Professor Christel Middeldorp

Professor Child & Youth Psychiatry

Child Health Research Centre
Faculty of Medicine
c.middeldorp@uq.edu.au
+61 7 3069 7595

Overview

Prof Christel Middeldorp has a conjoint appointment with the Child Health Research Centre (CHRC), UQ, and Child and Youth Mental Health Service (CYMHS), Children’s Health Queensland Hospital and Health Services (CHQ HHS). She is also affiliated with the Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands.

The large burden of disease by mental disorders is partly due to the sometimes chronic course. Her aim is to improve prognosis by providing targeted treatment for children and families at high risk for persistent symptoms. To that end, her research focuses on 1) improving recognition of children that are at higher risk for a chronic course and, following up on these findings 2) developing targeted treatment to prevent this unfavourable course.

Christel is the PI of CAPICE: Childhood and Adolescence Psychopathology, unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe, funded by an EU Marie Curie grant, coordinated by the Vrije Universiteit Amsterdam. This project aims to identify genetic variants underlying the development and persistence of common childhood psychopathology by using data from population based longitudinal child and adolescent cohorts from over the world. Many of these cohorts participate in the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium.

This research is complemented by studies in clinical populations. She established a clinical cohort of families with children with neurodevelopmental disorders. They are followed longitudinally to identify factors, including biomarkers influencing outcome. It is also investigated whether providing integrated care to parents and children improves outcomes. She also analyses the data as collected in electronic health records in the Child and Youth Mental Health Services to gain knowledge on treatment outcomes in the services and characteristics of the child, family and their circumstances thata are associated with these outcomes.

In 2019, Christel was appointed by the federal government as Co-Chair of the Childhood Mental Health and Wellbeing Strategy Working Party. The working group is developing a strategy which will provide a framework that embeds protective skills in early childhood, creates mentally healthy home environments, supports parents, and prevents or treats early childhood trauma.

Qualifications

  • Child and Adolescent Psychiatry, Netherlands
  • Arts, Netherlands
  • Propaedutic, Netherlands
  • Doctor, Vrije Universiteit

Publications

  • Shen, Xueyi, Howard, David M., Adams, Mark J., Hill, W. David, Clarke, Toni-Kim, Adams, Mark J., Clarke, Toni-Kim, McIntosh, Andrew M., Deary, Ian J., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard ... McIntosh, Andrew M. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1) 2301 doi: 10.1038/s41467-020-16022-0

  • Krishnamoorthy, Govind, Hessing, Paula, Middeldorp, Christel and Branjerdporn, Melissa (2020). Effects of the ‘Circle of Security’ group parenting program (COS-P) with foster carers: An observational study. Children and Youth Services Review, 115 105082, 105082. doi: 10.1016/j.childyouth.2020.105082

  • Najman, Jackob. M., Middeldorp, Christel, Williams, Gail M., Scott, James G., McGee, Tara, Bor, William, Clavarino, Alexandra M and Mamun, Abdullah (2020). Illicit drug use by mothers and their daughters in Australia: a comparison of two generations. Addictive Behaviors, 106 106321, 106321. doi: 10.1016/j.addbeh.2020.106321

View all Publications

Publications

Book Chapter

  • Nivard, Michel, Dolan, Conor V., Middeldorp, Christel M. and Boomsma, Dorret I. (2016). Behavior genetics: From heritability to gene finding. Handbook of Psychophysiology. (pp. 339-353) Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/9781107415782.015

  • van Dyck, Richard, van Balkom, Anton J.L.M., van den Heuvel, Odile A. and Middeldorp, Christel M. (2014). Psychiatric perspective. The Wiley handbook of anxiety disorders. (pp. 1371-1381) edited by Paul Emmelkamp and Thomas Ehring. Chichester, West Sussex, United Kingdom: John Wiley & Sons.

  • Middeldorp, Christel M. and Boomsma, Dorret I. (2009). Genetics and Psychopathology. Handbook of neuroscience for the behavioral sciences. (pp. 1180-1202) edited by Gary G. Berntson and John T. Cacioppo. New York, NY, United States: Wiley. doi: 10.1002/9780470478509.neubb002060

  • Middeldorp, Christel M., Cath, Danielle C., van den Berg, Mireille, Beem, A. Leo, van Dyck, Richard and Boomsma, Dorret I. (2006). The association of personality with anxious and depressive psychopathology. The biology of personality and individual differences. (pp. 251-272) edited by Turhan Canli. New York, NY, United States: Guilford Press.

Journal Article

  • Shen, Xueyi, Howard, David M., Adams, Mark J., Hill, W. David, Clarke, Toni-Kim, Adams, Mark J., Clarke, Toni-Kim, McIntosh, Andrew M., Deary, Ian J., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard ... McIntosh, Andrew M. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1) 2301 doi: 10.1038/s41467-020-16022-0

  • Krishnamoorthy, Govind, Hessing, Paula, Middeldorp, Christel and Branjerdporn, Melissa (2020). Effects of the ‘Circle of Security’ group parenting program (COS-P) with foster carers: An observational study. Children and Youth Services Review, 115 105082, 105082. doi: 10.1016/j.childyouth.2020.105082

  • Najman, Jackob. M., Middeldorp, Christel, Williams, Gail M., Scott, James G., McGee, Tara, Bor, William, Clavarino, Alexandra M and Mamun, Abdullah (2020). Illicit drug use by mothers and their daughters in Australia: a comparison of two generations. Addictive Behaviors, 106 106321, 106321. doi: 10.1016/j.addbeh.2020.106321

  • Hammerschlag, Anke R., Byrne, Enda M., Bartels, Meike, Wray, Naomi R., Middeldorp, Christel M., eQTLGen Consortium, BIOS Consortium, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Bonder, Marc Jan, Boomsma, Dorret I., Christiansen, Mark, Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Gregory, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette ... Agbessi, Mawussé (2020). Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression and DNA methylation studies. Biological Psychiatry doi: 10.1016/j.biopsych.2020.05.002

  • Cobham, Vanessa E., Hickling, Anna, Kimball, Hayley, Thomas, Hannah J., Scott, James G. and Middeldorp, Christel M. (2020). Systematic review: anxiety in children and adolescents with chronic medical conditions. Journal of the American Academy of Child and Adolescent Psychiatry, 59 (5), 595-618. doi: 10.1016/j.jaac.2019.10.010

  • Campbell, Timothy C. H., Reupert, Andrea, Sutton, Keith, Basu, Soumya, Davidson, Gavin, Middeldorp, Christel M., Naughton, Michael and Maybery, Darryl (2020). Prevalence of mental illness among parents of children receiving treatment within child and adolescent mental health services (CAMHS): a scoping review. European Child and Adolescent Psychiatry doi: 10.1007/s00787-020-01502-x

  • Coleman, Jonathan R. I., Peyrot, Wouter J., Purves, Kirstin L., Davis, Katrina A. S., Rayner, Christopher, Choi, Shing Wan, Hübel, Christopher, Gaspar, Héléna A., Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M., Choi, Karmel W., Dunn, Erin C., Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J., Lewis, Cathryn M., O’Reilly, Paul F., McIntosh, Andrew M., Smith, Daniel J., Wray, Naomi R., Hotopf, Matthew, Eley, Thalia C., Breen, Gerome, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, Maciej, Byrne, Enda M. ... Middeldorp, Christel M. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25 (7), 1430-1446. doi: 10.1038/s41380-019-0546-6

  • Jami, Eshim S., Eilertsen, Espen Moen, Hammerschlag, Anke R., Qiao, Zhen, Evans, David M., Ystrøm, Eivind, Bartels, Meike and Middeldorp, Christel M. (2020). Maternal and paternal effects on offspring internalizing problems: results from genetic and family-based analyses. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 183 (5), 258-267. doi: 10.1002/ajmg.b.32784

  • Byrne, Enda M., Henders, Anjali K., Hickie, Ian B., Middeldorp, Christel M. and Wray, Naomi R. (2020). Nick Martin and the genetics of depression: sample size, sample size, sample size. Twin Research and Human Genetics, 23 (2), 1-3. doi: 10.1017/thg.2020.13

