Professor Chen Chen

Dir, Internat/Prof Endocrinology

School of Biomedical Sciences
Faculty of Medicine
chen.chen@uq.edu.au
+61 7 336 53856

Overview

Prevention and treatment of diabetes, obesity, heart diseases, and cancers.

M.B.B.S. from Shanghai Fudan University Medical School, M.D. from Peking Union Medical College, China, and Ph.D. from the University of Bordeaux, France. Postdoctoral training was received at Glaxo Inc., USA, and then many years of research leadership at Prince Henry's Institute of Medical Research (now Hudson Institute of Medical Research) in Melbourne. The current position was taken in 2008. Professor Chen is an FQS (Fellow of Queensland Academy of Arts and Sciences).

Research Interests

  • Endocrine Cell Biology
    The Endocrinology laboratory focuses on the link between cell biological properties and functions. Functions of cells may be the secretion of hormones in endocrine cells, contraction, and dilation of cardiomyocytes, or proliferation and apoptosis of cancer cells. We concentrate on hormones, which are important in controlling growth, development, metabolic balance, body mass composition, aging process, and the plasma glucose levels, such as growth hormone, leptin, orexin, insulin, glucagon, ghrelin, LEAP2, etc. Several endogenous and synthetic regulatory peptides have been tested for their regulatory roles in pituitary and pancreatic islet endocrine cells on the membrane ion channel kinetics, exocytosis/endocytosis, key molecule expression and synthesis, receptor expression, and metabolism. The long-term goal of these researches is to find an effective way to therapeutically treat obesity, diabetes, and alcohol use disorders. In addition, the possible paracrine or autocrine effect of a newly discovered hormone system, Ghrelin-LEAP2-GHSR, in the regulation of growth hormone profiles, metabolism, and alcohol addiction, is under investigation in Chen's laboratory. We also investigate the function of cardiomyocytes in chronic heart failure, atrial fibrillation, ischemic cardiomyopathy, and diabetic cardiomyopathy. The laboratory is using cutting-edge techniques in single-cell research, including patch clamping, single-cell exocytosis measurement, cell image analysis, single-cell shortening (contraction), and super-sensitive hormone assay methods. Modern molecular biology techniques are also employed in the laboratory for different projects, including GFP-transgenic mouse, shRNA-gene knockdown using virus transfection, transgenic mouse lines, and real-time PCR.

Research Impacts

Over 295 peer-reviewed publications in peer-reviewed International Medical, Biomedical, and Scientific journals.

Qualifications

  • Bachelor in Medicine and Surgery, Fudan University
  • Doctor in NeuroSciences and Pharmacology, University of Bordeaux II

Publications

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Grants

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Huang, Lili, Huang, Zhengxiang, Chen, Yang and Chen, Chen (2020). Neuroendocrine and metabolic regulation of plasma growth hormone secretory profiles. Neurosecretion: secretory mechanisms. (pp. 195-218) edited by Jose R. Lemos, Govindan Dayanithi. Cham, Switzerland: Springer Nature Switzerland. doi: 10.1007/978-3-030-22989-4_10

  • Steyn, Frederik J. and Chen, Chen (2013). Adiponectin. Handbook of biologically active peptides. (pp. 983-989) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00130-5

  • Fung, Jenny N.T. and Chen, Chen (2012). Endometrial cancer: diagnosis, treatment and prevention. Horizons in cancer research. Volume 49. (pp. 1-32) edited by Hiroto S. Watanabe. Hauppauge, NY, USA: Nova Publishers.

  • Zhao, Yufeng and Chen, Chen (2011). Adipsin as an adipokine. Adipokines. (pp. 20-28) edited by Victor R. Preedy and Ross J. Hunter. Enfield, NH, United States: Science Publishers.

  • Chen, Chen (2002). Cell biology and membrane function. Textbook of Medical Physiology. (pp. 7-26) China: People's Health Press.

  • Chen, Chen and Clarke, Iain J. (1999). Intracellular GHRP signalling. Growth hormone secretagogues: basic findings and clinical implications. (pp. 53-63) edited by E. Ghigo, M. Boghen, F. F. Casanueva and C. Dieguez. Amsterdam, The Netherlands: Elsevier.

  • Chen, Chen (1998). Introduction of a new laboratory technique to investigate roles of intracellular signal pathways in the regulation of cell membrane ion channels. Proceedings of Chinese Academy of Medical Sciences. (pp. 1-26) Beijing, China: Peking Union Medical College and Chinese Academy of Medical Sciences.

  • Lledo, Pierre-Marie, Kukstas, Lucy A., Chen, Chen, Vincent, Jean-Didier and Israel, Jean-Marc (1990). Ionic currents in the regulation of stimulus-secretion coupling in normal and tumoral adenohypophyseal cells. Recent advances in basic and clinical neuroendocrinology. (pp. 65-74) edited by F. F. Casanueva and C. Dieguez. Amsterdam, The Netherlands: Elsevier Science Publishers.

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

Completed Supervision