Journal Article: The delivery and activation of growth factors using nanomaterials for bone repair
Li, Yiwei, Xu, Chun and Lei, Chang (2023). The delivery and activation of growth factors using nanomaterials for bone repair. Pharmaceutics, 15 (3) 1017, 1-24. doi: 10.3390/pharmaceutics15031017
Journal Article: Enabling two-electron redox chemistry of P-type organic cathode for high-capacity aluminium-ion batteries
Kong, Yueqi, Tang, Cheng, Lei, Chang, Nanjundan, Ashok K., Chen, Shuimei, Ahmed, Nashaat, Rakov, Dmitrii, Du, Aijun, Huang, Xiaodan and Yu, Chengzhong (2022). Enabling two-electron redox chemistry of P-type organic cathode for high-capacity aluminium-ion batteries. Nano Energy, 102 107727, 1-8. doi: 10.1016/j.nanoen.2022.107727
Journal Article: A comparative study of mesoporous silica and mesoporous bioactive glass nanoparticles as non-viral microRNA vectors for osteogenesis
Hosseinpour, Sepanta, Gomez-Cerezo, Maria Natividad, Cao, Yuxue, Lei, Chang, Dai, Huan, Walsh, Laurence J., Ivanovski, Saso and Xu, Chun (2022). A comparative study of mesoporous silica and mesoporous bioactive glass nanoparticles as non-viral microRNA vectors for osteogenesis. Pharmaceutics, 14 (11) 2302, 1-19. doi: 10.3390/pharmaceutics14112302
Next Generation Mass Spectrometry for Single-Cell Metabolomics
(2024–2026) ARC Discovery Early Career Researcher Award
Nano delivery system for guided dental stem cell differentiation
(2022) Australian Dental Research Fund Inc
(2020) Australian Dental Research Fund Inc
Promoting periodontal regeneration through 3D printed nano-engineered membrane delivering lithium and VEGF
Doctor Philosophy
Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment
(2022) Doctor Philosophy
Nanoparticle-Assisted Signal-Enhancement Technique for Lateral Flow Immunoassays
(2022) Doctor Philosophy
A Nano-platform for Affordable and Ultra-sensitive Bio-marker Detection
Biomolecules with clinical significance are most often various forms of proteins or peptides at very low concentrations in biological systems. Quantitative analysis of them is a big challenge due to the complexity of bio-samples, but essential for diagnosis and clinical applications. In this project, we focus on developing novel approaches for the sensitive detection of trace amount biomolecules using state-of-the-art nanotechnology. This project involves preparation and characterisation of porous nanomaterials, biomolecules detection and disease diagnosis. Students involved in this project will have opportunities to publish research articles with high impact.
Silica bio-nanomaterials assisted stem cell differentiation for bone repair
Bone defects, caused by infections, tumours, traumas, or congenial deformity, usually needs surgical interference and to be repaired with bone grafts or biomaterials. The traditional bone repair strategies usually have slow regeneration rate due to the poor cell adhesion and poor differentiation induction capacity of bone repair materials. This project aims to develop novel biomaterials to promote the differentiation of bone marrow stem cell for bone regeneration. Nanomaterials with functional compositions and porous nanostructures will be fabricated. Their cellular internalisation process and the resulted bone regeneration efficiency will be evaluated. On completion of this project, a next generation of biomaterial with high bone repair efficiency will be developed and the in-depth understanding on the interaction between nanomaterial and stem cell differentiation will be revealed.
Nanobiomaterials in craniofacial bone regeneration
Hosseinpour, Sepanta, Nanda, Ashwin, Lei, Chang, Lowe, Baboucarr, Ye, Qingsong and Xu, Chun (2021). Nanobiomaterials in craniofacial bone regeneration. Advances in Dental Implantology using Nanomaterials and Allied Technology Applications. (pp. 25-52) edited by Ramesh S. Chaughule and Rajesh Dashaputra. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-52207-0_2
Tooth bioengineering and whole tooth regeneration
Cheng, Ning, Wen, Juan, Hitching, Rita, Lei, Chang and Xu, Chun (2021). Tooth bioengineering and whole tooth regeneration. Regenerative approaches in dentistry: an evidence-based perspective. (pp. 89-102) edited by Sepanta Hosseinpour, Laurence J. Walsh and Keyvan Moharamzadeh. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-59809-9_5
The delivery and activation of growth factors using nanomaterials for bone repair
Li, Yiwei, Xu, Chun and Lei, Chang (2023). The delivery and activation of growth factors using nanomaterials for bone repair. Pharmaceutics, 15 (3) 1017, 1-24. doi: 10.3390/pharmaceutics15031017
Kong, Yueqi, Tang, Cheng, Lei, Chang, Nanjundan, Ashok K., Chen, Shuimei, Ahmed, Nashaat, Rakov, Dmitrii, Du, Aijun, Huang, Xiaodan and Yu, Chengzhong (2022). Enabling two-electron redox chemistry of P-type organic cathode for high-capacity aluminium-ion batteries. Nano Energy, 102 107727, 1-8. doi: 10.1016/j.nanoen.2022.107727
Hosseinpour, Sepanta, Gomez-Cerezo, Maria Natividad, Cao, Yuxue, Lei, Chang, Dai, Huan, Walsh, Laurence J., Ivanovski, Saso and Xu, Chun (2022). A comparative study of mesoporous silica and mesoporous bioactive glass nanoparticles as non-viral microRNA vectors for osteogenesis. Pharmaceutics, 14 (11) 2302, 1-19. doi: 10.3390/pharmaceutics14112302
Nanotechnology for the management of COVID-19 during the pandemic and in the post-pandemic era
Xu, Chun, Lei, Chang, Hosseinpour, Sepanta, Ivanovski, Saso, Walsh, Laurence J. and Khademhosseini, Ali (2022). Nanotechnology for the management of COVID-19 during the pandemic and in the post-pandemic era. National Science Review, 9 (10) nwac124, 1-13. doi: 10.1093/nsr/nwac124
Recent advances in silica-nanomaterial-assisted lateral flow assay
Zhuang, Han, Xu, Chun, Gao, Fang, Li, Yiwei, Lei, Chang and Yu, Chengzhong (2022). Recent advances in silica-nanomaterial-assisted lateral flow assay. Bioengineering, 9 (7) 266, 266. doi: 10.3390/bioengineering9070266
Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie International Edition, 61 (12) e202112752, 1-22. doi: 10.1002/anie.202112752
Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie, 134 (12) e202112752, 1-22. doi: 10.1002/ange.202112752
Gao, Fang, Liu, Chao, Yao, Yining, Lei, Chang, Li, Shumin, Yuan, Ling, Song, Hao, Yang, Yannan, Wan, Jingjing and Yu, Chengzhong (2022). Quantum dots’ size matters for balancing their quantity and quality in label materials to improve lateral flow immunoassay performance for C-Reactive protein determination. Biosensors and Bioelectronics, 199 113892, 113892. doi: 10.1016/j.bios.2021.113892
Cao, Yuxue, Xu, Chun, Wright, Patricia P., Liu, Jingyu, Kong, Yueqi, Wang, Yue, Huang, Xiaodan, Song, Hao, Fu, Jianye, Gao, Fang, Liu, Yang, Walsh, Laurence J. and Lei, Chang (2021). Calcium-doped silica nanoparticles mixed with phosphate-doped silica nanoparticles for rapid and stable occlusion of dentin tubules. ACS Applied Nano Materials, 4 (9) acsanm.1c01365, 8761-8769. doi: 10.1021/acsanm.1c01365
Gao, Fang, Lei, Chang, Liu, Yang, Song, Hao, Kong, Yueqi, Wan, Jingjing and Yu, Chengzhong (2021). Rational design of dendritic mesoporous silica nanoparticles’ surface chemistry for quantum dot enrichment and an ultrasensitive lateral flow immunoassay. ACS Applied Materials and Interfaces, 13 (18) acsami.1c02149, 21507-21515. doi: 10.1021/acsami.1c02149
Gao, Fang, Liu, Yang, Lei, Chang, Liu, Chao, Song, Hao, Gu, Zhengying, Jiang, Pei, Jing, Sheng, Wan, Jingjing and Yu, Chengzhong (2021). The role of dendritic mesoporous silica nanoparticles' size for quantum dots enrichment and lateral flow immunoassay performance. Small Methods, 5 (4) 2000924, e2000924. doi: 10.1002/smtd.202000924
Lei, Chang, Cao, Yuxue, Hosseinpour, Sepanta, Gao, Fang, Liu, Jingyu, Fu, Jianye, Staples, Reuben, Ivanovski, Saso and Xu, Chun (2021). Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo. Nano Research, 14 (3), 770-777. doi: 10.1007/s12274-020-3112-2
Tang, Jie, Meka, Anand Kumar, Theivendran, Shevanuja, Wang, Yue, Yang, Yannan, Song, Hao, Fu, Jianye, Ban, Wenhuang, Gu, Zhengying, Lei, Chang, Li, Shumin and Yu, Chengzhong (2020). Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation. Angewandte Chemie International Edition, 59 (49) anie.202001469, 22054-22062. doi: 10.1002/anie.202001469
Xu, Chun, Cao, Yuxue, Lei, Chang, Li, Zhihao, Kumeria, Tushar, Meka, Anand Kumar, Xu, Jia, Liu, Jingyu, Yan, Cheng, Luo, Lihua, Khademhosseini, Ali, Popat, Amirali, He, Yan and Ye, Qingsong (2020). Polymer-mesoporous silica nanoparticle core-shell nanofibers as a dual-drug-delivery system for guided tissue regeneration. ACS Applied Nano Materials, 3 (2), 1457-1467. doi: 10.1021/acsanm.9b02298
Tasia, Winda, Lei, Chang, Cao, Yuxue, Ye, Qingsong, He, Yan and Xu, Chun (2020). Enhanced eradication of bacterial biofilms with DNase I-loaded silver-doped mesoporous silica nanoparticles. Nanoscale, 12 (4), 2328-2332. doi: 10.1039/c9nr08467c
Xu, Chun, Xiao, Lan, Cao, Yuxue, He, Yan, Lei, Chang, Xiao, Yin, Sun, Wujin, Ahadian, Samad, Zhou, Xueting, Khademhosseini, Ali and Ye, Qingsong (2020). Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration. Nano Research, 13 (9), 2323-2331. doi: 10.1007/s12274-020-2783-z
Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment
Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g
Kalantari, Mohammad, Gu, Zhengying, Cao, Yuxue, Lei, Chang and Zhang, Jun (2020). Thiolated silica nanoadsorbents enable ultrahigh and fast decontamination of mercury(ii): understanding the contribution of thiol moieties' density and accessibility on adsorption performance. Environmental Science: Nano, 7 (3), 851-860. doi: 10.1039/c9en01123d
Li, Huimin, Guo, Huilin, Lei, Chang, Liu, Li, Xu, Liqin, Feng, Yaping, Ke, Jin, Fang, Wei, Song, Hao, Xu, Chun, Yu, Chengzhong and Long, Xing (2019). Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Advanced Materials, 31 (46) 1904535, 1904535. doi: 10.1002/adma.201904535
Kalantari, Mohammad, Ghosh, Trisha, Liu, Yang, Zhang, Jun, Zou, Jin, Lei, Chang and Yu, Chengzhong (2019). Highly thiolated dendritic mesoporous silica nanoparticles with high-content gold as nanozymes: the nano-gold size matters. ACS Applied Materials and Interfaces, 11 (14) acsami.9b01527, 13264-13272. doi: 10.1021/acsami.9b01527
Mesoporous silica nanoparticles for protein protection and delivery
Xu, Chun, Lei, Chang and Yu, Chengzhong (2019). Mesoporous silica nanoparticles for protein protection and delivery. Frontiers in Chemistry, 7 (APR) 290, 290. doi: 10.3389/fchem.2019.00290
Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 130 (36), 11938-11943. doi: 10.1002/ange.201807595
Hybrid nanoreactors enable an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy
Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors enable an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 57 (36), 11764-11769. doi: 10.1002/anie.201807595
Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy
Yang, Yannan, Lu, Yao, Abbaraju, Prasanna Lakshmi, Azimi, Iman, Lei, Chang, Tang, Jie, Jambhrunkar, Manasi, Fu, Jianye, Zhang, Min, Liu, Yang, Liu, Chao and Yu, Chengzhong (2018). Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy. Advanced Functional Materials, 28 (28) 1800706, 1800706. doi: 10.1002/adfm.201800706
Zhang, Jun, Zhang, Long, Lei, Chang, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2018). A concentration-dependent insulin immobilization behavior of alkyl-modified silica vesicles: the impact of alkyl chain length. Langmuir, 34 (17), 5011-5019. doi: 10.1021/acs.langmuir.8b00377
Double-layered microsphere based dual growth factor delivery system for guided bone regeneration
Xu, Chun, Xu, Jia, Xiao, Lan, Li, Zhihao, Xiao, Yin, Dargusch, Matthew, Lei, Chang, He, Yan and Ye, Qingsong (2018). Double-layered microsphere based dual growth factor delivery system for guided bone regeneration. RSC Advances, 8 (30), 16503-16512. doi: 10.1039/c8ra02072h
Xu, Chun, Lei, Chang, Huang, Lili, Zhang, Jun, Zhang, Hongwei, Song, Hao, Yu, Meihua, Wu, Yeda, Chen, Chen and Yu, Chengzhong (2017). Glucose-responsive nanosystem mimicking the physiological insulin secretion via an enzyme-polymer layer-by-layer coating strategy. Chemistry of Materials, 29 (18), 7725-7732. doi: 10.1021/acs.chemmater.7b01804
Dendritic mesoporous silica-titania nanospheres with enhanced photocatalytic activities
Lin, Chun Xiang Cynthia, Xu, Chun, Yang, Yannan, Lei, Chang, Zhang, Haijiao and Yu, Chengzhong (2017). Dendritic mesoporous silica-titania nanospheres with enhanced photocatalytic activities. New Journal of Chemistry, 41 (17), 8754-8760. doi: 10.1039/c7nj00713b
Sa, Yue, Feng, Xiaowei, Lei, Chang, Yu, Yan, Jiang, Tao and Wang, Yining (2017). Evaluation of the effectiveness of micro-Raman spectroscopy in monitoring the mineral contents change of human enamel in vitro. Lasers in Medical Science, 32 (5), 985-991. doi: 10.1007/s10103-017-2197-7
Binder-free TiO2 monolith-packed pipette tips for the enrichment of phosphorylated peptides
Lei, Chang, Zhou, Liang, Xu, Chun, Sun, Xiaoran, Nouwens, Amanda and Yu, Chengzhong (2016). Binder-free TiO2 monolith-packed pipette tips for the enrichment of phosphorylated peptides. Australian Journal of Chemistry, 69 (12), 1396-1401. doi: 10.1071/CH16443
Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles
Lei, Chang, Xu, Chun, Nouwens, Amanda and Yu, Chengzhong (2016). Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles. Journal of Materials Chemistry B, 4 (29), 4975-4979. doi: 10.1039/c6tb01023g
Xu, Chun, Yu, Meihua, Noonan, Owen, Zhang, Jun, Song, Hao, Zhang, Hongwei, Lei, Chang, Niu, Yuting, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2015). Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery. Small, 11 (44), 5949-5955. doi: 10.1002/smll.201501449
Lei, Chang, Xu, Chun, Noonan, Owen, Meka, Anand Kumar, Zhang, Long, Nouwens, Amanda and Yu, Chengzhong (2015). Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum. Chemical Communications, 51 (71), 13642-13645. doi: 10.1039/c5cc04458h
Sensitive detection of human insulin using a designed combined pore approach
Lei, Chang, Noonan, Owen, Jambhrunkar, Siddharth, Qian, Kun, Xu, Chun, Zhang, Jun, Nouwens, Amanda and Yu, Chengzhong (2014). Sensitive detection of human insulin using a designed combined pore approach. Small, 10 (12), 2413-2418. doi: 10.1002/smll.201303748
A combo-pore approach for the programmable extraction of peptides/proteins
Qian, Kun, Zhou, Liang, Zhang, Jun, Lei, Chang and Yu, Chengzhong (2014). A combo-pore approach for the programmable extraction of peptides/proteins. Nanoscale, 6 (10), 5121-5125. doi: 10.1039/c4nr00633j
Applications of nanomaterials in mass spectrometry analysis
Lei, Chang, Qian, Kun, Noonan, Owen, Nouwens, Amanda and Yu, Chengzhong (2013). Applications of nanomaterials in mass spectrometry analysis. Nanoscale, 5 (24), 12033-12042. doi: 10.1039/c3nr04194h
Chitosan as a barrier membrane material in periodontal tissue regeneration
Xu, Chun, Lei, Chang, Meng, Liuyan, Wang, Changning and Song, Yaling (2012). Chitosan as a barrier membrane material in periodontal tissue regeneration. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100 B (5), 1435-1443. doi: 10.1002/jbm.b.32662
Sa, Yue, Wang, Zhejun, Ma, Xiao, Lei, Chang, Hang, Shanshan, Sun, Lili, Jiang, Tao and Wang, Yining (2012). Investigation of three home-applied bleaching agents on enamel structure and mechanical properties: an in situ study. Journal of Biomedical Optics, 17 (3) 035002, 035002. doi: 10.1117/1.JBO.17.3.035002
Nanomaterial-based sensitive detection of biomolecules
Lei, Chang (2016). Nanomaterial-based sensitive detection of biomolecules. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2016.657
Next Generation Mass Spectrometry for Single-Cell Metabolomics
(2024–2026) ARC Discovery Early Career Researcher Award
Nano delivery system for guided dental stem cell differentiation
(2022) Australian Dental Research Fund Inc
(2020) Australian Dental Research Fund Inc
(2019–2021) Advance Queensland Women's Research Assistance Program
(2019–2020) UQ Amplify Women's Academic Research Equity
Nano-lateral flow assays for Rapid and Ultra-sensitive Influenza Detection
(2017–2021) Advance Queensland Research Fellowships
Promoting periodontal regeneration through 3D printed nano-engineered membrane delivering lithium and VEGF
Doctor Philosophy — Associate Advisor
Other advisors:
Development of Novel Bioinformatics Methods for Single Cell Sequencing Data
Doctor Philosophy — Associate Advisor
Other advisors:
Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment
(2022) Doctor Philosophy — Associate Advisor
Other advisors:
Nanoparticle-Assisted Signal-Enhancement Technique for Lateral Flow Immunoassays
(2022) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
A Nano-platform for Affordable and Ultra-sensitive Bio-marker Detection
Biomolecules with clinical significance are most often various forms of proteins or peptides at very low concentrations in biological systems. Quantitative analysis of them is a big challenge due to the complexity of bio-samples, but essential for diagnosis and clinical applications. In this project, we focus on developing novel approaches for the sensitive detection of trace amount biomolecules using state-of-the-art nanotechnology. This project involves preparation and characterisation of porous nanomaterials, biomolecules detection and disease diagnosis. Students involved in this project will have opportunities to publish research articles with high impact.
Silica bio-nanomaterials assisted stem cell differentiation for bone repair
Bone defects, caused by infections, tumours, traumas, or congenial deformity, usually needs surgical interference and to be repaired with bone grafts or biomaterials. The traditional bone repair strategies usually have slow regeneration rate due to the poor cell adhesion and poor differentiation induction capacity of bone repair materials. This project aims to develop novel biomaterials to promote the differentiation of bone marrow stem cell for bone regeneration. Nanomaterials with functional compositions and porous nanostructures will be fabricated. Their cellular internalisation process and the resulted bone regeneration efficiency will be evaluated. On completion of this project, a next generation of biomaterial with high bone repair efficiency will be developed and the in-depth understanding on the interaction between nanomaterial and stem cell differentiation will be revealed.