3p19

Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis

Kim, Yu-Hee, Barclay, Johanna L., He, Jingjing, Luo, Xiao, O'Neill, Hayley M., Keshvari, Sahar, Webster, Julie A., Ng, Choaping, Hutley, Louise J., Prins, Johannes B. and Whitehead, Jonathan P. (2016). Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis. FASEB Journal, 30 (7), 2528-2540. doi: 10.1096/fj.201500107R

Thrombospondin-1 is a glucocorticoid responsive protein in humans

Barclay, Johanna L., Petersons, Carolyn J., Keshvari, Sahar, Sorbello, Jane, Mangelsdorf, Brenda L., Thompson, Campbell H., Prins, Johannes B., Burt, Morton G., Whitehead, Jonathan P. and Inder, Warrick J. (2016). Thrombospondin-1 is a glucocorticoid responsive protein in humans. European Journal of Endocrinology, 174 (2), 193-201. doi: 10.1530/EJE-15-0964

Induction of heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: Evidence against a direct HO-1 - Adiponectin axis

Yang, Mengliu, Kimura, Masaki, Ng, Choaping, He, Jingjing, Keshvari, Sahar, Rose, Felicity J, Barclay, Johanna L and Whitehead, Jonathan P (2015). Induction of heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: Evidence against a direct HO-1 - Adiponectin axis. Molecular and Cellular Endocrinology, 413 (C), 209-216. doi: 10.1016/j.mce.2015.06.034

Characterisation of the adiponectin receptors: differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks

Keshvari, Sahar and Whitehead, Jonathan P. (2015). Characterisation of the adiponectin receptors: differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks. Molecular and Cellular Endocrinology, 409 (C), 121-129. doi: 10.1016/j.mce.2015.04.003

Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface

Keshvari, Sahar, Rose, Felicity J., Charlton, Hayley K., Scheiber, Nicole L., Webster, Julie, Kim, Yu-Hee, Choaping Ng, Parton, Robert G. and Whitehead, Jonathan P. (2013). Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface. Biochemical and Biophysical Research Communications, 432 (1), 28-33. doi: 10.1016/j.bbrc.2013.01.092

Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine, Caruso, Melanie, Patkar, Omkar, Sehgal, Anuj, Millard, Susan, Hume, David and Pettit, Allison (2023). Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer. 2022 Annual Meeting of the American Society for Bone and Mineral Research, Austin, TX, United States, 9-12 September 2022. Hoboken, NJ, United States: Wiley-Blackwell.

Targeted IL-22 Improves Glucose Tolerance and Reduces Hepatic Steatosis and Hepatic Fibrosis in Murine Models of Diabetes and Liver Disease

Prins, John B., Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Lockett, Jack, McGuckin, Michael and Hasnain, Sumaira Z. (2022). Targeted IL-22 Improves Glucose Tolerance and Reduces Hepatic Steatosis and Hepatic Fibrosis in Murine Models of Diabetes and Liver Disease. American Diabetes Association 82nd Scientific Sessions, New Orleans, LA United States, 3-7 June 2021. Arlington, VA United States: American Diabetes Association. doi: 10.2337/db22-119-lb

Building a case for liver and pancreas targeted interleukin-22 therapy for use in non-alcoholic fatty liver disease

Sajiir, Haressh, Wong, Kuanyau, Mueller, Alexander, Keshvari, Sahar, Wang, Ran, Macdonald, Graeme A., Prins, John, Mcguckin, Michael and Hasnain, Sumaira Z. (2022). Building a case for liver and pancreas targeted interleukin-22 therapy for use in non-alcoholic fatty liver disease. Digestive Disease Week 2022, San Diego, CA United States, 21-24 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60035-0

Pancreatic Interleukin-22 Receptor Signaling is Critical in Maintaining Beta-Cell Insulin Production and is Hepatoprotective

Sajiir, Haressh, Wong, Kuan Yau, Mueller, Alexandra, Keshvari, Sahar, Wang, Ran, Wiid, Percival, Macdonald, Graeme, Prins, John, McGuckin, Michael A. and Hasnain, Sumaira Z. (2022). Pancreatic Interleukin-22 Receptor Signaling is Critical in Maintaining Beta-Cell Insulin Production and is Hepatoprotective. Immunology 2022 Meeting, Portland, OR United States, 6-10 May 2022. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.208.supp.46.08

Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students

Akison, Lisa K., Gallo, Linda A., Barclay, Johanna L., Burgess, Danielle, Keshvari, Sahar, Fotheringham, Amelia K. and Moritz, Karen M. (2018). Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students. Joint Annual Scientific Meetings of Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB), Perth, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Chronic treatment with cobalt protoporphyrin or hemin compromises adipogenesis and adiponectin production in a manner indenpendent of heme-oxygenase-1

Yang, M., Kimura, M., Ng, C., Keshvari, S., He, J., Barclay, J. L. and Whitehead, J. P. (2016). Chronic treatment with cobalt protoporphyrin or hemin compromises adipogenesis and adiponectin production in a manner indenpendent of heme-oxygenase-1. 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Munich, Germany, Sep 12-16, 2016. Heidelberg, Germany: Springer. doi: 10.1007/s00125-016-4046-9

Thrombospondin-1 is a glucocorticoid responsive protein and potential biomarker of glucocorticoid activity

Barclay, Johanna L., Petersons, Carolyn J., Keshvari, Sahar, Sorbello, Jane, Mangelsdorf, Brenda L., Thompson, Campbell H., Prins, Johannes B., Burt, Morton G., Whitehead, Jonathan P. and Inder, Warrick (2016). Thrombospondin-1 is a glucocorticoid responsive protein and potential biomarker of glucocorticoid activity. Annual Scientific Meeting of the Endocrine-Society-of-Australia, Adelaide, Australia, 23-26 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans

Lockett, Jack , Saif, Zarqa, Nolan, Brendan J., Keshvari, Sahar, Cesana-Nigro, Nicole, Ewing, Adam, Inder, Warrick J. and Clifton, Vicki L. (2022). Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans. The University of Queensland. (Dataset) doi: 10.48610/ee0c38e

Molecular characterisation of the adiponectin receptors, AdipoR1 and AdipoR2

Keshvari, Sahar (2016). Molecular characterisation of the adiponectin receptors, AdipoR1 and AdipoR2. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2016.782