Dr Jo Pauls

Postdoctoral Research Fellow

Prince Charles Hospital Northside Clinical Unit
Faculty of Medicine

Overview

I am currently looking for PhD students! If you're a curious engineer, and interested in any of the following

  • Ventricular assist devices
  • Designing medical devices for mechanical circulatory support
  • Computational fluid dynamics
  • In vitro evaluation of medical device prototypes
  • ...and more

Then please contact me!

Qualifications

  • PhD- Doctor of Philosophy, Griffith University

Publications

View all Publications

Available Projects

  • Background: Right heart failure is a common post-operative complication following left ventricular assist device (LVAD) implantation. At present, there is no clinically-approved right ventricular assist device (RVAD) for long-term use, thus a second rotary LVAD may be used to support the failing right ventricle. Since LVADs are designed to support the systemic circulation where the pressure is notably greater than in the pulmonary circulation, LVADs are adapted for RVAD support. However, these adaptations come with inherent complications resulting in an increased risk of blood damage.

    Aim: The aim of the present project is to design and evaluate a hydraulic system (i.e. housing / impeller) of a novel axial flow blood pump for right ventricular support.

    Task: Specific tasks include:

    • Define End-User requirements for a novel RVAD.
    • 3D design of pump housing and impeller.
    • Prototype manufacturing and in vitro bench testing including pump performance curves (i.e. pump efficiency, H-Q curves).
    • Development of a Computational Fluid Design (CFD) model and validation against in vitro data.
    • Design improvement within CFD including haemocompatiblity evaluation.
    • Haemocompatibility testing of improved design in blood circulation loops.

    Significance: The present project will result in a hydraulic system for a novel RVAD which will be essential towards the development of a RVAD system.

    Skills needed: Knowledge in 3D design (Solidworks), Computational Fluid Design (Ansys, Fluent)

View all Available Projects

Publications

Book Chapter

  • Wu, Eric L., Stevens, Michael C., Pauls, Jo P. and Steinseifer, Ulrich (2018). First-generation ventricular assist devices. In Shaun D. Gregory, Michael C. Stevens and John F. Fraser (Ed.), Mechanical circulatory and respiratory support (pp. 93-115) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810491-0.00003-5

  • Pauls, Jo P., Bartnikowski, Nicole, Jansen, So-Hyun, Lim, Einly and Dasse, Kurt (2018). Preclinical evaluation. In Shaun D. Gregory, Michael C. Stevens and John F. Fraser (Ed.), Mechanical circulatory and respiratory support (pp. 407-438) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810491-0.00013-8

Journal Article

Conference Publication

  • Pauls, Jo P., Gregory, Shaun D., Stevens, Michael and Tansley, Geoff (2014). In-vitro Evaluation of Physiological Controller Response of Rotary Blood Pumps to Changes in Patient State. In: 2014 36Th Annual International Conference of the Ieee Engineering in Medicine and Biology Society (Embc). 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Chicago Il, (294-297). Aug 26-30, 2014. doi:10.1109/EMBC.2014.6943587

Other Outputs

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Background: Right heart failure is a common post-operative complication following left ventricular assist device (LVAD) implantation. At present, there is no clinically-approved right ventricular assist device (RVAD) for long-term use, thus a second rotary LVAD may be used to support the failing right ventricle. Since LVADs are designed to support the systemic circulation where the pressure is notably greater than in the pulmonary circulation, LVADs are adapted for RVAD support. However, these adaptations come with inherent complications resulting in an increased risk of blood damage.

    Aim: The aim of the present project is to design and evaluate a hydraulic system (i.e. housing / impeller) of a novel axial flow blood pump for right ventricular support.

    Task: Specific tasks include:

    • Define End-User requirements for a novel RVAD.
    • 3D design of pump housing and impeller.
    • Prototype manufacturing and in vitro bench testing including pump performance curves (i.e. pump efficiency, H-Q curves).
    • Development of a Computational Fluid Design (CFD) model and validation against in vitro data.
    • Design improvement within CFD including haemocompatiblity evaluation.
    • Haemocompatibility testing of improved design in blood circulation loops.

    Significance: The present project will result in a hydraulic system for a novel RVAD which will be essential towards the development of a RVAD system.

    Skills needed: Knowledge in 3D design (Solidworks), Computational Fluid Design (Ansys, Fluent)