Overview
Professor Michael O’Sullivan is a neuroscientist and neurologist with a special interest in mechanisms of resilience and recovery of the brain after injury. He is also interested in networks in the brain that support memory and cognitive control. He is a professor and member of the Executive of the UQ Centre for Clinical Research and a Staff Specialist in Neurology at the Royal Brisbane and Women's Hospital. Through this joint appointment he is forging a shared interdisciplinary research agenda in clinical neuroscience between UQ, Metro North/ Queensland Health and cutting-edge imaging technology in Brisbane. He is the Principal Investigator of STRATEGIC, a large observational study of cognitive function after stroke and a co-investigator of the cognitive substudy of TRIDENT, a trial of blood pressure lowering after acute haemorrhage. Prior to moving to Australia, Professor O’Sullivan was the strategic lead for stroke at King’s Health Partners, an Academic Health Sciences Centre connecting the University and three major NHS Foundation Trusts in South London and a member of the Vascular Experimental Medicine Group of the UK Dementias Platform. His group has substantial experience in the application of diffusion MRI, tractography and functional MRI to understand the interaction between focal damage and other processes involved in ageing and early cognitive decline, viewed from a network perspective.
Supervision
Professor O’Sullivan supervises PhD projects across multiple research areas, including clinical science, cognitive neuroscience, animal models and computational neuroscience (such as machine learning and deep learning algorithms for diagnosis and prediction of prognosis). Expressions of interest from potential PhD and honours students are welcome.
With significant clinical experience, Professor O’Sullivan’s research focus is translational in nature, promoting the restoration of function. His previous work has been aimed at identifying mechanisms of resilience and restoration of function that can be targeted by therapies that promote recovery; the STRATEGIC study targets such mechanistic insights in stroke. Professor O’Sullivan has consulted in numerous UK clinics and hospitals with a focus on hyperacute stroke services, microvascular disease and genetic forms, and post-stroke cognitive impairment and dementia.
Journal Article: Subacute Changes in N-Acetylaspartate (NAA) Following Ischemic Stroke: A Serial MR Spectroscopy Pilot Study
Mazibuko, Ndaba, Tuura, Ruth O'Gorman, Sztriha, Laszlo, O'Daly, Owen, Barker, Gareth J., Williams, Steven C. R., O'Sullivan, Michael and Kalra, Lalit (2020). Subacute Changes in N-Acetylaspartate (NAA) Following Ischemic Stroke: A Serial MR Spectroscopy Pilot Study. Diagnostics, 10 (7) 482, 482. doi: 10.3390/diagnostics10070482
Journal Article: Network neuroscience of apathy in cerebrovascular disease
Tay, Jonathan, Lisiecka-Ford, Danuta M., Hollocks, Matthew J., Tuladhar, Anil M., Barrick, Thomas R., Forster, Anne, O’Sullivan, Michael J., Husain, Masud, de Leeuw, Frank-Erik, Morris, Robin G. and Markus, Hugh S. (2020). Network neuroscience of apathy in cerebrovascular disease. Progress in Neurobiology, 188 101785, 101785. doi: 10.1016/j.pneurobio.2020.101785
Journal Article: UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings
McFall, Aisling, Hietamies, Tuuli M, Bernard, Ashton, Aimable, Margaux, Allan, Stuart M, Bath, Philip M, Brezzo, Gaia, Carare, Roxana O, Carswell, Hilary V, Clarkson, Andrew N, Currie, Gillian, Farr, Tracy D, Fowler, Jill H, Good, Mark, Hainsworth, Atticus H, Hall, Catherine, Horsburgh, Karen, Kalaria, Rajesh, Kehoe, Patrick, Lawrence, Catherine, Macleod, Malcolm, McColl, Barry W, McNeilly, Alison, Miller, Alyson A, Miners, Scott, Mok, Vincent, O’Sullivan, Michael, Platt, Bettina, Sena, Emily S ... Quinn, Terence J (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40 (7), 1402-1414. doi: 10.1177/0271678X20910552
Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT)
(2019–2020) The George Institute for Global Health
Apathy, motivation and cognitive control after stroke
(2018–2021) Research Donation Generic
The structural architecture of working memory in the human brain
Doctor Philosophy
Cerebral microbleeds and cognitive impairment
Werring, David J. and O’Sullivan, Mike (2011). Cerebral microbleeds and cognitive impairment. Cerebral Microbleeds: Pathophysiology to Clinical Practice. (pp. 152-158) Cambridge University Press. doi: 10.1017/CBO9780511974892.020
Mazibuko, Ndaba, Tuura, Ruth O'Gorman, Sztriha, Laszlo, O'Daly, Owen, Barker, Gareth J., Williams, Steven C. R., O'Sullivan, Michael and Kalra, Lalit (2020). Subacute Changes in N-Acetylaspartate (NAA) Following Ischemic Stroke: A Serial MR Spectroscopy Pilot Study. Diagnostics, 10 (7) 482, 482. doi: 10.3390/diagnostics10070482
Network neuroscience of apathy in cerebrovascular disease
Tay, Jonathan, Lisiecka-Ford, Danuta M., Hollocks, Matthew J., Tuladhar, Anil M., Barrick, Thomas R., Forster, Anne, O’Sullivan, Michael J., Husain, Masud, de Leeuw, Frank-Erik, Morris, Robin G. and Markus, Hugh S. (2020). Network neuroscience of apathy in cerebrovascular disease. Progress in Neurobiology, 188 101785, 101785. doi: 10.1016/j.pneurobio.2020.101785
McFall, Aisling, Hietamies, Tuuli M, Bernard, Ashton, Aimable, Margaux, Allan, Stuart M, Bath, Philip M, Brezzo, Gaia, Carare, Roxana O, Carswell, Hilary V, Clarkson, Andrew N, Currie, Gillian, Farr, Tracy D, Fowler, Jill H, Good, Mark, Hainsworth, Atticus H, Hall, Catherine, Horsburgh, Karen, Kalaria, Rajesh, Kehoe, Patrick, Lawrence, Catherine, Macleod, Malcolm, McColl, Barry W, McNeilly, Alison, Miller, Alyson A, Miners, Scott, Mok, Vincent, O’Sullivan, Michael, Platt, Bettina, Sena, Emily S ... Quinn, Terence J (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40 (7), 1402-1414. doi: 10.1177/0271678X20910552
Microstructural changes in the reward system are associated with post-stroke depression
Oestreich, Lena K. L., Wright, Paul and O'Sullivan, Michael J. (2020). Microstructural changes in the reward system are associated with post-stroke depression. NeuroImage: Clinical, 28 102360, 102360. doi: 10.1016/j.nicl.2020.102360
McDonald, Matthew W., Black, Sandra E., Copland, David A., Corbett, Dale, Dijkhuizen, Rick M., Farr, Tracy D., Jeffers, Matthew S., Kaaria, Rajesh N., Karayanidis, Frini, Leff, Alexander P., Nithianantharajah, Jess, Pendlebury, Sarah, Quinn, Terence J., Clarkson, Andrew N. and O'Sullivan, Michael J. (2019). Cognition in stroke rehabilitation and recovery research: consensus-based core recommendations from the second stroke recovery and rehabilitation roundtable. Neurorehabilitation and Neural Repair, 33 (11), 943-950. doi: 10.1177/1545968319886444
McDonald, Matthew W, Black, Sandra E, Copland, David A, Corbett, Dale, Dijkhuizen, Rick M, Farr, Tracy D, Jeffers, Matthew S, Kalaria, Rajesh N, Karayanidis, Frini, Leff, Alexander P, Nithianantharajah, Jess, Pendlebury, Sarah, Quinn, Terence J, Clarkson, Andrew N and O’Sullivan, Michael J (2019). Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14 (8), 1747493019873600-782. doi: 10.1177/1747493019873600
Language and language disorders: neuroscience to clinical practice
O'Sullivan, Michael, Brownsett, Sonia and Copland, David (2019). Language and language disorders: neuroscience to clinical practice. Practical Neurology, 19 (5), practneurol-2018. doi: 10.1136/practneurol-2018-001961
Setting the scene for the Second Stroke Recovery and Rehabilitation Roundtable
Bernhardt, Julie, Borschmann, Karen N., Kwakkel, Gert, Burridge, Jane H., Eng, Janice J., Walker, Marion F., Bird, Marie-Louise, Cramer, Steven C., Hayward, Kathryn S., O’Sullivan, Michael J., Clarkson, Andrew N. and Corbett, Dale (2019). Setting the scene for the Second Stroke Recovery and Rehabilitation Roundtable. International Journal of Stroke, 14 (5), 450-456. doi: 10.1177/1747493019851287