  • Czamara, Darina, Eraslan, Gökçen, Page, Christian M., Lahti, Jari, Lahti-Pulkkinen, Marius, Hämäläinen, Esa, Kajantie, Eero, Laivuori, Hannele, Villa, Pia M., Reynolds, Rebecca M., Nystad, Wenche, Håberg, Siri E., London, Stephanie J., O’Donnell, Kieran J., Garg, Elika, Meaney, Michael J., Entringer, Sonja, Wadhwa, Pathik D., Buss, Claudia, Jones, Meaghan J., Lin, David T. S., MacIsaac, Julie L., Kobor, Michael S., Koen, Nastassja, Zar, Heather J., Koenen, Karestan C., Dalvie, Shareefa, Stein, Dan J., Kondofersky, Ivan ... Binder, Elisabeth B. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10 (1) 2548 doi: 10.1038/s41467-019-10461-0

  • Doering, Sabrina, Lichtenstein, Paul, Gillberg, Christopher, Boomsma, D. I., Van Beijsterveldt, Toos C. E. M., Ligthart, Lannie, Willemsen, Gonneke, De Geus, Eco, Middeldorp, Christel M., Bartels, Meike, Kuja-Halkola, Ralf and Lundström, Sebastian (2019). Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: Results from two longitudinal studies. BMC Psychiatry, 19 (1) 363, 363. doi: 10.1186/s12888-019-2349-3

  • Middeldorp, Christel M. (2019). Editorial: childhood stress and psychopathology: it’s not too early to look at biological aging. Journal of the American Academy of Child and Adolescent Psychiatry, 59 (1), 38-39. doi: 10.1016/j.jaac.2019.09.020

  • Schwabe, I., Milaneschi, Y., Gerring, Z., Sullivan, P. F., Schulte, E., Suppli, N. P., Thorp, J. G., Derks, E. M. and Middeldorp, C. M. (2019). Unraveling the genetic architecture of major depressive disorder: Merits and pitfalls of the approaches used in genome-wide association studies. Psychological Medicine, 49 (16), 2646-2656. doi: 10.1017/S0033291719002502

  • Ensink, Judith B. M., de Moor, Marleen H. M., Zafarmand, Mohammad Hadi, de Laat, Sanne, Uitterlinden, André, Vrijkotte, Tanja G. M., Lindauer, Ramón and Middeldorp, Christel M. (2019). Maternal environmental risk factors and the development of internalizing and externalizing problems in childhood: the complex role of genetic factors. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 183 (1) ajmg.b.32755, 17-25. doi: 10.1002/ajmg.b.32755

  • Glanville, Kylie P., Coleman, Jonathan R. I., Hanscombe, Ken B., Euesden, Jack, Choi, Shing Wan, Purves, Kirstin L., Breen, Gerome, Air, Tracy M., Andlauer, Till F. M., Baune, Bernhard T., Binder, Elisabeth B., Blackwood, Douglas H. R., Boomsma, Dorret I., Buttenschøn, Henriette N., Colodro-Conde, Lucía, Dannlowski, Udo, Direk, Nese, Dunn, Erin C., Forstner, Andreas J., de Geus, Eco J. C., Grabe, Hans J., Hamilton, Steven P., Jones, Ian, Jones, Lisa A., Knowles, James A., Kutalik, Zoltán, Levinson, Douglas F., Lewis, Glyn, Lind, Penelope A. ... Børglum, Anders D. (2019). Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression. Biological Psychiatry, 87 (5), 419-430. doi: 10.1016/j.biopsych.2019.06.031

  • Hammerschlag, Anke R., de Leeuw, Christiaan A., Middeldorp, Christel M. and Polderman, Tinca J. C. (2019). Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders. Psychological Medicine, 50 (10), 1-11. doi: 10.1017/s0033291719001776

  • Middeldorp, C. M. (2019). Genetic diagnostics: part of the psychiatric clinic Genetisch onderzoek: onderdeel van psychiatrische kliniek. Tijdschrift voor psychiatrie, 61 (6), 373-374.

  • Gaspar, Héléna A., Gerring, Zachary, Hübel, Christopher, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Middeldorp, Christel M., Derks, Eske M. and Breen, Gerome (2019). Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder. Translational Psychiatry, 9 (1) 117, 117. doi: 10.1038/s41398-019-0451-4

  • Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel ... Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431-444. doi: 10.1038/s41588-019-0344-8

  • Middeldorp, Christel M., Felix, Janine F., Mahajan, Anubha, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) consortium, McCarthy, Mark I. and Mamun, Abdullah (2019). The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. European Journal of Epidemiology, 34 (3), 279-300. doi: 10.1007/s10654-019-00502-9

  • Arias-Vásquez, A., Groffen, A. J., Spijker, S., Ouwens, K. G., Klein, M., Vojinovic, D., Galesloot, T. E., Bralten, J., Hottenga, J. J., van der Most, P. J., Kattenberg, V. M., Pool, R., Nolte, I. M., Penninx, B. W.J.H., Fedko, I. O., Dolan, C. V., Nivard, M. G., den Braber, A., van Duijn, C. M., Hoekstra, P. J., Buitelaar, J. K., Kiemeney, L. A., Hoogman, M., Middeldorp, C. M., Draisma, H. H.M., Vermeulen, S. H., Sánchez-Mora, C., Ramos-Quiroga, J. A., Ribasés, M. ... Boomsma, D. I. (2019). A potential role for the STXBP5-AS1 gene in adult ADHD symptoms. Behavior Genetics, 49 (3), 270-285. doi: 10.1007/s10519-018-09947-2

  • Demontis, Ditte, Walters, Raymond K., Martin, Joanna, Mattheisen, Manuel, Als, Thomas D., Agerbo, Esben, Baldursson, Gísli, Belliveau, Rich, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Eriksson, Nicholas, Gandal, Michael, Goldstein, Jacqueline I., Grasby, Katrina L., Grove, Jakob, Gudmundsson, Olafur O., Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian B., Martin, Alicia R., Martin, Nicholas G., Moran, Jennifer ... Kemp, John P. (2019). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics, 51 (1), 63-75. doi: 10.1038/s41588-018-0269-7

  • Foo, Jerome C., Streit, Fabian, Frank, Josef, Witt, Stephanie H., Treutlein, Jens, Baune, Bernhard T., Moebus, Susanne, Joeckel, Karl-Heinz, Forstner, Andreas J., Noethen, Markus M., Rietschel, Marcella, Sartorius, Alexander, Kranaster, Laura, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1), 35-45. doi: 10.1002/ajmg.b.32700

  • Arnau-Soler, Aleix, Adams, Mark J., Hayward, Caroline, Thomson, Pippa A., Porteous, David, Campbell, Archie, Smith, Blair H., Black, Corri, Padmanabhan, Sandosh, McIntosh, Andrew, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13 (12) e0209160, e0209160. doi: 10.1371/journal.pone.0209160

  • de Jong, Simone, Abdalla Diniz, Mateus Jose, Saloma, Andiara, Gadelha, Ary, Santoro, Marcos L., Ota, Vanessa K., Noto, Cristiano, Curtis, Charlesg, Newhouse, Stephen J., Patel, Hamel, Hall, Lynsey S., O'Reilly, Paul F., Belangero, Sintia, Bressan, Rodrigo A., Breen, Gerome, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B. ... Shi, Jianxin (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology, 1 (163) 163 doi: 10.1038/s42003-018-0155-y

  • Wesseldijk, Laura W., Dieleman, Gwen C., van Steensel, Francisa J.A., Bleijenberg, Ellen J., Bartels, Meike, Bögels, Susan M. and Middeldorp, Christel M. (2018). Do parental psychiatric symptoms predict outcome in children with psychiatric disorders? A naturalistic clinical study. Journal of the American Academy of Child and Adolescent Psychiatry, 57 (9), 669-677.e6. doi: 10.1016/j.jaac.2018.05.017

  • Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K., Walters, Raymond K., Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J., Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A., Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H., Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-Francois, Duron, Emmanuelle, Vardarajan, Badri N., Reitz, Christiane, Goate, Alison M. ... The Brainstorm Consortium (2018). Analysis of shared heritability in common disorders of the brain. Science, 360 (6395) 8757, 1313-+. doi: 10.1126/science.aap8757

  • Bartels, Meike, Hendriks, Anne, Mauri, Matteo, Krapohl, Eva, Whipp, Alyce, Bolhuis, Koen, Conde, Lucia Colodro, Luningham, Justin, Fung Ip, Hill, Hagenbeek, Fiona, Roetman, Peter, Gatej, Raluca, Lamers, Audri, Nivard, Michel, van Dongen, Jenny, Lu, Yi, Middeldorp, Christel, van Beijsterveldt, Toos, Vermeiren, Robert, Hankemeijer, Thomas, Kluft, Cees, Medland, Sarah, Lundström, Sebastian, Rose, Richard, Pulkkinen, Lea, Vuoksimaa, Eero, Korhonen, Tellervo, Martin, Nicholas G., Lubke, Gitta ... Boomsma, Dorret I. (2018). Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. European Child & Adolescent Psychiatry, 27 (9), 1-17. doi: 10.1007/s00787-018-1169-1

  • Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till M. F., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan I. R., Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Crowley, Cheynna A. ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668-+. doi: 10.1038/s41588-018-0090-3

  • Wesseldijk, L. W., Dieleman, G. C., van Steensel, F. J. A., Bartels, M., Hudziak, J. J., Lindauer, R. J. L., Bögels, S. M. and Middeldorp, C. M. (2018). Risk factors for parental psychopathology: a study in families with children or adolescents with psychopathology. European Child & Adolescent Psychiatry, 27 (12), 1575-1584. doi: 10.1007/s00787-018-1156-6

  • Middeldorp, Christel M. and Wray, Naomi R. (2018). The value of polygenic analyses in psychiatry. World Psychiatry, 17 (1), 26-28. doi: 10.1002/wps.20480

  • Barbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien ... Whalley, Heather C. (2018). Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (1), 91-100. doi: 10.1016/j.bpsc.2018.07.006

  • Treur, Jorien L., Vink, Jacqueline M., Boomsma, Dorret I. and Middeldorp, Christel M. (2018). Corrigendum to “Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age” [Drug Alcohol Depend. 153 (2015) 221–228] (S0376871615002549) (10.1016/j.drugalcdep.2015.05.018)). Drug and Alcohol Dependence, 182, 123. doi: 10.1016/j.drugalcdep.2017.11.002

  • Rietschel, Liz, Streit, Fabian, Zhu, Gu, McAloney, Kerrie, Frank, Josef, Couvy-Duchesne, Baptiste, Witt, Stephanie H., Binz, Tina M., Bolton, Jennifer L., Hayward, Caroline, Direk, Nese, Anderson, Anna, Huffman, Jennifer, Wilson, James F., Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H., Velders, Fleur P., Hofman, Albert, Uitterlinden, Andre G., Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Kaakinen, Marika ... Rietschel, Marcella (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports, 7 (1) 15351, 15351. doi: 10.1038/s41598-017-11852-3

  • Nivard, Michel G., Gage, Suzanne H., Hottenga, Jouke J. , van Beijsterveldt, Catharina E. M., Abdellaoui, Abdel, Bartels, Meike, Baselmans, Bart M. L., Ligthart, Lannie, St Pourcain, Beate, Boomsma, Dorret I., Munafò, Marcus R. and Middeldorp, Christel M. (2017). Genetic overlap between schizophrenia and developmental psychopathology: longitudinal and multivariate polygenic risk prediction of common psychiatric traits during development. Schizophrenia Bulletin, 43 (6), 1197-1207. doi: 10.1093/schbul/sbx031

  • Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M. ... Rietschel, M. (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.. Translational psychiatry, 7 (6), e1155-e1155. doi: 10.1038/tp.2017.115

  • Wesseldijk, Laura W., Bartels, Meike, Vink, Jacqueline M., van Beijsterveldt, Catharina E. M., Ligthart, Lannie, Boomsma, Dorret I. and Middeldorp, Christel M. (2017). Genetic and environmental influences on conduct and antisocial personality problems in childhood, adolescence, and adulthood. European Child & Adolescent Psychiatry, 27 (9), 1-10. doi: 10.1007/s00787-017-1014-y

  • Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olie, E., Villafuerte, S., Air, T. M., Araya, R., Bowes, L., Burns, R., Byrne, E. M., Coffey, C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A. ... Bierut, L. J. (2017). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23 (1), 133-142. doi: 10.1038/mp.2017.44

  • Wesseldijk, Laura W., Fedko, Iryna O., Bartels, Meike, Nivard, Michel G., van Beijsterveldt, Catharina E. M., Boomsma, Dorret I. and Middeldorp, Christel M. (2017). Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 174 (3), 251-260. doi: 10.1002/ajmg.b.32500

  • Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S-A, Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschon, H. N., Byrne, E. M., Cichon, S., Clarke, T-K, Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F., Dunn, E. C., Edwards, A. C., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D., Grabe, H. J., Hamilton, S. P. ... Kendler, K. S. (2017). Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7 (3) e1074, e1074-e1074. doi: 10.1038/tp.2016.292

  • Fedko, Iryna O., Wesseldijk, Laura W., Nivard, Michel G., Hottenga, Jouke-Jan, van Beijsterveldt, Catharina E. M., Middeldorp, Christel M., Bartels, Meike and Boomsma, Dorret I. (2017). Heritability of behavioral problems in 7-year olds based on shared and unique aspects of parental views. Behavior Genetics, 47 (2), 152-163. doi: 10.1007/s10519-016-9823-1

  • Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A-L, Foecker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M., Adan, R., Brandys, M., van Elburg, A., Perica, V. Boraska, Franklin, C. S., Tschoep, M. H., Zeggini, E., Bulik, C. M., Collier, D. ... Middeldorp, Christel (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192-201. doi: 10.1038/mp.2016.71

  • Bot, M., Middeldorp, C. M., de Geus, E. J. C., Lau, H. M., Sinke, M., van Nieuwenhuizen, B., Smit, J. H., Boomsma, D. I. and Penninx, B. W. J. H. (2017). Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder. Psychological Medicine, 47 (2), 279-289. doi: 10.1017/S0033291716002312

  • Lee, Minyoung, Aggen, Steven H., Otowa, Takeshi, Castelao, Enrique, Preisig, Martin, Grabe, Hans J., Hartman, Catharina A., Oldehinkel, Albertine J., Middeldorp, Christel M., Tiemeier, Henning and Hettema, John M. (2016). Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. International Journal of Methods in Psychiatric Research, 25 (4), 255-266. doi: 10.1002/mpr.1519

  • Nivard, Michel G., Middeldorp, Christel M., Lubke, Gitta, Hottenga, Jouke-Jan, Abdellaoui, Abdel, Boomsma, Dorret I. and Dolan, Conor V. (2016). Detection of gene-environment interaction in pedigree data using genome-wide genotypes. European Journal of Human Genetics, 24 (12), 1803-1809. doi: 10.1038/ejhg.2016.88

  • Middeldorp, Christel M., Hammerschlag, Anke R., Ouwens, Klaasjan G., Groen-Blokhuis, Maria M., St Pourcain, Beate, Greven, Corina U., Pappa, Irene, Tiesler, Carla M. T., Ang, Wei, Nolte, Ilja M., Vilor-Tejedor, Natalia, Bacelis, Jonas, Ebejer, Jane L., Zhao, Huiying, Davies, Gareth E., Ehli, Erik A., Evans, David M., Fedko, Iryna O., Guxens, Monica, Hottenga, Jouke-Jan, Hudziak, James J., Jugessur, Astanand, Kemp, John P., Krapohl, Eva, Martin, Nicholas G., Murcia, Mario, Myhre, Ronny, Ormel, Johan, Ring, Susan M. ... Boomsma, Dorret I. (2016). A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts. Journal of the American Academy of Child and Adolescent Psychiatry, 55 (10), 896-905.e6. doi: 10.1016/j.jaac.2016.05.025

  • Lubke, Gitta H., Miller, Patrick J., Verhulst, Brad, Bartels, Meike, van Beijsterveldt, Toos, Willemsen, Gonneke, Boomsma, Dorret I. and Middeldorp, Christel M. (2016). A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (7), 948-957. doi: 10.1002/ajmg.b.32375

  • Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Auwera, S. V. der, Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J-J, Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F. ... Hettema, J. M. (2016). Erratum: Meta-analysis of genome-wide association studies of anxiety disorders (vol 21, pg 1391, 2016). Molecular Psychiatry, 21 (10), 1485-1485. doi: 10.1038/mp.2016.11

  • Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. -J., Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F. ... Hettema, J. M. (2016). Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry, 21 (10), 1391-1399. doi: 10.1038/mp.2015.197

  • Middeldorp, Christel M., Wesseldijk, Laura W., Hudziak, James J., Verhulst, Frank C., Lindauer, Ramon J. L. and Dieleman, Gwen C. (2016). Parents of children with psychopathology: psychiatric problems and the association with their child’s problems. European Child and Adolescent Psychiatry, 25 (8), 919-927. doi: 10.1007/s00787-015-0813-2

  • Nivard, Michel G., Lubke, Gitta H., Dolan, Conor V., Evans, David M., St. Pourcain, Beate, Munafo, Marcus R. and Middeldorp, Christel M. (2016). Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Development and Psychopathology, 29 (3), 1-10. doi: 10.1017/S0954579416000572

  • Hagenbeek, Fiona A., Kluft, Cornelis, Hankemeier, Thomas, Bartels, Meike, Draisma, Harmen H. M., Middeldorp, Christel M., Berger, Ruud, Noto, Antonio, Lussu, Milena, Pool, Rene, Fanos, Vassilios and Boomsma, Dorret I. (2016). Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (5), 719-732. doi: 10.1002/ajmg.b.32435

  • Porsch, Robert M., Middeldorp, Christel M., Cherny, Stacey S., Krapohl, Eva, van Beijsterveldt, Catharina E. M., Loukola, Anu, Korhonen, Tellervo, Pulkkinen, Lea, Corley, Robin, Rhee, Soo, Kaprio, Jaakko, Rose, Richard R., Hewitt, John. K., Sham, Pak, Plomin, Robert, Boomsma, Dorret I. and Bartels, Meike (2016). Longitudinal heritability of childhood aggression. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (5), 697-707. doi: 10.1002/ajmg.b.32420

  • Power, Robert A., Tansey, Katherine E., Buttenschøn, Henriette Nørmølle, Cohen-Woods, Sarah, Bigdeli, Tim, Hall, Lynsey S., Kutalik, Zoltán, Lee, S. Hong, Ripke, Stephan, Steinberg, Stacy, Teumer, Alexander, Viktorin, Alexander, Wray, Naomi R., Arolt, Volker, Baune, Bernard T., Boomsma, Dorret I., Børglum, Anders D., Byrne, Enda M., Castelao, Enrique, Craddock, Nick, Craig, Ian, Dannlowski, Udo, Deary, Ian J., Degenhardt, Franziska, Forstner, Andreas J., Gordon, Scott D., Grabe, Hans J., Grove, Jakob, Hamilton, Steven P. ... Lewis, Cathryn M. (2016). Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 81 (4), 325-335. doi: 10.1016/j.biopsych.2016.05.010

  • Wesseldijk, L. W., Dieleman, G. C., Lindauer, R. J. L., Bartels, M., Willemsen, G., Hudziak, J. J., Boomsma, D. I. and Middeldorp, C. M. (2016). Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology. European Psychiatry, 34, 49-55. doi: 10.1016/j.eurpsy.2016.01.2423

  • Van Veen, S. C., Batelaan, N. M., Wesseldijk, L. W., Rozeboom, J. and Middeldorp, C. M. (2016). Psychopathology in families: An integral approach via the family outpatient clinic Psychiatrische stoornissen binnen gezinnen: Een integrale benadering via de familiepoli. Tijdschrift voor Psychiatrie, 58 (2), 95-104.

  • Molenaar, Dylan, Middeldorp, Christel M., Willemsen, Gonneke, Ligthart, Lannie, Nivard, Michel G. and Boomsma, Dorret I. (2016). Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression. Behavior Genetics, 46 (1), 59-71. doi: 10.1007/s10519-015-9752-4

  • Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna ... Jaddoe, Vincent W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 (2), 389-403. doi: 10.1093/hmg/ddv472

  • Nivard, Michel G., Middeldorp, Christel M., Dolan, Conor V. and Boomsma, Dorret I. (2015). Genetic and Environmental Stability of Neuroticism From Adolescence to Adulthood. Twin Research and Human Genetics, 18 (6), 746-754. doi: 10.1017/thg.2015.80

  • Middeldorp, Christel M. (2015). Genetics and psychiatric disorders: Heritability and the search for genes Genetica en psychische stoornissen op de kinderleeftijd: Erfelijkheid en de zoektocht naar genen. Tijdschrift voor Psychiatrie, 57 (12), 876-880.

  • Paternoster, Lavinia, Standl, Marie, Waage, Johannes, Baurecht, Hansjoerg, Hotze, Melanie, Strachan, David P., Curtin, John A., Bonnelykke, Klaus, Tian, Chao, Takahashi, Atsushi, Esparza-Gordillo, Jorge, Alves, Alexessander Couto, Thyssen, Jacob P., den Dekker, Herman T., Ferreira, Manuel A., Altmaier, Elisabeth, Sleiman, Patrick M. A., Xiao, Feng Li, Gonzalez, Juan R., Marenholz, Ingo, Kalb, Birgit, Pino-Yanes, Maria, Xu, Cheng-Jian, Carstensen, Lisbeth, Groen-Blokhuis, Maria M., Venturini, Cristina, Pennell, Craig E., Barton, Sheila J., Levin, Albert M. ... Weidinger, Stephan (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47 (12), 1449-1456. doi: 10.1038/ng.3424

  • Molenaar, Dylan, Middeldorp, Christel, van Beijsterveldt, Toos and Boomsma, Dorret I. (2015). Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype × Environment Interaction. Child Development, 86 (6), 1999-2016. doi: 10.1111/cdev.12451

  • Pappa, Irene, Fedko, Iryna O., Mileva-Seitz, Viara R., Hottenga, Jouke-Jan, Bakermans-Kranenburg, Marian J., Bartels, Meike, van Beijsterveldt, Catharina E. M., Jaddoe, Vincent W. V., Middeldorp, Christel M., Rippe, Ralph C. A., Rivadeneira, Fernando, Tiemeier, Henning, Verhulst, Frank C., van Ijzendoorn, Marinus H. and Boomsma, Dorret I. (2015). Erratum: Single nucleotide polymorphism heritability of behavior problems in childhood: genome-wide complex trait analysis (vol 54, pg 737, 2015). Journal of the American Academy of Child and Adolescent Psychiatry, 54 (11), 965-965. doi: 10.1016/j.jaac.2015.09.002

  • Fedko, Iryna O., Hottenga, Jouke-Jan, Medina-Gomez, Carolina, Pappa, Irene, van Beijsterveldt, Catharina E. M., Ehli, Erik A., Davies, Gareth E., Rivadeneira, Fernando, Tiemeier, Henning, Swertz, Morris A., Middeldorp, Christel M., Bartels, Meike and Boomsma, Dorret I. (2015). Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height. Behavior Genetics, 45 (5), 514-528. doi: 10.1007/s10519-015-9725-7

  • Pappa, Irene, Fedko, Iryna O., Mileva-Seitz, Viara R., Hottenga, Jouke-Jan, Bakermans-Kranenburg, Marian J., Bartels, Meike, van Beijsterveldt, Catharina E. M., Jaddoe, Vincent W. V., Middeldorp, Christel M., Rippe, Ralph C. A., Rivadeneira, Fernando, Tiemeier, Henning, Verhulst, Frank C., van Ijzendoorn, Marinus H. and Boomsma, Dorret I. (2015). Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 54 (9), 737-744. doi: 10.1016/j.jaac.2015.06.004

  • Treur, Jorien L., Vink, Jacqueline M., Boomsma, Dorret I. and Middeldorp, Christel M. (2015). Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age. Drug and Alcohol Dependence, 153, 221-228. doi: 10.1016/j.drugalcdep.2015.05.018

  • Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A., Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and Middeldorp, Christel (2015). The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects. Molecular Psychiatry, 20 (6), 735-743. doi: 10.1038/mp.2015.50

  • Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G., Nolte, Ilja M., Tiesler, Carla M. T., Bakermans-Kranenburg, Marian J., Davies, Gareth E., Evans, David M., Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M., Hudziak, James J., Kemp, John P., Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R., Motazedi, Ehsan, Power, Christine, Raitakari, Olli T., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A., Seppälä, Ilkka, Snieder, Harold, Standl, Marie ... Tiemeier, Henning (2015). A genome-wide approach to children's aggressive behavior: the EAGLE consortium. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 171 (5), 1-11. doi: 10.1002/ajmg.b.32333

  • Arloth, Janine, Bogdan, Ryan, Weber, Peter, Frishman, Goar, Menke, Andreas, Wagner, Klaus V., Balsevich, Georgia, Schmidt, Mathias V., Karbalai, Nazanin, Czamara, Darina, Altmann, Andre, Truembach, Dietrich, Wurst, Wolfgang, Mehta, Divya, Uhr, Manfred, Klengel, Torsten, Erhardt, Angelika, Carey, Caitlin E., Conley, Emily Drabant, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC),, Middeldorp, Christel, Ruepp, Andreas, Mueller-Myhsok, Bertram, Hariri, Ahmad R. and Binder, Elisabeth B. (2015). Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron, 86 (5), 1189-1202. doi: 10.1016/j.neuron.2015.05.034

  • Byrne, Enda M, Raheja, Uttam K, Stephens, Sarah H, Heath, Andrew C, Madden, Pamela A, Vaswani, Dipika, Nijjar, Gagan V, Ryan, Kathleen A, Youssufi, Hassaan, Gehrman, Philip R, Shuldiner, Alan R, Martin, Nicholas G, Montgomery, Grant W, Wray, Naomi R, Nelson, Elliot C, Mitchell, Braxton D, Postolache, Teodor T, Psychiatric Genetics Consortium Major Depressive Disorder Working Group and Middeldorp, Christel (2015). Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 76 (2), 128-134. doi: 10.4088/JCP.14m08981

  • O'Dushlaine, Colm, Rossin, Lizzy, Lee, Phil H., Duncan, Laramie, Parikshak, Neelroop N., Newhouse, Stephen, Ripke, Stephan, Neale, Benjamin M., Purcell, Shaun M., Posthuma, Danielle, Nurnberger, John I., Lee, S. Hong, Faraone, Stephen V., Perlis, Roy H., Mowry, Bryan J, Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H. ... Breen, Gerome (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 18 (2), 199-209. doi: 10.1038/nn.3922

  • Nivard, M. G., Dolan, C. V., Kendler, K. S., Kan, K. J., Willemsen, G., Van Beijsterveldt, C. E.M., Lindauer, R. J.L., Van Beek, J. H.D.A., Geels, L. M., Bartels, M., Middeldorp, C. M. and Boomsma, D. I. (2015). Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years. Psychological Medicine, 45 (5), 1039-1049. doi: 10.1017/S003329171400213X

  • Lindauer, Ramon J. L., Brilleslijper-Kater, Sonja N., Diehle, Julia, Verlinden, Eva, Teeuw, Arianne H., Middeldorp, Christel M., Tuinebreijer, Wilco, Bosschaart, Thekla F., van Duin, Esther and Verhoeff, Arnoud (2014). The Amsterdam Sexual Abuse Case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet. Bmc Psychiatry, 14 (1) 295 doi: 10.1186/s12888-014-0295-7

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., Kan, Kees-Jan, Abdellaoui, Abdel, van Beijsterveldt, Catharina E. M., Ehli, Erik A., Davies, Gareth E., Scheet, Paul A., Xiao, Xiangjun, Hudziak, James J., Hottenga, Jouke-Jan, Neale, Ben M. and Boomsma, Dorret I. (2014). Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. Journal of the American Academy of Child and Adolescent Psychiatry, 53 (10), 1123-1129. doi: 10.1016/j.jaac.2014.06.014

  • Perry, John R. B., Day, Felix, Elks, Cathy E., Sulem, Patrick, Thompson, Deborah J., Ferreira, Teresa, He, Chunyan, Chasman, Daniel I., Esko, Toenu, Thorleifsson, Gudmar, Albrecht, Eva, Ang, Wei Q., Corre, Tanguy, Cousminer, Diana L., Feenstra, Bjarke, Franceschini, Nora, Ganna, Andrea, Johnson, Andrew D., Kjellqvist, Sanela, Lunetta, Kathryn L., McMahon, George, Nolte, Ilja M., Paternoster, Lavinia, Porcu, Eleonora, Smith, Albert V., Stolk, Lisette, Teumer, Alexander, Tsernikova, Natalia, Tikkanen, Emmi ... Middeldorp, Christel (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92-97. doi: 10.1038/nature13545

  • Cousminer, Diana L., Stergiakouli, Evangelia, Berry, Diane J., Ang, Wei, Groen-Blokhuis, Maria M., Koerner, Antje, Siitonen, Niina, Ntalla, Ioanna, Marinelli, Marcella, Perry, John R. B., Kettunen, Johannes, Jansen, Rick, Surakka, Ida, Timpson, Nicholas J., Ring, Susan, Mcmahon, George, Power, Chris, Wang, Carol, Kahonen, Mika, Viikari, Jorma, Lehtimaki, Terho, Middeldorp, Christel M., Pol, Hilleke E. Hulshoff, Neef, Madlen, Weise, Sebastian, Pahkala, Katja, Niinikoski, Harri, Zeggini, Eleftheria, Panoutsopoulou, Kalliope ... Warrington, Nicole M. (2014). Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human Molecular Genetics, 23 (16) ddu150, 4452-4464. doi: 10.1093/hmg/ddu150

  • Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Jansen, R., Penninx, B. W., Middeldorp, C. M. and Boomsma, D. I. (2014). Further confirmation of the association between anxiety and CTNND2: replication in humans. Genes, Brain and Behavior, 13 (2), 195-201. doi: 10.1111/gbb.12095

  • Ligthart, Lannie, Hottenga, Jouke-Jan, Lewis, Cathryn M., Farmer, Anne E., Craig, Ian W., Breen, Gerome, Willemsen, Gonneke, Vink, Jacqueline M., Middeldorp, Christel M., Byrne, Enda M., Heath, Andrew C., Madden, Pamela A. F., Pergadia, Michele L., Montgomery, Grant W., Martin, Nicholas G., Penninx, Brenda W. J. H., McGuffin, Peter, Boomsma, Dorret I. and Nyholt, Dale R. (2014). Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders. Human Genetics, 133 (2), 173-186. doi: 10.1007/s00439-013-1370-8

  • Benke, Kelly S., Nivard, Michel G., Velders, Fleur P., Walters, Raymond K., Pappa, Irene, Scheet, Paul A., Xiao, Xiangjun, Ehli, Erik A., Palmer, Lyle J., Whitehouse, Andrew J. O., Verhulst, Frank C., Jaddoe, Vincent W., Rivadeneira, Fernando, Groen-Blokhuis, Maria M., van Beijsterveldt, Catharina E. M., Davies, Gareth E., Hudziak, James J., Lubke, Gitta H., Boomsma, Dorret I., Pennell, Craig E., Tiemeier, Henning and Middeldorp, Christel M. (2014). A genome-wide association meta-analysis of preschool internalizing problems. Journal of the American Academy of Child and Adolescent Psychiatry, 53 (6), 667-676. doi: 10.1016/j.jaac.2013.12.028

  • Middeldorp, Christel M., Lamb, Diane J., Vink, Jacqueline M., Bartels, Meike, van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2014). Child care, socio-economic status and problem behavior: a study of gene-environment interaction in young Dutch twins. Behavior Genetics, 44 (4), 314-325. doi: 10.1007/s10519-014-9660-z

  • Wright, Fred A., Sullivan, Patrick F., Brooks, Andrew I., Zou, Fei, Sun, Wei, Xia, Kai, Madar, Vered, Jansen, Rick, Chung, Wonil, Zhou, Yi-Hui, Abdellaoui, Abdel, Batista, Sandra, Butler, Casey, Chen, Guanhua, Chen, Ting-Huei, D'Ambrosiol, David, Gallins, Paul, Ha, Min Jin, Hottenga, Jouke Jan, Huang, Shunping, Kattenberg, Mathijs, Kochar, Jaspreet, Middeldorp, Christel M., Qui, Ani, Shabalinn, Andrey, Tischfield, Jay, Todd, Laura, Tzeng, Jung-Ying, van Grootheest, Gerard ... Boomsma, Dorret I. (2014). Heritability and genomics of gene expression in peripheral blood. Nature Genetics, 46 (5), 430-437. doi: 10.1038/ng.2951

  • Wray, Naomi R., Lee, Sang Hong, Mehta, Divya, Vinkhuyzen, Anna A. E., Dudbridge, Frank and Middeldorp, Christel M. (2014). Research Review: Polygenic methods and their application to psychiatric traits. Journal of Child Psychology and Psychiatry, 55 (10), 1068-1087. doi: 10.1111/jcpp.12295

  • Culverhouse, Robert C., Bowes, Lucy, Breslau, Naomi, Nurnberger, John I. Jr, Burmeister, Margit, Fergusson, David M., Munafo, Marcus, Saccone, Nancy L., Bierut, Laura J., 5-HTTLPR, Stress, and Depression Consortium, Wray, Naomi and Middeldorp, Christel (2013). Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression. BMC Psychiatry, 13 (1) 304, 1-12. doi: 10.1186/1471-244X-13-304

  • Lee, S. Hong, Ripke, Stephan, Neale, Benjamin M., Faraone, Stephen V., Purcell, Shaun M., Perlis, Roy H., Mowry, Bryan J., Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H., Backlund, Lena, Badner, Judith A., Bailey, Anthony J., Banaschewski, Tobias, Barchas, Jack D., Barnes, Michael R., Barrett, Thomas B., Bass, Nicholas ... Wray, Naomi R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45 (9), 984-995. doi: 10.1038/ng.2711

  • Brandys, Marek K., Kas, Martien J. H., van Elburg, Annemarie A., Ophoff, Roel, Slof-Op't Landt, Margarita C. T., Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, P. Eline and Adan, Roger A. H. (2013). The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis. World Journal of Biological Psychiatry, 14 (6), 441-451. doi: 10.3109/15622975.2011.605470

  • Groen-Blokhuis, Maria M., Franic, S., van Beijsterveldt, Catharina E. M., de Geus, Eco, Bartels, Meike, Davies, Gareth E., Ehli, Erik A., Xiao, Xiangjun, Scheet, Paul A., Althoff, Robert, Hudziak, James J., Middeldorp, Christel M. and Boomsma, Dorret I. (2013). A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 162 (5), 457-465. doi: 10.1002/ajmg.b.32175

  • Cousminer D.L., Berry D.J., Timpson N.J., Ang W., Thiering E., Byrne E.M., Rob Taal H., Huikari V., Bradfield J.P., Kerkhof M., Groen-Blokhuis M.M., Kreiner-Moller E., Marinelli M., Holst C., Leinonen J.T., Perry J.R.B., Surakka I., Pietilainen O., Kettunen J., Anttila V., Kaakinen M., Sovio U., Pouta A., Das S., Lagou V., Power C., Prokopenko I., Evans D.M., Kemp J.P. ... Middeldorp, Christel (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22 (13), 2735-2747. doi: 10.1093/hmg/ddt104

  • de Geus, Eco J. C. and Middeldorp, Christel M. (2013). Serotonin transporter gene: will epigenetics prove less depressing than genetics?. Psychosomatic Medicine, 75 (6), 520-522. doi: 10.1097/PSY.0b013e318298708f

  • Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Wray, Naomi, Byrne, Enda M., Martin, Nicholas G., Gordon, Scott D., Henders, Anjali K., Montgomery, Grant M., Nyholt, Dale R. and Middeldorp, Christel M. (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, 18 (4), 497-511. doi: 10.1038/mp.2012.21

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., Van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2013). Erratum: Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems (Twin Research and Human Genetics (2011) 14 (393-400) doi:10.1375/twin.14.5.393). Twin Research and Human Genetics, 16 (2), 650-650. doi: 10.1017/thg.2012.52

  • Smoller, Jordan W., Craddock, Nicholas, Kendler, Kenneth, Lee, Phil Hyoun, Neale, Benjamin M., Nurnberger, John I., Ripke, Stephan, Santangelo, Susan, Sullivan, Patrick F., Cross-Disorder Group of the Psychiatric Genomics Consortium and Middeldorp, Christel (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet, 381 (9875), 1371-1379. doi: 10.1016/S0140-6736(12)62129-1

  • Peyrot, Wouter J., Middeldorp, Christel M., Jansen, Rick, Smit, Johannes H., de Geus, Eco J. C., Hottenga, Jouke-Jan, Willemsen, Gonneke, Vink, Jacqueline M., Virding, Susanne, Barragan, Isabel, Ingelman-Sundberg, Magnus, Sim, Sarah C., Boomsma, Dorret I. and Penninx, Brenda W. J. H. (2013). Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. Journal of Affective Disorders, 146 (1), 91-99. doi: 10.1016/j.jad.2012.08.044

  • van Beijsterveldt, Catharina E. M., Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Franic, Sanja, Hudziak, James J., Lamb, Diane, Huppertz, Charlotte, de Zeeuw, Eveline, Nivard, Michel, Schutte, Nienke, Swagerman, Suzanne, Glasner, Tina, van Fulpen, Michelle, Brouwer, Cyrina, Stroet, Therese, Nowotny, Dustin, Ehli, Erik A., Davies, Gareth E., Scheet, Paul, Orlebeke, Jacob F., Kan, Kees-Jan, Smit, Dirk, Dolan, Conor V., Middeldorp, Christel M., de Geus, Eco J. C., Bartels, Meike and Boomsma, Dorret I. (2013). The young Netherlands twin register (YNTR): Longitudinal twin and family studies in over 70,000 children. Twin Research and Human Genetics, 16 (1), 252-267. doi: 10.1017/thg.2012.118

  • Kan, Kees-Jan, Dolan, Conor V., Nivard, Michel G., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Willemsen, Gonneke and Boomsma, Dorret I. (2013). Genetic and environmental stability in attention problems across the lifespan: evidence from The Netherlands twin register. Journal of the American Academy of Child and Adolescent Psychiatry, 52 (1), 12-25. doi: 10.1016/j.jaac.2012.10.009

  • Slof-Op't Landt, Margarita C. T., Bartels, Meike, Middeldorp, Christel M., van Beijsterveldt, Catherina E. M., Slagboom, P. Eline, Boomsma, Dorret I., van Furth, Eric F. and Meulenbelt, Ingrid (2013). Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders. Behavior Genetics, 43 (1), 24-33. doi: 10.1007/s10519-012-9569-3

  • Geels, Lot M., Groen-Blokhuis, Maria M., van Beijsterveldt, Catharina E. M., Vink, Jacqueline M., Middeldorp, Christel M., Bartels, Meike, Nelson, Kelly A., Huizenga, Patricia E., Davies, Gareth E. and Boomsma, Dorret I. (2012). Maternal Prenatal Smoking and Offspring Emotional Problems: No Moderating Effect of Maternal or Child 5-HTTLPR Genotype. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 159B (8), 1009-1012. doi: 10.1002/ajmg.b.32110

  • Vink, Jacqueline M., Bartels, Meike, van Beijsterveldt, Toos C. E. M., van Dongen, Jenny, van Beek, Jenny H. D. A., Distel, Marijn A., de Moor, Marleen H. M., Smit, Dirk J. A., Minica, Camelia C., Ligthart, Lannie, Geels, Lot M., Abdellaoui, Abdel, Middeldorp, Christel M., Hottenga, Jouke Jan, Willemsen, Gonneke, de Geus, Eco J. C. and Boomsma, Dorret I. (2012). Sex differences in genetic architecture of complex phenotypes?. PLoS One, 7 (12) e47371, e47371.1-e47371.8. doi: 10.1371/journal.pone.0047371

  • Lubke, Gitta H., Hottenga, Jouke Jan, Walters, Raymond, Laurin, Charles, de Geus, Eco J. C., Willemsen, Gonneke, Smit, Jan H., Middeldorp, Christel M., Penninx, Brenda W. J. H., Vink, Jacqueline M. and Boomsma, Dorret I. (2012). Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biological Psychiatry, 72 (8), 707-709. doi: 10.1016/j.biopsych.2012.03.011

  • Luciano, Michelle, Huffman, Jennifer E., Arias-Vasquez, Alejandro, Vinkhuyzen, Anna A. E., Middeldorp, Christel M., Giegling, Ina, Payton, Antony, Davies, Gail, Zgaga, Lina, Janzing, Joost, Ke, Xiayi, Galesloot, Tessel, Hartmann, Annette M., Ollier, William, Tenesa, Albert, Hayward, Caroline, Verhagen, Maaike, Montgomery, Grant W., Hottenga, Jouke-Jan, Konte, Bettina, Starr, John M., Vitart, Veronique, Vos, Pieter E., Madden, Pamela A. F., Willemsen, Gonneke, Konnerth, Heike, Horan, Michael A., Porteous, David J., Campbell, Harry ... Deary, Ian J. (2012). Genome-wide association uncovers shared genetic effects among personality traits and mood states. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B (6), 684-695. doi: 10.1002/ajmg.b.32072

  • Lamb, Diane J., Middeldorp, Christel M., Van Beijsterveldt, Catarina E. M. and Boomsma, Dorret I. (2012). Gene-environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins. Journal of Child Psychology and Psychiatry, 53 (8), 818-825. doi: 10.1111/j.1469-7610.2011.02497.x

  • Brandys, Marek K., Landt, Margarita C. T. Slof-Op't, van Elburg, Annemarie A., Ophoff, Roel, Verduijn, Willem, Meulenbelt, Ingrid, Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, Eline, Kas, Martien J. H. and Adan, Roger A. H. (2012). Anorexia nervosa and the Val158Met polymorphism of the COMT gene: Meta-analysis and new data. Psychiatric Genetics, 22 (3), 130-136. doi: 10.1097/YPG.0b013e328351859e

  • Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Møller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Mònica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bønnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J. ... Middeldorp, Christel (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5), 532-538. doi: 10.1038/ng.2238

  • Webb, Bradley T., Guo, An-Yuan, Maher, Brion S., Zhao, Zhongming, van den Oord, Edwin J., Kendler, Kenneth S., Riley, Brien P., Gillespie, Nathan A., Prescott, Carol A., Middeldorp, Christel M., Willemsen, Gonneke, de Geus, Eco J. C., Hottenga, Jouke-Jan, Boomsma, Dorret I., Slagboom, Eline P., Wray, Naomi R., Montgomery, Grant W., Martin, Nicholas G., Wright, Margie J., Heath, Andrew C., Madden, Pamela A., Gelernter, Joel, Knowles, James A., Hamilton, Steven P., Weissman, Myrna M., Fyer, Abby J., Huezo-Diaz, Patricia, McGuffin, Peter, Farmer, Anne ... Hettema, John M. (2012). Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics, 20 (10), 1078-1084. doi: 10.1038/ejhg.2012.47

  • Lamb, Diane J., Vink, Jacqueline M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Haak, Monique C., Overbeek, Lucy I. H. and Boomsma, Dorret I. (2012). Effects of chorionicity and zygosity on triplet birth weight. Twin Research and Human Genetics, 15 (2), 149-157. doi: 10.1375/twin.15.2.149

  • Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stephanie, Vrooman, Henri A., Sigurdsson, S., Ropele, Sigurdur, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., Destefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack,Clifford R., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J. ... . (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539-544. doi: 10.1038/ng.2245

  • Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., MacLean, A. W., Smit, J. H., Hottenga, J. J., Willemsen, G., Middeldorp, C. M., De Geus, E. J. C., Lewis, C. M., McGuffin, P., Hickie, I. B., Van Den Oord, E. J. C. G., Liu, J. Z., MacGregor, S., McEvoy, B. P., Byrne, E. M., Medland, S. E., Statham, D. J., Henders, A. K., Heath, A. C., Montgomery, G. W., Martin, N. G. ... Sullivan, P. F. (2012). Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Molecular Psychiatry, 17 (1), 36-48. doi: 10.1038/mp.2010.109

  • Distel, Marijn A., Carlier, Angela, Middeldorp, Christel M., Derom, Catherine A., Lubke, Gitta H. and Boomsma, Dorret I. (2011). Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity. American Journal of Medical Genetics Part B - Neuropsychiatric Genetics, 156 (7), 817-825. doi: 10.1002/ajmg.b.31226

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2011). Evidence for a causal association of low birth weight and attention problems. Journal of the American Academy of Child and Adolescent Psychiatry, 50 (12), 1247-1254. doi: 10.1016/j.jaac.2011.09.007

  • Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2011). Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems. Twin Research and Human Genetics, 14 (5), 393-400. doi: 10.1375/twin.14.5.393

  • Lamb, Diane J., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Vink, Jacqueline M., Haak, Monique C. and Boomsma, Dorret I. (2011). Birth weight in a large series of triplets. BMC Pediatrics, 11 (1) 24, 24.1-24.11. doi: 10.1186/1471-2431-11-24

  • Distel, M. A., Middeldorp, C. M., Trull, T. J., Derom, C. A., Willemsen, G. and Boomsma, D. I. (2011). Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation. Psychological Medicine, 41 (4), 849-860. doi: 10.1017/S0033291710001297

  • Slof-Op't Landt, M. C. T. , Meulenbelt, I., Bartels, M., Suchiman, E., Middeldorp, C. M., Houwing-Duistermaat, J. J., van Trier, J., Onkenhout, E. J., Vink, J. M., van Beijsterveldt, C. E. M., Brandys, M. K., Sanders, N., Zipfel, S., Herzog, W., Herpertz-Dahlmann, B., Klampfl, K., Fleischhaker, C., Zeeck, A., de Zwaan, M., Herpertz, S., Ehrlich, S., van Elburg, A. A., Adan, R. A. H., Scherag, S., Hinney, A., Hebebrand, J., Boomsma, D. I., van Furth, E. F. and Slagboom, P. E. (2011). Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. Genes, Brain and Behavior, 10 (2), 236-243. doi: 10.1111/j.1601-183X.2010.00660.x

  • Bartels, Meike, van de Aa, Niels, van Beijsterveldt, Catherina E. M., Middeldorp, Christel M. and Boomsma, Dorret I. (2011). Adolescent self-report of emotional and behavioral problems: interactions of genetic factors with sex and age. Canadian Academy of Child and Adolescent Psychiatry, 20 (1), 35-52.

  • Demirkan, A., Phenninx, B. W. J. H., Hek, K., Wray, N. R., Amin, N., Aulchenko, Y. S., van Dyck, R., de Geus, E. J. C., Hofman, A., Uitterlanden, A. G., Hottenga, J.-J., Nolen, W. A., Oostra, B. A., Sullivan, P. F., Willemsen, G., Zitman, F. G., Tiemeier, H., Janssens, A. C. J. W., Boomsma, D. I., van Duijn, C. M. and Middeldorp, C. M. (2011). Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16 (7), 773-783. doi: 10.1038/mp.2010.65

  • van Beijsterveldt, Catherina E. M., Middeldorp, Christel M., Landt, Margarita C. T. Slof-Op't, Bartels, Meike, Hottenga, Jouke-Jan, Suchiman, H. Eka D., Slagboom, P. Eline and Boomsma, Dorret I. (2011). Influence of candidate genes on attention problems in children: a longitudinal study. Behavior Genetics, 41 (1), 155-164. doi: 10.1007/s10519-010-9406-5

  • Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, D. R., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J-J., Distel, M. A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C. A, Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A. ... Boomsma, D. I. (2011). The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry, 1 (10) e50, e50.1-e50.8. doi: 10.1038/tp.2011.45

  • Kendler, Kenneth S., Eaves, Lindon J., Loken, Erik K., Pedersen, Nancy L., Middeldorp, Christel M., Reynolds, Chandra, Boomsma, Dorret, Lichtenstein, Paul, Silberg, Judy and Gardner, Charles O. (2011). The impact of environmental experiences on symptoms of anxiety and depression across the life span. Psychological Science, 22 (10), 1343-1352. doi: 10.1177/0956797611417255

  • Perlis, Roy H., Huang, Jie, Purcell, Shaun, Fava, Maurizio, Rush, A. John, Sullivan, Patrick F., Hamilton, Steven P., McMahon, Francis J., Schulze, Thomas, Potash, James B., Zandi, Peter P., Willour, Virginia L., Penninx, Brenda W., Boomsma, Dorret I., Vogelzangs, Nicole, Middeldorp, Christel M., Rietschel, Marcella, Noethen, Markus, Cichon, Sven, Gurling, Hugh, Bass, Nick, McQuillin, Andrew, Hamshere, Marian, Craddock, Nick, Sklar, Pamela and Smoller, Jordan W. (2010). Genome-wide association study of suicide attempts in mood disorder patients. American Journal of Psychiatry, 167 (12), 1499-1507. doi: 10.1176/appi.ajp.2010.10040541

  • Middeldorp, Christel M., de Geus, Eco J. C., Willemsen, Gonneke, Hottenga, Jouke-Jan, Slagboom, P. Eline and Boomsma, Dorret I. (2010). The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin Research and Human Genetics, 13 (6), 544-549. doi: 10.1375/twin.13.6.544

  • Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Medland, S. E., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G., Hottenga, J. -J., de Geus, E. J. C., Suchiman, H. E. D., Dolan, C. V., Neale, M. C., Slagboom, P. E. and Boomsma, D. I. (2010). Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?. Genes, Brain and Behavior, 9 (7), 808-816. doi: 10.1111/j.1601-183X.2010.00619.x

  • Lamb, Diane J., Middeldorp, Christel M., van Beijsterveldt, Catarina E. M., Bartels, Meike, van der Aa, Niels, Polderman, Tinca J. C. and Boomsma, Dorret I. (2010). Heritability of Anxious-Depressive and Withdrawn Behavior: Age-Related Changes During Adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 49 (3), 248-255. doi: 10.1016/j.jaac.2009.11.014

  • Middeldorp, Christel M., Vink, Jacqueline M., Hettema, John M., de Geus, Eco J. C., Kendler, Kenneth S., Willemsen, Gonneke, Neale, Michael C., Boomsma, Dorret I. and Chen, Xiangning (2010). An association between Epac-1 gene variants and anxiety and depression in two independent samples. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 153 (1), 214-219. doi: 10.1002/ajmg.b.30976

  • Franic, Sanja, Middeldorp, Christel M., Dolan, Conor V., Ligthart, Lannie and Boomsma, Dorret I. (2010). Childhood and adolescent anxiety and depression: Beyond heritability. Journal of the American Academy of Child and Adolescent Psychiatry, 49 (8), 820-829. doi: 10.1016/j.jaac.2010.05.013

  • Swets, M., Middeldorp, C. M. and Schoevers, R. A. (2009). Heritability and environment in psychiatric disorders Erfelijkheid en omgevingsinvloeden bij psychiatrische stoornissen. Tijdschrift voor Psychiatrie, 51 (9), 651-663.

  • Middeldorp, C. M. and Boomsma, D. I. (2009). Reaction on 'gene environment interaction: Mechanism of action of early relationshiops?' Reactie op 'de gen-omgevingsinteractie en de psychiatrie: Nieuwe visie op de invloed van de vroege omgeving'. Tijdschrift voor Psychiatrie, 51 (4), 267-268.

  • Rodger, M. A., Paidas, M., McLintock, C., Middeldorp, C., Kahn, S., Martinelli, I., Hague, W., Montella, K. R. and Greer, I. (2008). Erratum: Inherited thrombophilia and pregnancy complications revisited (Obstetrics & Gynecology (2008) 112 (320-324)). Obstetrics and Gynecology, 112 (6) doi: 10.1097/01.AOG.0000341971.18168.2d

  • Middeldorp, C. M., Cath, D. C., Beem, A. L., Willemsen, G. and Boomsma, D. I. (2008). Life events, anxious depression and personality: A prospective and genetic study. Psychological Medicine, 38 (11), 1557-1565. doi: 10.1017/S0033291708002985

  • Middeldorp, CM, Sullivan, PF, Wray, NR, Hottenga, JJ, de Geus, EJC, van den Berg, M, Montgomery, GW, Coventry, WL, Statham, DJ, Andrews, G, Slagboom, PE, Boomsma, DI and Martin, NG (2008). Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B (3), 352-358. doi: 10.1002/ajmg.b.30817

  • Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G., Hettema, J. M., An, S. S., Neale, M. C., van den Oord, E. J., Kendler, K. S., Chen, X., Boomsma, D. I., Middeldorp, C. M., Hottenga, J. J., Slagboom, P. E. and Flint, J. (2008). A whole genome association study of neuroticism using DNA pooling. Molecular Psychiatry, 13 (3), 302-312. doi: 10.1038/sj.mp.4002048

  • Wray, Naomi R., Middeldorp, Christel M., Birley, Andrew J., Gordon, Scott D., Sullivan, Patrick F., Visscher, Peter M., Nyholt, Dale R, Willemsen, Gonneke, de Geus, Eco J.C., Slagboom, P. Eline, Montgomery, Grant W., Martin, Nicholas G. and Boomsma, Dorret I. (2008). Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Archives of General Psychiatry, 65 (6), 649-658. doi: 10.1001/archpsyc.65.6.649

  • Distel, Marijn A., Vink, Jacqueline M., Willemsen, Gonneke, Middeldorp, Christel M., Merckelbach, Harald L. G. J. and Boomsma, Dorret I. (2008). Heritability of self-reported phobic fear. Behavior Genetics, 38 (1), 24-33. doi: 10.1007/s10519-007-9182-z

  • Middeldorp, C. M., Hottenga, J-J, Slagboom, P. E., Sullivan, P. F., de Geus, E. J. C., Posthuma, D., Willemsen, G. and Boomsma, D. I. (2008). Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Molecular Psychiatry, 13 (1), 84-89. doi: 10.1038/sj.mp.4002061

  • Middeldorp, Christel M., de Geus, Eco J. C., Beem, A. Leo, Lakenberg, Nico, Hottenga, Jouke-Jan, Slagboom, P. Eline and Boomsma, Dorret I. (2007). Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behavior Genetics, 37 (2), 294-301. doi: 10.1007/s10519-006-9139-7

  • Middeldorp, CM, Cath, DC and Boomsma, DI (2006). A twin-family study of the association between employment, burnout and anxious depression. Journal of Affective Disorders, 90 (2-3), 163-169. doi: 10.1016/j.jad.2005.11.004

  • Middledorp, Christel M., Birley, Andrew J., Cath, Danielle C., Gillespie, Nathan A., Willemsen, Gonneke, Statham, Dixie J., de Geus, Eco J. C., Andrews, J. Gavin, van Dyck, Richard, Beem, A. Leo, Sullivan, Patrick F., Martin, Nicholas G. and Boomsma, Dorret I. (2005). Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. Twin Research and Human Genetics, 8 (6), 609-615. doi: 10.1375/183242705774860123

  • Middeldorp, CM, Cath, DC, Vink, JM and Boomsma, DI (2005). Twin and genetic effects on life events. Twin Research and Human Genetics, 8 (3), 224-231. doi: 10.1375/1832427054253130

  • Middeldorp, CM, Cath, DC, Van Dyck, R and Boomsma, DI (2005). The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychological Medicine, 35 (5), 611-624. doi: 10.1017/S003329170400412X

  • Middeldorp, CM, Stubbe, JH, Cath, DC and Boomsma, DI (2005). Familial clustering in burnout: A twin-family study. Psychological Medicine, 35 (1), 113-120. doi: 10.1017/S0033291704002983

  • Vink, JM, Willemsen, G, Stubbe, JH, Middeldorp, CM, Ligthart, RSL, Baas, KD, Dirkzwager, HJC, de Geus, EJC and Boomsma, DI (2004). Estimating non-response bias in family studies: Application to mental health and lifestyle. European Journal of Epidemiology, 19 (7), 623-630. doi: 10.1023/B:EJEP.0000036814.56108.66

  • Middeldorp, CM, Geerts, AT, Brouwer, TF, Peters, ACB, Stroink, H, van Donselaar, CA and Arts, WFM (2002). Nonsymptomatic generalized epilepsy in children younger than six years: Excellent prognosis, but classification should be reconsidered after follow-up: The Dutch Study of Epilepsy in Childhood. Epilepsia, 43 (7), 734-739. doi: 10.1046/j.1528-1157.2002.72601.x

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