Dr Seth Cheetham

Technology and Innovation Scientist

Australian Institute for Bioengineering and Nanotechnology

Honorary Research Fellow

Mater Research Institute-UQ
Faculty of Medicine

Overview

Dr Seth Cheetham is a NHMRC Early Career Fellow and holds a Career Track Fellow position at Mater Research Institute-University of Queensland. After his Bachelor of Science (Hons) at the University of Queensland, he completed his PhD at the University of Cambridge, supported by the Herchel Smith Research Studentship. He joined Mater Research in 2017 and is based at the Translational Research Institute. Seth is a molecular biologist and geneticist with a focus on epigenetics and RNA biology. He has a long-term interest in the functions of the so-called ‘junk’ DNA—noncoding DNA regions scattered throughout the genome with no obvious function— and its role in human biology. Seth leads a team within the Genome Plasticity and Disease group, where he is primary supervisor of two PhD students and is associate supervisor of one. He has authored 16 publications, including eight as a first author and three as a corresponding author. He has published in some of the most influential molecular biology journals including Science, Molecular Cell, Nature Reviews Genetics , Genome Biology and Nature Structural and Molecular Biology. His work has attracted > $1M in funding from an NHMRC Fellowship (2019), a Cancer Australia Grant (2021), Mater Foundation seeding grant (2019), a UQ ECR grant (2019) and the UQ Genome Innovation Hub (2020). In 2021 Seth was award the Genetics Society of Australasia Alan Wilton ECR award for his research in the field of noncoding RNA and epigenetics.

Publications

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Grants

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

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Available Projects

  • In cancer, but not healthy cells, ~100 L1 “jumping genes” can copy and paste themselves into the human genome. L1s can contribute to cancer initiation by activating oncogenes and inactivating tumour suppressor genes and can drive tumour evolution, underpinning resistance to chemotherapy. This project aims to determine the cause of L1 activation in cancer. This project will identify novel factors that regulate L1 expression in cancer, transforming our understanding of the mechanism of L1 activation. As L1 expression is highly correlated with cancer severity, these factors may hold important prognostic and diagnostic value.

View all Available Projects

Publications

Featured Publications

Book Chapter

  • Cheetham, Seth W. and Brand, Andrea H. (2020). Mapping RNA-Chromatin interactions in vivo with RNA-DamID. RNA-Chromatin Interactions. (pp. 255-264) edited by Ulf Andersson Vang Ørom. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0680-3_18

Journal Article

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • In cancer, but not healthy cells, ~100 L1 “jumping genes” can copy and paste themselves into the human genome. L1s can contribute to cancer initiation by activating oncogenes and inactivating tumour suppressor genes and can drive tumour evolution, underpinning resistance to chemotherapy. This project aims to determine the cause of L1 activation in cancer. This project will identify novel factors that regulate L1 expression in cancer, transforming our understanding of the mechanism of L1 activation. As L1 expression is highly correlated with cancer severity, these factors may hold important prognostic and diagnostic value.