A key role for subiculum-fornix connectivity in recollection in older age
Hartopp, Naomi, Wright, Paul, Ray, Nicola J., Evans, Tavia E., Metzler-Baddeley, Claudia, Aggleton, John P. and O’Sullivan, Michael J. (2019). A key role for subiculum-fornix connectivity in recollection in older age. Frontiers in Systems Neuroscience, 12 70, 70. doi: 10.3389/fnsys.2018.00070
Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia
Evans, Tavia E., Adams, Hieab H. H., Licher, Silvan, Wolters, Frank J., van der Lugt, Aad, Ikram, M. Kamran, O'Sullivan, Michael J., Vernooij, Meike W. and Ikram, M. Arfan (2018). Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia. NeuroImage, 178, 129-135. doi: 10.1016/j.neuroimage.2018.05.041
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology
Horsburgh, Karen, Wardlaw, Joanna M., van Agtmael, Tom, Allan, Stuart M., Ashford, Mike L.J., Bath, Philip M., Brown, Rosalind, Berwick, Jason, Cader, M. Zameel, Carare, Roxana O., Davis, John B., Duncombe, Jessica, Farr, Tracy D., Fowler, Jill H., Goense, Jozien, Granata, Alessandra, Hall, Catherine N., Hainsworth, Atticus H., Harvey, Adam, Hawkes, Cheryl A., Joutel, Anne, Kalaria, Rajesh N., Kehoe, Patrick G., Lawrence, Catherine B., Lockhart, Andy, Love, Seth, Macleod, Malcolm R., Macrae, I. Mhairi, Markus, Hugh S. ... Work, Lorraine M. (2018). Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132 (8), 851-868. doi: 10.1042/CS20171620
Gan, C. L., O'Sullivan, M. J., Metzler-Baddeley, C. and Halpin, S. (2017). Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment. Clinical Radiology, 72 (11), 915-922. doi: 10.1016/j.crad.2017.04.021
What can the topology of white matter structural networks tell us about mild cognitive impairment?
Berlot, Rok and O'Sullivan, Michael J. (2017). What can the topology of white matter structural networks tell us about mild cognitive impairment?. Future Neurology, 12 (1), 35-50. doi: 10.2217/fnl-2016-0022
Global efficiency of structural networks mediates cognitive control in mild cognitive impairment
Berlot, Rok, Metzler-Baddeley, Claudia, Ikram, M. Arfan, Jones, Derek K. and O'Sullivan, Michael J. (2016). Global efficiency of structural networks mediates cognitive control in mild cognitive impairment. Frontiers in Aging Neuroscience, 8 (DEC) 292. doi: 10.3389/fnagi.2016.00292
White matter microstructure improves stroke prediction in the general population
Evans, Tavia E., O’Sullivan, Michael J. , de Groot, Marius, Niessen, Wiro J., Hofman, Albert, Krestin, Gabriel P. , van der Lugt, Aad, Portegies, Marileen L. P. , Koudstaal, Peter J., Bos, Daniel, Vernooij, Meike W. and Ikram, M. Arfan (2016). White matter microstructure improves stroke prediction in the general population. Stroke, 47 (11), 2756-2762. doi: 10.1161/STROKEAHA.116.014651
Amyloid imaging and Alzheimer's disease: the unsolved cases
O'Sullivan, Michael J. and Vann, Seralynne D. (2016). Amyloid imaging and Alzheimer's disease: the unsolved cases. Brain, 139 (9), 2342-2344. doi: 10.1093/brain/aww166
Greenan, Caroline, Murphy, Lynn, Yu, Ly-Mee, Kehoe, Patrick G., Coulthard, Elizabeth, Bath, Philip, Stewart, Robert, Jones, Rob, Corbett, Anne, Thomas, Alan, Connelly, Peter, Arrojo, Frank, Canning, Rachel, Wallach, Sylvia, Henderson, Catherine, McGuinness, Bernadette, O'Sullivan, Mike, Holmes, Clive, Knapp, Martin, Ballard, Clive and Passmore, Peter (2016). A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol. Trials, 17 (324) 324. doi: 10.1186/s13063-016-1449-3
Small vessel disease and cognitive impairment: the relevance of central network connections
Reijmer, Yael D., Fotiadis, Panagiotis, Piantoni, Giovanni, Boulouis, Gregoire, Kelly, Kathleen E., Gurol, Mahmut E., Leemans, Alexander, O'Sullivan, Michael J., Greenberg, Steven M. and Viswanathan, Anand (2016). Small vessel disease and cognitive impairment: the relevance of central network connections. Human Brain Mapping, 37 (7), 2446-2454. doi: 10.1002/hbm.23186
Here, there and everywhere: higher visual function and the dorsal visual stream
Cooper, Sarah Anne and O'Sullivan, Michael (2016). Here, there and everywhere: higher visual function and the dorsal visual stream. Practical Neurology, 16 (3), 176-183. doi: 10.1136/practneurol-2015-001168
Christiansen, Kat, Aggleton, John P., Parker, Greg D., O'Sullivan, Michael J., Vann, Seralynne D. and Metzler-Baddeley, Claudia (2016). The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: an MRI tractography study. NeuroImage, 130, 35-47. doi: 10.1016/j.neuroimage.2015.12.055
White matter microstructure and cognitive function in young women with polycystic ovary syndrome
Rees, D. Aled, Udiawar, Maneesh, Berlot, Rok, Jones, Derek K. and O'Sullivan, Michael J. (2016). White matter microstructure and cognitive function in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 101 (1), 314-323. doi: 10.1210/jc.2015-2318
Reijmer, Y. D., Schultz, A. P., Leemans, A., O'Sullivan, M. J., Gurol, M. E., Sperling, R., Greenberg, S. M., Viswanathan, A. and Hedden, T. (2015). Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities. NeuroImage, 117, 222-229. doi: 10.1016/j.neuroimage.2015.05.054
Ray, Nicola J., Metzler-Baddeley, Claudia, Khondoker, Mizanur R., Grothe, Michel J., Teipel, Stefan, Wright, Paul, Heinsen, Helmut, Jones, Derek K., Aggleton, John P. and O'Sullivan, Michael J. (2015). Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience, 35 (2), 739-747. doi: 10.1523/JNEUROSCI.3617-14.2015
CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment
Berlot, Rok, Metzler-Baddeley, Claudia, Jones, Derek K. and O'Sullivan, Michael J. (2014). CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment. NeuroImage, 92, 27-35. doi: 10.1016/j.neuroimage.2014.01.031
Alzheimer disease and stroke: cognitive and neuroimaging predictors of AD and stroke
Ballard, Clive and O'Sullivan, Michael J. (2013). Alzheimer disease and stroke: cognitive and neuroimaging predictors of AD and stroke. Nature Reviews Neurology, 9 (11), 605-606. doi: 10.1038/nrneurol.2013.215
Individual differences in fornix microstructure and Body Mass Index
Metzler-Baddeley, Claudia, Baddeley, Roland J., Jones, Derek K., Aggleton, John P. and O'Sullivan, Michael J. (2013). Individual differences in fornix microstructure and Body Mass Index. PloS One, 8 (3) e59849, e59849. doi: 10.1371/journal.pone.0059849
Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment
Metzler-Baddeley, Claudia, Jones, Derek K., Steventon, Jessica, Westacott, Laura, Aggleton, John P. and O'Sullivan, Michael J. (2012). Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience, 32 (49), 17612-17619. doi: 10.1523/JNEUROSCI.3299-12.2012
Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment
Metzler-Baddeley, Claudia, Hunt, Sarah, Jones, Derek K., Leemans, Alexander, Aggleton, John P. and O'Sullivan, Michael J. (2012). Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology, 79 (23), 2233-2240. doi: 10.1212/WNL.0b013e31827689e8
How and how not to correct for CSF-contamination in diffusion MRI
Metzler-Baddeley, Claudia, O'Sullivan, Michael J., Bells, Sonya, Pasternak, Ofer and Jones, Derek K. (2012). How and how not to correct for CSF-contamination in diffusion MRI. NeuroImage, 59 (2), 1394-1403. doi: 10.1016/j.neuroimage.2011.08.043
Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL
Epelbaum, S., Benisty, S., Reyes, S., O'Sullivan, M., Jouvent, E., Duering, M., Herve, D., Opherk, C., Hernandez, K., Kurtz, A., Viswanathan, A., Bousser, M. G., Dichgans, M. and Chabriat, H. (2011). Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. Neurobiology of Aging, 32 (12), 2172-2182. doi: 10.1016/j.neurobiolaging.2009.12.018
Frontotemporal connections in episodic memory and aging: a diffusion MRI tractography study
Metzler-Baddeley, Claudia, Jones, Derek K., Belaroussi, Boubakeur, Aggleton, John P. and O'Sullivan, Michael J. (2011). Frontotemporal connections in episodic memory and aging: a diffusion MRI tractography study. Journal of Neuroscience, 31 (37), 13236-13245. doi: 10.1523/JNEUROSCI.2317-11.2011
O'Sullivan, Michael J., Neal, James W., Walters, R. Jon, Smith, Eric E. and Hughes, Thomas A. T. (2011). South Wales joint neuroscience meeting, Bridgend, 29 April 2010: A 66-year-old man who suddenly couldn't drive. Practical Neurology, 11 (3), 153-159. doi: 10.1136/practneurol-2011-000020
Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL
Viswanathan, Anand, Godin, Ophelia, Jouvent, Eric, O'Sullivan, Michael, Gschwendtner, Andreas, Peters, Nils, Duering, Marco, Guichard, Jean-Pierre, Holtmannspoetter, Markus, Dufouil, Carole, Pachai, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2010). Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL. Neurobiology of Aging, 31 (9), 1629-1636. doi: 10.1016/j.neurobiolaging.2008.09.001
Patterns of atrophy on MRI and the boundary between ageing and Alzheimer’s disease
O’Sullivan, Mike (2009). Patterns of atrophy on MRI and the boundary between ageing and Alzheimer’s disease. Reviews in Clinical Gerontology, 19 (4), 295-307. doi: 10.1017/S0959259809990426
Hippocampal volume is an independent predictor of cognitive performance in CADASIL
O'Sullivan, Mike, Ngo, Elmar, Viswanathan, Anand, Jouvent, Eric, Gschwendtner, Andreas, Saemann, Philipp G., Duering, Marco, Pachai, Chahin, Bousser, Marie-Germaine, Chabriat, Hugues and Dichgans, Martin (2009). Hippocampal volume is an independent predictor of cognitive performance in CADASIL. Neurobiology of Aging, 30 (6), 890-897. doi: 10.1016/j.neurobiolaging.2007.09.002
Apathy: A major symptom in Cadasil
Reyes, S., Viswanathan, A., Godin, O., Dufouil, C., Benisty, S., Hernandez, K., Kurtz, A., Jouvent, E., O'Sullivan, M., Czernecki, V., Bousser, M. G., Dichgans, M. and Chabriat, H. (2009). Apathy: A major symptom in Cadasil. Neurology, 72 (10), 905-910. doi: 10.1212/01.wnl.0000344166.03470.f8
O'Sullivan, Mike, Jouvent, Eric, Saernann, Philipp G., Mangin, Jean-Francois, Viswanathan, Anand, Gschwendtner, Andreas, Bracoud, Luc, Pachai, Chahin, Chabriat, Hugues and Dichgans, Martin (2008). Measurement of brain atrophy in subcortical vascular disease: A comparison of different approaches and the impact of ischaemic lesions. Neuroimage, 43 (2), 312-320. doi: 10.1016/j.neuroimage.2008.07.049
Cortical changes in cerebral small vessel diseases: A 3D MRI study of cortical morphology in CADASIL
Jouvent, Eric, Mangin, Jean-François, Porcher, Raphael, Viswanathan, Anand, O'Sullivan, Mike, Guichard, Jean-Pierre, Dichgans, Martin, Bousser, Marie-Germaine and Chabriat, Hugues (2008). Cortical changes in cerebral small vessel diseases: A 3D MRI study of cortical morphology in CADASIL. Brain, 131 (8), 2201-2208. doi: 10.1093/brain/awn129
Diagnostic criteria of vascular dementia in CADASIL
Benisty, Sarah, Hernandez, Karen, Viswanathan, Anand, Reyes, Sonia, Kurtz, Annie, O'Sullivan, Michael, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2008). Diagnostic criteria of vascular dementia in CADASIL. Stroke, 39 (3), 838-844. doi: 10.1161/STROKEAHA.107.490672
O'Sullivan, Mike (2008). Leukoaraiosis. Practical Neurology, 8 (1), 26-38. doi: 10.1136/jnnp.2007.139428
O'Sullivan, Mike (2008). Prestroke cognitive function and cerebrovascular disease: If they interact, it may not be through symptomatic stroke. Stroke, 39 (1), 3-4. doi: 10.1161/STROKEAHA.107.496679
Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL
Viswanathan, A., Gschwendtner, A., Guichard, J. P., Buffon, F., Cumurciuc, R., O'Sullivan, M., Holtmannspötter, M., Pachai, C., Bousser, M. G., Dichgans, M. and Chabriat, H. (2007). Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL. Neurology, 69 (2), 172-179. doi: 10.1212/01.wnl.0000265221.05610.70
Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL
Jouvent, Eric, Viswanathan, Anand, Mangin, Jean-François, O'Sullivan, Mike, Guichard, Jean-Pierre, Gschwendtner, Andreas, Cumurciuc, Rodica, Buffon, Frédérique, Peters, Nils, Pachaï, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues (2007). Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL. Stroke, 38 (6), 1786-1790. doi: 10.1161/STROKEAHA.106.478263
Correlations between MRS and DTI in cerebral small vessel disease
Nitkunan, Arani, McIntyre, Dominick J.O., Barrick, Thomas R., O'Sullivan, Michael, Shen, Yuji, Clark, Chris A., Howe, Franklyn A. and Markus, Hugh S. (2006). Correlations between MRS and DTI in cerebral small vessel disease. NMR in Biomedicine, 19 (5), 610-616. doi: 10.1002/nbm.1052
Jones, Derek K., Catani, Marco, Pierpaoli, Carlo, Reeves, Suzanne J. C., Shergill, Sukhwinder S., O'Sullivan, Michael, Golesworthy, Pasha, McGuire, Phillip, Horsfield, Mark A., Simmons, Andrew, Williams, Steven C. R. and Howard, Robert J. (2006). Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Human Brain Mapping, 27 (3), 230-238. doi: 10.1002/hbm.20179
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Charlton, R. A., Barrick, T. R., McIntyre, D. J., Shen, Y., O'Sullivan, M., Howe, F. A., Clark, C. A., Morris, R. G. and Markus, H. S. (2006). White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology, 66 (2), 217-222. doi: 10.1212/01.wnl.0000194256.15247.83
Brief cognitive assessment for patients with cerebral small vessel disease
O'Sullivan, Mike, Morris, R. G. and Markus, H. S. (2005). Brief cognitive assessment for patients with cerebral small vessel disease. Journal of Neurology, Neurosurgery and Psychiatry, 76 (8), 1140-1145. doi: 10.1136/jnnp.2004.045963
Jones, Derek K., Catani, Marco, Pierpaoli, Carlo, Reeves, Suzanne J., Shergill, Sukhwinder S., O'Sullivan, Michael, Maguire, Philip, Horsfield, Mark A., Simmons, Andrew, Williams, Steven C. R. and Howard, Robert J. (2005). A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis. American Journal of Geriatric Psychiatry, 13 (12), 1092-1099. doi: 10.1097/00019442-200512000-00009
Damage within a network of white matter regions underlies executive dysfunction in CADASIL
O'Sullivan, M., Barrick, T. R., Morris, R. G., Clark, C. A. and Markus, H. S. (2005). Damage within a network of white matter regions underlies executive dysfunction in CADASIL. Neurology, 65 (10), 1584-1590. doi: 10.1212/01.wnl.0000184480.07394.fb
Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia
O'Sullivan, Michael, Singhal, Sumeet, Charlton, Rebecca and Markus, Hugh S. (2004). Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia. Neurology, 62 (5), 702-707. doi: 10.1212/01.WNL.0000113760.72706.D2
Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis
O'Sullivan, M., Morris, R. G., Huckstep, B., Jones, D. K., Williams, S. C.R. and Markus, H. S. (2004). Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. Journal of Neurology, Neurosurgery and Psychiatry, 75 (3), 441-447. doi: 10.1136/jnnp.2003.014910
Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease
Hassan, A., Gormley, K., O'Sullivan, M., Knight, J., Sham, P., Vallance, P., Bamford, J. and Markus, Hugh (2004). Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease. Stroke, 35 (3), 654-659. doi: 10.1161/01.STR.0000117238.75736.53
Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction
Hassan, Ahamad, Hunt, Beverley J., O'Sullivan, Michael, Bell, Rachel, D'Souza, Reuben, Jeffery, Steve, Bamford, John M. and Markus, Hugh S. (2004). Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain, 127 (1), 212-219. doi: 10.1093/brain/awh023
O'Sullivan, Michael, Rich, Philip M., Barrick, Thomas R., Clark, Christopher A. and Markus, Hugh S. (2003). Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. American Journal of Neuroradiology, 24 (7), 1348-1354.
Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis
Hassan, Ahamad, Hunt, Beverley J., O'Sullivan, Michael, Parmar, Kiran, Bamford, John M., Briley, Dennis, Brown, Martin M., Thomas, Dafydd J. and Markus, Hugh S. (2003). Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain, 126 (2), 424-432. doi: 10.1093/brain/awg040
Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis
O'Sullivan, M., Lythgoe, D. J., Pereira, A. C., Summers, P. E., Jarosz, J. M., Williams, S. C.R. and Markus, H. S. (2002). Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology, 59 (3), 321-326. doi: 10.1212/WNL.59.3.321
Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study
O'Sullivan, M., Summers, P. E., Jones, D. K., Jarosz, J. M., Williams, S. C.R. and Markus, H. S. (2001). Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study. Neurology, 57 (12), 2307-2310. doi: 10.1212/WNL.57.12.2307
Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline
O'Sullivan, Mike, Jones, D. K., Summers, P. E., Morris, R. G., Williams, S. C.R. and Markus, H. S. (2001). Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology, 57 (4), 632-638. doi: 10.1212/WNL.57.4.632
MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL
O'Sullivan, Michael, Jarosz, J. M., Martin, R. J., Deasy, N., Powell, J. F. and Markus, H. S. (2001). MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology, 56 (5), 628-634. doi: 10.1212/WNL.56.5.628
Markus, H. S., Lythgoe, D. J., Ostegaard, L., O'Sullivan, M. and Williams, S. C.R. (2000). Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. Journal of Neurology Neurosurgery and Psychiatry, 69 (1), 48-53. doi: 10.1136/jnnp.69.1.48
Consensus building at the Second International Stroke Recovery and Rehabilitation Roundtable
Bernhardt, Julie, Borschmann, Karen, Kwakkel, Gert, Burridge, Jane, Eng, Janice, Walker, Marion, Bird, Marie-Louise, Cramer, Steven, Hayward, Kathryn, O'Sullivan, Michael, Clarkson, Andrew and Corbett, Dale (2019). Consensus building at the Second International Stroke Recovery and Rehabilitation Roundtable. SSA 2019 Conference, Canberra, Australia, 10 – 13 September 2019. London, United Kingdom: Sage Publications. doi: 10.1177/1747493019862960
Veronese, M., Wright, P., Mazibuko, N., Turkheimer, F. E., Rabiner, E. E., Ballard, C. G., Williams, S. C. R., Williams, R., Roncaroli, F. and O'Sullivan, M. J. (2019). Investigating neuroinflammation in small vessel disease with [11C]PBR28 PET imaging and post-mortem tissue validation. 29th International Symposium on Cerebral Blood Flow, Metabolism and Function / 14th International Conference on Quantification of Brain Function with PET (BRAIN and BRAIN Pet), Yokohama Japan, 4-7 July, 2019. London, United Kingdom: Sage Publications. doi: 10.1177/0271678X19850985
Towards the development of neuroimaging biomarkers for post-stroke depression
Oestreich, Lena, Wright, Paul, Williams, Steven and O'Sullivan, Michael (2019). Towards the development of neuroimaging biomarkers for post-stroke depression. SSA 2019 Conference, Canberra, Australia, 10 – 13 September 2019. London, United Kingdom: Sage Publications. doi: 10.1177/1747493019862960
Lacunar infarct burden within white matter tracts and cognitive function
Evans, T., O'Sullivan, M., Niessen, W., Ikram, M. A. and Vernooij, M. (2018). Lacunar infarct burden within white matter tracts and cognitive function. World Stroke Congress 2018, London, United Kingdom: Sage Publications.
Predictors of episodic memory recovery one year after stroke
Wright, P. and O'Sullivan, M. J. (2018). Predictors of episodic memory recovery one year after stroke. World Stroke Congress 2018, London, United Kingdom: Sage Publications.
O'Sullivan, Michael (2010). Imaging small vessel disease: Lesion topography, networks, and cognitive deficits investigated with MRI. 27th Princeton Conference 2010, Boston Ma, Apr 22-24, 2010. doi: 10.1161/STROKEAHA.110.595314
Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT)
(2019–2020) The George Institute for Global Health
Apathy, motivation and cognitive control after stroke
(2018–2021) Research Donation Generic
The structural architecture of working memory in the human brain
Doctor Philosophy — Principal Advisor
Other advisors: