Professor Ian Brereton

Director, Research and Technology

Centre for Advanced Imaging
i.brereton@uq.edu.au
+61 7 336 54245

Overview

Prof Ian Brereton, BSc, PhD is director, research and technology at the Centre for Advanced Imaging; Queensland NMR Network and Director, Queensland Node, National Imaging Facility. Professor Brereton is responsible for research infrastructure and facility managment at the Centre. He has over 30 years experience in the application of NMR imaging and spectroscopy to the chemical and biomedical sciences.

Research activities in the Brereton group are linked by a common aim of developing methods for the improved understanding of the molecular basis of biological function and disease, and informing the development of new diagnostic imaging technologies and approaches to therapy. The research is primarily based upon Magnetic Resonance Spectroscopy and Imaging methods and is applied to a breadth of scale, from the molecular structure and function of important biomolecules and metabolic profiling of living systems to targeted imaging agents and biomarkers for detection of disease and disorders. Current research interests include:

  • High resolution NMR spectroscopy in metabolomics and structural biology
  • The application 1H and multinuclear MR spectroscopy to study metabolic processes and to understand function and disease using MR molecular probes
  • Use of hyperpolarisation for MR molecular imaging
  • Development of purine nucleoside phosphonates as anti-malarial drugs targeting nucleoside synthesis in Plasmodium
  • Development of novel MRI and PET biomarkers for the early detection of neurodegenerative disease

Professor Brereton contributes to the education and training of the next generation of imaging scientist and technologists through coordination of fundamental MR imaging courses offered by the Centre within the Master programs in Magnetic Resonance Technology, Molecular Imaging Technology and MR-PET.

Research Interests

  • MR imaging and spectroscopy tools for the characterisation of metabolism in cancer and neurodegenerative disease.
    1. Multiparametric MRI and MRS methods have been applied to study lipid metabolism in liver cancer development, including T2W, Dixon and CSI. Animal models of liver cancer were established at UQ under this project (CDAA in rats). Collaboration with Yas Tesiram 2. Characterisation of demyelination in multiple sclerosis by MR diffusion-based methods. Methods applied to mouse brain were translated to spinal cord. Collaboration with Maree Smith and Nyoman Kurniawan.
  • Multimodal MR/PET imaging methods and agents in cancer and neurodegenerative disease
    1. Development of universal cancer theranostics targeting the tumour endothelial marker TEM8. Protective antigen, from B.anthracis is a natural ligand of TEM8 and therefore a potential candidate for detection and management of tumour vasculature, metastasis and growth. Collaboration with Yas Tesiram. 2. The collaboration with Clarity Pharmaceuticals funded by a CRC-P grant to develop protocols for novel copper-based radiopharmaceuticals achieved good progress with the initiation of a clinical trial in paediatric cancer conducted at the Peter McCallum Institute
  • NMR metabolomics: Characterisation of metabolic processes in biological systems
    A major program initiated in the use of NMR-based metabolomics as a diagnostic tool based on profiling biofluids and tissues in diseases such as prostate cancer, epilepsy, heart disease and diabetes, as well as characterisation of environmental impact on livestock production. NMR-based Metabolomics Facility within CAI led by Horst Schirra
  • Treasured Assets - Characterisation of new species
    3D Structural characterisation of a number of specimens held by the Australian Museum has led to the discovery of a new species of head shield sea slug (Philinidae) originating from deep waters off Taiwan. Micro-CT of the specimen revealed impressive gizzard plates and unusual food remnants as shown in the images. Project led by Karine Mardon

Qualifications

  • B.Sc (Hons), S.Aust.
  • PhD, S.Aust.

Publications

View all Publications

Supervision

  • (2019) Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

Conference Publication

  • Cowin, Gary, Leong, Lilly, Mardon, Karine, Janke, Andrew, Vegh, Viktor and Brereton, Ian (2015). Simultaneous MRI-PET bladder imaging of 18F-FDG and Gd-Magnevist. In: Australian Society for Molecular Imaging, Melbourne, Australia, (). December 2015.

  • Tieng, Quang, Vegh, Viktor, Brereton, Ian M., Reutens, David and Yang, Zhengyi (2012). The use of inverse phase Fourier image to accommodate intensity inhomogeneities in medical image registration. In: Proceedings: CIMSiM 2012 Fourth International Conference on Computational Intelligence, Modelling and Simulation. 2012 Fourth International Conference on Computational Intelligence, Modelling and Simulation (CIMSiM), Kuantan, Malaysia, (276-281). 25 - 27 September 2012. doi:10.1109/CIMSim.2012.60

  • Kerbler, Georg, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2011). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. In: 10th International Conference on Alzheimer's and Parkinson Diseases, Barcelona, Spain, (). 9-13 March 2011.

  • Georg Kerbler, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2010). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. In: 3rd Brain Plasticity Symposium, Brisbane, Australia, (). 14-16 September 2010.

  • Keller, Marianne D., Kerbler, Georg, Hamlin, Adam S., Brereton, Ian and Coulson, Elizabeth J. (2010). Tractography in a Saporine Alzheimer's Disease mouse model. In: Proceedings of the 2010 World Molecular Imaging Congress. World Molecular Imaging Conference in Kyoto, Japan, Kyoto, Japan, (). 8-11 September 2010.

  • Tieng, Q. M., Vegh, V. and Brereton, I. M. (2008). Minimum stored energy (MSE)compact superconducting magnets. In: 2008 Nuclear Science Symposium, Medical Imaging Conference and 16th Room Temperature Semiconductor Detector Workshop, Dresden, Germany, (). 19-25 Oct 2008.

  • Vegh, V., Brereton, I. M. and Galloway, G. (2008). Novel numerical modelling of lumped circuit elements in RF coils for identifying resonant frequencies. In: ISMRM-ESMRMB Joint Annual Meeting 2007. ISMRM-ESMRMB Joint Annual Meeting 2007, Berlin, Germany, (3248-3248). 19-25 May 2007.

  • Tucker, D. J., Lamb, D. L., Powell, K. S., Blanchfield, A. L. and Brereton, I. M. (2007). Detection of Phylloxera infestation in grapevines by NMR methods. In: Kevin S. Powell and Carolyn J. Threthowan, Proceedings of the Third International Grapevine Phylloxera Symposium. III International Grapevine Phylloxera Symposium, Fremantle, Australia, (173-181). 2-7 October 2005. doi:10.17660/ActaHortic.2007.733.19

  • Vegh, Viktor, Zhao, Huawei, Galloway, Graham J. and Brereton, Ian M. (2007). Tapered Head Gradient Coil Design Using the Wave Equation Method. In: Joint Annual Meeting International Symposium on Magnetic Resonance in Medicine (ISMRM) - ESMRMB, Berlin, Germany, (1015-1015). 19-25 May 2007.

  • Vegh, Viktor, Sanchez, Hector, Brereton, Ian M. and Crozier, Stuart (2007). Toward designing asymmetric head gradient coils for high-resolution imaging. In: Concepts In Magnetic Resonance Part B-magnetic Resonance Engineering . Proceedings of: 15th Scientific Meeting ISMRM. 15th Scientific Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Berlin, Germany, (1-11). 21 - 25 May, 2007. doi:10.1002/cmr.b.20082

  • Vegh, Viktor, Zhao, Huawei, Doddrell, David M., Galloway, Graham J. and Brereton, Ian M. (2006). A Flexible flow model for gradient coil design for the purpose of clinical MRI. In: ISMRM-2006 Proceedings. ISMRM 14th Scientific Meeting (ISMRM 2006), Seattle, Washington, USA, (671-671). 6-12 May 2006.

  • Cowin, Gary J., Weerasinghe, G., South, G., Tuck, A., Galloway, Graham J. and Brereton, Ian M. (2006). Contrast enhanced microimaging at 700 MHz. In: 45th Annual Meeting of the NMR Society of Japan, Kyoto, Japan, (). 22-24 October 2006.

  • Cowin, Gary J., Weerasinghe, G., South, S,, Tuck. A., Galloway, Graham J. and Brereton, Ian M. (2006). Contrast enhanced microimaging with Gd and Mn at 190 MHz and 700 MHz. In: Proceedings of: UWS Symposium and Workshop on NMR Imaging and Diffusion. UWS Symposium and Workshop on NMR Imaging and Diffusion, Sydney, NSW, Australia, (). 21-22 October 2006.

  • Tucker, D., Brereton, I., Powell, K., Blanchfield, A., Murison, R. and Lamb, D. (2006). Detection of Phylloxera Infestation in Grape Vines using NMR methods. In: ANZMAG2006, Abstracts of the 6th Conference of the Australian and New Zealand Society for Magnetic Resonance. ANZMAG2006, Murramarang, New South Wales, (77-77). Feb 2006.

  • Kurniawan, N. D., Fox , B., Rogers, F., Butler, T., Li, L., Wallace, R., Cowin, G., Rose, S., Coulson, E., Galloway, G., Bartlett, P. F. and Brereton, I. M. (2006). Magnetic resonance neuroimaging at 16.4T. In: UWS Symposium and Workshop on NMR Imaging and Diffusion, Sydney, Australia, (). 21-22 October 2006.

  • Talbot, Cavin Lee, Friese, Marlies Elly Joy, Rubensztein-Dunlop, Halina, Baldwin, Katie M., Whittaker, Andrew K., Brereton, Ian, Heckenberg, Norman R., Doddrell, David M. and Wang, Deming (2006). Using Laser Frequency Narrowing to Improve Production of Hyperpolarised Xe for Imaging and Surface Analysis. In: ISMRM-2006 Proceedings. ISMRM 14th Scientific Meeting (ISMRM 2006), Seattle, Washington, USA, (269-269). 6-12 May, 2006.

  • V. Vegh, H. Zhao, D. M. Doddrell, G. J. Galloway and I. M. Brereton (2005). A Novel Porous Media Fluid Propagation Approach for Designing Gradient Coils. In: international Society for Magnetic Resonance in Medicine, Miami, USA, (). 7-13 May.

  • Qu, J., Riley, M. J., Wang, D. and Brereton, I. M. (2005). Computational and experimental study of the interactions between xenon and crown ethers by 129Xe NMR. In: Scott Kable and Simon Apte, Connect 2005 : chemical challenges for the 21st century : abstract book : the 12th Royal Australian Chemical Institute (RACI) Convention. Connect 2005: 12th RACI Convention, Sydney, N.S.W., Australia, (). 3-7 July 2005.

  • Tucker, D., Brereton, I., Murison, R., Powell, K., Lamb, D. and Held, A. (2004). Detection of Phylloxera Infestation in Grape Vines using NMR methods. In: ANZMAG2004, Abstracts of the 5th Conference of the Australian and New Zealand Society for Magnetic Resonance. ANZMAG2004, Tanunda, South Australia, (76-76). 15-19 Feb, 2004.

  • Talbot, C. L., Friese, M. E. J., Wang, D., Doddrell, D., Brereton, I., Heckenberg, N. R. and Rubinsztein-Dunlop, H. (2003). Improved laser source for producing hyperpolarized noble gases for MRI applications. In: IFMBE Proceedings WC2003: World Congress on Medical Physics and Biomedical Engineering. World Congress in Medical Physics and Biomedical Engineering, Sydney Australia, (x-x). 24-29 August.

  • Talbot, C. L., Friese, M. E. J., Wang, D., Brereton, I., Heckenberg, N. R. and Rubinsztein-Dunlop, H. (2003). Production of Hyperpolarised Helium by Optical Pumping Using Laser Diode Arrays. In: ACOLS, Melbourne, (). 2003.

  • Devasahayam, S., Brereton, I. M., Whittaker, A. K. and Hill, D. (2001). Radiation chemistry of Ultem by NMR. In: 24th Australiasian Polymer Symposium. 24th Australiasian Polymer Symposium, Beechworth, Victoria, (PB9-PB9). 4-8 February, 2001.

  • Graham, V., Brereton, I. M. and De Jersey, J. (2001). Reaction of acetaldehyde with cysteine and its potential significance in alcoholic liver disease. In: Combio 2001. Combio 2001, Canberra, (1-028 (Poster)). 1-4 Oct, 2001.

  • Devasahayam, S., Brereton, I. M., Whittaker, A. K. and Hill, D. (2000). Identifying the crosslink structures formed in Y-irradiated Ultem using NMR. In: Radiation 2000 Conference Handbook. Radiation 2000, AINSE, Lucas Hts, NSW, (49). 26-28 Nov, 2000.

  • Kurniawan, N. D., Brereton, I. M., Aliabadizadeh, K., Kroon, P. A. and Smith, R. W. (2000). Solution structure of the epidermal growth factor-homology modules of the human low-density lipoprotein receptor. In: ICMRBS XIX. ICMRBS XIX, Florence, Italy, ((Abstract)). 20-25 Aug, 2000.

  • Crozier, S., Doddrell, D. M., Roffmann, W. U., Brereton, I. M., Luescher, K. and Hinds, G. W. (2000). The Tilt Coil, a tool to study structural anisotropy in cartilage. In: Proceedings of ANZMAG 2000. ANZMAG 2000, Mt Buller, Vic, (23-24). 13-17 February 2000.

  • Brereton, I. M., Clayton, D., Kroon, P. A. and Smith, R. W. (2000). Three-dimensional structure of the sixth ligand-binding repeat of the human low-density lipoprotein receptor. In: 25th Lorne Protein Conference. 25th Lorne Protein Conf, Lorne, Vic, ((Abstract)). 7 Feb 2000.

  • Kurniawan, N., Atkins, A. R., Bieri, S., Brereton, I. M., Kroon, P. A. and Smith, R. W. (1999). Solution structure of the first and second ligand binding modules of the human low density lipoprotein receptor. In: 24th Annual Lorne Conference on Protein Structure and Function. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House Lorne, Vic., (B56). 6-11 February, 1999.

  • Towner, RA, Williams, JP, Endre, ZH, Kadkhodaee, M, Wilson, S, Brereton, IM, Hanson, G and Doddrell, DM (1995). MR Assessment of Oxidative Stress Processes in Rat Liver and Kidneys. In: Gorenstein, DG, Bulletin of Magnetic Resonance: Proceedings of the International Society of Magnetic Resonance Xllth Meeting. International Society of Magnetic Resonance, ISMAR 95, Sydney, Australia, (190-192). 16th - 21st July 1995.

  • Irving, MG, Brooks, WM, Galloway, GJ, Brereton, IM, Brooks, WM, Baddeley, H and Doddrell, DM (1987). Invivo Volume-Selected H-1 Magnetic-Resonance Spectroscopy of Leukemia in Humans. In: Australian and New Zealand Journal of Medicine. , , (176-176). .

Grants (Administered at UQ)

PhD and MPhil Supervision

Note for students: Professor Ian Brereton is not currently available to take on new students.

Current Supervision

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision