The University of Queensland

Behavior genetics: From heritability to gene finding

Nivard, Michel, Dolan, Conor V., Middeldorp, Christel M. and Boomsma, Dorret I. (2016). Behavior genetics: From heritability to gene finding. Handbook of Psychophysiology. (pp. 339-353) Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/9781107415782.015

Psychiatric perspective

van Dyck, Richard, van Balkom, Anton J.L.M., van den Heuvel, Odile A. and Middeldorp, Christel M. (2014). Psychiatric perspective. The Wiley handbook of anxiety disorders. (pp. 1371-1381) edited by Paul Emmelkamp and Thomas Ehring. Chichester, West Sussex, United Kingdom: John Wiley & Sons.

Genetics and Psychopathology

Middeldorp, Christel M. and Boomsma, Dorret I. (2009). Genetics and Psychopathology. Handbook of neuroscience for the behavioral sciences. (pp. 1180-1202) edited by Gary G. Berntson and John T. Cacioppo. New York, NY, United States: Wiley. doi: 10.1002/9780470478509.neubb002060

The association of personality with anxious and depressive psychopathology

Middeldorp, Christel M., Cath, Danielle C., van den Berg, Mireille, Beem, A. Leo, van Dyck, Richard and Boomsma, Dorret I. (2006). The association of personality with anxious and depressive psychopathology. The biology of personality and individual differences. (pp. 251-272) edited by Turhan Canli. New York, NY, United States: Guilford Press.

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Shen, Xueyi, Howard, David M., Adams, Mark J., Hill, W. David, Clarke, Toni-Kim, Adams, Mark J., Clarke, Toni-Kim, McIntosh, Andrew M., Deary, Ian J., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard ... McIntosh, Andrew M. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1) 2301 doi: 10.1038/s41467-020-16022-0

Effects of the ‘Circle of Security’ group parenting program (COS-P) with foster carers: An observational study

Krishnamoorthy, Govind, Hessing, Paula, Middeldorp, Christel and Branjerdporn, Melissa (2020). Effects of the ‘Circle of Security’ group parenting program (COS-P) with foster carers: An observational study. Children and Youth Services Review, 115 105082, 105082. doi: 10.1016/j.childyouth.2020.105082

Illicit drug use by mothers and their daughters in Australia: a comparison of two generations

Najman, Jackob. M., Middeldorp, Christel, Williams, Gail M., Scott, James G., McGee, Tara, Bor, William, Clavarino, Alexandra M and Mamun, Abdullah (2020). Illicit drug use by mothers and their daughters in Australia: a comparison of two generations. Addictive Behaviors, 106 106321, 106321. doi: 10.1016/j.addbeh.2020.106321

Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression and DNA methylation studies

Hammerschlag, Anke R., Byrne, Enda M., Bartels, Meike, Wray, Naomi R., Middeldorp, Christel M., eQTLGen Consortium, BIOS Consortium, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Bonder, Marc Jan, Boomsma, Dorret I., Christiansen, Mark, Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Gregory, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette ... Agbessi, Mawussé (2020). Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression and DNA methylation studies. Biological Psychiatry doi: 10.1016/j.biopsych.2020.05.002

Systematic review: anxiety in children and adolescents with chronic medical conditions

Cobham, Vanessa E., Hickling, Anna, Kimball, Hayley, Thomas, Hannah J., Scott, James G. and Middeldorp, Christel M. (2020). Systematic review: anxiety in children and adolescents with chronic medical conditions. Journal of the American Academy of Child and Adolescent Psychiatry, 59 (5), 595-618. doi: 10.1016/j.jaac.2019.10.010

Prevalence of mental illness among parents of children receiving treatment within child and adolescent mental health services (CAMHS): a scoping review

Campbell, Timothy C. H., Reupert, Andrea, Sutton, Keith, Basu, Soumya, Davidson, Gavin, Middeldorp, Christel M., Naughton, Michael and Maybery, Darryl (2020). Prevalence of mental illness among parents of children receiving treatment within child and adolescent mental health services (CAMHS): a scoping review. European Child and Adolescent Psychiatry doi: 10.1007/s00787-020-01502-x

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Coleman, Jonathan R. I., Peyrot, Wouter J., Purves, Kirstin L., Davis, Katrina A. S., Rayner, Christopher, Choi, Shing Wan, Hübel, Christopher, Gaspar, Héléna A., Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M., Choi, Karmel W., Dunn, Erin C., Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J., Lewis, Cathryn M., O’Reilly, Paul F., McIntosh, Andrew M., Smith, Daniel J., Wray, Naomi R., Hotopf, Matthew, Eley, Thalia C., Breen, Gerome, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, Maciej, Byrne, Enda M. ... Middeldorp, Christel M. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25 (7), 1430-1446. doi: 10.1038/s41380-019-0546-6

Maternal and paternal effects on offspring internalizing problems: results from genetic and family-based analyses

Jami, Eshim S., Eilertsen, Espen Moen, Hammerschlag, Anke R., Qiao, Zhen, Evans, David M., Ystrøm, Eivind, Bartels, Meike and Middeldorp, Christel M. (2020). Maternal and paternal effects on offspring internalizing problems: results from genetic and family-based analyses. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 183 (5), 258-267. doi: 10.1002/ajmg.b.32784

Nick Martin and the genetics of depression: sample size, sample size, sample size

Byrne, Enda M., Henders, Anjali K., Hickie, Ian B., Middeldorp, Christel M. and Wray, Naomi R. (2020). Nick Martin and the genetics of depression: sample size, sample size, sample size. Twin Research and Human Genetics, 23 (2), 1-3. doi: 10.1017/thg.2020.13

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Czamara, Darina, Eraslan, Gökçen, Page, Christian M., Lahti, Jari, Lahti-Pulkkinen, Marius, Hämäläinen, Esa, Kajantie, Eero, Laivuori, Hannele, Villa, Pia M., Reynolds, Rebecca M., Nystad, Wenche, Håberg, Siri E., London, Stephanie J., O’Donnell, Kieran J., Garg, Elika, Meaney, Michael J., Entringer, Sonja, Wadhwa, Pathik D., Buss, Claudia, Jones, Meaghan J., Lin, David T. S., MacIsaac, Julie L., Kobor, Michael S., Koen, Nastassja, Zar, Heather J., Koenen, Karestan C., Dalvie, Shareefa, Stein, Dan J., Kondofersky, Ivan ... Binder, Elisabeth B. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10 (1) 2548 doi: 10.1038/s41467-019-10461-0

Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: Results from two longitudinal studies

Doering, Sabrina, Lichtenstein, Paul, Gillberg, Christopher, Boomsma, D. I., Van Beijsterveldt, Toos C. E. M., Ligthart, Lannie, Willemsen, Gonneke, De Geus, Eco, Middeldorp, Christel M., Bartels, Meike, Kuja-Halkola, Ralf and Lundström, Sebastian (2019). Anxiety at age 15 predicts psychiatric diagnoses and suicidal ideation in late adolescence and young adulthood: Results from two longitudinal studies. BMC Psychiatry, 19 (1) 363, 363. doi: 10.1186/s12888-019-2349-3

Editorial: childhood stress and psychopathology: it’s not too early to look at biological aging

Middeldorp, Christel M. (2019). Editorial: childhood stress and psychopathology: it’s not too early to look at biological aging. Journal of the American Academy of Child and Adolescent Psychiatry, 59 (1), 38-39. doi: 10.1016/j.jaac.2019.09.020

Unraveling the genetic architecture of major depressive disorder: Merits and pitfalls of the approaches used in genome-wide association studies

Schwabe, I., Milaneschi, Y., Gerring, Z., Sullivan, P. F., Schulte, E., Suppli, N. P., Thorp, J. G., Derks, E. M. and Middeldorp, C. M. (2019). Unraveling the genetic architecture of major depressive disorder: Merits and pitfalls of the approaches used in genome-wide association studies. Psychological Medicine, 49 (16), 2646-2656. doi: 10.1017/S0033291719002502

Maternal environmental risk factors and the development of internalizing and externalizing problems in childhood: the complex role of genetic factors

Ensink, Judith B. M., de Moor, Marleen H. M., Zafarmand, Mohammad Hadi, de Laat, Sanne, Uitterlinden, André, Vrijkotte, Tanja G. M., Lindauer, Ramón and Middeldorp, Christel M. (2019). Maternal environmental risk factors and the development of internalizing and externalizing problems in childhood: the complex role of genetic factors. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 183 (1) ajmg.b.32755, 17-25. doi: 10.1002/ajmg.b.32755

Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression

Glanville, Kylie P., Coleman, Jonathan R. I., Hanscombe, Ken B., Euesden, Jack, Choi, Shing Wan, Purves, Kirstin L., Breen, Gerome, Air, Tracy M., Andlauer, Till F. M., Baune, Bernhard T., Binder, Elisabeth B., Blackwood, Douglas H. R., Boomsma, Dorret I., Buttenschøn, Henriette N., Colodro-Conde, Lucía, Dannlowski, Udo, Direk, Nese, Dunn, Erin C., Forstner, Andreas J., de Geus, Eco J. C., Grabe, Hans J., Hamilton, Steven P., Jones, Ian, Jones, Lisa A., Knowles, James A., Kutalik, Zoltán, Levinson, Douglas F., Lewis, Glyn, Lind, Penelope A. ... Børglum, Anders D. (2019). Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression. Biological Psychiatry, 87 (5), 419-430. doi: 10.1016/j.biopsych.2019.06.031

Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders

Hammerschlag, Anke R., de Leeuw, Christiaan A., Middeldorp, Christel M. and Polderman, Tinca J. C. (2019). Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders. Psychological Medicine, 50 (10), 1-11. doi: 10.1017/s0033291719001776

Genetic diagnostics: part of the psychiatric clinic Genetisch onderzoek: onderdeel van psychiatrische kliniek

Middeldorp, C. M. (2019). Genetic diagnostics: part of the psychiatric clinic Genetisch onderzoek: onderdeel van psychiatrische kliniek. Tijdschrift voor psychiatrie, 61 (6), 373-374.

Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

Gaspar, Héléna A., Gerring, Zachary, Hübel, Christopher, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Middeldorp, Christel M., Derks, Eske M. and Breen, Gerome (2019). Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder. Translational Psychiatry, 9 (1) 117, 117. doi: 10.1038/s41398-019-0451-4

Identification of common genetic risk variants for autism spectrum disorder

Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel ... Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431-444. doi: 10.1038/s41588-019-0344-8

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Middeldorp, Christel M., Felix, Janine F., Mahajan, Anubha, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) consortium, McCarthy, Mark I. and Mamun, Abdullah (2019). The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. European Journal of Epidemiology, 34 (3), 279-300. doi: 10.1007/s10654-019-00502-9

A potential role for the STXBP5-AS1 gene in adult ADHD symptoms

Arias-Vásquez, A., Groffen, A. J., Spijker, S., Ouwens, K. G., Klein, M., Vojinovic, D., Galesloot, T. E., Bralten, J., Hottenga, J. J., van der Most, P. J., Kattenberg, V. M., Pool, R., Nolte, I. M., Penninx, B. W.J.H., Fedko, I. O., Dolan, C. V., Nivard, M. G., den Braber, A., van Duijn, C. M., Hoekstra, P. J., Buitelaar, J. K., Kiemeney, L. A., Hoogman, M., Middeldorp, C. M., Draisma, H. H.M., Vermeulen, S. H., Sánchez-Mora, C., Ramos-Quiroga, J. A., Ribasés, M. ... Boomsma, D. I. (2019). A potential role for the STXBP5-AS1 gene in adult ADHD symptoms. Behavior Genetics, 49 (3), 270-285. doi: 10.1007/s10519-018-09947-2

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Demontis, Ditte, Walters, Raymond K., Martin, Joanna, Mattheisen, Manuel, Als, Thomas D., Agerbo, Esben, Baldursson, Gísli, Belliveau, Rich, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Eriksson, Nicholas, Gandal, Michael, Goldstein, Jacqueline I., Grasby, Katrina L., Grove, Jakob, Gudmundsson, Olafur O., Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian B., Martin, Alicia R., Martin, Nicholas G., Moran, Jennifer ... Kemp, John P. (2019). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics, 51 (1), 63-75. doi: 10.1038/s41588-018-0269-7

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

Foo, Jerome C., Streit, Fabian, Frank, Josef, Witt, Stephanie H., Treutlein, Jens, Baune, Bernhard T., Moebus, Susanne, Joeckel, Karl-Heinz, Forstner, Andreas J., Noethen, Markus M., Rietschel, Marcella, Sartorius, Alexander, Kranaster, Laura, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1), 35-45. doi: 10.1002/ajmg.b.32700

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Arnau-Soler, Aleix, Adams, Mark J., Hayward, Caroline, Thomson, Pippa A., Porteous, David, Campbell, Archie, Smith, Blair H., Black, Corri, Padmanabhan, Sandosh, McIntosh, Andrew, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13 (12) e0209160, e0209160. doi: 10.1371/journal.pone.0209160

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

de Jong, Simone, Abdalla Diniz, Mateus Jose, Saloma, Andiara, Gadelha, Ary, Santoro, Marcos L., Ota, Vanessa K., Noto, Cristiano, Curtis, Charlesg, Newhouse, Stephen J., Patel, Hamel, Hall, Lynsey S., O'Reilly, Paul F., Belangero, Sintia, Bressan, Rodrigo A., Breen, Gerome, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B. ... Shi, Jianxin (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology, 1 (163) 163 doi: 10.1038/s42003-018-0155-y

Do parental psychiatric symptoms predict outcome in children with psychiatric disorders? A naturalistic clinical study

Wesseldijk, Laura W., Dieleman, Gwen C., van Steensel, Francisa J.A., Bleijenberg, Ellen J., Bartels, Meike, Bögels, Susan M. and Middeldorp, Christel M. (2018). Do parental psychiatric symptoms predict outcome in children with psychiatric disorders? A naturalistic clinical study. Journal of the American Academy of Child and Adolescent Psychiatry, 57 (9), 669-677.e6. doi: 10.1016/j.jaac.2018.05.017

Analysis of shared heritability in common disorders of the brain

Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K., Walters, Raymond K., Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J., Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A., Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H., Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-Francois, Duron, Emmanuelle, Vardarajan, Badri N., Reitz, Christiane, Goate, Alison M. ... The Brainstorm Consortium (2018). Analysis of shared heritability in common disorders of the brain. Science, 360 (6395) 8757, 1313-+. doi: 10.1126/science.aap8757

Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project

Bartels, Meike, Hendriks, Anne, Mauri, Matteo, Krapohl, Eva, Whipp, Alyce, Bolhuis, Koen, Conde, Lucia Colodro, Luningham, Justin, Fung Ip, Hill, Hagenbeek, Fiona, Roetman, Peter, Gatej, Raluca, Lamers, Audri, Nivard, Michel, van Dongen, Jenny, Lu, Yi, Middeldorp, Christel, van Beijsterveldt, Toos, Vermeiren, Robert, Hankemeijer, Thomas, Kluft, Cees, Medland, Sarah, Lundström, Sebastian, Rose, Richard, Pulkkinen, Lea, Vuoksimaa, Eero, Korhonen, Tellervo, Martin, Nicholas G., Lubke, Gitta ... Boomsma, Dorret I. (2018). Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. European Child & Adolescent Psychiatry, 27 (9), 1-17. doi: 10.1007/s00787-018-1169-1

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till M. F., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan I. R., Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Crowley, Cheynna A. ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668-+. doi: 10.1038/s41588-018-0090-3

Risk factors for parental psychopathology: a study in families with children or adolescents with psychopathology

Wesseldijk, L. W., Dieleman, G. C., van Steensel, F. J. A., Bartels, M., Hudziak, J. J., Lindauer, R. J. L., Bögels, S. M. and Middeldorp, C. M. (2018). Risk factors for parental psychopathology: a study in families with children or adolescents with psychopathology. European Child & Adolescent Psychiatry, 27 (12), 1575-1584. doi: 10.1007/s00787-018-1156-6

The value of polygenic analyses in psychiatry

Middeldorp, Christel M. and Wray, Naomi R. (2018). The value of polygenic analyses in psychiatry. World Psychiatry, 17 (1), 26-28. doi: 10.1002/wps.20480

Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank

Barbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien ... Whalley, Heather C. (2018). Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (1), 91-100. doi: 10.1016/j.bpsc.2018.07.006

Corrigendum to “Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age” [Drug Alcohol Depend. 153 (2015) 221–228] (S0376871615002549) (10.1016/j.drugalcdep.2015.05.018))

Treur, Jorien L., Vink, Jacqueline M., Boomsma, Dorret I. and Middeldorp, Christel M. (2018). Corrigendum to “Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age” [Drug Alcohol Depend. 153 (2015) 221–228] (S0376871615002549) (10.1016/j.drugalcdep.2015.05.018)). Drug and Alcohol Dependence, 182, 123. doi: 10.1016/j.drugalcdep.2017.11.002

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, Liz, Streit, Fabian, Zhu, Gu, McAloney, Kerrie, Frank, Josef, Couvy-Duchesne, Baptiste, Witt, Stephanie H., Binz, Tina M., Bolton, Jennifer L., Hayward, Caroline, Direk, Nese, Anderson, Anna, Huffman, Jennifer, Wilson, James F., Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H., Velders, Fleur P., Hofman, Albert, Uitterlinden, Andre G., Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Kaakinen, Marika ... Rietschel, Marcella (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports, 7 (1) 15351, 15351. doi: 10.1038/s41598-017-11852-3

Genetic overlap between schizophrenia and developmental psychopathology: longitudinal and multivariate polygenic risk prediction of common psychiatric traits during development

Nivard, Michel G., Gage, Suzanne H., Hottenga, Jouke J. , van Beijsterveldt, Catharina E. M., Abdellaoui, Abdel, Bartels, Meike, Baselmans, Bart M. L., Ligthart, Lannie, St Pourcain, Beate, Boomsma, Dorret I., Munafò, Marcus R. and Middeldorp, Christel M. (2017). Genetic overlap between schizophrenia and developmental psychopathology: longitudinal and multivariate polygenic risk prediction of common psychiatric traits during development. Schizophrenia Bulletin, 43 (6), 1197-1207. doi: 10.1093/schbul/sbx031

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M. ... Rietschel, M. (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.. Translational psychiatry, 7 (6), e1155-e1155. doi: 10.1038/tp.2017.115

Genetic and environmental influences on conduct and antisocial personality problems in childhood, adolescence, and adulthood

Wesseldijk, Laura W., Bartels, Meike, Vink, Jacqueline M., van Beijsterveldt, Catharina E. M., Ligthart, Lannie, Boomsma, Dorret I. and Middeldorp, Christel M. (2017). Genetic and environmental influences on conduct and antisocial personality problems in childhood, adolescence, and adulthood. European Child & Adolescent Psychiatry, 27 (9), 1-10. doi: 10.1007/s00787-017-1014-y

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olie, E., Villafuerte, S., Air, T. M., Araya, R., Bowes, L., Burns, R., Byrne, E. M., Coffey, C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A. ... Bierut, L. J. (2017). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23 (1), 133-142. doi: 10.1038/mp.2017.44

Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology

Wesseldijk, Laura W., Fedko, Iryna O., Bartels, Meike, Nivard, Michel G., van Beijsterveldt, Catharina E. M., Boomsma, Dorret I. and Middeldorp, Christel M. (2017). Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 174 (3), 251-260. doi: 10.1002/ajmg.b.32500

Genetic effects influencing risk for major depressive disorder in China and Europe

Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S-A, Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschon, H. N., Byrne, E. M., Cichon, S., Clarke, T-K, Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F., Dunn, E. C., Edwards, A. C., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D., Grabe, H. J., Hamilton, S. P. ... Kendler, K. S. (2017). Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7 (3) e1074, e1074-e1074. doi: 10.1038/tp.2016.292

Heritability of behavioral problems in 7-year olds based on shared and unique aspects of parental views

Fedko, Iryna O., Wesseldijk, Laura W., Nivard, Michel G., Hottenga, Jouke-Jan, van Beijsterveldt, Catharina E. M., Middeldorp, Christel M., Bartels, Meike and Boomsma, Dorret I. (2017). Heritability of behavioral problems in 7-year olds based on shared and unique aspects of parental views. Behavior Genetics, 47 (2), 152-163. doi: 10.1007/s10519-016-9823-1

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A-L, Foecker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M., Adan, R., Brandys, M., van Elburg, A., Perica, V. Boraska, Franklin, C. S., Tschoep, M. H., Zeggini, E., Bulik, C. M., Collier, D. ... Middeldorp, Christel (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192-201. doi: 10.1038/mp.2016.71

Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder

Bot, M., Middeldorp, C. M., de Geus, E. J. C., Lau, H. M., Sinke, M., van Nieuwenhuizen, B., Smit, J. H., Boomsma, D. I. and Penninx, B. W. J. H. (2017). Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder. Psychological Medicine, 47 (2), 279-289. doi: 10.1017/S0033291716002312

Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts

Lee, Minyoung, Aggen, Steven H., Otowa, Takeshi, Castelao, Enrique, Preisig, Martin, Grabe, Hans J., Hartman, Catharina A., Oldehinkel, Albertine J., Middeldorp, Christel M., Tiemeier, Henning and Hettema, John M. (2016). Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. International Journal of Methods in Psychiatric Research, 25 (4), 255-266. doi: 10.1002/mpr.1519

Detection of gene-environment interaction in pedigree data using genome-wide genotypes

Nivard, Michel G., Middeldorp, Christel M., Lubke, Gitta, Hottenga, Jouke-Jan, Abdellaoui, Abdel, Boomsma, Dorret I. and Dolan, Conor V. (2016). Detection of gene-environment interaction in pedigree data using genome-wide genotypes. European Journal of Human Genetics, 24 (12), 1803-1809. doi: 10.1038/ejhg.2016.88

A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts

Middeldorp, Christel M., Hammerschlag, Anke R., Ouwens, Klaasjan G., Groen-Blokhuis, Maria M., St Pourcain, Beate, Greven, Corina U., Pappa, Irene, Tiesler, Carla M. T., Ang, Wei, Nolte, Ilja M., Vilor-Tejedor, Natalia, Bacelis, Jonas, Ebejer, Jane L., Zhao, Huiying, Davies, Gareth E., Ehli, Erik A., Evans, David M., Fedko, Iryna O., Guxens, Monica, Hottenga, Jouke-Jan, Hudziak, James J., Jugessur, Astanand, Kemp, John P., Krapohl, Eva, Martin, Nicholas G., Murcia, Mario, Myhre, Ronny, Ormel, Johan, Ring, Susan M. ... Boomsma, Dorret I. (2016). A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts. Journal of the American Academy of Child and Adolescent Psychiatry, 55 (10), 896-905.e6. doi: 10.1016/j.jaac.2016.05.025

A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18

Lubke, Gitta H., Miller, Patrick J., Verhulst, Brad, Bartels, Meike, van Beijsterveldt, Toos, Willemsen, Gonneke, Boomsma, Dorret I. and Middeldorp, Christel M. (2016). A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (7), 948-957. doi: 10.1002/ajmg.b.32375

Erratum: Meta-analysis of genome-wide association studies of anxiety disorders (vol 21, pg 1391, 2016)

Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Auwera, S. V. der, Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J-J, Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F. ... Hettema, J. M. (2016). Erratum: Meta-analysis of genome-wide association studies of anxiety disorders (vol 21, pg 1391, 2016). Molecular Psychiatry, 21 (10), 1485-1485. doi: 10.1038/mp.2016.11

Meta-analysis of genome-wide association studies of anxiety disorders

Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. -J., Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F. ... Hettema, J. M. (2016). Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry, 21 (10), 1391-1399. doi: 10.1038/mp.2015.197

Parents of children with psychopathology: psychiatric problems and the association with their child’s problems

Middeldorp, Christel M., Wesseldijk, Laura W., Hudziak, James J., Verhulst, Frank C., Lindauer, Ramon J. L. and Dieleman, Gwen C. (2016). Parents of children with psychopathology: psychiatric problems and the association with their child’s problems. European Child and Adolescent Psychiatry, 25 (8), 919-927. doi: 10.1007/s00787-015-0813-2

Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence

Nivard, Michel G., Lubke, Gitta H., Dolan, Conor V., Evans, David M., St. Pourcain, Beate, Munafo, Marcus R. and Middeldorp, Christel M. (2016). Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Development and Psychopathology, 29 (3), 1-10. doi: 10.1017/S0954579416000572

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry

Hagenbeek, Fiona A., Kluft, Cornelis, Hankemeier, Thomas, Bartels, Meike, Draisma, Harmen H. M., Middeldorp, Christel M., Berger, Ruud, Noto, Antonio, Lussu, Milena, Pool, Rene, Fanos, Vassilios and Boomsma, Dorret I. (2016). Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (5), 719-732. doi: 10.1002/ajmg.b.32435

Longitudinal heritability of childhood aggression

Porsch, Robert M., Middeldorp, Christel M., Cherny, Stacey S., Krapohl, Eva, van Beijsterveldt, Catharina E. M., Loukola, Anu, Korhonen, Tellervo, Pulkkinen, Lea, Corley, Robin, Rhee, Soo, Kaprio, Jaakko, Rose, Richard R., Hewitt, John. K., Sham, Pak, Plomin, Robert, Boomsma, Dorret I. and Bartels, Meike (2016). Longitudinal heritability of childhood aggression. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171 (5), 697-707. doi: 10.1002/ajmg.b.32420

Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Power, Robert A., Tansey, Katherine E., Buttenschøn, Henriette Nørmølle, Cohen-Woods, Sarah, Bigdeli, Tim, Hall, Lynsey S., Kutalik, Zoltán, Lee, S. Hong, Ripke, Stephan, Steinberg, Stacy, Teumer, Alexander, Viktorin, Alexander, Wray, Naomi R., Arolt, Volker, Baune, Bernard T., Boomsma, Dorret I., Børglum, Anders D., Byrne, Enda M., Castelao, Enrique, Craddock, Nick, Craig, Ian, Dannlowski, Udo, Deary, Ian J., Degenhardt, Franziska, Forstner, Andreas J., Gordon, Scott D., Grabe, Hans J., Grove, Jakob, Hamilton, Steven P. ... Lewis, Cathryn M. (2016). Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 81 (4), 325-335. doi: 10.1016/j.biopsych.2016.05.010

Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology

Wesseldijk, L. W., Dieleman, G. C., Lindauer, R. J. L., Bartels, M., Willemsen, G., Hudziak, J. J., Boomsma, D. I. and Middeldorp, C. M. (2016). Spousal resemblance in psychopathology: a comparison of parents of children with and without psychopathology. European Psychiatry, 34, 49-55. doi: 10.1016/j.eurpsy.2016.01.2423

Psychopathology in families: An integral approach via the family outpatient clinic Psychiatrische stoornissen binnen gezinnen: Een integrale benadering via de familiepoli

Van Veen, S. C., Batelaan, N. M., Wesseldijk, L. W., Rozeboom, J. and Middeldorp, C. M. (2016). Psychopathology in families: An integral approach via the family outpatient clinic Psychiatrische stoornissen binnen gezinnen: Een integrale benadering via de familiepoli. Tijdschrift voor Psychiatrie, 58 (2), 95-104.

Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression

Molenaar, Dylan, Middeldorp, Christel M., Willemsen, Gonneke, Ligthart, Lannie, Nivard, Michel G. and Boomsma, Dorret I. (2016). Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression. Behavior Genetics, 46 (1), 59-71. doi: 10.1007/s10519-015-9752-4

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna ... Jaddoe, Vincent W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 (2), 389-403. doi: 10.1093/hmg/ddv472

Genetic and Environmental Stability of Neuroticism From Adolescence to Adulthood

Nivard, Michel G., Middeldorp, Christel M., Dolan, Conor V. and Boomsma, Dorret I. (2015). Genetic and Environmental Stability of Neuroticism From Adolescence to Adulthood. Twin Research and Human Genetics, 18 (6), 746-754. doi: 10.1017/thg.2015.80

Genetics and psychiatric disorders: Heritability and the search for genes Genetica en psychische stoornissen op de kinderleeftijd: Erfelijkheid en de zoektocht naar genen

Middeldorp, Christel M. (2015). Genetics and psychiatric disorders: Heritability and the search for genes Genetica en psychische stoornissen op de kinderleeftijd: Erfelijkheid en de zoektocht naar genen. Tijdschrift voor Psychiatrie, 57 (12), 876-880.

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, Lavinia, Standl, Marie, Waage, Johannes, Baurecht, Hansjoerg, Hotze, Melanie, Strachan, David P., Curtin, John A., Bonnelykke, Klaus, Tian, Chao, Takahashi, Atsushi, Esparza-Gordillo, Jorge, Alves, Alexessander Couto, Thyssen, Jacob P., den Dekker, Herman T., Ferreira, Manuel A., Altmaier, Elisabeth, Sleiman, Patrick M. A., Xiao, Feng Li, Gonzalez, Juan R., Marenholz, Ingo, Kalb, Birgit, Pino-Yanes, Maria, Xu, Cheng-Jian, Carstensen, Lisbeth, Groen-Blokhuis, Maria M., Venturini, Cristina, Pennell, Craig E., Barton, Sheila J., Levin, Albert M. ... Weidinger, Stephan (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47 (12), 1449-1456. doi: 10.1038/ng.3424

Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype × Environment Interaction

Molenaar, Dylan, Middeldorp, Christel, van Beijsterveldt, Toos and Boomsma, Dorret I. (2015). Analysis of Behavioral and Emotional Problems in Children Highlights the Role of Genotype × Environment Interaction. Child Development, 86 (6), 1999-2016. doi: 10.1111/cdev.12451

Erratum: Single nucleotide polymorphism heritability of behavior problems in childhood: genome-wide complex trait analysis (vol 54, pg 737, 2015)

Pappa, Irene, Fedko, Iryna O., Mileva-Seitz, Viara R., Hottenga, Jouke-Jan, Bakermans-Kranenburg, Marian J., Bartels, Meike, van Beijsterveldt, Catharina E. M., Jaddoe, Vincent W. V., Middeldorp, Christel M., Rippe, Ralph C. A., Rivadeneira, Fernando, Tiemeier, Henning, Verhulst, Frank C., van Ijzendoorn, Marinus H. and Boomsma, Dorret I. (2015). Erratum: Single nucleotide polymorphism heritability of behavior problems in childhood: genome-wide complex trait analysis (vol 54, pg 737, 2015). Journal of the American Academy of Child and Adolescent Psychiatry, 54 (11), 965-965. doi: 10.1016/j.jaac.2015.09.002

Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height

Fedko, Iryna O., Hottenga, Jouke-Jan, Medina-Gomez, Carolina, Pappa, Irene, van Beijsterveldt, Catharina E. M., Ehli, Erik A., Davies, Gareth E., Rivadeneira, Fernando, Tiemeier, Henning, Swertz, Morris A., Middeldorp, Christel M., Bartels, Meike and Boomsma, Dorret I. (2015). Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height. Behavior Genetics, 45 (5), 514-528. doi: 10.1007/s10519-015-9725-7

Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis

Pappa, Irene, Fedko, Iryna O., Mileva-Seitz, Viara R., Hottenga, Jouke-Jan, Bakermans-Kranenburg, Marian J., Bartels, Meike, van Beijsterveldt, Catharina E. M., Jaddoe, Vincent W. V., Middeldorp, Christel M., Rippe, Ralph C. A., Rivadeneira, Fernando, Tiemeier, Henning, Verhulst, Frank C., van Ijzendoorn, Marinus H. and Boomsma, Dorret I. (2015). Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 54 (9), 737-744. doi: 10.1016/j.jaac.2015.06.004

Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age

Treur, Jorien L., Vink, Jacqueline M., Boomsma, Dorret I. and Middeldorp, Christel M. (2015). Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age. Drug and Alcohol Dependence, 153, 221-228. doi: 10.1016/j.drugalcdep.2015.05.018

The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects

Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A., Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and Middeldorp, Christel (2015). The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects. Molecular Psychiatry, 20 (6), 735-743. doi: 10.1038/mp.2015.50

A genome-wide approach to children's aggressive behavior: the EAGLE consortium

Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G., Nolte, Ilja M., Tiesler, Carla M. T., Bakermans-Kranenburg, Marian J., Davies, Gareth E., Evans, David M., Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M., Hudziak, James J., Kemp, John P., Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R., Motazedi, Ehsan, Power, Christine, Raitakari, Olli T., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A., Seppälä, Ilkka, Snieder, Harold, Standl, Marie ... Tiemeier, Henning (2015). A genome-wide approach to children's aggressive behavior: the EAGLE consortium. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 171 (5), 1-11. doi: 10.1002/ajmg.b.32333

Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders

Arloth, Janine, Bogdan, Ryan, Weber, Peter, Frishman, Goar, Menke, Andreas, Wagner, Klaus V., Balsevich, Georgia, Schmidt, Mathias V., Karbalai, Nazanin, Czamara, Darina, Altmann, Andre, Truembach, Dietrich, Wurst, Wolfgang, Mehta, Divya, Uhr, Manfred, Klengel, Torsten, Erhardt, Angelika, Carey, Caitlin E., Conley, Emily Drabant, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC),, Middeldorp, Christel, Ruepp, Andreas, Mueller-Myhsok, Bertram, Hariri, Ahmad R. and Binder, Elisabeth B. (2015). Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron, 86 (5), 1189-1202. doi: 10.1016/j.neuron.2015.05.034

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

Byrne, Enda M, Raheja, Uttam K, Stephens, Sarah H, Heath, Andrew C, Madden, Pamela A, Vaswani, Dipika, Nijjar, Gagan V, Ryan, Kathleen A, Youssufi, Hassaan, Gehrman, Philip R, Shuldiner, Alan R, Martin, Nicholas G, Montgomery, Grant W, Wray, Naomi R, Nelson, Elliot C, Mitchell, Braxton D, Postolache, Teodor T, Psychiatric Genetics Consortium Major Depressive Disorder Working Group and Middeldorp, Christel (2015). Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 76 (2), 128-134. doi: 10.4088/JCP.14m08981

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

O'Dushlaine, Colm, Rossin, Lizzy, Lee, Phil H., Duncan, Laramie, Parikshak, Neelroop N., Newhouse, Stephen, Ripke, Stephan, Neale, Benjamin M., Purcell, Shaun M., Posthuma, Danielle, Nurnberger, John I., Lee, S. Hong, Faraone, Stephen V., Perlis, Roy H., Mowry, Bryan J, Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H. ... Breen, Gerome (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 18 (2), 199-209. doi: 10.1038/nn.3922

Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years

Nivard, M. G., Dolan, C. V., Kendler, K. S., Kan, K. J., Willemsen, G., Van Beijsterveldt, C. E.M., Lindauer, R. J.L., Van Beek, J. H.D.A., Geels, L. M., Bartels, M., Middeldorp, C. M. and Boomsma, D. I. (2015). Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years. Psychological Medicine, 45 (5), 1039-1049. doi: 10.1017/S003329171400213X

The Amsterdam Sexual Abuse Case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet

Lindauer, Ramon J. L., Brilleslijper-Kater, Sonja N., Diehle, Julia, Verlinden, Eva, Teeuw, Arianne H., Middeldorp, Christel M., Tuinebreijer, Wilco, Bosschaart, Thekla F., van Duin, Esther and Verhoeff, Arnoud (2014). The Amsterdam Sexual Abuse Case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet. Bmc Psychiatry, 14 (1) 295 doi: 10.1186/s12888-014-0295-7

Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children

Groen-Blokhuis, Maria M., Middeldorp, Christel M., Kan, Kees-Jan, Abdellaoui, Abdel, van Beijsterveldt, Catharina E. M., Ehli, Erik A., Davies, Gareth E., Scheet, Paul A., Xiao, Xiangjun, Hudziak, James J., Hottenga, Jouke-Jan, Neale, Ben M. and Boomsma, Dorret I. (2014). Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. Journal of the American Academy of Child and Adolescent Psychiatry, 53 (10), 1123-1129. doi: 10.1016/j.jaac.2014.06.014

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry, John R. B., Day, Felix, Elks, Cathy E., Sulem, Patrick, Thompson, Deborah J., Ferreira, Teresa, He, Chunyan, Chasman, Daniel I., Esko, Toenu, Thorleifsson, Gudmar, Albrecht, Eva, Ang, Wei Q., Corre, Tanguy, Cousminer, Diana L., Feenstra, Bjarke, Franceschini, Nora, Ganna, Andrea, Johnson, Andrew D., Kjellqvist, Sanela, Lunetta, Kathryn L., McMahon, George, Nolte, Ilja M., Paternoster, Lavinia, Porcu, Eleonora, Smith, Albert V., Stolk, Lisette, Teumer, Alexander, Tsernikova, Natalia, Tikkanen, Emmi ... Middeldorp, Christel (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92-97. doi: 10.1038/nature13545

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

Cousminer, Diana L., Stergiakouli, Evangelia, Berry, Diane J., Ang, Wei, Groen-Blokhuis, Maria M., Koerner, Antje, Siitonen, Niina, Ntalla, Ioanna, Marinelli, Marcella, Perry, John R. B., Kettunen, Johannes, Jansen, Rick, Surakka, Ida, Timpson, Nicholas J., Ring, Susan, Mcmahon, George, Power, Chris, Wang, Carol, Kahonen, Mika, Viikari, Jorma, Lehtimaki, Terho, Middeldorp, Christel M., Pol, Hilleke E. Hulshoff, Neef, Madlen, Weise, Sebastian, Pahkala, Katja, Niinikoski, Harri, Zeggini, Eleftheria, Panoutsopoulou, Kalliope ... Warrington, Nicole M. (2014). Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human Molecular Genetics, 23 (16) ddu150, 4452-4464. doi: 10.1093/hmg/ddu150

Further confirmation of the association between anxiety and CTNND2: replication in humans

Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Jansen, R., Penninx, B. W., Middeldorp, C. M. and Boomsma, D. I. (2014). Further confirmation of the association between anxiety and CTNND2: replication in humans. Genes, Brain and Behavior, 13 (2), 195-201. doi: 10.1111/gbb.12095

Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

Ligthart, Lannie, Hottenga, Jouke-Jan, Lewis, Cathryn M., Farmer, Anne E., Craig, Ian W., Breen, Gerome, Willemsen, Gonneke, Vink, Jacqueline M., Middeldorp, Christel M., Byrne, Enda M., Heath, Andrew C., Madden, Pamela A. F., Pergadia, Michele L., Montgomery, Grant W., Martin, Nicholas G., Penninx, Brenda W. J. H., McGuffin, Peter, Boomsma, Dorret I. and Nyholt, Dale R. (2014). Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders. Human Genetics, 133 (2), 173-186. doi: 10.1007/s00439-013-1370-8

A genome-wide association meta-analysis of preschool internalizing problems

Benke, Kelly S., Nivard, Michel G., Velders, Fleur P., Walters, Raymond K., Pappa, Irene, Scheet, Paul A., Xiao, Xiangjun, Ehli, Erik A., Palmer, Lyle J., Whitehouse, Andrew J. O., Verhulst, Frank C., Jaddoe, Vincent W., Rivadeneira, Fernando, Groen-Blokhuis, Maria M., van Beijsterveldt, Catharina E. M., Davies, Gareth E., Hudziak, James J., Lubke, Gitta H., Boomsma, Dorret I., Pennell, Craig E., Tiemeier, Henning and Middeldorp, Christel M. (2014). A genome-wide association meta-analysis of preschool internalizing problems. Journal of the American Academy of Child and Adolescent Psychiatry, 53 (6), 667-676. doi: 10.1016/j.jaac.2013.12.028

Child care, socio-economic status and problem behavior: a study of gene-environment interaction in young Dutch twins

Middeldorp, Christel M., Lamb, Diane J., Vink, Jacqueline M., Bartels, Meike, van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2014). Child care, socio-economic status and problem behavior: a study of gene-environment interaction in young Dutch twins. Behavior Genetics, 44 (4), 314-325. doi: 10.1007/s10519-014-9660-z

Heritability and genomics of gene expression in peripheral blood

Wright, Fred A., Sullivan, Patrick F., Brooks, Andrew I., Zou, Fei, Sun, Wei, Xia, Kai, Madar, Vered, Jansen, Rick, Chung, Wonil, Zhou, Yi-Hui, Abdellaoui, Abdel, Batista, Sandra, Butler, Casey, Chen, Guanhua, Chen, Ting-Huei, D'Ambrosiol, David, Gallins, Paul, Ha, Min Jin, Hottenga, Jouke Jan, Huang, Shunping, Kattenberg, Mathijs, Kochar, Jaspreet, Middeldorp, Christel M., Qui, Ani, Shabalinn, Andrey, Tischfield, Jay, Todd, Laura, Tzeng, Jung-Ying, van Grootheest, Gerard ... Boomsma, Dorret I. (2014). Heritability and genomics of gene expression in peripheral blood. Nature Genetics, 46 (5), 430-437. doi: 10.1038/ng.2951

Research Review: Polygenic methods and their application to psychiatric traits

Wray, Naomi R., Lee, Sang Hong, Mehta, Divya, Vinkhuyzen, Anna A. E., Dudbridge, Frank and Middeldorp, Christel M. (2014). Research Review: Polygenic methods and their application to psychiatric traits. Journal of Child Psychology and Psychiatry, 55 (10), 1068-1087. doi: 10.1111/jcpp.12295

Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Culverhouse, Robert C., Bowes, Lucy, Breslau, Naomi, Nurnberger, John I. Jr, Burmeister, Margit, Fergusson, David M., Munafo, Marcus, Saccone, Nancy L., Bierut, Laura J., 5-HTTLPR, Stress, and Depression Consortium, Wray, Naomi and Middeldorp, Christel (2013). Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression. BMC Psychiatry, 13 (1) 304, 1-12. doi: 10.1186/1471-244X-13-304

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Lee, S. Hong, Ripke, Stephan, Neale, Benjamin M., Faraone, Stephen V., Purcell, Shaun M., Perlis, Roy H., Mowry, Bryan J., Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H., Backlund, Lena, Badner, Judith A., Bailey, Anthony J., Banaschewski, Tobias, Barchas, Jack D., Barnes, Michael R., Barrett, Thomas B., Bass, Nicholas ... Wray, Naomi R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45 (9), 984-995. doi: 10.1038/ng.2711

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis

Brandys, Marek K., Kas, Martien J. H., van Elburg, Annemarie A., Ophoff, Roel, Slof-Op't Landt, Margarita C. T., Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, P. Eline and Adan, Roger A. H. (2013). The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis. World Journal of Biological Psychiatry, 14 (6), 441-451. doi: 10.3109/15622975.2011.605470

A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems

Groen-Blokhuis, Maria M., Franic, S., van Beijsterveldt, Catharina E. M., de Geus, Eco, Bartels, Meike, Davies, Gareth E., Ehli, Erik A., Xiao, Xiangjun, Scheet, Paul A., Althoff, Robert, Hudziak, James J., Middeldorp, Christel M. and Boomsma, Dorret I. (2013). A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 162 (5), 457-465. doi: 10.1002/ajmg.b.32175

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Cousminer D.L., Berry D.J., Timpson N.J., Ang W., Thiering E., Byrne E.M., Rob Taal H., Huikari V., Bradfield J.P., Kerkhof M., Groen-Blokhuis M.M., Kreiner-Moller E., Marinelli M., Holst C., Leinonen J.T., Perry J.R.B., Surakka I., Pietilainen O., Kettunen J., Anttila V., Kaakinen M., Sovio U., Pouta A., Das S., Lagou V., Power C., Prokopenko I., Evans D.M., Kemp J.P. ... Middeldorp, Christel (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22 (13), 2735-2747. doi: 10.1093/hmg/ddt104

Serotonin transporter gene: will epigenetics prove less depressing than genetics?

de Geus, Eco J. C. and Middeldorp, Christel M. (2013). Serotonin transporter gene: will epigenetics prove less depressing than genetics?. Psychosomatic Medicine, 75 (6), 520-522. doi: 10.1097/PSY.0b013e318298708f

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Wray, Naomi, Byrne, Enda M., Martin, Nicholas G., Gordon, Scott D., Henders, Anjali K., Montgomery, Grant M., Nyholt, Dale R. and Middeldorp, Christel M. (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, 18 (4), 497-511. doi: 10.1038/mp.2012.21

Erratum: Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems (Twin Research and Human Genetics (2011) 14 (393-400) doi:10.1375/twin.14.5.393)

Groen-Blokhuis, Maria M., Middeldorp, Christel M., Van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2013). Erratum: Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems (Twin Research and Human Genetics (2011) 14 (393-400) doi:10.1375/twin.14.5.393). Twin Research and Human Genetics, 16 (2), 650-650. doi: 10.1017/thg.2012.52

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

Smoller, Jordan W., Craddock, Nicholas, Kendler, Kenneth, Lee, Phil Hyoun, Neale, Benjamin M., Nurnberger, John I., Ripke, Stephan, Santangelo, Susan, Sullivan, Patrick F., Cross-Disorder Group of the Psychiatric Genomics Consortium and Middeldorp, Christel (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet, 381 (9875), 1371-1379. doi: 10.1016/S0140-6736(12)62129-1

Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample

Peyrot, Wouter J., Middeldorp, Christel M., Jansen, Rick, Smit, Johannes H., de Geus, Eco J. C., Hottenga, Jouke-Jan, Willemsen, Gonneke, Vink, Jacqueline M., Virding, Susanne, Barragan, Isabel, Ingelman-Sundberg, Magnus, Sim, Sarah C., Boomsma, Dorret I. and Penninx, Brenda W. J. H. (2013). Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. Journal of Affective Disorders, 146 (1), 91-99. doi: 10.1016/j.jad.2012.08.044

The young Netherlands twin register (YNTR): Longitudinal twin and family studies in over 70,000 children

van Beijsterveldt, Catharina E. M., Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Franic, Sanja, Hudziak, James J., Lamb, Diane, Huppertz, Charlotte, de Zeeuw, Eveline, Nivard, Michel, Schutte, Nienke, Swagerman, Suzanne, Glasner, Tina, van Fulpen, Michelle, Brouwer, Cyrina, Stroet, Therese, Nowotny, Dustin, Ehli, Erik A., Davies, Gareth E., Scheet, Paul, Orlebeke, Jacob F., Kan, Kees-Jan, Smit, Dirk, Dolan, Conor V., Middeldorp, Christel M., de Geus, Eco J. C., Bartels, Meike and Boomsma, Dorret I. (2013). The young Netherlands twin register (YNTR): Longitudinal twin and family studies in over 70,000 children. Twin Research and Human Genetics, 16 (1), 252-267. doi: 10.1017/thg.2012.118

Genetic and environmental stability in attention problems across the lifespan: evidence from The Netherlands twin register

Kan, Kees-Jan, Dolan, Conor V., Nivard, Michel G., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Willemsen, Gonneke and Boomsma, Dorret I. (2013). Genetic and environmental stability in attention problems across the lifespan: evidence from The Netherlands twin register. Journal of the American Academy of Child and Adolescent Psychiatry, 52 (1), 12-25. doi: 10.1016/j.jaac.2012.10.009

Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders

Slof-Op't Landt, Margarita C. T., Bartels, Meike, Middeldorp, Christel M., van Beijsterveldt, Catherina E. M., Slagboom, P. Eline, Boomsma, Dorret I., van Furth, Eric F. and Meulenbelt, Ingrid (2013). Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders. Behavior Genetics, 43 (1), 24-33. doi: 10.1007/s10519-012-9569-3

Maternal Prenatal Smoking and Offspring Emotional Problems: No Moderating Effect of Maternal or Child 5-HTTLPR Genotype

Geels, Lot M., Groen-Blokhuis, Maria M., van Beijsterveldt, Catharina E. M., Vink, Jacqueline M., Middeldorp, Christel M., Bartels, Meike, Nelson, Kelly A., Huizenga, Patricia E., Davies, Gareth E. and Boomsma, Dorret I. (2012). Maternal Prenatal Smoking and Offspring Emotional Problems: No Moderating Effect of Maternal or Child 5-HTTLPR Genotype. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 159B (8), 1009-1012. doi: 10.1002/ajmg.b.32110

Sex differences in genetic architecture of complex phenotypes?

Vink, Jacqueline M., Bartels, Meike, van Beijsterveldt, Toos C. E. M., van Dongen, Jenny, van Beek, Jenny H. D. A., Distel, Marijn A., de Moor, Marleen H. M., Smit, Dirk J. A., Minica, Camelia C., Ligthart, Lannie, Geels, Lot M., Abdellaoui, Abdel, Middeldorp, Christel M., Hottenga, Jouke Jan, Willemsen, Gonneke, de Geus, Eco J. C. and Boomsma, Dorret I. (2012). Sex differences in genetic architecture of complex phenotypes?. PLoS One, 7 (12) e47371, e47371.1-e47371.8. doi: 10.1371/journal.pone.0047371

Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms

Lubke, Gitta H., Hottenga, Jouke Jan, Walters, Raymond, Laurin, Charles, de Geus, Eco J. C., Willemsen, Gonneke, Smit, Jan H., Middeldorp, Christel M., Penninx, Brenda W. J. H., Vink, Jacqueline M. and Boomsma, Dorret I. (2012). Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biological Psychiatry, 72 (8), 707-709. doi: 10.1016/j.biopsych.2012.03.011

Genome-wide association uncovers shared genetic effects among personality traits and mood states

Luciano, Michelle, Huffman, Jennifer E., Arias-Vasquez, Alejandro, Vinkhuyzen, Anna A. E., Middeldorp, Christel M., Giegling, Ina, Payton, Antony, Davies, Gail, Zgaga, Lina, Janzing, Joost, Ke, Xiayi, Galesloot, Tessel, Hartmann, Annette M., Ollier, William, Tenesa, Albert, Hayward, Caroline, Verhagen, Maaike, Montgomery, Grant W., Hottenga, Jouke-Jan, Konte, Bettina, Starr, John M., Vitart, Veronique, Vos, Pieter E., Madden, Pamela A. F., Willemsen, Gonneke, Konnerth, Heike, Horan, Michael A., Porteous, David J., Campbell, Harry ... Deary, Ian J. (2012). Genome-wide association uncovers shared genetic effects among personality traits and mood states. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B (6), 684-695. doi: 10.1002/ajmg.b.32072

Gene-environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins

Lamb, Diane J., Middeldorp, Christel M., Van Beijsterveldt, Catarina E. M. and Boomsma, Dorret I. (2012). Gene-environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins. Journal of Child Psychology and Psychiatry, 53 (8), 818-825. doi: 10.1111/j.1469-7610.2011.02497.x

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: Meta-analysis and new data

Brandys, Marek K., Landt, Margarita C. T. Slof-Op't, van Elburg, Annemarie A., Ophoff, Roel, Verduijn, Willem, Meulenbelt, Ingrid, Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, Eline, Kas, Martien J. H. and Adan, Roger A. H. (2012). Anorexia nervosa and the Val158Met polymorphism of the COMT gene: Meta-analysis and new data. Psychiatric Genetics, 22 (3), 130-136. doi: 10.1097/YPG.0b013e328351859e

Common variants at 12q15 and 12q24 are associated with infant head circumference

Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Møller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Mònica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bønnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J. ... Middeldorp, Christel (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5), 532-538. doi: 10.1038/ng.2238

Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes

Webb, Bradley T., Guo, An-Yuan, Maher, Brion S., Zhao, Zhongming, van den Oord, Edwin J., Kendler, Kenneth S., Riley, Brien P., Gillespie, Nathan A., Prescott, Carol A., Middeldorp, Christel M., Willemsen, Gonneke, de Geus, Eco J. C., Hottenga, Jouke-Jan, Boomsma, Dorret I., Slagboom, Eline P., Wray, Naomi R., Montgomery, Grant W., Martin, Nicholas G., Wright, Margie J., Heath, Andrew C., Madden, Pamela A., Gelernter, Joel, Knowles, James A., Hamilton, Steven P., Weissman, Myrna M., Fyer, Abby J., Huezo-Diaz, Patricia, McGuffin, Peter, Farmer, Anne ... Hettema, John M. (2012). Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics, 20 (10), 1078-1084. doi: 10.1038/ejhg.2012.47

Effects of chorionicity and zygosity on triplet birth weight

Lamb, Diane J., Vink, Jacqueline M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Haak, Monique C., Overbeek, Lucy I. H. and Boomsma, Dorret I. (2012). Effects of chorionicity and zygosity on triplet birth weight. Twin Research and Human Genetics, 15 (2), 149-157. doi: 10.1375/twin.15.2.149

Common variants at 6q22 and 17q21 are associated with intracranial volume

Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stephanie, Vrooman, Henri A., Sigurdsson, S., Ropele, Sigurdur, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., Destefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack,Clifford R., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J. ... . (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539-544. doi: 10.1038/ng.2245

Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned

Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., MacLean, A. W., Smit, J. H., Hottenga, J. J., Willemsen, G., Middeldorp, C. M., De Geus, E. J. C., Lewis, C. M., McGuffin, P., Hickie, I. B., Van Den Oord, E. J. C. G., Liu, J. Z., MacGregor, S., McEvoy, B. P., Byrne, E. M., Medland, S. E., Statham, D. J., Henders, A. K., Heath, A. C., Montgomery, G. W., Martin, N. G. ... Sullivan, P. F. (2012). Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Molecular Psychiatry, 17 (1), 36-48. doi: 10.1038/mp.2010.109

Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity

Distel, Marijn A., Carlier, Angela, Middeldorp, Christel M., Derom, Catherine A., Lubke, Gitta H. and Boomsma, Dorret I. (2011). Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: a genetic analysis of comorbidity. American Journal of Medical Genetics Part B - Neuropsychiatric Genetics, 156 (7), 817-825. doi: 10.1002/ajmg.b.31226

Evidence for a causal association of low birth weight and attention problems

Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2011). Evidence for a causal association of low birth weight and attention problems. Journal of the American Academy of Child and Adolescent Psychiatry, 50 (12), 1247-1254. doi: 10.1016/j.jaac.2011.09.007

Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems

Groen-Blokhuis, Maria M., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M. and Boomsma, Dorret I. (2011). Crying without a cause and being easily upset in two-year-olds: Heritability and predictive power of behavioral problems. Twin Research and Human Genetics, 14 (5), 393-400. doi: 10.1375/twin.14.5.393

Birth weight in a large series of triplets

Lamb, Diane J., Middeldorp, Christel M., van Beijsterveldt, Catharina E. M., Vink, Jacqueline M., Haak, Monique C. and Boomsma, Dorret I. (2011). Birth weight in a large series of triplets. BMC Pediatrics, 11 (1) 24, 24.1-24.11. doi: 10.1186/1471-2431-11-24

Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation

Distel, M. A., Middeldorp, C. M., Trull, T. J., Derom, C. A., Willemsen, G. and Boomsma, D. I. (2011). Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation. Psychological Medicine, 41 (4), 849-860. doi: 10.1017/S0033291710001297

Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting

Slof-Op't Landt, M. C. T. , Meulenbelt, I., Bartels, M., Suchiman, E., Middeldorp, C. M., Houwing-Duistermaat, J. J., van Trier, J., Onkenhout, E. J., Vink, J. M., van Beijsterveldt, C. E. M., Brandys, M. K., Sanders, N., Zipfel, S., Herzog, W., Herpertz-Dahlmann, B., Klampfl, K., Fleischhaker, C., Zeeck, A., de Zwaan, M., Herpertz, S., Ehrlich, S., van Elburg, A. A., Adan, R. A. H., Scherag, S., Hinney, A., Hebebrand, J., Boomsma, D. I., van Furth, E. F. and Slagboom, P. E. (2011). Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. Genes, Brain and Behavior, 10 (2), 236-243. doi: 10.1111/j.1601-183X.2010.00660.x

Adolescent self-report of emotional and behavioral problems: interactions of genetic factors with sex and age

Bartels, Meike, van de Aa, Niels, van Beijsterveldt, Catherina E. M., Middeldorp, Christel M. and Boomsma, Dorret I. (2011). Adolescent self-report of emotional and behavioral problems: interactions of genetic factors with sex and age. Canadian Academy of Child and Adolescent Psychiatry, 20 (1), 35-52.

Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Demirkan, A., Phenninx, B. W. J. H., Hek, K., Wray, N. R., Amin, N., Aulchenko, Y. S., van Dyck, R., de Geus, E. J. C., Hofman, A., Uitterlanden, A. G., Hottenga, J.-J., Nolen, W. A., Oostra, B. A., Sullivan, P. F., Willemsen, G., Zitman, F. G., Tiemeier, H., Janssens, A. C. J. W., Boomsma, D. I., van Duijn, C. M. and Middeldorp, C. M. (2011). Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16 (7), 773-783. doi: 10.1038/mp.2010.65

Influence of candidate genes on attention problems in children: a longitudinal study

van Beijsterveldt, Catherina E. M., Middeldorp, Christel M., Landt, Margarita C. T. Slof-Op't, Bartels, Meike, Hottenga, Jouke-Jan, Suchiman, H. Eka D., Slagboom, P. Eline and Boomsma, Dorret I. (2011). Influence of candidate genes on attention problems in children: a longitudinal study. Behavior Genetics, 41 (1), 155-164. doi: 10.1007/s10519-010-9406-5

The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, D. R., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J-J., Distel, M. A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C. A, Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A. ... Boomsma, D. I. (2011). The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry, 1 (10) e50, e50.1-e50.8. doi: 10.1038/tp.2011.45

The impact of environmental experiences on symptoms of anxiety and depression across the life span

Kendler, Kenneth S., Eaves, Lindon J., Loken, Erik K., Pedersen, Nancy L., Middeldorp, Christel M., Reynolds, Chandra, Boomsma, Dorret, Lichtenstein, Paul, Silberg, Judy and Gardner, Charles O. (2011). The impact of environmental experiences on symptoms of anxiety and depression across the life span. Psychological Science, 22 (10), 1343-1352. doi: 10.1177/0956797611417255

Genome-wide association study of suicide attempts in mood disorder patients

Perlis, Roy H., Huang, Jie, Purcell, Shaun, Fava, Maurizio, Rush, A. John, Sullivan, Patrick F., Hamilton, Steven P., McMahon, Francis J., Schulze, Thomas, Potash, James B., Zandi, Peter P., Willour, Virginia L., Penninx, Brenda W., Boomsma, Dorret I., Vogelzangs, Nicole, Middeldorp, Christel M., Rietschel, Marcella, Noethen, Markus, Cichon, Sven, Gurling, Hugh, Bass, Nick, McQuillin, Andrew, Hamshere, Marian, Craddock, Nick, Sklar, Pamela and Smoller, Jordan W. (2010). Genome-wide association study of suicide attempts in mood disorder patients. American Journal of Psychiatry, 167 (12), 1499-1507. doi: 10.1176/appi.ajp.2010.10040541

The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms

Middeldorp, Christel M., de Geus, Eco J. C., Willemsen, Gonneke, Hottenga, Jouke-Jan, Slagboom, P. Eline and Boomsma, Dorret I. (2010). The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin Research and Human Genetics, 13 (6), 544-549. doi: 10.1375/twin.13.6.544

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Medland, S. E., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G., Hottenga, J. -J., de Geus, E. J. C., Suchiman, H. E. D., Dolan, C. V., Neale, M. C., Slagboom, P. E. and Boomsma, D. I. (2010). Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?. Genes, Brain and Behavior, 9 (7), 808-816. doi: 10.1111/j.1601-183X.2010.00619.x

Heritability of Anxious-Depressive and Withdrawn Behavior: Age-Related Changes During Adolescence

Lamb, Diane J., Middeldorp, Christel M., van Beijsterveldt, Catarina E. M., Bartels, Meike, van der Aa, Niels, Polderman, Tinca J. C. and Boomsma, Dorret I. (2010). Heritability of Anxious-Depressive and Withdrawn Behavior: Age-Related Changes During Adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 49 (3), 248-255. doi: 10.1016/j.jaac.2009.11.014

An association between Epac-1 gene variants and anxiety and depression in two independent samples

Middeldorp, Christel M., Vink, Jacqueline M., Hettema, John M., de Geus, Eco J. C., Kendler, Kenneth S., Willemsen, Gonneke, Neale, Michael C., Boomsma, Dorret I. and Chen, Xiangning (2010). An association between Epac-1 gene variants and anxiety and depression in two independent samples. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 153 (1), 214-219. doi: 10.1002/ajmg.b.30976

Childhood and adolescent anxiety and depression: Beyond heritability

Franic, Sanja, Middeldorp, Christel M., Dolan, Conor V., Ligthart, Lannie and Boomsma, Dorret I. (2010). Childhood and adolescent anxiety and depression: Beyond heritability. Journal of the American Academy of Child and Adolescent Psychiatry, 49 (8), 820-829. doi: 10.1016/j.jaac.2010.05.013

Heritability and environment in psychiatric disorders Erfelijkheid en omgevingsinvloeden bij psychiatrische stoornissen

Swets, M., Middeldorp, C. M. and Schoevers, R. A. (2009). Heritability and environment in psychiatric disorders Erfelijkheid en omgevingsinvloeden bij psychiatrische stoornissen. Tijdschrift voor Psychiatrie, 51 (9), 651-663.

Reaction on 'gene environment interaction: Mechanism of action of early relationshiops?' Reactie op 'de gen-omgevingsinteractie en de psychiatrie: Nieuwe visie op de invloed van de vroege omgeving'

Middeldorp, C. M. and Boomsma, D. I. (2009). Reaction on 'gene environment interaction: Mechanism of action of early relationshiops?' Reactie op 'de gen-omgevingsinteractie en de psychiatrie: Nieuwe visie op de invloed van de vroege omgeving'. Tijdschrift voor Psychiatrie, 51 (4), 267-268.

Erratum: Inherited thrombophilia and pregnancy complications revisited (Obstetrics & Gynecology (2008) 112 (320-324))

Rodger, M. A., Paidas, M., McLintock, C., Middeldorp, C., Kahn, S., Martinelli, I., Hague, W., Montella, K. R. and Greer, I. (2008). Erratum: Inherited thrombophilia and pregnancy complications revisited (Obstetrics & Gynecology (2008) 112 (320-324)). Obstetrics and Gynecology, 112 (6) doi: 10.1097/01.AOG.0000341971.18168.2d

Life events, anxious depression and personality: A prospective and genetic study

Middeldorp, C. M., Cath, D. C., Beem, A. L., Willemsen, G. and Boomsma, D. I. (2008). Life events, anxious depression and personality: A prospective and genetic study. Psychological Medicine, 38 (11), 1557-1565. doi: 10.1017/S0033291708002985

Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression

Middeldorp, CM, Sullivan, PF, Wray, NR, Hottenga, JJ, de Geus, EJC, van den Berg, M, Montgomery, GW, Coventry, WL, Statham, DJ, Andrews, G, Slagboom, PE, Boomsma, DI and Martin, NG (2008). Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B (3), 352-358. doi: 10.1002/ajmg.b.30817

A whole genome association study of neuroticism using DNA pooling

Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G., Hettema, J. M., An, S. S., Neale, M. C., van den Oord, E. J., Kendler, K. S., Chen, X., Boomsma, D. I., Middeldorp, C. M., Hottenga, J. J., Slagboom, P. E. and Flint, J. (2008). A whole genome association study of neuroticism using DNA pooling. Molecular Psychiatry, 13 (3), 302-312. doi: 10.1038/sj.mp.4002048

Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands

Wray, Naomi R., Middeldorp, Christel M., Birley, Andrew J., Gordon, Scott D., Sullivan, Patrick F., Visscher, Peter M., Nyholt, Dale R, Willemsen, Gonneke, de Geus, Eco J.C., Slagboom, P. Eline, Montgomery, Grant W., Martin, Nicholas G. and Boomsma, Dorret I. (2008). Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Archives of General Psychiatry, 65 (6), 649-658. doi: 10.1001/archpsyc.65.6.649

Heritability of self-reported phobic fear

Distel, Marijn A., Vink, Jacqueline M., Willemsen, Gonneke, Middeldorp, Christel M., Merckelbach, Harald L. G. J. and Boomsma, Dorret I. (2008). Heritability of self-reported phobic fear. Behavior Genetics, 38 (1), 24-33. doi: 10.1007/s10519-007-9182-z

Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype

Middeldorp, C. M., Hottenga, J-J, Slagboom, P. E., Sullivan, P. F., de Geus, E. J. C., Posthuma, D., Willemsen, G. and Boomsma, D. I. (2008). Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Molecular Psychiatry, 13 (1), 84-89. doi: 10.1038/sj.mp.4002061

Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression

Middeldorp, Christel M., de Geus, Eco J. C., Beem, A. Leo, Lakenberg, Nico, Hottenga, Jouke-Jan, Slagboom, P. Eline and Boomsma, Dorret I. (2007). Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behavior Genetics, 37 (2), 294-301. doi: 10.1007/s10519-006-9139-7

A twin-family study of the association between employment, burnout and anxious depression

Middeldorp, CM, Cath, DC and Boomsma, DI (2006). A twin-family study of the association between employment, burnout and anxious depression. Journal of Affective Disorders, 90 (2-3), 163-169. doi: 10.1016/j.jad.2005.11.004

Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings

Middledorp, Christel M., Birley, Andrew J., Cath, Danielle C., Gillespie, Nathan A., Willemsen, Gonneke, Statham, Dixie J., de Geus, Eco J. C., Andrews, J. Gavin, van Dyck, Richard, Beem, A. Leo, Sullivan, Patrick F., Martin, Nicholas G. and Boomsma, Dorret I. (2005). Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. Twin Research and Human Genetics, 8 (6), 609-615. doi: 10.1375/183242705774860123

Twin and genetic effects on life events

Middeldorp, CM, Cath, DC, Vink, JM and Boomsma, DI (2005). Twin and genetic effects on life events. Twin Research and Human Genetics, 8 (3), 224-231. doi: 10.1375/1832427054253130

The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies

Middeldorp, CM, Cath, DC, Van Dyck, R and Boomsma, DI (2005). The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychological Medicine, 35 (5), 611-624. doi: 10.1017/S003329170400412X

Familial clustering in burnout: A twin-family study

Middeldorp, CM, Stubbe, JH, Cath, DC and Boomsma, DI (2005). Familial clustering in burnout: A twin-family study. Psychological Medicine, 35 (1), 113-120. doi: 10.1017/S0033291704002983

Estimating non-response bias in family studies: Application to mental health and lifestyle

Vink, JM, Willemsen, G, Stubbe, JH, Middeldorp, CM, Ligthart, RSL, Baas, KD, Dirkzwager, HJC, de Geus, EJC and Boomsma, DI (2004). Estimating non-response bias in family studies: Application to mental health and lifestyle. European Journal of Epidemiology, 19 (7), 623-630. doi: 10.1023/B:EJEP.0000036814.56108.66

Nonsymptomatic generalized epilepsy in children younger than six years: Excellent prognosis, but classification should be reconsidered after follow-up: The Dutch Study of Epilepsy in Childhood

Middeldorp, CM, Geerts, AT, Brouwer, TF, Peters, ACB, Stroink, H, van Donselaar, CA and Arts, WFM (2002). Nonsymptomatic generalized epilepsy in children younger than six years: Excellent prognosis, but classification should be reconsidered after follow-up: The Dutch Study of Epilepsy in Childhood. Epilepsia, 43 (7), 734-739. doi: 10.1046/j.1528-1157.2002.72601.x

GENE EXPRESSION IN BRAIN CELL TYPES AND BIOLOGICAL FUNCTIONS UNDERLYING NEUROPSYCHIATRIC DISORDERS

Akingbuwa, Wonuola, Nivard, Michel, Hammerschlag, Anke, Bartels, Meike and Middeldorp, Christel M. (2019). GENE EXPRESSION IN BRAIN CELL TYPES AND BIOLOGICAL FUNCTIONS UNDERLYING NEUROPSYCHIATRIC DISORDERS. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles Ca, Oct 26-31, 2019. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2019.08.164

GENOME-WIDE ASSOCIATION META-ANALYSIS OF CHILDHOOD AND ADOLESCENT INTERNALISING PROBLEMS

Jami, Eshim, Hammerschlag, Anke, Bartels, Meike and Middeldorp, Christel M. (2019). GENOME-WIDE ASSOCIATION META-ANALYSIS OF CHILDHOOD AND ADOLESCENT INTERNALISING PROBLEMS. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles Ca, Oct 26-31, 2019. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2019.08.044

POLYGENIC ANALYSES OF CHILDHOOD PSYCHOPATHOLOGY IN LARGE POPULATION BASED SAMPLES PROVIDE INSIGHT INTO PERSISTENCE OF SYMPTOMS AND THE EFFECTS OF THE (EARLY) ENVIRONMENT

Middeldorp, Christel M., Sallis, Hannah and Thapar, Anita (2019). POLYGENIC ANALYSES OF CHILDHOOD PSYCHOPATHOLOGY IN LARGE POPULATION BASED SAMPLES PROVIDE INSIGHT INTO PERSISTENCE OF SYMPTOMS AND THE EFFECTS OF THE (EARLY) ENVIRONMENT. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles Ca, Oct 26-31, 2019. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2019.07.031

A cross-country, cross-reporter twin study of oppositional defiant disorder

Grasby, Katrina, Colodro-Conde, Lucia, Morosoli, Jose J., Middeldorp, Christel, van Beijsterveldt, Toos, Boomsma, Dorret, Martin, Nicholas, Bartels, Meike and Medland, Sarah (2019). A cross-country, cross-reporter twin study of oppositional defiant disorder. 49th Annual Meeting of the Behavior Genetics Association (BGA), Stockholm, Sweden, 26-29 June, 2019. New York, NY, United States: Springer New York LLC. doi: 10.1007/s10519-019-09973-8

Clinical update: recent advances in attention-deficit hyperactivity disorder

Coghill, D. and Middeldorp, C. (2019). Clinical update: recent advances in attention-deficit hyperactivity disorder. RANZCP 2019 Congress, Cairns Convention Centre, 12-16 May 2019. London, United Kingdom: Sage Publications.

Do shared genetic factors explain the prediction of bipolar disorder by childhood psychiatric symptoms?

Middeldorp, C. M., Akingbuwa, O., Jarvelin, M. -R., Lichtenstein, P., Lundstrom, S., Munafo, M., Plomin, R., Tiemeier, H., Ystrom, E. and Bartels, M. (2019). Do shared genetic factors explain the prediction of bipolar disorder by childhood psychiatric symptoms?. 21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney, Australia, 20-23 March, 2019. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/bdi.06_12743

Factors influencing the course of mental disorders in childhood and beyond

Middeldorp, C. M., Scott, J. G., Tunbridge, M., Stathis, S., Guastella, A. J. and Coghill, D. (2019). Factors influencing the course of mental disorders in childhood and beyond. RANZCP 2019 Congress, Cairns Convention Centre, 12-16 May 2019. London, United Kingdom: Sage Publications.

Genetic overlap between childhood psychopathology and adult traits

Akingbuwa, Wonuola, Bartels, Meike and Middeldorp, Christel M. (2019). Genetic overlap between childhood psychopathology and adult traits. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October, 2019. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2019.07.032

Genome-wide DNA methylation differences and their relationship with neural abnormalities in youth with and without posttraumatic stress disorder

Ensink, Judith, Keding, Taylor J., Henneman, Peter, Zantvoord, Jasper, Middeldorp, Christel M., Mannens, Marcel M. A. M., Herringa, Ryan J. and Lindauer, Ramon J. L. (2019). Genome-wide DNA methylation differences and their relationship with neural abnormalities in youth with and without posttraumatic stress disorder. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.180

Integrative analysis of genome-wide association study results of attention-deficit/hyperactivity disorder (ADHD) and human fetal brain methylation data reveals novel genes associated with ADHD

Hammerschlag, Anke, Byrne, Enda, Bartels, Meike, Wray, Naomi and Middeldorp, Christel M. (2019). Integrative analysis of genome-wide association study results of attention-deficit/hyperactivity disorder (ADHD) and human fetal brain methylation data reveals novel genes associated with ADHD. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.063

M73 - Capice: childhood and adolescence psychopathology: unravelling the complex etiology by a large interdisciplinary collaboration in Europe

Middeldorp, Christel M., Drevets, Wayne, Jarvelin, Marjo-Riitta, Lichtenstein, Paul, Lundstrom, Sebastian, Munafo, Marcus, Plomin, Robert, Tiemeier, Henning, van den Berg, Stephanie M., Fanos, Vassilios and Bartels, Meike (2019). M73 - Capice: childhood and adolescence psychopathology: unravelling the complex etiology by a large interdisciplinary collaboration in Europe. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL, United States, 13-17 October 2017. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2017.08.380

Maternal and paternal effects on offspring internalising problems: findings from family data and extended GCTA analyses

Shahid, Eshim, Eilertsen, Espen, Hammerschlag, Anke, Sallis, Hannah, Qiao, Zhen, Evans, David, Ystrom, Eivind, Bartels, Meike and Middeldorp, Christel M. (2019). Maternal and paternal effects on offspring internalising problems: findings from family data and extended GCTA analyses. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October, 2019. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2019.07.034

The course of childhood psychopathology: the role of genetic factors and the association with parental symptoms

Middeldorp, C. M. (2019). The course of childhood psychopathology: the role of genetic factors and the association with parental symptoms. RANZCP 2019 Congress, Cairns Convention Centre, 12-16 May 2019. London, United Kingdom: Sage Publications.

The value of polygenic risk scores in predicting the transition from childhood and adolescent psychiatric symptoms into chronic adult psychopathology

Middeldorp, Christel M., Akingbuwa, Omowonuola, Jarvelin, Marjo-Riitta, Lichtenstein, Paul, Lundstrom, Sebastian, Kuja-Halkola, Ralf, Munafo, Marcus, Plomin, Robert, Rimfeld, Kaili, Sallis, Hannah, Tiemeier, Henning, Ystrom, Eivind and Bartels, Meike (2019). The value of polygenic risk scores in predicting the transition from childhood and adolescent psychiatric symptoms into chronic adult psychopathology. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.455

A cross-cultural comparison of the longitudinal heritability of childhood aggression

Porsch, Robert, Middeldorp, Christel, Cherny, Stacey, Krapohl, Eva, van Beijsterveldt, Catherina, Loukola, Anu, Korhonen, Tellervo, Pulkkinen, Lea, Corley, Robin, Rhee, Soo, Kaprio, Jaakko, Rose, Richard, Hewitt, John, Sham, Pak, Plomin, Robert, Boomsma, Dorret and Bartels, Meike (2016). A cross-cultural comparison of the longitudinal heritability of childhood aggression. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, Jun 20-23, 2016. SPRINGER.

Differences in maternal and paternal ratings of psychopathology and the genetic epidemiology in 12,000 7-year old twin pairs

Wesseldijk, Laura, Fedko, Iryna, Bartels, Meike, Nivard, Michel, Hottenga, Jouke-Jan, van Beijsterveldt, Catherina, Boomsma, Dorret and Middeldorp, Christel (2016). Differences in maternal and paternal ratings of psychopathology and the genetic epidemiology in 12,000 7-year old twin pairs. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, Jun 20-23, 2016. SPRINGER.

Heritability of different aggression phenotypes in an Australian and a Dutch cohort

Conde, Lucia Colodro, Martin, Nicholas, Hatemi, Peter, Boomsma, Dorret, Middeldorp, Christel, van Beijsterveldt, Toos, Bartels, Meike and Medland, Sarah (2016). Heritability of different aggression phenotypes in an Australian and a Dutch cohort. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, Jun 20-23, 2016. SPRINGER.

Integrating GWAS of ADHD and continuous ADHD-related traits

Walters, Raymond, Mattheisen, Manuel, Demontis, Ditte, Daly, Mark, Borglum, Anders, Faraone, Stephen, Middeldorp, Christel, Boomsma, Dorret and Neale, Benjamin (2016). Integrating GWAS of ADHD and continuous ADHD-related traits. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, Jun 20-23, 2016. SPRINGER.

Multivariate and repeated measure GWAS of aggression phenotypes

Nivard, Michel, Middeldorp, Christel, Hottenga, Jouke-Jan, Fedko, Iryna, Ehli, Erik, Davies, Gareth, van Beijsterveldt, Catherina, Bartels, Meike and Boomsma, Dorret (2016). Multivariate and repeated measure GWAS of aggression phenotypes. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane, Australia, Jun 20-23, 2016. SPRINGER.

Self-reported online assessment of lifetime major depressive disorder: a validation study

Bot, M., Middeldorp, C., de Geus, E., Lau, H. M., Sinke, M., van Nieuwenhuizen, B., Smit, J., Boomsma, D. and Penninx, B. (2016). Self-reported online assessment of lifetime major depressive disorder: a validation study. 18th Annual Conference of the International-Society-for-Bipolar-Disorders / 8th Biennial Conference of the International-Society-for-Affective-Disorders, Amsterdam, Netherlands, Jul 13-16, 2016. WILEY-BLACKWELL.

Choosing a powerful depression phenotype: trajectories of anxiety and depression between age 7 and age 18 and the influence of genetic factors in Dutch twins

Miller, Patrick, Verhulst, Brad, Bartels, Meike, van Beijsterveldt, Toos, Willemsen, Gonneke, Boomsma, Dorret, Middeldorp, Christel and Lubke, Gitta (2015). Choosing a powerful depression phenotype: trajectories of anxiety and depression between age 7 and age 18 and the influence of genetic factors in Dutch twins. 45th Annual Meeting of the Behavior-Genetics-Association, San Diego Ca, Jun 20, 2015. SPRINGER.

Prediction from polygenic scores based on GWA of Neuroticism to psychiatric and lifestyle traits

Boomsma, Dorret, van den Berg, Stephanie, Abdellaoui, Abdel, de Geus, Eco, Willemsen, Gonneke, Hottenga, Jouke-Jan, Middeldorp, Christel, Milaneschi, Yuri, Nivard, Michel, Vink, Jacqueline, Bartels, Meike, Van Grootheest, Gerard, Penninx, Brenda and de Moor, Marleen (2015). Prediction from polygenic scores based on GWA of Neuroticism to psychiatric and lifestyle traits. 45th Annual Meeting of the Behavior-Genetics-Association, San Diego Ca, Jun 20, 2015. SPRINGER.

Rapid genetic (co) variance estimation based on measured SNPs applied to item level data

Nivard, Michel, Dolan, Conor, Peyrot, Wouter, Abdellaoui, Abdel, Hottenga, Jouke-Jan, Middeldorp, Christel and Boomsma, Dorret (2015). Rapid genetic (co) variance estimation based on measured SNPs applied to item level data. 45th Annual Meeting of the Behavior-Genetics-Association, San Diego Ca, Jun 20, 2015. SPRINGER.

The Amsterdam sexual abuse case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet

Lindauer, R., Brilleslijper-kater, S., Diehle, J., Verlinden, E., Teeuw, A., Middeldorp, C., Tuinebreijer, W., Bosschaart, T., Van Duin, E. and Verhoeff, A. (2015). The Amsterdam sexual abuse case (ASAC)-study in day care centers: longitudinal effects of sexual abuse on infants and very young children and their parents, and the consequences of the persistence of abusive images on the internet. SPRINGER.

Are symptoms of anxiety and depression during childhood and adolescence influenced by similar genetic factors as major depression in adulthood?

Middeldorp, Christel, Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Scheet, Paul, Nivard, Michel, van Beijsterveldt, Toos, Bartels, Meike, Vink, Jacqueline, de Geus, Eco, Willemsen, Gonneke, Hudziak, Jim and Boomsma, Dorret (2012). Are symptoms of anxiety and depression during childhood and adolescence influenced by similar genetic factors as major depression in adulthood?. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, Jun 22-25, 2012. SPRINGER.

Phenotypic complexity as genetic dark matter: A network explanation of missing heritability

Nivard, Michel, van der Sluis, Sophie, Franic, Sanja, Cramer, Angelique, Visser, Ingmar, Middeldorp, Christel, Lubke, Gitta, Boomsma, Dorret and Borsboom, Denny (2012). Phenotypic complexity as genetic dark matter: A network explanation of missing heritability. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, Jun 22-25, 2012. SPRINGER.

Short and long-term effects of nonparental child care on internalizing and externalizing problems: A behavior genetic study in Dutch twins

Lamb, Diane, Middeldorp, Christel, Vink, Jacqueline, van Beijsterveldt, Toos, Lindauer, Ramon and Boomsma, Dorret (2012). Short and long-term effects of nonparental child care on internalizing and externalizing problems: A behavior genetic study in Dutch twins. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, Jun 22-25, 2012. SPRINGER.

Stability and change in anxious depression as a function of genes and environment. A longitudinal twin and GWA study from age 3 to 65 years

Abdellaoui, Abdel, Bartels, Meike, Boomsma, Dorret, Davies, Gareth, Dolan, Conor, Geels, Lot, Groen-Blokhuis, Maria, Hottenga, Jouke Jan, Kendler, Kenneth, Middeldorp, Christel, Nivard, Michel, Scheet, Paul, Sullivan, Patrick, van Beek, Jenny, van Beijsterveldt, Toos and Willemsen, Gonneke (2012). Stability and change in anxious depression as a function of genes and environment. A longitudinal twin and GWA study from age 3 to 65 years. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, Jun 22-25, 2012. SPRINGER.

The influence of early anesthesia exposure on ADHD

Groen-Blokhuis, Maria, de Graaff, Jurgen, Bartels, Meike, Duran, Maryse, van Beijsterveldt, Toos, Kalkman, Cor, Middeldorp, Christel and Boomsma, Dorret (2012). The influence of early anesthesia exposure on ADHD. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, Jun 22-25, 2012. SPRINGER.

What have modern genetic studies told us about depression?

Breen, Gerome, Alsabban, Shaza, Nivard, Michel and Middeldorp, Christel (2012). What have modern genetic studies told us about depression?. 42nd Annual Meeting of the Behavior-Genetics-Association, Edinburgh Scotland, Jun 22-25, 2012. SPRINGER.

Life events and borderline personality disorder

Distel, Marijn A., Middeldorp, Christel M., Willemsen, Gonneke, Trull, Timothy J., Derom, Catherine A. and Boomsma, Dorret I. (2009). Life events and borderline personality disorder. 39th Annual Meeting of the Behavior-Genetics-Association, Mineapolis Mn, Jun 17-20, 2009. SPRINGER.

Significant linkage on chromosome 14 for anxiety

Middeldorp, Christel, Hottenga, Jouke Jan, Slagboom, P. Eline, Sullivan, Patrick F., Beem, A. Leo, Willemsen, Gonneke and Boomsma, Dorret I. (2006). Significant linkage on chromosome 14 for anxiety. 14th World Congress on Psychiatric Genetics, Cagliari Italy, Oct 28-Nov 01, 2006. WILEY-LISS.

Genetic epidemiology of depression in a selected population of Dutch twins and their siblings

Middeldorp, CM, Cath, DC, Beem, AL and Boomsma, DI (2004). Genetic epidemiology of depression in a selected population of Dutch twins and their siblings. 34th Annual Meeting of the Behavior-Genetics-Association, Aix en Provence France, Jun 27-30, 2004. SPRINGER.

Candidate genes for mood disorders in humans. A literature review

Middeldorp, CM, Ruigrok, P, Cath, DC, Van Dyck, R and Boomsma, DI (2002). Candidate genes for mood disorders in humans. A literature review. 10th World Congress of Psychiatric Genetics, Brussels Belgium, Oct 09-13, 2002. WILEY-LISS.