Dr Chang Lei

UQ Amplify Researcher

Australian Institute for Bioengineering and Nanotechnology
c.lei1@uq.edu.au
+61 7 334 63823

Overview

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Masters, Wuhan University
  • Bachelor of Stomatology, Wuhan University

Publications

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Grants

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Supervision

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Available Projects

  • Biomolecules with clinical significance are most often various forms of proteins or peptides at very low concentrations in biological systems. Quantitative analysis of them is a big challenge due to the complexity of bio-samples, but essential for diagnosis and clinical applications. In this project, we focus on developing novel approaches for the sensitive detection of trace amount biomolecules using state-of-the-art nanotechnology. This project involves preparation and characterisation of porous nanomaterials, biomolecules detection and disease diagnosis. Students involved in this project will have opportunities to publish research articles with high impact.

  • Bone defects, caused by infections, tumours, traumas, or congenial deformity, usually needs surgical interference and to be repaired with bone grafts or biomaterials. The traditional bone repair strategies usually have slow regeneration rate due to the poor cell adhesion and poor differentiation induction capacity of bone repair materials. This project aims to develop novel biomaterials to promote the differentiation of bone marrow stem cell for bone regeneration. Nanomaterials with functional compositions and porous nanostructures will be fabricated. Their cellular internalisation process and the resulted bone regeneration efficiency will be evaluated. On completion of this project, a next generation of biomaterial with high bone repair efficiency will be developed and the in-depth understanding on the interaction between nanomaterial and stem cell differentiation will be revealed.

View all Available Projects

Publications

Book Chapter

  • Hosseinpour, Sepanta, Nanda, Ashwin, Lei, Chang, Lowe, Baboucarr, Ye, Qingsong and Xu, Chun (2021). Nanobiomaterials in craniofacial bone regeneration. Advances in Dental Implantology using Nanomaterials and Allied Technology Applications. (pp. 25-52) edited by Ramesh S. Chaughule and Rajesh Dashaputra. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-52207-0_2

  • Cheng, Ning, Wen, Juan, Hitching, Rita, Lei, Chang and Xu, Chun (2021). Tooth bioengineering and whole tooth regeneration. Regenerative Approaches in Dentistry. (pp. 89-102) Cham, Switzerland: Springer. doi: 10.1007/978-3-030-59809-9_5

Journal Article

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Biomolecules with clinical significance are most often various forms of proteins or peptides at very low concentrations in biological systems. Quantitative analysis of them is a big challenge due to the complexity of bio-samples, but essential for diagnosis and clinical applications. In this project, we focus on developing novel approaches for the sensitive detection of trace amount biomolecules using state-of-the-art nanotechnology. This project involves preparation and characterisation of porous nanomaterials, biomolecules detection and disease diagnosis. Students involved in this project will have opportunities to publish research articles with high impact.

  • Bone defects, caused by infections, tumours, traumas, or congenial deformity, usually needs surgical interference and to be repaired with bone grafts or biomaterials. The traditional bone repair strategies usually have slow regeneration rate due to the poor cell adhesion and poor differentiation induction capacity of bone repair materials. This project aims to develop novel biomaterials to promote the differentiation of bone marrow stem cell for bone regeneration. Nanomaterials with functional compositions and porous nanostructures will be fabricated. Their cellular internalisation process and the resulted bone regeneration efficiency will be evaluated. On completion of this project, a next generation of biomaterial with high bone repair efficiency will be developed and the in-depth understanding on the interaction between nanomaterial and stem cell differentiation will be revealed.