The University of Queensland

Cell surface plasticity in response to shape change in the whole organism

Hall, Thomas E., Ariotti, Nicholas, Lo, Harriet P., Rae, James, Ferguson, Charles, Martel, Nick, Lim, Ye-Wheen, Giacomotto, Jean and Parton, Robert G. (2023). Cell surface plasticity in response to shape change in the whole organism. Current Biology, 33 (19), 4276-4284.e4. doi: 10.1016/j.cub.2023.08.068

The Role of Membrane Lipids in the Formation and Function of Caveolae

Kenworthy, Anne K., Han, Bing, Ariotti, Nicholas and Parton, Robert G. (2023). The Role of Membrane Lipids in the Formation and Function of Caveolae. Cold Spring Harbor Perspectives in Biology, 15 (9) a041413, a041413. doi: 10.1101/cshperspect.a041413

Physico-chemical properties of functionally adhesive spider silk nanofibres

Joel, Anna-Christin, Rawal, Aditya, Yao, Yin, Jenner, Andrew, Ariotti, Nicholas, Weissbach, Margret, Adler, Lewis, Stafstrom, Jay and Blamires, Sean J. (2023). Physico-chemical properties of functionally adhesive spider silk nanofibres. Biomaterials Science, 11 (6), 2139-2150. doi: 10.1039/d2bm01599d

Microtubule–mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast

Chacko, Leeba Ann, Mikus, Felix, Ariotti, Nicholas, Dey, Gautam and Ananthanarayanan, Vaishnavi (2023). Microtubule–mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast. Journal of Cell Science, 136 (1) jcs260705, 1-8. doi: 10.1242/jcs.260705

Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers

Longatte, Guillaume, Lisi, Fabio, Chen, Xueqian, Walsh, James, Wang, Wenqian, Ariotti, Nicholas, Boecking, Till, Gaus, Katharina and Gooding, J. Justin (2022). Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers. Physical Chemistry Chemical Physics, 24 (45), 28029-28039. doi: 10.1039/d2cp03627d

Macrophage-targeting and complete lysosomal degradation of self-assembled two-dimensional poly(ε-caprolactone) platelet particles

Ganda, Sylvia, Wong, Chin Ken, Biazik, Joanna, Raveendran, Radhika, Zhang, Lin, Chen, Fan, Ariotti, Nicholas and Stenzel, Martina H. (2022). Macrophage-targeting and complete lysosomal degradation of self-assembled two-dimensional poly(ε-caprolactone) platelet particles. ACS Applied Materials and Interfaces, 14 (31), 35333-35343. doi: 10.1021/acsami.2c06555

Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands

Zhang, Lin, Cao, Cheng, Kaushik, Natasha, Lai, Rebecca Y., Liao, Jiayan, Wang, Guannan, Ariotti, Nicholas, Jin, Dayong and Stenzel, Martina H. (2022). Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands. Biomacromolecules, 23 (6), 2572-2585. doi: 10.1021/acs.biomac.2c00265

Nanovoid formation induces property variation within and across individual silkworm silk threads

Craig, Hamish C., Yao, Yin, Ariotti, Nicholas, Setty, Mohan, Remadevi, Rechana, Kasumovic, Michael M., Rajkhowa, Rangam, Rawal, Aditya and Blamires, Sean J. (2022). Nanovoid formation induces property variation within and across individual silkworm silk threads. Journal of Materials Chemistry B, 10 (29), 5561-5570. doi: 10.1039/d2tb00357k

Trehalose coated nanocellulose to inhibit the infections by S. aureus

Li, Yimeng, Milewska, Malgorzata, Khine, Yee Yee, Ariotti, Nicholas and Stenzel, Martina H. (2022). Trehalose coated nanocellulose to inhibit the infections by S. aureus. Polymer Chemistry, 13 (11), 1502-1509. doi: 10.1039/d1py01422f

Green Stealth Engineering of Lifetime-Biocatalytic Nanocatalyst for Neuroblastoma Therapy

Mehmood, Rashid, Amaldoss, Maria J. N., Mofarah, Sajjad S., Zheng, Qinxiang, Kaushik, Natasha K., Ariotti, Nicholas, Rawal, Aditya, Yang, Jia-Lin, Koshy, Pramod and Sorrell, Charles C. (2022). Green Stealth Engineering of Lifetime-Biocatalytic Nanocatalyst for Neuroblastoma Therapy. Applied Surface Science, 572 151464, 151464. doi: 10.1016/j.apsusc.2021.151464

SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

Ecker, Manuela, Schregle, Richard, Kapoor-Kaushik, Natasha, Rossatti, Pascal, Betzler, Verena M., Kempe, Daryan, Biro, Maté, Ariotti, Nicholas, Redpath, Gregory M. I. and Rossy, Jeremie (2022). SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling. eLife, 11 e67550. doi: 10.7554/eLife.67550

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Lo, Harriet P., Lim, Ye-Wheen, Xiong, Zherui, Martel, Nick, Ferguson, Charles, Ariotti, Nicholas, Giacomotto, Jean, Rae, James, Floetenmeyer, Matthias, Moradi, Shayli Varasteh, Gao, Ya, Tillu, Vikas A., Xia, Di, Wang, Huang, Rahnama, Samira, Nixon, Susan J., Bastiani, Michele, Day, Ryan D., Smith, Kelly A., Palpant, Nathan J., Johnston, Wayne A., Alexandrov, Kirill, Collins, Brett M., Hall, Thomas E. and Parton, Robert G. (2021). Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Journal of Cell Biology, 220 (12) e201905065. doi: 10.1083/jcb.201905065

Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation

Cagigas, Maria Lastra, Bryce, Nicole S., Ariotti, Nicholas, Brayford, Simon, Gunning, Peter W. and Hardeman, Edna C. (2021). Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation. Nature Materials, 21 (1), 120-128. doi: 10.1038/s41563-021-01087-z

Inhibition of S. aureus infection of human umbilical vein endothelial cells (HUVECs) by trehalose- and glucose-functionalized gold nanoparticles

Li, Yimeng, Ariotti, Nicholas, Aghaei, Behnaz, Pandzic, Elvis, Ganda, Sylvia, Willcox, Mark, Sanchez-Felix, Manuel and Stenzel, Martina (2021). Inhibition of S. aureus infection of human umbilical vein endothelial cells (HUVECs) by trehalose- and glucose-functionalized gold nanoparticles. Angewandte Chemie - International Edition, 60 (42), 22652-22658. doi: 10.1002/anie.202106544

A robust method for particulate detection of a genetic tag for 3D electron microscopy

Rae, James, Ferguson, Charles, Ariotti, Nicholas, Webb, Richard I., Cheng, Han-Hao, Mead, James L., Riches, James D., Hunter, Dominic J.B., Martel, Nick, Baltos, Joanne, Christopoulos, Arthur, Bryce, Nicole S., Cagigas, Maria Lastra, Fonseka, Sachini, Sayre, Marcel E., Hardeman, Edna C., Gunning, Peter W., Gambin, Yann, Hall, Thomas E. and Parton, Robert G. (2021). A robust method for particulate detection of a genetic tag for 3D electron microscopy. eLife, 10 e64630, 1-17. doi: 10.7554/eLife.64630

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Tillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G. and Collins, Brett M. (2021). Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nature Communications, 12 (1) 931, 931. doi: 10.1038/s41467-021-21035-4

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

Zhou, Yong, Ariotti, Nicholas, Rae, James, Liang, Hong, Tillu, Vikas, Tee, Shern, Bastiani, Michele, Bademosi, Adekunle T., Collins, Brett M., Meunier, Frederic A., Hancock, John F. and Parton, Robert G. (2021). Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. Journal of Cell Biology, 220 (3) e202005138. doi: 10.1083/jcb.202005138

Formation of retromer transport carriers is disrupted by the Parkinson disease‐linked Vps35 D620N variant

Cui, Yi, Yang, Zhe, Flores‐Rodriguez, Neftali, Follett, Jordan, Ariotti, Nicholas, Wall, Adam A., Parton, Robert G. and Teasdale, Rohan D. (2021). Formation of retromer transport carriers is disrupted by the Parkinson disease‐linked Vps35 D620N variant. Traffic, 22 (4) tra.12779, 123-136. doi: 10.1111/tra.12779

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells

Ariotti, Nicholas, Wu, Yeping, Okano, Satomi, Gambin, Yann, Follett, Jordan, Rae, James, Ferguson, Charles, Teasdale, Rohan D., Alexandrov, Kirill, Meunier, Frederic A., Hill, Michelle M. and Parton, Robert G. (2020). An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells. Autophagy, 17 (9), 1-17. doi: 10.1080/15548627.2020.1820787

In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

Hall, Thomas E., Martel, Nick, Ariotti, Nicholas, Xiong, Zherui, Lo, Harriet P., Ferguson, Charles, Rae, James, Lim, Ye-Wheen and Parton, Robert G. (2020). In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation. Nature Communications, 11 (1) 3711, 3711. doi: 10.1038/s41467-020-17486-w

Self-assembly of fluorescent HIV capsid spheres for detection of capsid binders

Lau, Derrick, Walsh, James C., Mousapasandi, Amir, Ariotti, Nicholas, Shah, Vaibhav B., Turville, Stuart, Jacques, David A. and Böcking, Till (2020). Self-assembly of fluorescent HIV capsid spheres for detection of capsid binders. Langmuir, 36 (13), 3624-3632. doi: 10.1021/acs.langmuir.0c00103

Caveolae and lipid sorting: shaping the cellular response to stress

Parton, Robert G., Kozlov, Michael M. and Ariotti, Nicholas (2020). Caveolae and lipid sorting: shaping the cellular response to stress. Journal of Cell Biology, 219 (4) e201905071. doi: 10.1083/jcb.201905071

Gold nanoparticles immobilised in a superabsorbent hydrogel matrix: facile synthesis and application for the catalytic reduction of toxic compounds

Alzahrani, Hassan A. H., Buckingham, Mark A., Wardley, William P., Tilley, Richard D., Ariotti, Nicholas and Aldous, Leigh (2019). Gold nanoparticles immobilised in a superabsorbent hydrogel matrix: facile synthesis and application for the catalytic reduction of toxic compounds. Chemical Communications, 56 (8), 1263-1266. doi: 10.1039/c9cc07046j

An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation

Echarri, Asier, Pavón, Dácil M., Sánchez, Sara, García-García, María, Calvo, Enrique, Huerta-López, Carla, Velázquez-Carreras, Diana, Viaris de Lesegno, Christine, Ariotti, Nicholas, Lázaro-Carrillo, Ana, Strippoli, Raffaele, De Sancho, David, Alegre-Cebollada, Jorge, Lamaze, Christophe, Parton, Robert G. and Del Pozo, Miguel A. (2019). An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation. Nature Communications, 10 (1) 5828, 1-16. doi: 10.1038/s41467-019-13782-2

Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis

Redpath, Gregory M. I., Ecker, Manuela, Kapoor-Kaushik, Natasha, Vartoukian, Haig, Carnell, Michael, Kempe, Daryan, Biro, Maté, Ariotti, Nicholas and Rossy, Jérémie (2019). Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis. Nature Communications, 10 (1) 4392. doi: 10.1038/s41467-019-12352-w

The use of a personal glucose meter for detecting procalcitonin through glucose encapsulated within liposomes

Alshawawreh, Fida'a, Lisi, Fabio, Ariotti, Nicholas, Bakthavathsalam, Padmavathy, Benedetti, Tania, Tilley, Richard D. and Gooding, J. Justin (2019). The use of a personal glucose meter for detecting procalcitonin through glucose encapsulated within liposomes. Analyst, 144 (21), 6225-6230. doi: 10.1039/c9an01519a

Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres

Meiring, Joyce C. M., Bryce, Nicole S., Cagigas, Maria Lastra, Benda, Aleš, Whan, Renee M., Ariotti, Nicholas, Parton, Robert G., Stear, Jeffrey H., Hardeman, Edna C. and Gunning, Peter W. (2019). Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres. Journal of Cell Science, 132 (15) jcs228916, jcs.228916. doi: 10.1242/jcs.228916

Membrane curvature and tension control the formation and collapse of caveolar superstructures

Golani, Gonen, Ariotti, Nicholas, Parton, Robert G. and Kozlov, Michael M. (2019). Membrane curvature and tension control the formation and collapse of caveolar superstructures. Developmental Cell, 48 (4), 523-538.e4. doi: 10.1016/j.devcel.2018.12.005

Thiol-reactive star polymers functionalized with short ethoxy-containing moieties exhibit enhanced uptake in acute lymphoblastic leukemia cells

Bayat, Narges, McOrist, Nathan, Ariotti, Nicholas, Lai, May, Sia, Keith C. S., Li, Yuhuan, Grace, James L., Quinn, John F., Whittaker, Michael R., Kavallaris, Maria, Davis, Thomas P. and Lock, Richard B. (2019). Thiol-reactive star polymers functionalized with short ethoxy-containing moieties exhibit enhanced uptake in acute lymphoblastic leukemia cells. International Journal of Nanomedicine, 14, 9795-9808. doi: 10.2147/IJN.S220326

Retromer has a selective function in cargo sorting via endosome transport carriers

Cui, Yi, Carosi, Julian M., Yang, Zhe, Ariotti, Nicholas, Kerr, Markus C., Parton, Robert G., Sargeant, Timothy J. and Teasdale, Rohan D. (2018). Retromer has a selective function in cargo sorting via endosome transport carriers. The Journal of Cell Biology, 218 (2), jcb.201806153-631. doi: 10.1083/jcb.201806153

Electron microscopic detection of proteins and protein complexes in mammalian cells using APEX-tagged, conditionally stable nanobodies

Hall, Thomas E., Rae, James, Ariotti, Nicholas and Parton, Robert G. (2018). Electron microscopic detection of proteins and protein complexes in mammalian cells using APEX-tagged, conditionally stable nanobodies. Bio-Protocol, 8 (22), e3088. doi: 10.21769/BioProtoc.3088

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography

Kovtun, Oleksiy, Leneva, Natalya, Bykov, Yury S., Ariotti, Nicholas, Teasdale, Rohan D., Schaffer, Miroslava, Engel, Benjamin D., Owen, David. J., Briggs, John A. G. and Collins, Brett M. (2018). Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561 (7724), 561-+. doi: 10.1038/s41586-018-0526-z

Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood

Tavallaie, Roya, McCarroll, Joshua, Le Grand, Marion, Ariotti, Nicholas, Schuhmann, Wolfgang, Bakker, Eric, Tilley, Richard David, Hibbert, David Brynn, Kavallaris, Maria and Gooding, John Justin (2018). Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood. Nature Nanotechnology, 13 (11), 1066-1071. doi: 10.1038/s41565-018-0232-x

Cell-free formation and interactome analysis of caveolae

Jung, WooRam, Sierecki, Emma, Bastiani, Michele, O'Carroll, Ailis, Alexandrov, Kirill, Rae, James, Johnston, Wayne, Hunter, Dominic J. B., Ferguson, Charles, Gambin, Yann, Ariotti, Nicholas and Parton, Robert G. (2018). Cell-free formation and interactome analysis of caveolae. The Journal of Cell Biology, 217 (6), 2141-2165. doi: 10.1083/jcb.201707004

Ultrastructural localisation of protein interactions using conditionally stable nanobodies

Ariotti, Nicholas, Rae, James, Giles, Nichole, Martel, Nick, Sierecki, Emma, Gambin, Yann, Hall, Thomas E. and Parton, Robert G. (2018). Ultrastructural localisation of protein interactions using conditionally stable nanobodies. PLoS Biology, 16 (4) e2005473, e2005473. doi: 10.1371/journal.pbio.2005473

PH-responsive morphology-controlled redox behavior and cellular uptake of nanoceria in fibrosarcoma

Mehmood, Rashid, Ariotti, Nicholas, Yang, Jia Lin, Koshy, Pramod and Sorrell, Charles C. (2018). PH-responsive morphology-controlled redox behavior and cellular uptake of nanoceria in fibrosarcoma. ACS Biomaterials Science and Engineering, 4 (3), 1064-1072. doi: 10.1021/acsbiomaterials.7b00806

Real-time synchrotron small-angle x-ray scattering studies of collagen structure during leather processing

Zhang, Yi, Ingham, Bridget, Cheong, Soshan, Ariotti, Nicholas, Tilley, Richard D., Naffa, Rafea, Holmes, Geoff, Clarke, David J. and Prabakar, Sujay (2018). Real-time synchrotron small-angle x-ray scattering studies of collagen structure during leather processing. Industrial and Engineering Chemistry Research, 57 (1), 63-69. doi: 10.1021/acs.iecr.7b03860

Journey to the centre of the cell: Virtual reality immersion into scientific data

Johnston, Angus P. R., Rae, James, Ariotti, Nicholas, Bailey, Benjamin, Lija, Andrew, Webb, Robyn, Ferguson, Charles, Maher, Sheryl, Davis, Thomas P., Webb, Richard I., McGhee, John and Parton, Robert G. (2017). Journey to the centre of the cell: Virtual reality immersion into scientific data. Traffic (Copenhagen, Denmark), 19 (2), 105-110. doi: 10.1111/tra.12538

Correlative light and electron microscopic detection of GFP-labeled proteins using modular APEX

Ariotti, Nicholas, Hall, Thomas E. and Parton, Robert G. (2017). Correlative light and electron microscopic detection of GFP-labeled proteins using modular APEX. Methods in Cell Biology, 140, 105-121. doi: 10.1016/bs.mcb.2017.03.002

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence

Sierecki, Emma, Giles, Nichole, Bowden, Quill, Polinkovsky, Mark E., Steinbeck, Janina, Arrioti, Nicholas, Rahman, Diya, Bhumkar, Akshay, Nicovich, Philip R., Ross, Ian, Parton, Robert G., Bocking, Till and Gambin, Yann (2016). Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence. Scientific Reports, 6 (1) 37630, 37630. doi: 10.1038/srep37630

Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation

Follett, Jordan, Bugarcic, Andrea, Yang, Zhe, Ariotti, Nicholas, Norwood, Suzanne J., Collins, Brett M., Parton, Robert G. and Teasdale, Rohan D. (2016). Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation. Journal of Biological Chemistry, 291 (35), 18283-18298. doi: 10.1074/jbc.M115.703157

New transgenic lines for localization of GFP-tagged proteins by electron microscope

Hall, Thomas, Ariotti, Nicholas, Ferguson, Charles, Zherui, Xiong and Parton, Robert G. (2016). New transgenic lines for localization of GFP-tagged proteins by electron microscope. Zebrafish, 13 (3), 232-233. doi: 10.1089/zeb.2016.29002.hal

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering

Blazevits, Olga, Mideksa, Yonatan G., Solman, Maja, Ligabue, Alessio, Ariotti, Nicholas, Nakhaeizadeh, Hossein, Fansa, Eyad K., Papageorgiou, Anastassios C., Wittinghofer, Alfred, Ahmadian, Mohammad R. and Abankwa, Daniel (2016). Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. Scientific Reports, 6 (1) 24165, 24165. doi: 10.1038/srep24165

Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms

Ariotti, Nicholas, Hall, Thomas, Rae, James, Ferguson, Charles, McMahon, Kerrie-Ann, Martel, Nick, Webb, Robyn E., Webb, Richard I., Teasdale, Rohan D. and Parton, Robert G. (2015). Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms. Developmental Cell, 35 (4), 513-525. doi: 10.1016/j.devcel.2015.10.016

Molecular characterization of caveolin-induced membrane curvature

Ariotti, Nicholas, Rae, James, Leneva, Natalya, Ferguson, Charles, Loo, Dorothy, Okano, Satomi, Hill, Michelle M., Walser, Piers, Collins, Brett M. and Parton, Robert G. (2015). Molecular characterization of caveolin-induced membrane curvature. Journal of Biological Chemistry, 290 (41), 24875-24890. doi: 10.1074/jbc.M115.644336

Cavin family proteins and the assembly of caveolae

Kovtun, Oleksiy, Tillu, Vikas A., Ariotti, Nicholas, Parton, Robert G. and Collins, Brett M. (2015). Cavin family proteins and the assembly of caveolae. Journal of Cell Science, 128 (7), 1269-1278. doi: 10.1242/jcs.167866

Structural insights into the organization of the cavin membrane coat complex

Kovtun, Oleksiy, Tilu, Vikas A., Jung, WooRam, Leneva, Natalya, Ariotti, Nicholas, Chaudhary, Natasha, Mandyam, Ramya A., Ferguson, Charles, Morgan, Garry P., Johnston, Wayne A., Harrop, Stephen J., Alexandrov, Kirill, Parton, Robert G. and Collins, Brett M. (2014). Structural insights into the organization of the cavin membrane coat complex. Developmental Cell, 31 (4), 405-419. doi: 10.1016/j.devcel.2014.10.002

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

Ariotti, Nicholas, Fernández-Rojo, Manuel, Zhou, Yong, Hill, Michelle M., Rodkey, Travis L., Inder, Kerry L., Tanner, Lukas B., Wenk, Markus R., Hancock, John F. and Parton, Robert G. (2014). Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. Journal of Cell Biology, 204 (5), 777-792. doi: 10.1083/jcb.201307055

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

Gambin, Yann, Ariotti, Nicholas, McMahon, Kerrie-Ann, Bastiani, Michele, Sierecki, Emma, Kovtun, Oleksiy, Polinkovsky, Mark E., Magenau, Astrid, Jung, WooRam, Okano, Satomi, Zhou, Yong, Leneva, Natalya, Mureev, Sergey, Johnston, Wayne, Gaus, Katharina, Hancock, John F., Collins, Brett M., Alexandrov, Kirill and Parton, Robert G. (2014). Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. eLIFE, 2014 (3) e01434, e01434.1-e01434.18. doi: 10.7554/eLife.01434

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

Lakshminarayan, Ramya, Wunder, Christian, Becken, Ulrike, Howes, Mark T., Benzing, Carola, Arumugam, Senthil, Sales, Susanne, Ariotti, Nicholas, Chambon, Valérie, Lamaze, Christophe, Loew, Damarys, Shevchenko, Andrej, Gaus, Katharina, Parton, Robert G. and Johannes, Ludger (2014). Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers. Nature Cell Biology, 16 (6), 592-603. doi: 10.1038/ncb2970

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters

Zhou, Yong, Liang, Hong, Rodkey, Travis, Ariotti, Nicholas, Parton, Robert G. and Hancock, John F. (2013). Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters. Molecular and Cellular Biology, 34 (5), 862-876. doi: 10.1128/MCB.01227-13

Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity

Herms, Albert, Bosch, Marta, Ariotti, Nicholas, Reddy, Babu J. N., Fajardo, Alba, Fernandez-Vidal, Andrea, Alvarez-Guaita, Anna, Fernandez-Rojo, Manuel Alejandro, Rentero, Carles, Tebar, Francesc, Enrich, Carlos, Geli, Maria-Isabel, Parton, Robert G., Gross, Steven P. and Pol, Albert (2013). Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity. Current Biology, 23 (15), 1489-1496. doi: 10.1016/j.cub.2013.06.032

SnapShot: caveolae, caveolins, and cavins

Ariotti, Nicholas and Parton Robert G. (2013). SnapShot: caveolae, caveolins, and cavins. Cell, 154 (3), 704-705. doi: 10.1016/j.cell.2013.07.009

Constitutive formation of caveolae in a bacterium

Walser, Piers, Ariotti, Nicholas, Howes, Mark, Ferguson, Charles, Webb, Richard, Schwudke, Dominik, Leneva, Natalya, Cho, Kwang-Jin, Cooper, Leanne, Rae, James, Floetenmeyer, Matthias, Oorschot, Viola M. J., Skoglund, Ulf, Simons, Kai, Hancock, John F. and Parton, Robert G. (2012). Constitutive formation of caveolae in a bacterium. Cell, 150 (4), 752-763. doi: 10.1016/j.cell.2012.06.042

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors

Kohnke, Monika, Schmitt, Steven, Ariotti, Nicholas, Piggott, Andrew, Parton, Robert G., Lacey, Ernest, Capon, Robert, Alexandrov, Kirill and Abankwa, Daniel (2012). Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors. Chemistry and Biology, 19 (7), 866-874. doi: 10.1016/j.chembiol.2012.05.019

Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes

Ariotti, Nicholas, Samantha Murphy, Hamilton, Nicholas A., Wu, Lizhen, Green, Kathryn, Nicole Schieber, Li, Peng, Martin, Sally and Parton, Robert G. (2012). Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes. Molecular Biology of The Cell, 23 (10), 1826-1837. doi: 10.1091/mbc.E11-10-0847

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

Fairn, Gregory D., Schieber, Nicole L., Ariotti, Nicholas, Murphy, Samantha, Kuerschner, Lars, Webb, Richard I., Grinstein, Sergio and Parton, Robert G. (2011). High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine. Journal of Cell Biology, 194 (2), 257-275. doi: 10.1083/jcb.201012028

Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation

Ariotti, Nicholas, Liang, Hong, Xu, Yufei, Zhang, Yueqiang, Yonekubo, Yoshiya, Inder, Kerry, Du, Guangwei, Parton, Robert G., Hancock, John F. and Plowman, Sarah J. (2010). Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation. Molecular and Cellular Biology, 30 (15), 3795-3804. doi: 10.1128/MCB.01615-09

K-Ras Nanoclustering is Subverted by Overexpression of the Scaffold Protein Galectin-3

Shalom-Feuerstein, R., Plowman, S. J., Rotblat, B., Ariotti, N., Tian, T., Hancock, J. F. and Kloog, Y. (2008). K-Ras Nanoclustering is Subverted by Overexpression of the Scaffold Protein Galectin-3. Cancer Research, 68 (16), 6608-6616. doi: 10.1158/0008-5472.CAN-08-1117

Electrostatic interactions positively regulate K-Ras nanocluster formation and function

Plowman, S. J., Ariotti, N., Goodall, A., Parton, R. G. and Hancock, J. F. (2008). Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Molecular and Cellular Biology, 28 (13), 4377-4385. doi: 10.1128/MCB.00050-08

A novel switch region regulated H-ras membrane orientation and signal output

Abankwa, Daniel, Hanzal-Bayer, Michael, Ariotti, Nicolas, Plowman, Sarah J., Gorfe, Alemayehu A, Parton, Robert G., McCammon, J. Andrew and Hancock, John F. (2008). A novel switch region regulated H-ras membrane orientation and signal output. The EMBO journal, 27 (5), 727-735. doi: 10.1038/emboj.2008.10

Journey to the centre of the cell (JTCC)∗: a 3D VR experience derived from migratory breast cancer cell image data

McGhee, John, Bailey, Benjamin, Parton, Robert G., Ariotti, Nicholas and Johnston, Angus (2016). Journey to the centre of the cell (JTCC)∗: a 3D VR experience derived from migratory breast cancer cell image data. 2016 SIGGRAPH ASIA VR Showcase, SA 2016, Macau, China, 5 - 8 December 2016. New York, NY, United States: Association for Computing Machinery. doi: 10.1145/2996376.2996385

Structural dissection of architecture of caveolar protein coat

Kovtun, O., Tillu, V., Jung, W., Leneva, N., Ariotti, N., Alexandrov, K., Parton, R. and Collins, B. (2014). Structural dissection of architecture of caveolar protein coat. FEBS EMBO 2014 Conference, Paris, France, 30 August - 4 September, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Protozoan symbionts in hindgut-fermenting mammals

O'Donoghue, P. J., Yuen, S. Y. and Ariotti, N. R. (2007). Protozoan symbionts in hindgut-fermenting mammals. Australian Society for Parasitology Annual Scientific Meeting, Canberra, ACT, Australia, 8-11 July 2007.

Unique endosymbiotic ciliates of wombats in Australia

Ariotti, N. R. and O'Donoghue, P J (2006). Unique endosymbiotic ciliates of wombats in Australia. ASP & ARC/NHMRC Network for Parasitology Annual Conference, Gold Coast, 2-5 July, 2006.

A structural and functional characterisation of caveolae

Ariotti, Nicholas Richard (2012). A structural and functional characterisation of caveolae. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.