Dr Emma Gordon

Natl Heart FDTN of Aus Future

Institute for Molecular Bioscience

Affiliate Sr Research Fellow

School of Chemistry and Molecular Biosciences
Faculty of Science
e.gordon@imb.uq.edu.au
+61 7 334 62052

Overview

Dr Gordon’s research is focused on the formation and maintenance of the blood and lymphatic vascular systems. Vessels form complex branched networks that supply oxygen and nutrients to all body tissues. The signals controlling blood vessel expansion, identity and migration are all downstream of a single, common complex at the cell surface, yet exactly how this diverse range of functions is differentially regulated, depending on the physiological need, remains unknown.

The specific focus of Dr Gordon’s research is to determine the precise molecular signals that control cell adhesion within the vessel wall the surrounding environment. If the signals controlling cell adhesion become deregulated, normal vessel growth and function is lost. This contributes to the progression of a wide range of human diseases, including cancer growth and metastasis, diabetic eye disease and stroke. Dr Gordon aims to use novel biological models, biochemical assays and imaging techniques to better understand vessel biology, which will enable improved treatment of disease and aid in the development of vascularised, bioengineered organs.

Dr Gordon received her Bachelor of Science (2005) and PhD (2011) from The University of Adelaide, after which she undertook six years of postdoctoral studies at Yale University in the USA and Uppsala University in Sweden. With the support of an ARC DECRA Fellowship, Dr Gordon relocated to IMB in 2017 to establish her independent research career as an IMB Fellow. In 2019, she was appointed as Group Leader of the Vessel Dynamics Laboratory.

Qualifications

  • Doctor of Philosophy, The University of Adelaide

Publications

  • Englert, Hanna, Rangaswamy, Chandini, Deppermann, Carsten, Sperhake, Jan-Peter, Krisp, Christoph, Schreier, Danny, Gordon, Emma, Konrath, Sandra, Haddad, Munif, Pula, Giordano, Mailer, Reiner K, Schlüter, Hartmut, Kluge, Stefan, Langer, Florian, Püschel, Klaus, Panousis, Kosta, Stavrou, Evi X, Maas, Coen, Renné, Thomas and Frye, Maike (2021). Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine, 67 103382, 103382. doi: 10.1016/j.ebiom.2021.103382

  • Vion, Anne-Clémence, Perovic, Tijana, Petit, Charlie, Hollfinger, Irene, Bartels-Klein, Eireen, Frampton, Emmanuelle, Gordon, Emma, Claesson-Welsh, Lena and Gerhardt, Holger (2021). Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways. Frontiers in Physiology, 11 623769, 623769. doi: 10.3389/fphys.2020.623769

  • Karunakaran, Denuja, Nguyen, My-Anh, Geoffrion, Michele, Vreeken, Dianne, Lister, Zachary, Cheng, Henry S., Otte, Nicola, Essebier, Patricia, Wyatt, Hailey, Kandiah, Joshua W., Jung, Richard, Alenghat, Francis J., Mompeon, Ana, Lee, Richard, Pan, Calvin, Gordon, Emma, Rasheed, Adil, Lusis, Aldons J., Liu, Peter, Matic, Ljubica Perisic, Hedin, Ulf, Fish, Jason E., Guo, Liang, Kolodgie, Frank, Virmani, Renu, van Gils, Janine M. and Rayner, Katey J. (2021). RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-κB activation and atherogenesis in mice. Circulation, 143 (2) CIRCULATIONAHA.118.038379, 163-177. doi: 10.1161/CIRCULATIONAHA.118.038379

View all Publications

Supervision

  • Master Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Master Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor