The University of Queensland

Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

Evans, Tavia E., Adams, Hieab H. H., Licher, Silvan, Wolters, Frank J., van der Lugt, Aad, Ikram, M. Kamran, O'Sullivan, Michael J., Vernooij, Meike W. and Ikram, M. Arfan (2018) Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia. NeuroImage, 178 129-135. doi:10.1016/j.neuroimage.2018.05.041

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Horsburgh, Karen, Wardlaw, Joanna M., van Agtmael, Tom, Allan, Stuart M., Ashford, Mike L.J., Bath, Philip M., Brown, Rosalind, Berwick, Jason, Cader, M. Zameel, Carare, Roxana O., Davis, John B., Duncombe, Jessica, Farr, Tracy D., Fowler, Jill H., Goense, Jozien, Granata, Alessandra, Hall, Catherine N., Hainsworth, Atticus H., Harvey, Adam, Hawkes, Cheryl A., Joutel, Anne, Kalaria, Rajesh N., Kehoe, Patrick G., Lawrence, Catherine B., Lockhart, Andy, Love, Seth, Macleod, Malcolm R., Macrae, I. Mhairi, Markus, Hugh S., McCabe, Chris, McColl, Barry W., Meakin, Paul J., Miller, Alyson, Nedergaard, Maiken, O'Sullivan, Michael, Quinn, Terry J., Rajani, Rikesh, Saksida, Lisa M., Smith, Colin, Smith, Kenneth J., Touyz, Rhian M., Trueman, Rebecca C., Wang, Tao, Williams, Anna, Williams, Steven C.R. and Work, Lorraine M. (2018) Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132 8: 851-868. doi:10.1042/CS20171620

Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment

Gan, C. L., O'Sullivan, M. J., Metzler-Baddeley, C. and Halpin, S. (2017) Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment. Clinical Radiology, 72 11: 915-922. doi:10.1016/j.crad.2017.04.021

What can the topology of white matter structural networks tell us about mild cognitive impairment?

Berlot, Rok and O'Sullivan, Michael J. (2017) What can the topology of white matter structural networks tell us about mild cognitive impairment?. Future Neurology, 12 1: 35-50. doi:10.2217/fnl-2016-0022

Global efficiency of structural networks mediates cognitive control in mild cognitive impairment

Berlot, Rok, Metzler-Baddeley, Claudia, Ikram, M. Arfan, Jones, Derek K. and O'Sullivan, Michael J. (2016) Global efficiency of structural networks mediates cognitive control in mild cognitive impairment. Frontiers in Aging Neuroscience, 8 DEC: . doi:10.3389/fnagi.2016.00292

White matter microstructure improves stroke prediction in the general population

Evans, Tavia E., O’Sullivan, Michael J. , de Groot, Marius, Niessen, Wiro J., Hofman, Albert, Krestin, Gabriel P. , van der Lugt, Aad, Portegies, Marileen L. P. , Koudstaal, Peter J., Bos, Daniel, Vernooij, Meike W. and Ikram, M. Arfan (2016) White matter microstructure improves stroke prediction in the general population. Stroke, 47 11: 2756-2762. doi:10.1161/STROKEAHA.116.014651

Amyloid imaging and Alzheimer's disease: the unsolved cases

O'Sullivan, Michael J. and Vann, Seralynne D. (2016) Amyloid imaging and Alzheimer's disease: the unsolved cases. Brain, 139 9: 2342-2344. doi:10.1093/brain/aww166

A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol

Greenan, Caroline, Murphy, Lynn, Yu, Ly-Mee, Kehoe, Patrick G., Coulthard, Elizabeth, Bath, Philip, Stewart, Robert, Jones, Rob, Corbett, Anne, Thomas, Alan, Connelly, Peter, Arrojo, Frank, Canning, Rachel, Wallach, Sylvia, Henderson, Catherine, McGuinness, Bernadette, O'Sullivan, Mike, Holmes, Clive, Knapp, Martin, Ballard, Clive and Passmore, Peter (2016) A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol. Trials, 17 324: . doi:10.1186/s13063-016-1449-3

Small vessel disease and cognitive impairment: the relevance of central network connections

Reijmer, Yael D., Fotiadis, Panagiotis, Piantoni, Giovanni, Boulouis, Gregoire, Kelly, Kathleen E., Gurol, Mahmut E., Leemans, Alexander, O'Sullivan, Michael J., Greenberg, Steven M. and Viswanathan, Anand (2016) Small vessel disease and cognitive impairment: the relevance of central network connections. Human Brain Mapping, 37 7: 2446-2454. doi:10.1002/hbm.23186

Here, there and everywhere: higher visual function and the dorsal visual stream

Cooper, Sarah Anne and O'Sullivan, Michael (2016) Here, there and everywhere: higher visual function and the dorsal visual stream. Practical Neurology, 16 3: 176-183. doi:10.1136/practneurol-2015-001168

The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: an MRI tractography study

Christiansen, Kat, Aggleton, John P., Parker, Greg D., O'Sullivan, Michael J., Vann, Seralynne D. and Metzler-Baddeley, Claudia (2016) The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: an MRI tractography study. NeuroImage, 130 35-47. doi:10.1016/j.neuroimage.2015.12.055

White matter microstructure and cognitive function in young women with polycystic ovary syndrome

Rees, D. Aled, Udiawar, Maneesh, Berlot, Rok, Jones, Derek K. and O'Sullivan, Michael J. (2016) White matter microstructure and cognitive function in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 101 1: 314-323. doi:10.1210/jc.2015-2318

Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities

Reijmer, Y. D., Schultz, A. P., Leemans, A., O'Sullivan, M. J., Gurol, M. E., Sperling, R., Greenberg, S. M., Viswanathan, A. and Hedden, T. (2015) Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities. NeuroImage, 117 222-229. doi:10.1016/j.neuroimage.2015.05.054

Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment

Ray, Nicola J., Metzler-Baddeley, Claudia, Khondoker, Mizanur R., Grothe, Michel J., Teipel, Stefan, Wright, Paul, Heinsen, Helmut, Jones, Derek K., Aggleton, John P. and O'Sullivan, Michael J. (2015) Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience, 35 2: 739-747. doi:10.1523/JNEUROSCI.3617-14.2015

CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment

Berlot, Rok, Metzler-Baddeley, Claudia, Jones, Derek K. and O'Sullivan, Michael J. (2014) CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment. NeuroImage, 92 27-35. doi:10.1016/j.neuroimage.2014.01.031

Alzheimer disease and stroke: cognitive and neuroimaging predictors of AD and stroke

Ballard, Clive and O'Sullivan, Michael J. (2013) Alzheimer disease and stroke: cognitive and neuroimaging predictors of AD and stroke. Nature Reviews Neurology, 9 11: 605-606. doi:10.1038/nrneurol.2013.215

Individual differences in fornix microstructure and Body Mass Index

Metzler-Baddeley, Claudia, Baddeley, Roland J., Jones, Derek K., Aggleton, John P. and O'Sullivan, Michael J. (2013) Individual differences in fornix microstructure and Body Mass Index. PloS One, 8 3: e59849. doi:10.1371/journal.pone.0059849

Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment

Metzler-Baddeley, Claudia, Jones, Derek K., Steventon, Jessica, Westacott, Laura, Aggleton, John P. and O'Sullivan, Michael J. (2012) Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience, 32 49: 17612-17619. doi:10.1523/JNEUROSCI.3299-12.2012

Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment

Metzler-Baddeley, Claudia, Hunt, Sarah, Jones, Derek K., Leemans, Alexander, Aggleton, John P. and O'Sullivan, Michael J. (2012) Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology, 79 23: 2233-2240. doi:10.1212/WNL.0b013e31827689e8

How and how not to correct for CSF-contamination in diffusion MRI

Metzler-Baddeley, Claudia, O'Sullivan, Michael J., Bells, Sonya, Pasternak, Ofer and Jones, Derek K. (2012) How and how not to correct for CSF-contamination in diffusion MRI. NeuroImage, 59 2: 1394-1403. doi:10.1016/j.neuroimage.2011.08.043

Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL

Epelbaum, S., Benisty, S., Reyes, S., O'Sullivan, M., Jouvent, E., Duering, M., Herve, D., Opherk, C., Hernandez, K., Kurtz, A., Viswanathan, A., Bousser, M. G., Dichgans, M. and Chabriat, H. (2011) Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. Neurobiology of Aging, 32 12: 2172-2182. doi:10.1016/j.neurobiolaging.2009.12.018

Frontotemporal connections in episodic memory and aging: a diffusion MRI tractography study

Metzler-Baddeley, Claudia, Jones, Derek K., Belaroussi, Boubakeur, Aggleton, John P. and O'Sullivan, Michael J. (2011) Frontotemporal connections in episodic memory and aging: a diffusion MRI tractography study. Journal of Neuroscience, 31 37: 13236-13245. doi:10.1523/JNEUROSCI.2317-11.2011

South Wales joint neuroscience meeting, Bridgend, 29 April 2010: A 66-year-old man who suddenly couldn't drive

O'Sullivan, Michael J., Neal, James W., Walters, R. Jon, Smith, Eric E. and Hughes, Thomas A. T. (2011) South Wales joint neuroscience meeting, Bridgend, 29 April 2010: A 66-year-old man who suddenly couldn't drive. Practical Neurology, 11 3: 153-159. doi:10.1136/practneurol-2011-000020

Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL

Viswanathan, Anand, Godin, Ophelia, Jouvent, Eric, O'Sullivan, Michael, Gschwendtner, Andreas, Peters, Nils, Duering, Marco, Guichard, Jean-Pierre, Holtmannspoetter, Markus, Dufouil, Carole, Pachai, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2010) Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL. Neurobiology of Aging, 31 9: 1629-1636. doi:10.1016/j.neurobiolaging.2008.09.001

Patterns of atrophy on MRI and the boundary between ageing and Alzheimer’s disease

O’Sullivan, Mike (2009) Patterns of atrophy on MRI and the boundary between ageing and Alzheimer’s disease. Reviews in Clinical Gerontology, 19 4: 295-307. doi:10.1017/S0959259809990426

Hippocampal volume is an independent predictor of cognitive performance in CADASIL

O'Sullivan, Mike, Ngo, Elmar, Viswanathan, Anand, Jouvent, Eric, Gschwendtner, Andreas, Saemann, Philipp G., Duering, Marco, Pachai, Chahin, Bousser, Marie-Germaine, Chabriat, Hugues and Dichgans, Martin (2009) Hippocampal volume is an independent predictor of cognitive performance in CADASIL. Neurobiology of Aging, 30 6: 890-897. doi:10.1016/j.neurobiolaging.2007.09.002

Apathy: A major symptom in Cadasil

Reyes, S., Viswanathan, A., Godin, O., Dufouil, C., Benisty, S., Hernandez, K., Kurtz, A., Jouvent, E., O'Sullivan, M., Czernecki, V., Bousser, M. G., Dichgans, M. and Chabriat, H. (2009) Apathy: A major symptom in Cadasil. Neurology, 72 10: 905-910. doi:10.1212/01.wnl.0000344166.03470.f8

Measurement of brain atrophy in subcortical vascular disease: A comparison of different approaches and the impact of ischaemic lesions

O'Sullivan, Mike, Jouvent, Eric, Saernann, Philipp G., Mangin, Jean-Francois, Viswanathan, Anand, Gschwendtner, Andreas, Bracoud, Luc, Pachai, Chahin, Chabriat, Hugues and Dichgans, Martin (2008) Measurement of brain atrophy in subcortical vascular disease: A comparison of different approaches and the impact of ischaemic lesions. Neuroimage, 43 2: 312-320. doi:10.1016/j.neuroimage.2008.07.049

Cortical changes in cerebral small vessel diseases: A 3D MRI study of cortical morphology in CADASIL

Jouvent, Eric, Mangin, Jean-François, Porcher, Raphael, Viswanathan, Anand, O'Sullivan, Mike, Guichard, Jean-Pierre, Dichgans, Martin, Bousser, Marie-Germaine and Chabriat, Hugues (2008) Cortical changes in cerebral small vessel diseases: A 3D MRI study of cortical morphology in CADASIL. Brain, 131 8: 2201-2208. doi:10.1093/brain/awn129

Diagnostic criteria of vascular dementia in CADASIL

Benisty, Sarah, Hernandez, Karen, Viswanathan, Anand, Reyes, Sonia, Kurtz, Annie, O'Sullivan, Michael, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2008) Diagnostic criteria of vascular dementia in CADASIL. Stroke, 39 3: 838-844. doi:10.1161/STROKEAHA.107.490672

Leukoaraiosis

O'Sullivan, Mike (2008) Leukoaraiosis. Practical Neurology, 8 1: 26-38. doi:10.1136/jnnp.2007.139428

Prestroke cognitive function and cerebrovascular disease: If they interact, it may not be through symptomatic stroke

O'Sullivan, Mike (2008) Prestroke cognitive function and cerebrovascular disease: If they interact, it may not be through symptomatic stroke. Stroke, 39 1: 3-4. doi:10.1161/STROKEAHA.107.496679

Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL

Viswanathan, A., Gschwendtner, A., Guichard, J. P., Buffon, F., Cumurciuc, R., O'Sullivan, M., Holtmannspötter, M., Pachai, C., Bousser, M. G., Dichgans, M. and Chabriat, H. (2007) Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL. Neurology, 69 2: 172-179. doi:10.1212/01.wnl.0000265221.05610.70

Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL

Jouvent, Eric, Viswanathan, Anand, Mangin, Jean-François, O'Sullivan, Mike, Guichard, Jean-Pierre, Gschwendtner, Andreas, Cumurciuc, Rodica, Buffon, Frédérique, Peters, Nils, Pachaï, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2007) Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL. Stroke, 38 6: 1786-1790. doi:10.1161/STROKEAHA.106.478263

Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia

Jones, Derek K., Catani, Marco, Pierpaoli, Carlo, Reeves, Suzanne J. C., Shergill, Sukhwinder S., O'Sullivan, Michael, Golesworthy, Pasha, McGuire, Phillip, Horsfield, Mark A., Simmons, Andrew, Williams, Steven C. R. and Howard, Robert J. (2006) Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Human Brain Mapping, 27 3: 230-238. doi:10.1002/hbm.20179

White matter damage on diffusion tensor imaging correlates with age-related cognitive decline

Charlton, R. A., Barrick, T. R., McIntyre, D. J., Shen, Y., O'Sullivan, M., Howe, F. A., Clark, C. A., Morris, R. G. and Markus, H. S. (2006) White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology, 66 2: 217-222. doi:10.1212/01.wnl.0000194256.15247.83

Brief cognitive assessment for patients with cerebral small vessel disease

O'Sullivan, Mike, Morris, R. G. and Markus, H. S. (2005) Brief cognitive assessment for patients with cerebral small vessel disease. Journal of Neurology, Neurosurgery and Psychiatry, 76 8: 1140-1145. doi:10.1136/jnnp.2004.045963

A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis

Jones, Derek K., Catani, Marco, Pierpaoli, Carlo, Reeves, Suzanne J., Shergill, Sukhwinder S., O'Sullivan, Michael, Maguire, Philip, Horsfield, Mark A., Simmons, Andrew, Williams, Steven C. R. and Howard, Robert J. (2005) A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis. American Journal of Geriatric Psychiatry, 13 12: 1092-1099. doi:10.1097/00019442-200512000-00009

Damage within a network of white matter regions underlies executive dysfunction in CADASIL

O'Sullivan, M., Barrick, T. R., Morris, R. G., Clark, C. A. and Markus, H. S. (2005) Damage within a network of white matter regions underlies executive dysfunction in CADASIL. Neurology, 65 10: 1584-1590. doi:10.1212/01.wnl.0000184480.07394.fb

Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia

O'Sullivan, Michael, Singhal, Sumeet, Charlton, Rebecca and Markus, Hugh S. (2004) Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia. Neurology, 62 5: 702-707. doi:10.1212/01.WNL.0000113760.72706.D2

Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis

O'Sullivan, M., Morris, R. G., Huckstep, B., Jones, D. K., Williams, S. C.R. and Markus, H. S. (2004) Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. Journal of Neurology, Neurosurgery and Psychiatry, 75 3: 441-447. doi:10.1136/jnnp.2003.014910

Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease

Hassan, A., Gormley, K., O'Sullivan, M., Knight, J., Sham, P., Vallance, P., Bamford, J. and Markus, Hugh (2004) Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease. Stroke, 35 3: 654-659. doi:10.1161/01.STR.0000117238.75736.53

Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction

Hassan, Ahamad, Hunt, Beverley J., O'Sullivan, Michael, Bell, Rachel, D'Souza, Reuben, Jeffery, Steve, Bamford, John M. and Markus, Hugh S. (2004) Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain, 127 1: 212-219. doi:10.1093/brain/awh023

Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

O'Sullivan, Michael, Rich, Philip M., Barrick, Thomas R., Clark, Christopher A. and Markus, Hugh S. (2003) Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. American Journal of Neuroradiology, 24 7: 1348-1354.

Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis

Hassan, Ahamad, Hunt, Beverley J., O'Sullivan, Michael, Parmar, Kiran, Bamford, John M., Briley, Dennis, Brown, Martin M., Thomas, Dafydd J. and Markus, Hugh S. (2003) Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain, 126 2: 424-432. doi:10.1093/brain/awg040

Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis

O'Sullivan, M., Lythgoe, D. J., Pereira, A. C., Summers, P. E., Jarosz, J. M., Williams, S. C.R. and Markus, H. S. (2002) Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology, 59 3: 321-326. doi:10.1212/WNL.59.3.321

Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

O'Sullivan, M., Summers, P. E., Jones, D. K., Jarosz, J. M., Williams, S. C.R. and Markus, H. S. (2001) Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study. Neurology, 57 12: 2307-2310. doi:10.1212/WNL.57.12.2307

Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline

O'Sullivan, Mike, Jones, D. K., Summers, P. E., Morris, R. G., Williams, S. C.R. and Markus, H. S. (2001) Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology, 57 4: 632-638. doi:10.1212/WNL.57.4.632

MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL

O'Sullivan, Michael, Jarosz, J. M., Martin, R. J., Deasy, N., Powell, J. F. and Markus, H. S. (2001) MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology, 56 5: 628-634. doi:10.1212/WNL.56.5.628

Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI

Markus, H. S., Lythgoe, D. J., Ostegaard, L., O'Sullivan, M. and Williams, S. C.R. (2000) Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. Journal of Neurology Neurosurgery and Psychiatry, 69 1: 48-53. doi:10.1136/jnnp.69.1.48

Imaging small vessel disease: Lesion topography, networks, and cognitive deficits investigated with MRI

O'Sullivan, Michael (2010). Imaging small vessel disease: Lesion topography, networks, and cognitive deficits investigated with MRI. In: 27th Princeton Conference 2010, Boston Ma, (S154-S158). Apr 22-24, 2010. doi:10.1161/STROKEAHA.110.595314